Article
Biochemistry & Molecular Biology
Marina Kurbasic, Ana M. Garcia, Simone Viada, Silvia Marchesan
Summary: The study focused on the catalytic effects of bioactive hydrogels based on tripeptide self-assembly, specifically exploring the impact of modifications on the hydrogel and esterase mimicry activity.
The synthesis and characterization of three analogues with terminal modifications were analyzed, and their self-assembly, hydrogelation, and esterase-like biocatalysis were tested through various techniques.
These findings offer valuable insights into how chemical modifications affect the self-assembly of biocatalytic hydrogels and can potentially aid in the design of supramolecular catalysts for enhanced performance in the future.
Article
Engineering, Biomedical
Ziv Azoulay, Polina Aibinder, Ayala Gancz, Jacob Moran-Gilad, Shiri Navon-Venezia, Hanna Rapaport
Summary: FKF, a tripeptide with potential antimicrobial activity, forms a pure peptide hydrogel phase made of natural amino acids. The hydrogel exhibits bactericidal activity against E. coli and P. aeruginosa, and reduces P. aeruginosa contamination in a rat skin lesion model.
ACTA BIOMATERIALIA
(2021)
Article
Chemistry, Physical
Miryam Criado-Gonzalez, Deborah Wagner, Muhammad Haseeb Iqbal, Aymeric Ontani, Alain Carvalho, Marc Schmutz, Joseph B. Schlenoff, Pierre Schaaf, Loic Jierry, Fouzia Boulmedais
Summary: The spatial control of supramolecular self-assembly plays a vital role in the design of artificial cells, with the study demonstrating the successful self-assembly of phosphorylated peptides on complex coacervate microdroplets. This process leads to the formation of structured peptide/PAH capsules and fibrillar self-assembled structures at interfaces, showing potential for the development of compartmentalized structures in artificial cells.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2021)
Article
Engineering, Biomedical
Yong Sun, Xing Li, Mingda Zhao, Yafang Chen, Yang Xu, Kefeng Wang, Shaoquan Bian, Qing Jiang, Yujiang Fan, Xingdong Zhang
Summary: A new class of biphenyl-tripeptides capable of self-assembling into robust supramolecular nanofiber hydrogels was developed. Molecular dynamics simulations revealed that reasonable hydrogen bond interactions and the presence of FF brick promoted the formation of the hydrogels. Rheology and spectroscopy analysis were used to analyze the biomechanical properties and intermolecular interactions of the hydrogels, and optimize the amino acid sequence. The results demonstrated the good biocompatibility and biological activity of these supramolecular nanofiber hydrogels, making them promising for applications in regenerative medicine.
BIOACTIVE MATERIALS
(2022)
Article
Nanoscience & Nanotechnology
Yan Mei, Kai Yu, Hossein Yazdani-Ahmadabadi, Dirk Lange, Jayachandran N. Kizhakkedathu
Summary: Mussel-inspired surface chemistry based on polycatecholamines and polyphenols has been widely used in surface modification. In this study, we investigated the coassembly and codeposition process using six different ultrahigh molecular weight hydrophilic polymers and three catecholamines and a polyphenol. The chemistry of the polymers was found to affect the interaction between the polycatecholamine and the hydrophilic polymers, thus influencing the self-assembly, nanoaggregate formation, steric stabilization, and surface deposition. The codeposition method was also used to develop antifouling and antibiofilm coatings and evaluate their efficiency.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Engineering, Environmental
Peng Hu, Qingyi Xie, Chunfeng Ma, Guangzhao Zhang
Summary: The new poly(dimethylsiloxane) coating cross-linked via coordination bonds between 2-(2-benzimidazolyl)ethanethiol (BET) and zinc ions shows improved adhesion strength and self-healing ability, leading to enhanced fouling resistance against marine bacteria and diatoms. The presence of zinc-imidazole complexes further contributes to the antifouling function of the coating.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Chemistry, Physical
Wenrui Dong, Bucheng Li, Jinfei Wei, Ning Tian, Weidong Liang, Junping Zhang
Summary: A new type of smooth anti-fouling coatings based on methyltrimethoxysilane was developed, showing excellent anti-fouling properties and potential applications. These transparent coatings not only effectively prevent fouling, but also exhibit good mechanical, chemical, and thermal stability.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2021)
Article
Chemistry, Multidisciplinary
Nandini Bhandaru, Gagandeep Kaur, Apurva Panjla, Sandeep Verma
Summary: This article discusses the control of self-assembled peptide molecules' morphology and nanostructure using spin coating. By adjusting spin coating parameters, different morphologies of self-assembled structures can be obtained. This method opens up a new potential route for creating complex peptide assemblies on demand.
