期刊
CHEMICAL COMMUNICATIONS
卷 50, 期 36, 页码 4690-4692出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4cc01290a
关键词
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资金
- UNL UCARE program
- National Science Foundation (GAANN) [P200A100041, CHE-0955439, MRSEC DMR-0820521]
- Direct For Mathematical & Physical Scien
- Division Of Chemistry [0955439] Funding Source: National Science Foundation
We incorporated short thiolated oligonucleotides as passivating diluents in the fabrication of electrochemical peptide-based (E-PB) sensors, with the goal of creating a negatively charged layer capable of resisting nonspecific adsorption of matrix contaminants. The E-PB HIV sensors fabricated using these diluents were found to be more specific and selective, while retaining attributes similar to the sensor fabricated without these diluents. Overall, these results highlight the advantages of using oligonucleotides as anti-fouling diluents in self-assembled monolayer-based sensors.
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