期刊
CHEMICAL COMMUNICATIONS
卷 50, 期 94, 页码 14793-14796出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4cc06747a
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资金
- National Natural Science Foundation of China [21172076, 21202046]
- National Basic Research Program of China (973 Program) [2011CB808600]
- Guangdong Natural Science Foundation [10351064101000000]
- Fundamental Research Funds for the Central Universities [2014ZP0004, 2014ZZ0046]
Various 1,3- and 1,3,4-substituted pyrazoles are smoothly formed via copper-catalyzed cascade reactions of oxime acetates, amines and aldehydes. This relay oxidative process involves copper-promoted N-O bond cleavage and C-C/C-N/N-N bond formations to furnish pyrazolines, and sequential Cu-O-2 system-involved oxidative dehydrogenation of pyrazolines to afford pyrazoles. This transformation provides a novel and versatile approach for the synthesis of pyrazoles, with an inexpensive copper catalyst and green oxidants. It is atom-and step-economical, and possesses a good functional group tolerance, as well as operational simplicity.
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