Article
Chemistry, Multidisciplinary
Andreas Peil, Ling Xin, Steffen Both, Luyao Shen, Yonggang Ke, Thomas Weiss, Pengfei Zhan, Na Liu
Summary: Researchers have successfully demonstrated the DNA assembly of a rotary nanodevice that mimics the mechanism of bacterial flagellar motor. This study provides new insights for designing and building artificial nanomachinery.
Article
Multidisciplinary Sciences
M. Golan, J. Boulanger-Weill, A. Pinot, P. Fontanaud, A. Faucherre, D. S. Gajbhiye, L. Hollander-Cohen, T. Fiordelisio-Coll, A. O. Martin, P. Mollard
Summary: Research in awake zebrafish larvae has shown that migrating GnRH neurons pause at the nasal-forebrain junction and form clusters that act as interhemisphere neuronal ensembles. Within these ensembles, GnRH neurons create an isolated, spontaneously active circuit that is internally wired through monosynaptic glutamatergic synapses, driving a phenotypic switch essential for proper migration toward their hypothalamic destination. This highlights the critical role of synaptic communication between migrating GnRH neurons in the reproductive process.
Article
Chemistry, Multidisciplinary
Du Gong, Dawei Zhang, Xiaoying Zhang, Xiaohong He, Yao Ji, Kun Jia
Summary: Emulsion confinement self-assembly technique has been utilized to synthesize polymeric microparticles with pendent nitrile and carboxyl groups. The encapsulation capacity of polyarylene ether (PAE-NC) was evaluated using hydrophobic fluorescent quantum dots (QD). The co-self-assembly of red-emitting QD and PAE-NC enables the phase transfer of hydrophobic QD into hydrophilic luminescent microparticles.
FRONTIERS IN CHEMISTRY
(2022)
Article
Engineering, Environmental
Dejun Feng, Yuanmiaoliang Chen, Zhangxin Wang, Shihong Lin
Summary: A simple and scalable method for fabricating Janus MD membrane with wetting and fouling resistance has been reported, along with the mechanism of wetting resistance. Experimental results show that the dense Janus membrane can resist wetting and fouling simultaneously, providing important insight for the preparation and application of MD membranes.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
V. S. Marangoni, M. C. F. Costa, P. R. Ng, H. T. L. Nguyen, M. Trushin, A. Carvalho, X. Zhao, S. J. Pennycook, R. K. Donato, A. H. Castro Neto
Summary: The synthesis of composite nanofibres using functionalised graphene structures in liquid medium as building blocks involves simultaneous scrolling and reacting 2D electrolytes, resulting in a dimensional reduction of 2D materials into one-dimensional nanostructures. The spontaneous self-assembly and cross-linking processes enable the production of nanofibres without the need for fibrillation techniques, such as wet-spinning or external templates.
MATERIALS TODAY CHEMISTRY
(2021)
Article
Materials Science, Multidisciplinary
Dong Zhou, Meikang Han, Bchara Sidnawi, Qianhong Wu, Yury Gogotsi, Bo Li
Summary: The study demonstrates a rapid and eco-friendly assembly and regeneration of nanomaterial networks on a hydrophobic polymer substrate. The method is applicable to a wide range of hydrophobic nanomaterials and can be combined with other deposition methods to build heterostructures and integrated devices. The ultrafast withdrawal speed and insensitivity to substrate geometry make it a promising approach for high-throughput manufacturing of flexible electronics.
