Review
Chemistry, Multidisciplinary
Ayman Akhdar, Arnaud Gautier, Thomas Hjelmgaard, Sophie Faure
Summary: This review discusses the characteristics, synthetic pathways, and foldameric properties of N-alkylated aromatic poly- and oligoamides, with detailed descriptions of representative members.
Article
Chemistry, Multidisciplinary
Subhasis Dey, Soumya Chatterjee, Anjali Patel, Nirmalya Pradhan, Diship Srivastava, Niladri Patra, Arindam Bhattacharyya, Debasis Manna
Summary: The development of NIR-light-responsive macrocyclic cationic gemini amphiphiles resulted in the transformation from spherical to nanotubular self-assembly, leading to controlled release of the anticancer drug Doxorubicin. The potent cationic gemini amphiphile showed lower cytotoxicity and efficient NIR-light-mediated Dox release efficacy to cancerous cells.
CHEMICAL COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Junwu Chen, Xianmin Wu, Huining Ding, Ning Liu, Binyuan Liu, Lirong He
Summary: A new type of sustainable bimetallic zinc complexes has been developed for the chemical fixation of carbon dioxide into cyclic carbonates. The catalyst showed excellent performance with high stability to moisture and oxygen, resistance to impurities, and good recyclability. The catalytic mechanism involves a Lewis acidic zinc center and a nucleophilic halide counterion from the cocatalyst.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2021)
Article
Chemistry, Physical
Tanlong Xue, Boyuan Huang, Yang Li, Xin Li, Jun Nie, Xiaoqun Zhu
Summary: In this study, three enone dyes with different peripheral groups were synthesized and characterized to investigate their photoinitiation ability. The results showed that the peripheral group strongly affects the initiation efficiency, with different effects observed for different types of enone dyes. Experimental and theoretical calculations were performed to reveal the mechanism of the peripheral group's impact on the initiation efficiency.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
(2021)
Article
Chemistry, Physical
Andres Aracena, Marcos Caroli Rezende, Macarena Garcia, Karina Munoz-Becerra, Kerry Wrighton-Araneda, Cristian Valdebenito, Freddy Celis, Octavio Vasquez
Summary: Three photobicyclized benzodithienoquinolizinium tetrafluoroborates were prepared and evaluated as potential organic n-type semiconductors. One derivative with a long alkyl chain appended to the polycyclic planar pi-system showed higher charge carrier mobilities, confirming its potential in this regard.
Article
Crystallography
Grazia Giuseppina Politano, Stefano Burza, Carlo Versace
Summary: This study investigates the enhancement of graphene oxide (GO) performances on n-type and p-type Si samples. The conductivity and photocurrent of GO on n-type Si samples are significantly increased, which could be beneficial for a wide range of optoelectronic applications and future usage of GO in the Si semiconductor industry.
Article
Chemistry, Multidisciplinary
Panagiota Kafourou, Byoungwook Park, Joel Luke, Luxi Tan, Julianna Panidi, Florian Glocklhofer, Jehan Kim, Thomas D. Anthopoulos, Ji-Seon Kim, Kwanghee Lee, Sooncheol Kwon, Martin Heeney
Summary: This report introduces a new high electron affinity acceptor end group TCNBT for use in n-type organic semiconductors, demonstrating improved molecular properties and orientation. Organic field-effect transistors based on TCNBT showed a high charge-carrier mobility and excellent ambient stability, highlighting the benefits of the cyanated end group and synthetic approach.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Review
Chemistry, Multidisciplinary
Sourajit Bera, Lalit Mohan Kabadwal, Debasis Banerjee
Summary: This review discusses the synthesis of cyclic compounds using (1,n) annulation reactions, highlighting the progress from 2015 to March 2021. It covers the synthesis of various cyclic structures and their applications, including mechanistic studies, new catalytic methods, and synthetic applications.
CHEMICAL COMMUNICATIONS
(2021)
Article
Biochemical Research Methods
Yuxue Liang, Yamil Simon-Manso, Pedatsur Neta, Xiaoyu Yang, Stephen E. Stein
Summary: This study investigated tandem mass spectral characteristics and reaction mechanisms of aromatic sulfonamides, showing different product ions under different conditions, and involving nitrogen-oxygen rearrangement mechanism and Smiles-type rearrangement. The experimental results and Density Functional Theory calculations provided corresponding activation energies, supporting the proposed parallel mechanism.
