期刊
CHEMICAL COMMUNICATIONS
卷 50, 期 73, 页码 10687-10690出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4cc03320e
关键词
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资金
- National Key Basic Research Program of China [2013CB932703, 2013CB933704]
- National Natural Science Foundation of China [21390414, 31271072, 31200751, 31300827, 81201133, 81101743]
Au-25 clusters stabilized by tridecapeptides were firstly synthesized, which can well penetrate the cell membrane and exactly locate in the cytoplasm. Hence the Au clusters significantly suppress the TrxR1 activity in the cytoplasm, and further induce the up-regulation of the activated PARP level which allows the tumor cell apoptosis to occur in a Au dose dependent manner.
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