APPLIED MATERIALS TODAY
(2021)
Article
Materials Science, Multidisciplinary
Yuchen Wang, Zuodong Liu, Wei Feng, Teng Zhang, Weiwei Xing
Summary: In this study, a novel Ni-P-TiO2 composite coating was successfully prepared on 316 stainless steel surface using electroless plating. The fouling inhibition characteristics of the composite coating were investigated and compared with stainless steel. Experimental results showed that the fouling thermal resistance of the composite coating was significantly lower, indicating its effectiveness in inhibiting fouling deposition. The coating demonstrated lasting and efficient fouling inhibition, making it a potential solution for heat exchange equipment.
Article
Chemistry, Multidisciplinary
Abhijit Saha, Sivan Nir, Meital Reches
Review
Chemistry, Multidisciplinary
Prithwidip Saha, Tal Duanis-Assaf, Meital Reches
ADVANCED MATERIALS INTERFACES
(2020)
Article
Biochemistry & Molecular Biology
Noam Y. Steinman, Tan Hu, Aviv Dombrovsky, Meital Reches, Abraham J. Domb
Summary: The N-halamine technology has effectively introduced antiviral functionality into commonly used polymers, showing good antiviral activity against viruses such as T4 bacteriophage and tomato brown rugose fruit virus.
Article
Chemistry, Multidisciplinary
Avia Leader, Ori Molad, Aviv Dombrovsky, Meital Reches, Daniel Mandler
Summary: By using the Langmuir-Blodgett technique, the interactions of various microorganisms at the air/water interface were studied, revealing cucumber green mottle mosaic virus as a promising candidate for further research due to its interaction with Langmuir lipid monolayers being mainly driven by electrostatic interactions.
Article
Nanoscience & Nanotechnology
Tan Hu, Omer Agazani, Sivan Nir, Mor Cohen, Siyi Pan, Meital Reches
Summary: This study demonstrates that peptide-based assemblies can kill viruses and form antiviral coatings on surfaces, potentially reducing the risk of viral transmission in sterile environments.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Multidisciplinary
Tal Duanis-Assaf, Tan Hu, Maayan Lavie, Zhuo Zhang, Meital Reches
Summary: Understanding the interactions between collagen and hydroxyapatite is crucial for biomineralization and bone formation. In this study, the researchers investigated the interactions between a short peptide and hydroxyapatite. They found that the peptide binds to hydroxyapatite through electrostatic interactions and that cationic residues play a crucial role in the binding. Molecular dynamics simulations revealed that the peptide structure is also important for adhesion. These findings enhance our understanding of peptide adhesion to hydroxyapatite and have potential implications in designing functional groups for modifying hydroxyapatite surfaces.
Review
Polymer Science
Noor Buchholz, Alberto Budia, Julia de la Cruz, Wolfgang Kram, Owen Humphreys, Meital Reches, Raquel Valero Boix, Federico Soria
Summary: This study summarizes and evaluates pre-clinical assessment models for urinary stents, including in vitro, ex vivo, and in vivo models. The study finds that computer simulation poses challenges and further in vitro, ex vivo, and in vivo evaluations are necessary. The study provides a step-by-step guide for setting up ex vivo models and discusses the pros and cons of available animal models. A transparent multidisciplinary approach is essential for successful implementation of new or modified stents.
Article
Chemistry, Multidisciplinary
Tan Hu, Michaela Kaganovich, Zohar Shpilt, Apurba Pramanik, Omer Agazani, Siyi Pan, Edit Tshuva, Meital Reches
Summary: In this study, two extremely short peptides, DOPA-Phe-NH2 and DOPA-Phe(4F)-NH2, were found to self-assemble into spherical nanoparticles with antiviral activity. When applied on a glass substrate, these peptide assemblies effectively deactivated viruses and showed low toxicity towards mammalian cells. These findings provide a new strategy for the design and development of antiviral coatings.
