High yield and high specific activity synthesis of [18F] fallypride in a batch microfluidic reactor for micro-PET imaging

[F-18] fallypride was synthesized in a batch microfluidic chip with a radiochemical yield of 65 +/- 6% ( n = 7) and an average specific activity of 730 GBq mu mol(-1) ( 20 Ci mu mol(-1)) ( n = 4). Specific activity was similar to 2-fold higher than [F-18] fallypride synthesized in a macroscale radiosynthesizer, despite starting with significantly less radioactivity, and thus safer conditions, in the microchip.