期刊
CHEMICAL COMMUNICATIONS
卷 54, 期 70, 页码 9817-9820出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8cc05665j
关键词
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A novel supramolecular hybrid material ZIF-8@DOX@WP6@G constructed from the host-guest complexation between carboxylated pillar[6]arene (WP6) and a galactose derivative (G), and doxorubicin (DOX)-loaded ZIF-8 has been synthesized for targeted drug delivery. The results showed that ZIF-8@DOX@WP6@G not only maintained the pH-sensitive drug release properties of ZIF-8 but also exhibited excellent water dispersibility and selective toxicity for hepatoma cancer cells due to the assembly of WP6 and G. The strategy used in this study opens up a new avenue for constructing multifunctional supramolecular hybrid materials for therapeutic applications in cancer treatment.
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