Article
Chemistry, Multidisciplinary
Manoj Trivedi, Santosh Kumar Dubey, Gurmeet Kaur, Nigam P. Rath
Summary: New water-soluble ruthenium(ii) and ruthenium(iv) DMSO complexes have been synthesized and characterized, showing good efficiency and selectivity for aqueous-phase nitrile hydration, with complex 3 performing the best. The catalyst exhibited stability, high turnover numbers, and could be reused multiple times without significant loss in catalytic activity.
NEW JOURNAL OF CHEMISTRY
(2021)
Article
Chemistry, Organic
Xinhao Zhu, Kerou Wan, Jin Zhang, Hui Zhao, Yang He, Yangmin Ma, Xiufang Yang, Michal Szostak
Summary: This study reports an extremely mild method for the direct, transition-metal-free esterification of thioamides through the selective generation of tetrahedral intermediates. It represents the first transition-metal-free approach to the thioamide to thionoester transformation in organic synthesis. The ground-state destabilization of single-atom bioisosteric thioamides will expand the arsenal of valuable amide bond functionalization reactions.
Article
Chemistry, Multidisciplinary
Sevval Efe, Carsten Schauerte, Klaus Merz
Summary: Crystallization under hydrothermal conditions is an interesting method to selectively influence crystallization pathways and processes. The crystallization of 3-cyanopyridine and glutaric acid from aqueous solutions under ambient conditions resulted in the formation of the 2:1 cocrystalline entity 1. Crystallizations under thermal and hydrothermal conditions, depending on the amounts of water used, led to the polymorphic forms 1 and 2 of the 2:1 cocrystalline entity of 3-cyanopyridine and glutaric acid, as well as the cocrystalline entity of nicotinamide and glutaric acid.
CRYSTAL GROWTH & DESIGN
(2022)
Article
Chemistry, Inorganic & Nuclear
Jayeeta Bhattacharjee, Parveen Rawal, Suman Das, Adimulam Harinath, Puneet Gupta, Tarun K. Panda
Summary: In this paper, the synthesis of titanium catalysts through salt metathesis reaction is reported, and the detailed steps of a series of reactions are described. The study found that the titanium catalyst exhibited good selective catalytic activity towards ester functionalities under solvent-free conditions, and the key steps of the reaction mechanism were revealed through DFT studies.
DALTON TRANSACTIONS
(2022)
Article
Chemistry, Organic
Xiaoting Wen, Jingxi He, Hui Xi, Qi Zheng, Weiping Liu
Summary: A general and practical methodology for the hydration of nitriles to primary amides enabled by manganese catalyst is described. This protocol demonstrates a broad substrate scope and good functional group tolerance, allowing for the synthesis of corresponding amides in good to excellent yields. Preliminary mechanistic studies suggest the involvement of metal-ligand cooperation (MLC) mode in the catalytic process.
ASIAN JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Laurynas Gausas, Ralf Jackstell, Troels Skrydstrup, Matthias Beller
Summary: Amide bond reduction is an important transformation for the synthesis of valuable alcohols and amines. Catalytic amide hydrogenation has attracted increasing attention due to its high efficiency and low environmental impact. We report a mild amide hydrogenation method that selectively converts 2 degrees-benzamides to anilines and alcohols with commercially available precursors under basic conditions.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2022)
Article
Chemistry, Multidisciplinary
Brady J. H. Austen, Marissa L. Clapson, Marcus W. Drover
Summary: This report describes the use of metal-ligand cooperativity to convert unsaturated small molecules such as nitriles into reduced products. The study reveals the reactivity differences in nitrogen and phosphorus carbon triple bond systems and investigates the effect of SCS stabilization using nitrile dihydroboration as a model reaction.
Article
Chemistry, Multidisciplinary
Muhammad Asif Hussain, Eun Ju Choi, Adnan Maqbool, Muhammad Atif, Hassan Zeb, JaeGoo Yeo, Jung-A Yu, Yong-Hun Cho, Moses Noh, Jung Won Kim
Summary: A facile eco-friendly heterogeneous catalytic system has been developed for amide synthesis using Ru/MnO2 catalyst in water, showing outstanding activity for a wide range of nitriles and tolerance for heteroatom-containing nitriles. Pharmaceutically important compounds have been synthesized with appreciable yields and selectivities. The catalyst can be reused multiple times, demonstrating a green and technologically acceptable protocol.
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Zhujun Zhang, Yihao Jiang, Jiang Li, Masayoshi Miyazaki, Masaaki Kitano, Hideo Hosono
Summary: This study reports a 2D electride compound of Ba2N with anionic electrons that efficiently facilitates TM-free N-2 dissociation under mild conditions. The reaction of anionic electrons with N-2 molecules stabilizes diazenide and significantly lowers the activation energy for dissociation.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Li Liu, Yingdong Zhou, Lixian Guo, Guiying Li, Changwei Hu
Summary: A method for producing nitrogen-containing compounds from natural microalgae was developed and the effects of different conditions on the yield were studied. Addition of ZrO2 resulted in an increase in the yields of fatty amides and nitriles, while the total yield of fatty acids decreased.