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
(2021)
Article
Chemistry, Applied
Xuefeng Jia, Jieting He
Summary: In this study, three copper complexes were synthesized and used in the construction of C-N bonds. Among them, complex II displayed higher activity in the reaction compared to the other two complexes. The reaction showed advantages such as a wide scope of substrates, high yields, and mild reaction conditions.
APPLIED ORGANOMETALLIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Zhuo-Ya Mao, Xiao-Di Nie, Yi-Man Feng, Chang-Mei Si, Bang-Guo Wei, Guo-Qiang Lin
Summary: The Cu(OTf)(2) catalyzed Ugi-type reactions of N,O-acetals with isocyanides were described for the synthesis of pyrrolidinyl and piperidinyl 2-carboxamides, providing high diastereoselectivities for 4-hydroxy-5-substituted-prolinamides (2,4-cis/trans > 19:1) and proposing a stereoselective model for 2,4-cis selectivity. Additionally, a novel analog of the VHL ligand, 4-F-VH 032, was conveniently obtained using this method.
CHEMICAL COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Xin Tao, Wenhao Li, Qingbo Wu, Huan Wei, Yongkun Yan, Lingli Zhao, Yuanyuan Hu, Yan Zhao, Huajie Chen, Yunqi Liu
Summary: This study demonstrates the integration of ladder-like aromatic diketones (LADK) into n-type polymers, resulting in excellent n-type characteristics with high electron mobility and inverter gain values.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Yaping Yu, Genming Zhu, Liuyuan Lan, Junxin Chen, Xiuyuan Zhu, Jiayao Duan, Shengyu Cong, Zhengke Li, Yunxia Wang, Zhaohui Wang, Iain McCulloch, Wan Yue
Summary: In this study, two n-type glycolated imide-fused polycyclic aromatic hydrocarbons (IPAHs) were developed to explore the effects of molecular conformation on the properties of organic electrochemical transistors (OECTs). It was found that the highly twisted scaffold in one of the materials significantly improved the charge storage properties, resulting in the highest volumetric capacitance reported for small-molecule OECT materials. Furthermore, the use of this material in solid-electrolyte OECTs led to even higher transconductance values. These findings highlight the potential of these IPAHs and demonstrate the importance of conformation manipulation in materials design for high-performance electrochemical devices.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Inorganic & Nuclear
B. Archana, S. Sreedaran
Summary: A series of binuclear manganese(III) complexes were synthesized and their structures and properties were studied. One of the complexes exhibited enhanced DNA binding affinity.
Article
Chemistry, Organic
Menghan Cui, Rong Wang, Qing Yang, Chunxiang Kuang
Summary: In this study, we report a copper-catalyzed one-pot Sandmeyer-type reaction that enables the synthesis of N-aryl-1,2,3-triazoles under mild conditions. The developed method shows good yields and tolerance towards a wide range of aromatic amines and triazoles.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Physical
Hubert Casajus, Aurelie Lagarde, Lionel Nauton, Nazim Ocal, Martin Leremboure, Wolf-Dieter Fessner, Nicolas Duguet, Franck Charmantray, Laurence Hecquet
Summary: This study demonstrates the successful cleavage of aliphatic alpha-hydroxy ketones using thermostable transketolase variants obtained through rational design, offering a promising biocatalytic strategy as a one-step alternative for cleavage reactions.
Article
Chemistry, Organic
Maxime Pypec, Laurent Jouffret, Claude Taillefumier, Olivier Roy
Summary: The synthesis and conformational analysis of peptoid oligomers composed of consecutive N-(alkylamino)glycine units were investigated. N-(Methylamino)glycine homooligomers were successfully synthesized in solution and their structures were analyzed using various techniques. It was found that N-(methylamino)peptoids preferentially adopt trans amide bonds and can form intermolecular associations via hydrogen bonding.
