Review
Biochemistry & Molecular Biology
Gaoxiang Zhao, Zhutie Li, Renshuai Zhang, Liman Zhou, Haibo Zhao, Hongfei Jiang
Summary: Bioorthogonal chemistry represents highly efficient and biocompatible reactions that proceed selectively and rapidly in biological situations. Tetrazine bioorthogonal reactions play an important role in in vivo imaging applications, allowing for the easy tracking of real signals through controlled fluorescence or radiation off-on mechanism.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Zichao Luo, Dehong Hu, Duyang Gao, Zhigao Yi, Hairong Zheng, Zonghai Sheng, Xiaogang Liu
Summary: This study introduces the use of bioorthogonal nanoprobes with high tumor-targeting specificity for in vivo NIR-IIb luminescence imaging and MRI, improving imaging quality and reducing toxicity.
ADVANCED MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Liangkui Hu, Bing Li, Yulong Liao, Simeng Wang, Peng Hou, Yangyang Cheng, Shiyong Zhang
Summary: This article reports a novel cancer imaging and therapy strategy through the regulation of overexpressed nitroreductase in solid tumors. This approach enables traceless activation of prodrugs, minimizing the side effects of byproducts in living systems and holding great potential for cancer treatment.
BIOORGANIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Yuxuan Hu, Junya Zhang, Yinxing Miao, Xidan Wen, Jian Wang, Yidan Sun, Yinfei Chen, Jianguo Lin, Ling Qiu, Kai Guo, Hong-Yuan Chen, Deju Ye
Summary: By combining enzyme-mediated fluorogenic reaction and in situ self-assembly with the inverse electron demand Diels-Alder (IEDDA) reaction, an activatable pretargeted strategy for multimodality imaging has been developed. This strategy allows for amplification of NIR FL and MRI signals, enrichment of TCOs, and simultaneous achievement of strong NIR FL, MRI, and PET signals for pretargeted multimodality imaging of ALP activity.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Dahye Kang, Sanghyeon Lee, Justin Kim
Summary: This article describes a chemically revertible bioconjugation strategy using enamine N-oxides for a bio-orthogonal dissociative reaction. The reaction is rapid, complete, and relatively insensitive to common buffers and pH levels. It can be paired with a bioorthogonal hydroamination reaction to create an integrated click and release system.
Article
Chemistry, Multidisciplinary
Xiaorong Song, Wei Zhu, Xiaoguang Ge, Renfu Li, Shihua Li, Xian Chen, Jibin Song, Jianping Xie, Xueyuan Chen, Huanghao Yang
Summary: The development of bright NIR-II luminescent nanomaterials for efficient protein labelling in vivo without altering their physiological properties is challenging. The synthesized CD-Au NCs can label proteins/antibodies effectively and enable highly efficient in vivo tracking, leading to sensitive tumor-targeted imaging. Additionally, they exhibit good biocompatibility and high renal clearance efficiency in harsh biological environments.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Analytical
Shiyue Zheng, Junqian Peng, Long Jiang, Hao Gu, Fang Wang, Chongqing Wang, Sheng Lu, Xiaoqiang Chen
Summary: Biological thiols play a crucial role in biological processes, and the development of a probe capable of targeting and imaging these thiols in living cells, as well as rapidly labeling them in proteins, is highly desired. In this study, a probe called FRB-T containing alpha, beta-unsaturated ketones was designed and synthesized. It demonstrated high specificity towards thiols, and exhibited remarkable fluorescence enhancement and color changes upon reaction with thiols. The probe was also successfully applied for biothiol imaging in Hela cells, and enabled rapid labeling of sulfhydryl-containing proteins without the need for a washing step.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Review
Chemistry, Multidisciplinary
Zheao Zhang, Kelong Fan
Summary: Transition metal catalysts (TMCs) based bioorthogonal reactions have potential for biomedical applications, but their toxicity, stability and targeting properties limit their widespread use in vivo. Bioorthogonal nanozymes, which combine the catalytic activity of TMCs, physical and chemical properties of nanomaterials, and enzymatic properties of classical nanozymes, provide opportunities to address these challenges and serve as multifunctional catalytic platforms for disease treatment.
