Article
Medicine, Research & Experimental
Chunxi Qian, Bandar Al-Hamyari, Xiaofei Tang, Bo Hou, Shuaibo Yang, Guifang Zhang, Huijuan Lv, Zhigang Yang, Zhaohui Wang, Yanbin Shi
Summary: A biodegradable hollow mesoporous organosilica nanoparticle (HMON)-based nanoplatform for photothermal-enhanced chemotherapy of tumor was successfully fabricated, demonstrating high drug-loading capacity and photothermal properties. The constructed nanosystem showed great potential in combinational antitumor therapy with significant tumor growth suppression under NIR laser irradiation.
MOLECULAR PHARMACEUTICS
(2021)
Article
Chemistry, Applied
Xiaojing Zhang, Yang Meng, Weiwei Shen, Jingcheng Dou, Ruixue Liu, Qingxian Jin, Shaoming Fang
Summary: This study successfully prepared a family of injectable nanocomposite hydrogels through the Schiff base reaction between OCAPS, CS, and HPC, demonstrating good biocompatibility and biodegradability. The addition of OCAPS enhanced the mechanical properties and drug load efficiency of the hydrogels, showing great potential for drug delivery and tissue engineering applications.
REACTIVE & FUNCTIONAL POLYMERS
(2021)
Article
Chemistry, Multidisciplinary
Maryam Neysi, Dawood Elhamifar
Summary: In this study, a novel magnetic ethylene-based periodic mesoporous organosilica supported Pd-Schiff base complex (Fe3O4@PMO/SB-Pd) was synthesized and characterized. It was applied as a recoverable nanocatalyst for green synthesis of Suzuki products under ultrasonic conditions, leading to high yields. The advantages of this study include simple purification of products, the use of water solvent, easy catalyst separation, short reaction time, and high catalyst efficiency and recoverability.
FRONTIERS IN CHEMISTRY
(2023)
Article
Biotechnology & Applied Microbiology
Fangman Chen, Fan Zhang, Yanbin Wang, Jiahui Peng, Lei Cao, Qian Mei, Mingfeng Ge, Li Li, Meiwan Chen, Wen-fei Dong, Zhimin Chang
Summary: In this study, mesoporous organosilica nanoparticles (MON) coated with biomimetic cancer cell membrane were developed for controlled release of cisplatin and reduction inactivation, aiming to enhance platinum-based chemotherapy.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Haolei Shi, Dongxu Ma, Di Wu, Xiao Qiu, Shuai Yang, Yingying Wang, Lei Xiao, Xinyao Ji, Wei Zhang, Shuaiyuan Han, Pengfei Huo, Jidong Dong, Xianzhi Kong, Xue Guan, Dawei Zhang
Summary: A smart hydrogel with pH-responsive, injectable, and self-healing properties was prepared for controlled drug release. The hydrogel demonstrated tunable drug release rate and shape, and showed no cytotoxicity. Animal experiments revealed favorable biodegradability and compatibility of the hydrogel.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Nanoscience & Nanotechnology
Yue Huang, Lingyun Zou, Jing Wang, Qiao Jin, Jian Ji
Summary: This review provides an extensive overview of recent progress in endogenous and exogenous stimuli-responsive nanoplatforms for antibacterial applications. The mechanisms and strategies of designing endogenous stimuli-responsive nanoplatforms using specific infected microenvironments are discussed, with a focus on improving therapeutic efficacy and reducing side effects. Additionally, the use of exogenous stimuli-responsive nanoplatforms, particularly light-responsive nanoparticles, for controlled drug delivery is highlighted.
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
(2022)
Article
Materials Science, Multidisciplinary
Jun-Lan Yang, Hou-Qun Yuan, Bao-Sheng Liu, Jia-Xin He, Qing Fan, Ke Deng, Deping Song, Guang-Ming Bao
Summary: In this study, pH-responsive enrofloxacin nanoparticles (ENR-NPs) were fabricated by amphiphilic functionalization of chitosan (CS) through acid-labile Schiff-base with cinnamaldehyde and drug encapsulation. The release rate of enrofloxacin from ENR-NPs was significantly faster at pH 5.0 compared to pH 7.4, and antimicrobial effects were improved with increased acidity of the culture medium. ENR-NPs provide a potential application for enrofloxacin in bacterial-response drug delivery.
MATERIALS TODAY COMMUNICATIONS
(2021)
Article
Materials Science, Multidisciplinary
Lei Wang, Xiaoqi Zhao, Shiming Ren, Zheng Hu, Yamei Wang
Summary: Plant-derived preservatives show excellent antifungal effects, but their active ingredients easily leach out. In this study, a pH-responsive preservative delivery system was designed and synthesized to achieve controlled release. The system effectively reduced leaching, extended the service life of wood, and had potential applications for other preservatives.