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Laurent Gavara, Federica Verdirosa, Laurent Sevaille, Alice Legru, Giuseppina Corsica, Lionel Nauton, Paola Sandra Mercuri, Filomena Sannio, Filomena De Luca, Margot Hadjadj, Giulia Cerboni, Yen Vo Hoang, Patricia Licznar-Fajardo, Moreno Galleni, Jean -Denis Docquier, Jean-Francois Hernandez
Summary: Metallo-S-lactamases (MBLs) pose an increasing threat to public health due to their prevalence in opportunistic Gram-negative pathogens worldwide. We are developing a new series of inhibitors with high inhibitory activity against tested MBLs, some of which are broad-spectrum and non-toxic. This series provides a promising basis for further research.
BIOORGANIC & MEDICINAL CHEMISTRY
(2022)
Review
Mycology
Julien Renou, Rodnay Sormani, Eric Gelhaye, Claude Didierjean, Melanie Morel-Rouhier
Summary: The eEF1B protein plays a crucial role in protein translation and stress response. Recent studies have shown that there is diversification of eEF1B sequences in fungi, which might be associated with the adaptation of fungi to environmental constraints.
FUNGAL BIOLOGY REVIEWS
(2022)
Article
Biochemistry & Molecular Biology
Elodie Sylvestre-Gonon, Laura Morette, Morgane Viloria, Sandrine Mathiot, Alexis Boutilliat, Frederique Favier, Nicolas Rouhier, Claude Didierjean, Arnaud Hecker
Summary: This study focuses on the expression and function of glutathione transferases (GSTs) in Populus trichocarpa. The results reveal that the tau class (GSTU) is the most abundant in this species. The study also identifies a common ancestor for PtGSTU19 and PtGSTU20 genes and highlights the structural differences between them. Interaction with flavonoids is found to potentially play a role in the GSH-conjugation activity of these two genes.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Mathilde Defois, Chloe Remondin, Beatrice Josselin, Lionel Nauton, Vincent Thery, Fabrice Anizon, Sandrine Ruchaud, Francis Giraud, Pascale Moreau
Summary: A new series of pyrazolo[3,4-g]isoquinoline derivatives, diverse in substitution at the 4- or 8-position, were synthesized and evaluated for their kinase inhibitory potency. The results showed that the introduction of a bromine atom at the 8-position had a negative effect on Haspin inhibition, while the introduction of an alkyl group at the 4-position led to a modification of the kinase inhibition profiles. Overall, the new pyrazolo[3,4-g]isoquinolines represent a novel family of kinase inhibitors with various selectivity profiles.
Article
Chemistry, Medicinal
Vassili Prudhomme, Melissa Cucca, Lionel Nauton, Elsa Andrieu, Mathilde Fereyrolles, Sylvain Lamoine, Clement Michelin, Khalil Bennis, Aurore Collin, Frederic De Ceuninck, Iuliana Botez, Christophe Mallet, Sylvie Ducki
Summary: This study designed and synthesized a series of compounds as inhibitors of tubulin assembly and vascular-disrupting agents. Among them, indole 4j demonstrated good inhibition of angiogenesis and tubulin assembly, and exhibited vascular disrupting activity comparable to the gold standard CA4.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Nicolas Mast, William Erb, Lionel Nauton, Pascale Moreau, Olivier Mongin, Thierry Roisnel, Margaux Macaigne, Thomas Robert, Stephane Bach, Laurent Picot, Valerie Thiery, Jean-Pierre Hurvois, Florence Mongin
Summary: Polycyclic heterocycles are important precursors to molecules with different properties. Through the development of new synthesis methods and reaction strategies, a series of novel polycyclic compounds were successfully synthesized, and their biological activity and photophysical properties were evaluated.
NEW JOURNAL OF CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Elodie Mauchauffee, Jeremy Leroy, Jihanne Chamcham, Abdelaziz Ejjoummany, Manon Maurel, Lionel Nauton, Booma Ramassamy, Karima Mezghenna, Jean-Luc Boucher, Anne-Dominique Lajoix, Jean-Francois Hernandez
Summary: We developed dipeptidomimetic compounds as potent inhibitors of nNOS and iNOS, showing significant selectivity against eNOS. The extension size was increased to improve interactions in the NOS substrate access channel. Molecular modeling explained the selectivity towards nNOS over eNOS, and spectral studies confirmed interaction at the heme active site. These selected inhibitors were effective in inhibiting intra-cellular nNOS and iNOS in RAW264.7 and INS-1 cells.