Article
Chemistry, Analytical
Yingying Tian, Kaitao Li, Rui Tian, Chao Lu
Summary: A strategy for lifetime determination of degraded polymers is proposed using three-dimensional fluorescence imaging. The fluorescence volume of degraded sites is quantified and correlated with microstructural variations and mechanical properties. This cost-effective and sensitive strategy can be applied for the lifetime prediction of other polymeric materials.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Chemistry, Multidisciplinary
Xianzhi Zhang, Yuanchang Liu, Jeerapat Doungchawee, Laura J. Castellanos-Garcia, Kristen N. Sikora, Taewon Jeon, Ritabrita Goswami, Stefano Fedeli, Aarohi Gupta, Rui Huang, Cristina -Maria Hirschbiegel, Roberto Cao-Mil, Prabin K. D. Majhi, Yagiz Anil Cicek, Liang Liu, D. Joseph Jerry, Richard W. Vachet, Vincent M. Rotello
Summary: Bioorthogonal catalysis via transition metal catalysts (TMCs) allows the production of therapeutics locally through chemical reactions that are inaccessible to biological systems. This localized approach can improve the effectiveness of anticancer treatment and minimize off-target effects. By encapsulating TMCs into nanomaterials, nanozymes are created to activate imaging and therapeutic agents. In this study, cationic bioorthogonal nanozymes were used to establish localized drug factories for cancer therapy in vivo. These nanozymes remained at the tumor site for at least seven days after a single injection due to interactions with cell membranes and tissue components. The non-toxic prodrugs were then systemically administered and continuously converted into active drugs by the nanozymes. This strategy significantly reduced tumor growth in an aggressive breast cancer model, with reduced liver damage compared to traditional chemotherapy.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Chemistry, Physical
Hui Li, Yanfeng Zhong, Shumin Wang, Menglei Zha, Wenxing Gu, Guoyong Liu, Bohan Wang, Zhendong Yu, Yu Wang, Kai Li, Yuxin Yin, Jing Mu, Xiaoyuan Chen
Summary: The use of tumor-derived extracellular vesicles (EVs) as a targeting approach in combination with ternary downconversion nanoparticles (DCNPs) improves tumor imaging and accumulation. Bioorthogonal labeling of NIR-II optical probes with EVs enhances luminescence signals and prolongs retention at tumor sites.
Article
Chemistry, Medicinal
Carsten Peukert, Laura N. B. Langer, Sophie M. Wegener, Anna Tutov, Jens P. Bankstahl, Bianka Karge, Frank M. Bengel, Tobias L. Ross, Mark Broenstrup
Summary: The diagnosis of bacterial infections at deep body sites can benefit from noninvasive imaging techniques utilizing molecular probes labeled with iron transport-specific siderophores and PET technology. Probes containing gallium-68 linked to iron-binding siderophores were found to be suitable for in vivo imaging of bacteria, showing promise in discerning infection from inflammation.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Chuanqi Wang, He Zhang, Tao Zhang, Xiaoyu Zou, Hui Wang, Julia E. Rosenberger, Raghu Vannam, William S. Trout, Jonathan B. Grimm, Luke D. Lavis, Colin Thorpe, Xinqiao Jia, Zibo Li, Joseph M. Fox
Summary: Silicon-Rhodamine compounds (SiRs) have been identified as effective photocatalysts for inducing rapid bioorthogonal chemistry using 660 nm light, by oxidizing a dihydrotetrazine to a tetrazine in the presence of trans-cyclooctene dienophiles. SiRs, commonly used as fluorophores for bioimaging, have shown potential for catalyzing chemical reactions as well.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Materials Science, Biomaterials
Xueqian Chen, Yong Zhang, Qing Yuan, Mingrui Li, Yongning Bian, Dongdong Su, Xueyun Gao
Summary: Multifunctional bioimaging probes based on metal clusters possess promising applications in biomedical imaging and tumor diagnosis. The development of a concise design strategy using bioorthogonal reactions allows for efficient introduction of functional conjugates on azido-functionalized metal clusters, leading to the design of a copper cluster-based multifunctional near-infrared (NIR) fluorescent probe. This strategy enables specific targeting ligands and fluorophores to be chemically conjugated to metal clusters for real-time imaging applications in vivo.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Article
Chemistry, Physical
Hui Li, Yanfeng Zhong, Shumin Wang, Menglei Zha, Wenxing Gu, Guoyong Liu, Bohan Wang, Zhendong Yu, Yu Wang, Kai Li, Yuxin Yin, Jing Mu, Xiaoyuan Chen
Summary: This study proposes a bioorthogonal approach mediated by extracellular vesicles (EVs) derived from tumors to improve in vivo tumor imaging. By labeling ternary downconversion nanoparticles (DCNPs) with strong near infrared II (NIR-II) luminescence using EVs metabolically engineered with azide groups, remarkable improvement in tumor accumulation was achieved compared to passive targeting. This bioorthogonal labeling significantly increased NIR-II luminescence signals and prolonged retention at tumor sites.
