Article
Clinical Neurology
Chiara Vantaggiato, Genny Orso, Giulia Guarato, Francesca Brivio, Barbara Napoli, Elena Panzeri, Simona Masotti, Filippo Maria Santorelli, Maria Lamprou, Sentiljana Gumeni, Emilio Clementi, Maria Teresa Bassi
Summary: SPG15 is a hereditary spastic paraplegia subtype caused by mutations in the ZFYVE26 gene. Mutations in this gene lead to defects in autophagic lysosome reformation, resulting in symptoms such as enlarged lysosomes and accumulation of autophagosomes. Currently, the only available treatments are symptomatic and rehabilitative therapies.
Article
Gastroenterology & Hepatology
Mirco Glitscher, David Heiler Martin, Kathrin Woytinek, Benjamin Schmidt, Denna Tabari, Catharina Scholl, Julia C. Stingl, Evelyn Seelow, Mira Choi, Eberhard Hildt
Summary: The study found that HEV infection leads to decreased cellular cholesterol levels and affects lipid concentrations in patients. Modulating intracellular cholesterol content through drug treatment can impact HEV release, with cholesterol playing a crucial role in this process. This highlights the potential of targeting cholesterol metabolism as an antiviral strategy against HEV.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Health Care Sciences & Services
Lars Hammarstrom, Ove Hellzen, Siri Andreassen Devik
Summary: This study aimed to describe the phenomenon of fleeing the encounter when facing resistance experienced by carers in forensic inpatient care. The findings revealed that carers alternated between primitive instincts and expectant empathy to gain control and deal with the interaction, influenced by their self-perception and professional identity.
Article
Plant Sciences
Shan Yin, Wendy Y. Chen, Chunjiang Liu
Summary: Urban forests offer various ecosystem services, with a growing focus on their role in improving public health by reducing mental stress and providing attractive spaces for physical activities, especially in the context of the ongoing COVID-19 pandemic and the urgent need for post-pandemic urban transformation towards healthier cities. This communication summarizes existing empirical evidence on the connection between urban forests and public health maintenance and improvement, highlights three underlying mechanisms (physiological, psychological, and immunological pathways), and outlines practical implications for the establishment and management of urban forests as a strategy for planning healthy cities.
URBAN FORESTRY & URBAN GREENING
(2023)
Article
Business
Ru-Shiun Liou, Leon Faifman, Kimberly Ellis
Summary: The rise of protectionism has led to increased scrutiny of cross-border mergers and acquisitions (CBAs). Based on the legitimacy-based view, heightened protectionism in host countries triggers concerns about legitimacy towards foreign firms and presents a political risk that affects foreign acquirers' ownership strategy in CBAs. Analyzing CBAs over the past decade, it is found that foreign acquirers tend to acquire greater ownership stakes to mitigate the political risk associated with protectionism. Moreover, the bilateral relationships between host and home countries, including economic dependence, political animosity, and social interactions related to migration, have differential moderating effects on legitimacy concerns.
JOURNAL OF BUSINESS RESEARCH
(2023)
Article
Chemistry, Physical
Jianguo Li, Srinivasaraghavan Kannan, Pietro Aronica, Christopher J. Brown, Anthony W. Partridge, Chandra S. Verma
Summary: Cyclic peptides have potential as drug candidates, but predicting their membrane permeability is challenging. Molecular dynamics simulations were used to evaluate parameters for describing membrane permeability of cyclic peptides. Two new descriptors, charge reweighted PSA and non-polar surface area to PSA ratio, showed improved correlation with permeability. Crosslinking of peptide chains may reduce accessible polar surface area and increase permeability, offering a new approach for cyclic peptide drug development.
JOURNAL OF CHEMICAL PHYSICS
(2022)
Review
Biochemistry & Molecular Biology
Wojciech Trybus, Ewa Trybus, Teodora Krol
Summary: Lysosomes are organelles that contain acidic hydrolases and play a crucial role in cellular degradation and homeostasis. They are involved in autophagy and various cell death pathways, including lysosomal and apoptotic death. Compounds such as lysosomotropic compounds, antihistamines, DNA-damaging drugs, and chemotherapeutics can induce lysosomal membrane permeability, promoting lysosomal-mediated cell death. Combining lysosomotropic compounds with autophagy modulators may be a promising approach in cancer treatment and overcoming chemoresistance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Medicinal
Wenbo Yin, Lei Liu, Hong Jiang, Tianxiao Wu, Hengxian Cui, Yuxin Zhang, Zixuan Gao, Yin Sun, Qiaohua Qin, Liyu Zhao, Xin Su, Dongmei Zhao, Maosheng Cheng
Summary: Invasive fungal infections (IFIs) are becoming serious infectious diseases worldwide. Due to the lack of effective antifungal agents and serious drug resistance, the limited efficacy of existing drugs leads to high morbidity and mortality in patients. Researchers optimized compound 7 to obtain a series of new compounds, among which compound 21b showed excellent inhibitory activity against pathogenic and drug-resistant fungi.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Review
Environmental Studies
Benjamin K. Sovacool, Jonn Axsen, Laurence L. Delina, Hilary Schaffer Boudet, Varun Rai, Roman Sidortsov, Sefa Awaworyi Churchill, Kirsten E. H. Jenkins, Ray Galvin
Summary: Peer review is crucial for academic research, but issues such as poor reports, disregarded advice, and process undermining exist. This paper proposes codes of practice for peer review in the energy and social science research community, offering suggestions for reviewers, editors, and authors based on 60 years of editorial experience. The aim is to enhance the effectiveness, meaningfulness, and efficiency of the peer review process.