Article
Biochemistry & Molecular Biology
Ibrahima Goudiaby, Therese E. Malliavin, Eva Mocchetti, Sandrine Mathiot, Samir Acherar, Celine Frochot, Muriel Barberi-Heyob, Benoit Guillot, Frederique Favier, Claude Didierjean, Christian Jelsch
Summary: Neuropilin 1 (NRP1), a cell-surface co-receptor, has been implicated in the development and progression of various cancers. Researchers have utilized a combination of the KDKPPR peptide, a photosensitizer, and a contrast agent to target NRP1 and treat glioblastoma. By mutating specific amino acids on the protein surface, crystallography was used to determine the structure of the mutated fragment and its complex with the KDKPPR peptide, providing insights into the electrostatic interactions involved in ligand binding. Molecular dynamics simulations further analyzed the binding and mobility of the wild-type and mutant proteins.
Article
Chemistry, Organic
Gaetano Angelici, Nicholus Bhattacharjee, Maxime Pypec, Laurent Jouffret, Claude Didierjean, Franck Jolibois, Lionel Perrin, Olivier Roy, Claude Taillefumier
Summary: The synthesis and conformational study of N-substituted beta-alanines with tert-butyl side chains are described in this article. Experimental solution NMR spectroscopy, X-ray crystallography, and molecular modeling were used to investigate the conformational preferences of these compounds. It was found that despite their higher flexibility, they still adopt preferred secondary structures including helical and ribbon-like conformations.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2022)
Article
Chemistry, Physical
Hubert Casajus, Aurelie Lagarde, Lionel Nauton, Nazim Ocal, Martin Leremboure, Wolf-Dieter Fessner, Nicolas Duguet, Franck Charmantray, Laurence Hecquet
Summary: Thermostable transketolase variants from Geobacillus stearothermophilus obtained through rational design can be used in vitro to cleave aliphatic alpha-hydroxy ketones, with high activity and yield.
Article
Chemistry, Organic
Ayman Akhdar, Sophie Faure, Arnaud Gautier
Summary: An efficient on-resin click chemistry protocol using a stable copper(I)-N-heterocyclic carbene catalyst is developed for the post-functionalization of N-alkylated aminomethylbenzamide oligomers (arylopeptoids). The feasibility of obtaining a panel of polyfunctionalized N-substituted aromatic oligoamides by solid-phase synthesis is demonstrated using combinatorial and sequential approaches.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Flavien Zannini, Sandrine Mathiot, Jeremy Couturier, Claude Didierjean, Nicolas Rouhier
Summary: This study reveals the three-dimensional structure of a natural hybrid protein formed by the fusion of an N-terminal glutaredoxin-like domain and an FDR domain in the marine bacterium Desulfotalea psychrophila Lsv54. The structure provides insights into the dispensability of the variable subunit that normally protects the Fe-S cluster in FDR proteins and the electron flow involving RBX, FDR, and GRX protein domains observed in anaerobic methanogen archaea.
Article
Materials Science, Multidisciplinary
Paul Legentil, Fabrice Leroux, Rachid Mahiou, Sandrine Therias, Damien Boyer, Francois Reveret, Lionel Nauton, Vincent Thery, Rodolphe Valleix, Genevieve Chadeyron
Summary: The study investigates the optical properties of sulforhodamine B hosted in surfactant-modified layered double hydroxide, examining the effects of different spacers on the luminescence of the optically active molecules. It demonstrates that intercalation of spacers allows for adjustment of distance between LDH sheets based on the size of the luminescent molecule guest, and identifies the surfactant with n = 11 as providing the best performance in terms of optical properties. The use of computational approaches and silicon composite films with LDH loadings further reveal insights into the distribution and effects of different alkyl chain lengths on the luminescent molecule within the LDH interlayer.
MATERIALS ADVANCES
(2022)
Review
Chemistry, Multidisciplinary
Dan He, Yawen Li, Fuwen Zhao, Yuze Lin
Summary: High trap density in organic solar cells leads to localized charge carriers and reduced carrier lifetime, limiting device efficiency. This feature article summarizes the recent advances of trap suppression by material design and device engineering.