MATERIALS & DESIGN
(2023)
Article
Nanoscience & Nanotechnology
Li Wan, Yuting Cao, Chen Cheng, Rui Tang, Nianhong Wu, Ying Zhou, Xialin Xiong, Hongye He, Xiaohong Lin, Qinqin Jiang, Xiaoting Wang, Xun Guo, Dong Wang, Haitao Ran, Jianli Ren, Yang Zhou, Zhongqian Hu, Pan Li
Summary: Photothermal therapy (PTT) is a noninvasive technique that uses light to generate heat for tumor thermal ablation. However, current photothermal agents (PTAs) derived from exogenous materials have poor tumor targeting and short circulation time. This study developed a pH-responsive nanoprobe, created by coating cancer cell membranes onto polydopamine (PDA)-CaCO3 nanoparticles (CPCaNPs), for image-guided PTT. The CPCaNPs showed enhanced ultrasonic signals and efficient PTT of primary tumors in the acidic microenvironment. Additionally, combining immune checkpoint pathway blockade significantly inhibited tumor recurrence and metastasis. These biomimetic pH-responsive CPCaNPs show great potential for clinical translation in precise PTT immunotherapy.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Engineering, Biomedical
Dawei Li, Guoke Tang, Hui Yao, Yuqi Zhu, Changgui Shi, Qiang Fu, Fei Yang, Xing Wang
Summary: In response to the global crisis of antibiotic resistance, a new drug delivery system has been developed, which exhibits pH-responsive and programmable drug release behavior, leading to outstanding antibacterial therapy both in vitro and in vivo. The results of this study provide important guidance for the rational design of multifunctional antimicrobial vehicles.
BIOACTIVE MATERIALS
(2022)
Article
Chemistry, Physical
Yiqian Xie, Yuan Xu, Jian Xu
Summary: The study found that the foamability of responsive surfactant systems based on dynamic covalent bonds can be improved by introducing the Pickering effect, which depends on the control of hydrophobicity and aggregation behavior of polymers by the dynamic bonds. Experiments showed that the reversible and responsive foaming in the system is achieved through the continuous formation and breakage of dynamic bonds.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2021)
Article
Chemistry, Applied
Yasar Gok, Osman Tayyar Arli, Halil Zeki Gok, Tugce Turkaslan
Summary: Studying solutions to increase the bioavailability of cancer treatment drugs in the cancerous region is crucial for achieving more effective results in cancer treatment. Mesoporous organosilica nanoparticles, especially when designed according to the drug to be transported, can provide significant advantages. In this study, a pH-responsive mesoporous organosilica nanocarrier functionalized with 2-aminothiophenol (MON-B) was synthesized and characterized for efficient transport and controlled release of curcumin. The results showed that MON-B can transport curcumin at physiological pH without leakage and provide pH-controlled and prolonged release through its acid-labile C=N bond.
JOURNAL OF POROUS MATERIALS
(2023)
Article
Materials Science, Multidisciplinary
Hao Sun, Shen Shen, Liangliang Zhu
Summary: Purely organic room-temperature phosphorescent (RTP) materials are gaining increasing interest due to their long lifetime, persistent luminescence, and potential applications. This review summarizes recent advances in photo-stimuli-responsive organic RTP materials and discusses their tunable properties, design mechanisms, and promising applications. It aims to provide guidance for future development in this field.
ACS MATERIALS LETTERS
(2022)
Review
Pharmacology & Pharmacy
Bharath Singh Padya, Abhijeet Pandey, Muralidhar Pisay, K. B. Koteshwara, Raghu Chandrashekhar Hariharapura, Kuruveri Udaya Bhat, Swati Biswas, Srinivas Mutalik
Summary: Interdisciplinary applications of nanopharmaceutical sciences show great potential in enhancing pharmacokinetics, efficacy, and safety of cancer therapy. Different nanotechnological approaches, including polymeric, lipidic and inorganic nanoplatforms, have been experimented for the treatment of skin cancer. Stimuli-responsive nanoplatforms, surface engineering, conjugation with drugs, and multimodal effects are discussed as strategies for potentiating nanoparticles application for cancer therapy.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Oncology
Jian Song, Bingbing Xu, Hui Yao, Xiaofang Lu, Yang Tan, Bingyang Wang, Xing Wang, Zheng Yang
Summary: The study demonstrated a pH-responsive PEGylated doxorubicin prodrug that could achieve high drug loading and pH-responsive drug release within tumor cells, with good stability. Furthermore, the nanoparticles showed similar cytotoxicity to MCF-7 tumor cells as free DOX drug, and were able to encapsulate small DOX drugs with enhanced therapeutic effects.