Review
Oncology
Eric O. Aboagye, Tara D. Barwick, Uwe Haberkorn
Summary: Theranostics is a rapidly evolving field of medicine that combines diagnosis and treatment using similar tools. It offers the potential for high therapeutic efficacy with minimal toxicity. In oncology, theranostics relies on the identification of unique proteins and factors expressed in cancer cells, advances in imaging technology, and targeted chemicals and nanodevices for imaging and therapy. Radiotheranostics, using radiopharmaceuticals, is becoming routine in prostate cancer and neuroendocrine tumors. Although not all patients benefit from radiotheranostics, those who do often show high response rates.
CA-A CANCER JOURNAL FOR CLINICIANS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xingfeng Li, Diana Marcus, James Russell, Eric O. Aboagye, Laura Burney Ellis, Alexander Sheeka, Won-Ho Edward Park, Nishat Bharwani, Sadaf Ghaem-Maghami, Andrea G. Rockall
Summary: A comprehensive model combining features from MRI and clinical variables can improve the estimation of survival time in women with endometrial cancer.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Andrej Corovic, Christopher Wall, Meritxell Nus, Deepa Gopalan, Yuan Huang, Maria Imaz, Michal Zulcinski, Marta Peverelli, Anna Uryga, Jordi Lambert, Dario Bressan, Robert T. Maughan, Charis Pericleous, Suraiya Dubash, Natasha Jordan, David R. Jayne, Stephen P. Hoole, Patrick A. Calvert, Andrew F. Dean, Doris Rassl, Tara Barwick, Mark Iles, Mattia Frontini, Greg Hannon, Roido Manavaki, Tim D. Fryer, Luigi Aloj, Martin J. Graves, Fiona J. Gilbert, Marc R. Dweck, David E. Newby, Zahi A. Fayad, Gary Reynolds, Ann W. Morgan, Eric O. Aboagye, Anthony P. Davenport, Helle F. Jorgensen, Ziad Mallat, Martin R. Bennett, James E. Peters, James H. F. Rudd, Justin C. Mason, Jason M. Tarkin
Summary: This study investigates the feasibility of using somatostatin receptor 2 (SST2) as a molecular imaging target for inflammation in large vessel vasculitis (LVV), and provides evidence for its potential in the diagnosis and therapeutic monitoring of LVV.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Review
Biotechnology & Applied Microbiology
Thomas Talbot, Haonan Lu, Eric O. Aboagye
Summary: High-grade serous ovarian carcinoma is characterized by universal TP53 mutations and widespread copy number alterations, including deletion of tumor suppressors and amplification of driver oncogenes. Amplified driver genes have been proposed as therapeutic targets. However, lack of validation and variable experimental procedures hinder clinical translation. This review collates candidate amplified therapeutic targets in high-grade serous ovarian carcinoma and quantitatively appraises the evidence for each gene.
CANCER GENE THERAPY
(2023)
Article
Oncology
Mitchell Chen, Haonan Lu, Susan J. Copley, Yidong Han, Andrew Logan, Patrizia Viola, Alessio Cortellini, David J. Pinato, Danielle Power, Eric O. Aboagye
Summary: This study developed a radiomic-based signature for predicting disease response in patients with NSCLC undergoing PD-1 or PD-L1 immunotherapy. The radiomic signature was validated in two independent testing cohorts and demonstrated good prediction of treatment response and prognosis.