ADVANCED MATERIALS INTERFACES
(2023)
Article
Multidisciplinary Sciences
Yuhe Shen, Rongxin Su, Dongzhao Hao, Xiaojian Xu, Meital Reches, Jiwei Min, Heng Chang, Tao Yu, Qing Li, Xiaoyu Zhang, Yuefei Wang, Yuefei Wang, Wei Qi
Summary: The authors investigated the effect of the molecular chirality of (L)-3,4-dihydroxyphenylalanine on the improved structural and thermal stability of self-assembled films by tyrosinase-induced oxidative polymerization. The pure enantiomers showed altered kinetics and morphology upon co-assembly, allowing the fabrication of layer-to-layer stacked nanostructures and films with enhanced properties. The (L+D)-racemic mixtures exhibited different molecular arrangements and self-assembly mechanisms, resulting in stronger intermolecular forces and increased elastic modulus.
NATURE COMMUNICATIONS
(2023)
Article
Engineering, Biomedical
Elisheva Sasson, Omer Agazani, Eyal Malka, Meital Reches, Shlomo Margel
Summary: In March 2020, a pandemic caused by the novel beta-coronavirus SARS-CoV-2 was declared by the World Health Organization, originating from China. This led to an increased demand for antiviral surfaces. This study describes the preparation and characterization of new antiviral coatings on polycarbonate (PC) for controlled release of activated chlorine (Cl+) and thymol separately and combined. The results showed that the combination of thymol and chlorine had an improved antiviral activity, reducing the amounts of T4 bacteriophage and canine coronavirus (CCV) by four orders of magnitude.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2023)
Article
Chemistry, Organic
Pulikanti Guruprasad Reddy, Tan Hu, Meital Reches, Abraham J. Domb
Summary: This study developed a series of chlorine-rich transition metal complexes/TBA salts of Na-DCC for extended chlorine release studies. These DCC-salts exhibited poor water solubility and slow decomposition chlorine release compared to Na-DCC. Moreover, the DCC-salts demonstrated excellent antiviral and antibacterial properties.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2023)
Article
Chemistry, Physical
Tan Hu, Zhuo Zhang, Meital Reches
Summary: The study designed a self-standing superhydrophobic material through the self-assembly of a functionalized aromatic amino acid. The material exhibited fibrous structures and showed high mechanical strength and resistance to enzymatic degradation.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2024)
Article
Chemistry, Multidisciplinary
Michaela Kaganovich, Koranit Shlosman, Evgeniya Goldman, Marina Benchis, Tamar Eitan, Rotem Shemesh, Abraham Gamliel, Meital Reches
Summary: This paper presents the compression molding of peptide assemblies with LDPE for the production of antimicrobial polymeric films. These films show a significant reduction in bacterial and fungal growth. They have potential applications in medical device wrapping, food packaging, and agriculture.
CHEMICAL COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Omer Agazani, Alon Tulpin, Meital Reches
Summary: The amino acid DOPA can serve as a catalyst in prebiotic conditions similar to the harsh environment of early life forms. Research indicates that DOPA is able to catalyze reactions, suggesting its potential role as a prebiotic catalyst. Debates still exist regarding whether RNA polymerization or protein synthesis occurred first in the evolution of enzymes.
Article
Nanoscience & Nanotechnology
Abeer Karmi, Haya Dachlika, Gowri Priya Sakala, Dvir Rotem, Meital Reches, Danny Porath
Summary: Solid-state nanopores can be used as affordable and user-friendly detectors for biological molecules, such as DNA, RNA, and proteins, with chemically modified coatings for improved pore current stability. The system can distinguish between different molecules based on the translocation of nanoparticles, providing a promising detection platform for diagnostic purposes.
ACS APPLIED NANO MATERIALS
(2021)
Review
Chemistry, Multidisciplinary
Dan He, Yawen Li, Fuwen Zhao, Yuze Lin
Summary: High trap density in organic solar cells leads to localized charge carriers and reduced carrier lifetime, limiting device efficiency. This feature article summarizes the recent advances of trap suppression by material design and device engineering.
