期刊
CHEMICAL COMMUNICATIONS
卷 50, 期 96, 页码 15148-15151出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4cc06905f
关键词
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资金
- Nanosciences Foundation (Grenoble) through the Chair of Excellence Project [GAG2D]
- NanoBio programme
- ICMG FR [2607]
- LabEx ARCANE [ANR-11-LABX-0003-01]
We demonstrate the quartz crystal microbalance as a novel method to quantify the reaction yields and stability of the terminal conjugation of chemically complex molecules. Oxime ligation is identified as a facile, broadly applicable method for the reducing-end conjugation of glycosaminoglycans that overcomes the limited stability and yield of popular hydrazone ligation.
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