JOURNAL OF THORACIC ONCOLOGY
(2023)
Article
Oncology
Xingfeng Li, Michele Dessi, Diana Marcus, James Russell, Eric O. O. Aboagye, Laura Burney Ellis, Alexander Sheeka, Won-Ho Edward Park, Nishat Bharwani, Sadaf Ghaem-Maghami, Andrea G. G. Rockall
Summary: Machine learning classification methods can be used to predict deep myometrial infiltration, clinical risk category, histological type, and lymphovascular space invasion in endometrial cancer. Combining clinical and image signatures can improve the accuracy of these prediction models, which has important implications for patient management.
Article
Cell Biology
Haonan Lu, Hantao Lou, Georg Wengert, Reema Paudel, Naina Patel, Saral Desai, Bill Crum, Kristofer Linton-Reid, Mitchell Chen, Dongyang Li, Jacey Ip, Francesco Mauri, David J. Pinato, Andrea Rockall, Susan J. Copley, Sadaf Ghaem-Maghami, Eric O. Aboagye
Summary: This study confirms that the presence of tertiary lymphoid structure (TLS) in high-grade serous ovarian cancer (HGSOC) is associated with better progression-free survival (PFS). TLS is linked to B cell maturation and activation of cytotoxic tumor-specific T cells in HGSOC tumors. Copy-number loss of genes IL15 and CXCL10 may hinder TLS formation in HGSOC, and a list of dysregulated genes affecting TLS function is proposed. A radiomics-based signature is developed to predict TLS presence, which independently predicts PFS in HGSOC and non-small cell lung cancer (NSCLC) patients treated with immune checkpoint inhibitors (ICIs). Overall, this study reveals the role of TLS in coordinating immune responses in HGSOC and how the cancer genome evolves to counteract TLS formation.
CELL REPORTS MEDICINE
(2023)
Article
Oncology
Benjamin Hunter, Christos Argyros, Marianna Inglese, Kristofer Linton-Reid, Ilaria Pulzato, Andrew G. Nicholson, Samuel V. Kemp, Pallav L. Shah, Philip L. Molyneaux, Cillian Mcnamara, Toby Burn, Emily Guilhem, Marcos Mestas Nunez, Julia Hine, Anika Choraria, Prashanthi Ratnakumar, Susannah Bloch, Simon Jordan, Simon Padley, Carole A. Ridge, Graham Robinson, Hasti Robbie, Joseph Barnett, Mario Silva, Sujal Desai, Richard W. Lee, Eric O. Aboagye, Anand Devaraj
Summary: This study developed a radiomics model to assist in the diagnosis of lung cancer. By extracting radiomics features and using clustering methods, patients were stratified into different risk groups. The model showed high accuracy in predicting malignancy and has potential clinical applications.
BRITISH JOURNAL OF CANCER
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Shahriar Islam, Marianna Inglese, Matthew Grech-Sollars, Preetha Aravind, Suraiya Dubash, Tara D. Barwick, Kevin O'Neill, James Wang, Azeem Saleem, James O'Callaghan, Giulio Anchini, Matthew Williams, Adam Waldman, Eric O. Aboagye
Summary: MRI and PET are used in neuro-oncology to detect and characterize malignant lesions. In this study, the uptake of FPIA in brain tumors was investigated using PET/MRI.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Andrea G. Rockall, Xingfeng Li, Nicholas Johnson, Ioannis Lavdas, Shalini Santhakumaran, A. Toby Prevost, Shonit Punwani, Vicky Goh, Tara D. Barwick, Nishat Bharwani, Amandeep Sandhu, Harbir Sidhu, Andrew Plumb, James Burn, Aisling Fagan, Georg J. Wengert, Dow-Mu Koh, Krystyna Reczko, Qi Dou, Jane Warwick, Xinxue Liu, Christina Messiou, Nina Tunariu, Peter Boavida, Neil Soneji, Edward W. Johnston, Christian Kelly-Morland, Katja N. De Paepe, Heminder Sokhi, Kathryn Wallitt, Amish Lakhani, James Russell, Miriam Salib, Sarah Vinnicombe, Adam Haq, Eric O. Aboagye, Stuart Taylor, Ben Glocker
Summary: The study aimed to develop a machine learning algorithm to improve radiologists' sensitivity and specificity for metastasis detection in whole-body magnetic resonance imaging (WB-MRI). The results showed that using the algorithm can enhance the detection accuracy and reduce reading times for radiologists.