ENERGY RESEARCH & SOCIAL SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Daoxia Guo, Xiaoyuan Ji, Hui Xie, Jia Ma, Chunchen Xu, Yanfeng Zhou, Nan Chen, Hui Wang, Chunhai Fan, Haiyun Song
Summary: Cancer-associated fibroblasts (CAFs) play a role in chemoresistance and immunosuppression, but direct depletion may lead to increased invasiveness and metastasis. Gemini-like targeting nanoparticles (NPs) have been designed to transform CAFs and eliminate cancer cells, enhancing drug susceptibility and immune cell infiltration. In mouse models of various resistant cancers, a single dose of these NPs resulted in improved chemosensitivity, immune activation, tumor regression, and long-term protection against tumor rechallenge.
ADVANCED MATERIALS
(2023)
Article
Environmental Sciences
Rhys Jones, Papaarangi Reid, Alexandra Macmillan
Summary: Planetary health plays a crucial role in guiding humanity towards a healthy and sustainable future. However, it is important to address the dominant colonial and capitalist ideologies that can perpetuate exploitative power dynamics. This Personal View emphasizes the need for a decolonial vision grounded in Indigenous epistemologies and relational ecocentric norms and values. It identifies key tensions that need to be addressed by planetary health scholars and offers suggestions for a progressive approach towards a decolonial vision of planetary health that recognizes our responsibilities to all relations.
LANCET PLANETARY HEALTH
(2022)
Article
Chemistry, Multidisciplinary
Ruirui Li, Bo Li, Hongpeng Zhang, Cheng-Wei Ju, Ying Qin, Xiao-Song Xue, Dongbing Zhao
Summary: This study presents a novel ring expansion strategy involving the cross-dimerization of different strained rings through synergistic bimetallic catalysis, providing an efficient and scalable method for assembling diverse N-heterocycles. Preliminary mechanistic studies reveal that the C-C bond of strained ring ketones is cleaved by the Pd-0 species during the reaction.
Article
Green & Sustainable Science & Technology
Christopher M. Raymond, Christopher B. Anderson, Simone Athayde, Arild Vatn, Ariane M. Amin, Paola Arias-Arevalo, Michael Christie, Mariana Cantu-Fernandez, Rachelle K. Gould, Austin Himes, Jasper O. Kenter, Dominic Lenzi, Barbara Muraca, Ranjini Murali, Sebastian O'Connor, Unai Pascual, Sonya Sachdeva, Aibek Samakov, Eglee Zent
Summary: Achieving justice and sustainability requires transformative changes and diverse perspectives. An inclusive typology of nature's values can guide decision-making and promote better participation and conflict management.
CURRENT OPINION IN ENVIRONMENTAL SUSTAINABILITY
(2023)
Article
Multidisciplinary Sciences
Saswati Adhikary, Kaustuv Mukherjee, Biswadip Banerji
Summary: The field of biomedical science has made significant advancements in the past decade, particularly in diagnostic tools and fluorescent probes. Synthetic manipulations have allowed the creation of fluorescent molecules with specific functions, which can be targeted to specific organelles such as lysosomes and mitochondria, enabling more accurate and specific disease diagnosis.
SCIENTIFIC REPORTS
(2022)
Review
Pharmacology & Pharmacy
Kai Tang, Shu Wang, Wenshuo Gao, Yihui Song, Bin Yu
Summary: The design of new ligands with high affinity and specificity against the targets of interest is crucial in drug discovery. Cyclization, as a common strategy, allows the identification of new lead compounds by increasing novelty and diversity. This review summarizes the use of cyclization strategy in discovering new small-molecule lead compounds, focusing on four main strategies: fused ring cyclization, chain cyclization, spirocyclization, and macrocyclization. The challenges in synthetic complexity, pharmacokinetics profiles, and rational structure-based cyclization are also discussed.