FRONTIERS IN ONCOLOGY
(2021)
Review
Chemistry, Multidisciplinary
Dan He, Yawen Li, Fuwen Zhao, Yuze Lin
Summary: High trap density in organic solar cells leads to localized charge carriers and reduced carrier lifetime, limiting device efficiency. This feature article summarizes the recent advances of trap suppression by material design and device engineering.
CHEMICAL COMMUNICATIONS
(2024)
Review
Chemistry, Multidisciplinary
Olivier Monfort, Arshitha Madhusudhan, Martin Motola
Summary: This article presents the advantages of coupling photocatalysis and Fenton-based processes for environmental remediation and discusses their synergy. It critically examines the simultaneous triggering of these two processes and provides insights into research approaches. The study aims to enhance understanding of this complex process and highlight the potential integration of new catalysts in current wastewater treatment technology.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Manideepa Dhar, Chittaranjan Mishra, Avijit Das, Uttam Manna
Summary: An approach of 'polymerization of monomers in its aggregated form' has been introduced to tailor the water wettability of fibrous and porous substrates, achieving hydrophobicity to superhydrophobicity transition, as well as patterned wettability. This facile chemical method provides a durable coating with adjustable and patterned wettability for various potential applications.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Saswat Ranjan Bhoi, Chhanda Debnath, Shikha Gandhi
Summary: In this article, a novel catalytic reaction using Pd(0) and Bronsted acid is reported for the synthesis of biologically important imidazolidinone-fused N-heterocycles through redox-neutral intramolecular N-allylation of indoles and pyrroles with alkynes. This atom-economical method is applicable to a wide range of substrates and eliminates the need for leaving groups or oxidizing agents commonly used in traditional allylation reactions.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Longkun Chen, Mingshuai Zhang, Meichen Liu, Zhuoyuan Liu, Yuetong Qiu, Zhilai Zhang, Fuchao Yu, Jiuzhong Huang
Summary: In this study, an efficient Rh(III)-catalyzed selective mono- and dual-C-H bond functionalization/cyclization with iodonium ylide as the sole coupling partner was demonstrated. Fused benzodiazepine skeletons were obtained in excellent yields, providing an improved approach to dual C-H unsymmetrical functionalization.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Alice Kennett, Sven Epple, Gabriella van der Valk, Irene Georgiou, Evelyne Gout, Romain R. Vives, Angela J. Russell
Summary: This study presents the design and synthesis of sulfated disaccharide inhibitors based on IdoA(2S)-GlcNS(6S), which showed potent inhibition of Sulf-2. The results suggest that IdoA(2S)-GlcNS(6S) is the shortest fragment size required for effective inhibition of Sulfs, and a trisulfated disaccharide is identified as the minimal fragment size of heparan sulfate for effective endosulfatase inhibition.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Mauro Garbini, Andrea Brunetti, Riccardo Pedrazzani, Magda Monari, Massimo Marcaccio, Giulio Bertuzzi, Marco Bandini
Summary: The self-adaptability of galvanostatic electrolysis was found to be helpful in a multistage chemo- and diastereoselective electrochemically promoted cyclodimerization of chalcones. Through a series of reductive events, densely functionalized cyclopentanes with five contiguous stereocenters were obtained (25 examples, yields up to 95%, dr values up to >20:1). Further experimental and electrochemical investigations indicated the crucial role of dynamic kinetic resolution of the aldol intermediate in the reaction mechanism.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Dhananjay S. Nipate, Neha Meena, Prakash N. Swami, Krishnan Rangan, Anil Kumar
Summary: In this study, the synthesis of functionalized benzo[a]phenazines and indazolo[2,3-a]quinolines was achieved through Rh(III)-catalyzed oxidative annulation of 2-arylquinoxalines and 2-aryl-2H-indazoles with allyl alcohols. The method showed a wide substrate scope, excellent functional group tolerance, good to high yields of annulated products, and the capability for scaled-up synthesis. A tentative mechanism of the annulation reaction was proposed based on a preliminary mechanistic investigation.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Ruonan Zhang, Abudukadi Tudi, Xia Yang, Xuping Wang, Zhihua Yang, Shujuan Han, Shilie Pan
Summary: A new lead tellurium borate material with a unique fundamental building block [B4O10] was synthesized and found to exhibit high birefringence. The structure-property relationship was discussed using first-principles calculations.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Amresh Kumar Singh, Baishali Thakurta, Anupam Giri, Monalisa Pal
Summary: This study introduces three key concepts for the quick synthesis of large-scale high-quality 2D materials films and their utilization in device fabrication.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Reina Hagiwara, Shun Nishimura, Kosuke Okeyoshi
Summary: A copolymer-conjugated nanocatalytic system has been developed to improve electron transfer and enhance photoinduced H2 generation.
CHEMICAL COMMUNICATIONS
(2024)