INVESTIGATIVE RADIOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Stanislav S. Piletsky, Ekaterina Baidyuk, Elena V. Piletska, Larissa Lezina, Konstantin Shevchenko, Donald J. L. Jones, Thong H. Cao, Rajinder Singh, Alan C. Spivey, Eric O. Aboagye, Sergey A. Piletsky, Nickolai A. Barlev
Summary: Molecularly imprinted polymer nanoparticles (nanoMIPs) have shown potential as an alternative to antibodies in diagnostic and therapeutic applications. Targeting intracellular epitopes can modulate protein function, making them a new tool for cancer therapy.
Article
Oncology
Mitchell Chen, Susan J. Copley, Patrizia Viola, Haonan Lu, Eric O. Aboagye
Summary: Lung cancer, the leading cause of cancer-related deaths worldwide, can be captured non-invasively on medical imaging as radiomic features, which can be used in an artificial intelligence paradigm to predict clinical outcomes and improve patient care. Compared to tissue sampling-driven approaches, radiomics-based methods are superior for being non-invasive, reproducible, cheaper, and less susceptible to intra-tumoral heterogeneity.
SEMINARS IN CANCER BIOLOGY
(2023)
Letter
Medicine, General & Internal
Benjamin Hunter, Catey Bunce, Matthew Blackledge, Eric Aboagye, Richard Lee, LIBRA study
Article
Oncology
Preetha Aravind, Sanjay Popat, Tara D. Barwick, Neil Soneji, Mark Lythgoe, Katherina B. Sreter, Jingky P. Lozano-Kuehne, Mattias Bergqvist, Neva Patel, Eric O. Aboagye, Laura M. Kenny
Summary: This study aimed to investigate the early drug action of the antifolate drug pemetrexed on thymidylate synthase (TS) inhibition using F-18-FLT PET/CT imaging. The results showed that patients who exhibited changes in the imaging biomarker had a better therapy response and longer overall survival. These findings suggest the potential use of F-18-FLT PET/CT in understanding the basis of drug action in studies involving TS inhibitors.
Article
Chemistry, Multidisciplinary
Zixuan Yang, Chris Barnes, Juozas Domarkas, Joanna Koch-Paszkowski, John Wright, Ala Amgheib, Isaline Renard, Ruisi Fu, Stephen Archibald, Eric O. Aboagye, Louis Allott
Summary: Sulfur-[F-18]fluoride exchange radiochemistry is a rapid and convenient method for incorporating fluorine-18 into biologically active molecules. We reported a fully automated radiolabelling procedure using the GE FASTLab(TM) cassette-based platform to synthesize a [F-18]SO3F-bearing prostate specific membrane antigen (PSMA) targeted ligand ([F-18](5)), which showed favorable biodistribution and pharmacokinetic profiles correlated with PSMA expression.
REACTION CHEMISTRY & ENGINEERING
(2023)
Review
Chemistry, Multidisciplinary
Dan He, Yawen Li, Fuwen Zhao, Yuze Lin
Summary: High trap density in organic solar cells leads to localized charge carriers and reduced carrier lifetime, limiting device efficiency. This feature article summarizes the recent advances of trap suppression by material design and device engineering.