CHEMICAL COMMUNICATIONS
(2024)
Review
Chemistry, Multidisciplinary
Olivier Monfort, Arshitha Madhusudhan, Martin Motola
Summary: This article presents the advantages of coupling photocatalysis and Fenton-based processes for environmental remediation and discusses their synergy. It critically examines the simultaneous triggering of these two processes and provides insights into research approaches. The study aims to enhance understanding of this complex process and highlight the potential integration of new catalysts in current wastewater treatment technology.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Manideepa Dhar, Chittaranjan Mishra, Avijit Das, Uttam Manna
Summary: An approach of 'polymerization of monomers in its aggregated form' has been introduced to tailor the water wettability of fibrous and porous substrates, achieving hydrophobicity to superhydrophobicity transition, as well as patterned wettability. This facile chemical method provides a durable coating with adjustable and patterned wettability for various potential applications.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Saswat Ranjan Bhoi, Chhanda Debnath, Shikha Gandhi
Summary: In this article, a novel catalytic reaction using Pd(0) and Bronsted acid is reported for the synthesis of biologically important imidazolidinone-fused N-heterocycles through redox-neutral intramolecular N-allylation of indoles and pyrroles with alkynes. This atom-economical method is applicable to a wide range of substrates and eliminates the need for leaving groups or oxidizing agents commonly used in traditional allylation reactions.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Longkun Chen, Mingshuai Zhang, Meichen Liu, Zhuoyuan Liu, Yuetong Qiu, Zhilai Zhang, Fuchao Yu, Jiuzhong Huang
Summary: In this study, an efficient Rh(III)-catalyzed selective mono- and dual-C-H bond functionalization/cyclization with iodonium ylide as the sole coupling partner was demonstrated. Fused benzodiazepine skeletons were obtained in excellent yields, providing an improved approach to dual C-H unsymmetrical functionalization.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Alice Kennett, Sven Epple, Gabriella van der Valk, Irene Georgiou, Evelyne Gout, Romain R. Vives, Angela J. Russell
Summary: This study presents the design and synthesis of sulfated disaccharide inhibitors based on IdoA(2S)-GlcNS(6S), which showed potent inhibition of Sulf-2. The results suggest that IdoA(2S)-GlcNS(6S) is the shortest fragment size required for effective inhibition of Sulfs, and a trisulfated disaccharide is identified as the minimal fragment size of heparan sulfate for effective endosulfatase inhibition.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Mauro Garbini, Andrea Brunetti, Riccardo Pedrazzani, Magda Monari, Massimo Marcaccio, Giulio Bertuzzi, Marco Bandini
Summary: The self-adaptability of galvanostatic electrolysis was found to be helpful in a multistage chemo- and diastereoselective electrochemically promoted cyclodimerization of chalcones. Through a series of reductive events, densely functionalized cyclopentanes with five contiguous stereocenters were obtained (25 examples, yields up to 95%, dr values up to >20:1). Further experimental and electrochemical investigations indicated the crucial role of dynamic kinetic resolution of the aldol intermediate in the reaction mechanism.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Dhananjay S. Nipate, Neha Meena, Prakash N. Swami, Krishnan Rangan, Anil Kumar
Summary: In this study, the synthesis of functionalized benzo[a]phenazines and indazolo[2,3-a]quinolines was achieved through Rh(III)-catalyzed oxidative annulation of 2-arylquinoxalines and 2-aryl-2H-indazoles with allyl alcohols. The method showed a wide substrate scope, excellent functional group tolerance, good to high yields of annulated products, and the capability for scaled-up synthesis. A tentative mechanism of the annulation reaction was proposed based on a preliminary mechanistic investigation.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Ruonan Zhang, Abudukadi Tudi, Xia Yang, Xuping Wang, Zhihua Yang, Shujuan Han, Shilie Pan
Summary: A new lead tellurium borate material with a unique fundamental building block [B4O10] was synthesized and found to exhibit high birefringence. The structure-property relationship was discussed using first-principles calculations.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Amresh Kumar Singh, Baishali Thakurta, Anupam Giri, Monalisa Pal
Summary: This study introduces three key concepts for the quick synthesis of large-scale high-quality 2D materials films and their utilization in device fabrication.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Reina Hagiwara, Shun Nishimura, Kosuke Okeyoshi
Summary: A copolymer-conjugated nanocatalytic system has been developed to improve electron transfer and enhance photoinduced H2 generation.
CHEMICAL COMMUNICATIONS
(2024)