CHEMICAL COMMUNICATIONS
(2024)
Review
Chemistry, Multidisciplinary
Olivier Monfort, Arshitha Madhusudhan, Martin Motola
Summary: This article presents the advantages of coupling photocatalysis and Fenton-based processes for environmental remediation and discusses their synergy. It critically examines the simultaneous triggering of these two processes and provides insights into research approaches. The study aims to enhance understanding of this complex process and highlight the potential integration of new catalysts in current wastewater treatment technology.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Manideepa Dhar, Chittaranjan Mishra, Avijit Das, Uttam Manna
Summary: An approach of 'polymerization of monomers in its aggregated form' has been introduced to tailor the water wettability of fibrous and porous substrates, achieving hydrophobicity to superhydrophobicity transition, as well as patterned wettability. This facile chemical method provides a durable coating with adjustable and patterned wettability for various potential applications.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Saswat Ranjan Bhoi, Chhanda Debnath, Shikha Gandhi
Summary: In this article, a novel catalytic reaction using Pd(0) and Bronsted acid is reported for the synthesis of biologically important imidazolidinone-fused N-heterocycles through redox-neutral intramolecular N-allylation of indoles and pyrroles with alkynes. This atom-economical method is applicable to a wide range of substrates and eliminates the need for leaving groups or oxidizing agents commonly used in traditional allylation reactions.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Longkun Chen, Mingshuai Zhang, Meichen Liu, Zhuoyuan Liu, Yuetong Qiu, Zhilai Zhang, Fuchao Yu, Jiuzhong Huang
Summary: In this study, an efficient Rh(III)-catalyzed selective mono- and dual-C-H bond functionalization/cyclization with iodonium ylide as the sole coupling partner was demonstrated. Fused benzodiazepine skeletons were obtained in excellent yields, providing an improved approach to dual C-H unsymmetrical functionalization.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Alice Kennett, Sven Epple, Gabriella van der Valk, Irene Georgiou, Evelyne Gout, Romain R. Vives, Angela J. Russell
Summary: This study presents the design and synthesis of sulfated disaccharide inhibitors based on IdoA(2S)-GlcNS(6S), which showed potent inhibition of Sulf-2. The results suggest that IdoA(2S)-GlcNS(6S) is the shortest fragment size required for effective inhibition of Sulfs, and a trisulfated disaccharide is identified as the minimal fragment size of heparan sulfate for effective endosulfatase inhibition.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Mauro Garbini, Andrea Brunetti, Riccardo Pedrazzani, Magda Monari, Massimo Marcaccio, Giulio Bertuzzi, Marco Bandini
Summary: The self-adaptability of galvanostatic electrolysis was found to be helpful in a multistage chemo- and diastereoselective electrochemically promoted cyclodimerization of chalcones. Through a series of reductive events, densely functionalized cyclopentanes with five contiguous stereocenters were obtained (25 examples, yields up to 95%, dr values up to >20:1). Further experimental and electrochemical investigations indicated the crucial role of dynamic kinetic resolution of the aldol intermediate in the reaction mechanism.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Dhananjay S. Nipate, Neha Meena, Prakash N. Swami, Krishnan Rangan, Anil Kumar
Summary: In this study, the synthesis of functionalized benzo[a]phenazines and indazolo[2,3-a]quinolines was achieved through Rh(III)-catalyzed oxidative annulation of 2-arylquinoxalines and 2-aryl-2H-indazoles with allyl alcohols. The method showed a wide substrate scope, excellent functional group tolerance, good to high yields of annulated products, and the capability for scaled-up synthesis. A tentative mechanism of the annulation reaction was proposed based on a preliminary mechanistic investigation.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Ruonan Zhang, Abudukadi Tudi, Xia Yang, Xuping Wang, Zhihua Yang, Shujuan Han, Shilie Pan
Summary: A new lead tellurium borate material with a unique fundamental building block [B4O10] was synthesized and found to exhibit high birefringence. The structure-property relationship was discussed using first-principles calculations.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Amresh Kumar Singh, Baishali Thakurta, Anupam Giri, Monalisa Pal
Summary: This study introduces three key concepts for the quick synthesis of large-scale high-quality 2D materials films and their utilization in device fabrication.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Reina Hagiwara, Shun Nishimura, Kosuke Okeyoshi
Summary: A copolymer-conjugated nanocatalytic system has been developed to improve electron transfer and enhance photoinduced H2 generation.
CHEMICAL COMMUNICATIONS
(2024)