CHEMICAL COMMUNICATIONS
(2024)
Review
Chemistry, Multidisciplinary
Olivier Monfort, Arshitha Madhusudhan, Martin Motola
Summary: This article presents the advantages of coupling photocatalysis and Fenton-based processes for environmental remediation and discusses their synergy. It critically examines the simultaneous triggering of these two processes and provides insights into research approaches. The study aims to enhance understanding of this complex process and highlight the potential integration of new catalysts in current wastewater treatment technology.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Manideepa Dhar, Chittaranjan Mishra, Avijit Das, Uttam Manna
Summary: An approach of 'polymerization of monomers in its aggregated form' has been introduced to tailor the water wettability of fibrous and porous substrates, achieving hydrophobicity to superhydrophobicity transition, as well as patterned wettability. This facile chemical method provides a durable coating with adjustable and patterned wettability for various potential applications.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Saswat Ranjan Bhoi, Chhanda Debnath, Shikha Gandhi
Summary: In this article, a novel catalytic reaction using Pd(0) and Bronsted acid is reported for the synthesis of biologically important imidazolidinone-fused N-heterocycles through redox-neutral intramolecular N-allylation of indoles and pyrroles with alkynes. This atom-economical method is applicable to a wide range of substrates and eliminates the need for leaving groups or oxidizing agents commonly used in traditional allylation reactions.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Longkun Chen, Mingshuai Zhang, Meichen Liu, Zhuoyuan Liu, Yuetong Qiu, Zhilai Zhang, Fuchao Yu, Jiuzhong Huang
Summary: In this study, an efficient Rh(III)-catalyzed selective mono- and dual-C-H bond functionalization/cyclization with iodonium ylide as the sole coupling partner was demonstrated. Fused benzodiazepine skeletons were obtained in excellent yields, providing an improved approach to dual C-H unsymmetrical functionalization.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Alice Kennett, Sven Epple, Gabriella van der Valk, Irene Georgiou, Evelyne Gout, Romain R. Vives, Angela J. Russell
Summary: This study presents the design and synthesis of sulfated disaccharide inhibitors based on IdoA(2S)-GlcNS(6S), which showed potent inhibition of Sulf-2. The results suggest that IdoA(2S)-GlcNS(6S) is the shortest fragment size required for effective inhibition of Sulfs, and a trisulfated disaccharide is identified as the minimal fragment size of heparan sulfate for effective endosulfatase inhibition.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Mauro Garbini, Andrea Brunetti, Riccardo Pedrazzani, Magda Monari, Massimo Marcaccio, Giulio Bertuzzi, Marco Bandini
Summary: The self-adaptability of galvanostatic electrolysis was found to be helpful in a multistage chemo- and diastereoselective electrochemically promoted cyclodimerization of chalcones. Through a series of reductive events, densely functionalized cyclopentanes with five contiguous stereocenters were obtained (25 examples, yields up to 95%, dr values up to >20:1). Further experimental and electrochemical investigations indicated the crucial role of dynamic kinetic resolution of the aldol intermediate in the reaction mechanism.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Dhananjay S. Nipate, Neha Meena, Prakash N. Swami, Krishnan Rangan, Anil Kumar
Summary: In this study, the synthesis of functionalized benzo[a]phenazines and indazolo[2,3-a]quinolines was achieved through Rh(III)-catalyzed oxidative annulation of 2-arylquinoxalines and 2-aryl-2H-indazoles with allyl alcohols. The method showed a wide substrate scope, excellent functional group tolerance, good to high yields of annulated products, and the capability for scaled-up synthesis. A tentative mechanism of the annulation reaction was proposed based on a preliminary mechanistic investigation.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Ruonan Zhang, Abudukadi Tudi, Xia Yang, Xuping Wang, Zhihua Yang, Shujuan Han, Shilie Pan
Summary: A new lead tellurium borate material with a unique fundamental building block [B4O10] was synthesized and found to exhibit high birefringence. The structure-property relationship was discussed using first-principles calculations.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Amresh Kumar Singh, Baishali Thakurta, Anupam Giri, Monalisa Pal
Summary: This study introduces three key concepts for the quick synthesis of large-scale high-quality 2D materials films and their utilization in device fabrication.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Reina Hagiwara, Shun Nishimura, Kosuke Okeyoshi
Summary: A copolymer-conjugated nanocatalytic system has been developed to improve electron transfer and enhance photoinduced H2 generation.
CHEMICAL COMMUNICATIONS
(2024)