ACTA PHARMACEUTICA SINICA B
(2022)
Review
Chemistry, Multidisciplinary
Dan He, Yawen Li, Fuwen Zhao, Yuze Lin
Summary: High trap density in organic solar cells leads to localized charge carriers and reduced carrier lifetime, limiting device efficiency. This feature article summarizes the recent advances of trap suppression by material design and device engineering.
CHEMICAL COMMUNICATIONS
(2024)
Review
Chemistry, Multidisciplinary
Olivier Monfort, Arshitha Madhusudhan, Martin Motola
Summary: This article presents the advantages of coupling photocatalysis and Fenton-based processes for environmental remediation and discusses their synergy. It critically examines the simultaneous triggering of these two processes and provides insights into research approaches. The study aims to enhance understanding of this complex process and highlight the potential integration of new catalysts in current wastewater treatment technology.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Manideepa Dhar, Chittaranjan Mishra, Avijit Das, Uttam Manna
Summary: An approach of 'polymerization of monomers in its aggregated form' has been introduced to tailor the water wettability of fibrous and porous substrates, achieving hydrophobicity to superhydrophobicity transition, as well as patterned wettability. This facile chemical method provides a durable coating with adjustable and patterned wettability for various potential applications.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Saswat Ranjan Bhoi, Chhanda Debnath, Shikha Gandhi
Summary: In this article, a novel catalytic reaction using Pd(0) and Bronsted acid is reported for the synthesis of biologically important imidazolidinone-fused N-heterocycles through redox-neutral intramolecular N-allylation of indoles and pyrroles with alkynes. This atom-economical method is applicable to a wide range of substrates and eliminates the need for leaving groups or oxidizing agents commonly used in traditional allylation reactions.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Longkun Chen, Mingshuai Zhang, Meichen Liu, Zhuoyuan Liu, Yuetong Qiu, Zhilai Zhang, Fuchao Yu, Jiuzhong Huang
Summary: In this study, an efficient Rh(III)-catalyzed selective mono- and dual-C-H bond functionalization/cyclization with iodonium ylide as the sole coupling partner was demonstrated. Fused benzodiazepine skeletons were obtained in excellent yields, providing an improved approach to dual C-H unsymmetrical functionalization.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Alice Kennett, Sven Epple, Gabriella van der Valk, Irene Georgiou, Evelyne Gout, Romain R. Vives, Angela J. Russell
Summary: This study presents the design and synthesis of sulfated disaccharide inhibitors based on IdoA(2S)-GlcNS(6S), which showed potent inhibition of Sulf-2. The results suggest that IdoA(2S)-GlcNS(6S) is the shortest fragment size required for effective inhibition of Sulfs, and a trisulfated disaccharide is identified as the minimal fragment size of heparan sulfate for effective endosulfatase inhibition.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Mauro Garbini, Andrea Brunetti, Riccardo Pedrazzani, Magda Monari, Massimo Marcaccio, Giulio Bertuzzi, Marco Bandini
Summary: The self-adaptability of galvanostatic electrolysis was found to be helpful in a multistage chemo- and diastereoselective electrochemically promoted cyclodimerization of chalcones. Through a series of reductive events, densely functionalized cyclopentanes with five contiguous stereocenters were obtained (25 examples, yields up to 95%, dr values up to >20:1). Further experimental and electrochemical investigations indicated the crucial role of dynamic kinetic resolution of the aldol intermediate in the reaction mechanism.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Dhananjay S. Nipate, Neha Meena, Prakash N. Swami, Krishnan Rangan, Anil Kumar
Summary: In this study, the synthesis of functionalized benzo[a]phenazines and indazolo[2,3-a]quinolines was achieved through Rh(III)-catalyzed oxidative annulation of 2-arylquinoxalines and 2-aryl-2H-indazoles with allyl alcohols. The method showed a wide substrate scope, excellent functional group tolerance, good to high yields of annulated products, and the capability for scaled-up synthesis. A tentative mechanism of the annulation reaction was proposed based on a preliminary mechanistic investigation.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Ruonan Zhang, Abudukadi Tudi, Xia Yang, Xuping Wang, Zhihua Yang, Shujuan Han, Shilie Pan
Summary: A new lead tellurium borate material with a unique fundamental building block [B4O10] was synthesized and found to exhibit high birefringence. The structure-property relationship was discussed using first-principles calculations.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Amresh Kumar Singh, Baishali Thakurta, Anupam Giri, Monalisa Pal
Summary: This study introduces three key concepts for the quick synthesis of large-scale high-quality 2D materials films and their utilization in device fabrication.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Reina Hagiwara, Shun Nishimura, Kosuke Okeyoshi
Summary: A copolymer-conjugated nanocatalytic system has been developed to improve electron transfer and enhance photoinduced H2 generation.
CHEMICAL COMMUNICATIONS
(2024)