Article
Chemistry, Multidisciplinary
Huan Zhang, An Cai, Hongwei He, Qicheng Zhang, Fengbao Zhang, Guoliang Zhang, Xiaobin Fan, Wenchao Peng, Yang Li
Summary: Heteroatom-doped carbon-based materials, such as nitrogen-doped 3D hollow carbon spheres (N-HCSs), show great potential as metal-free catalysts for selective oxidation of C-H bonds. The catalytic performance of N-HCSs is influenced by deposition temperature, nitrogen content, and pore structure. Higher mesopore abundance and moderate graphite nitrogen content enhance the catalytic activity of N-HCSs.
NEW JOURNAL OF CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Carla Casadevall, Vlad Martin-Diaconescu, Wesley R. Browne, Sergio Fernandez, Federico Franco, Noemi Cabello, Jordi Benet-Buchholz, Benedikt Lassalle-Kaiser, Julio Lloret-Fillol
Summary: In this study, a Ru(IV) side-on peroxo complex is reported as a 'missing link' for species formed after the rate-determining O-O bond-forming step, confirming water nucleophilic attack as a viable mechanism for O-O bond formation.
Article
Engineering, Chemical
Ananda Karak, Bholanath Mahanty, Prasanta K. Mohapatra, Richard J. M. Egberink, Thichur P. Valsala, Darshan B. Sathe, Raj B. Bhatt, Jurriaan Huskens, Willem Verboom
Summary: Liquid-liquid extraction of actinide ions UO22+, Pu4+, and Am3+ using tripodal amide extractants HONTA and HDDNTA in nitric acid feed solutions showed that HONTA was more effective than HDDNTA in extracting the metal ions. Different chemical species were formed for each metal ion under various conditions, and efficient back extraction methods were identified for quantitatively stripping Pu(IV), U(VI), and Am(III). The ligand solutions exhibited good radiation stability and distribution data were obtained for possible nuclear fuel cycle applications under U(VI) loading conditions.
SEPARATION AND PURIFICATION TECHNOLOGY
(2021)
Article
Chemistry, Analytical
Dayi Guo, Bo Cai, Rui Kang, Shuai Wang, Junfeng Feng, Hui Pan
Summary: A new catalyst, Ni1Co3Al2-600, was developed for the hydrodeoxygenation process of biomass to produce biofuels and chemicals. The catalyst showed excellent catalytic performance and stability.
JOURNAL OF ANALYTICAL AND APPLIED PYROLYSIS
(2023)
Article
Chemistry, Physical
Zhongmiao Chen, Wei Chen, Lei Zhang, Wenqian Fu, Guoren Cai, Anmin Zheng, Tiandi Tang
Summary: The acidic mesoporous ZSM-5 assembled palladium (Pd/ZSM-5-H) can efficiently convert primary amides to nitriles without the need for any additives, offering excellent applicability. The highly dispersive Pd(II) species grafted on ZSM-5-H via strong binding interaction drive significantly higher reaction activity compared to other catalysts. The active centers of Pd/ZSM-5-H were attributed to [PdOH]+, which catalyzes the conversion of primary amides to nitriles with high thermodynamic and kinetic favorability.
APPLIED CATALYSIS B-ENVIRONMENTAL
(2022)
Review
Chemistry, Physical
Victorio Cadierno
Review
Chemistry, Organic
Vittorio Cadierno
Summary: Recent developments in the metal-catalyzed hydrofunctionalization of alkynes with carboxylic acids are comprehensively reviewed in this study, with a focus on both inter- and intramolecular processes and their implications in the synthesis of natural products and biologically active molecules. This review also highlights the use of cascade processes for the assembly of complex heterocyclic compounds.
CURRENT ORGANIC CHEMISTRY
(2021)
Editorial Material
Chemistry, Physical
Victorio Cadierno
Article
Chemistry, Multidisciplinary
Ludivine Delfau, Samantha Nichilo, Florian Molton, Julie Broggi, Eder Tomas-Mendivil, David Martin
Summary: This study reported the synthesis of acyl azolium salts from various types of carbenes and the generation of their corresponding radicals and enolates, revealing the role of additives in the redox behavior of these compounds and correcting misconceptions about radical transformations of aldehyde derivatives. The reducing ability of enolates derived from certain carbenes was found to be underestimated, and catalytic intermediates were shown to transfer electrons efficiently at room temperature. Enol derivatives of certain carbenes were identified as powerful reducing agents.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Physical
Victorio Cadierno
Summary: Metal-catalyzed hydrofunctionalization reactions of alkynes, especially conjugated 1,3-diynes, have been extensively studied. These reactions provide a straightforward and efficient route to functionalized olefins and various heterocyclic and carbocyclic compounds. However, the regio- and stereocontrol issues associated with conjugated 1,3-diynes make the hydrofunctionalization reactions challenging.
Article
Chemistry, Organic
Javier Francos, Victorio Cadierno
Summary: This study presents a new synthetic procedure for obtaining two previously reported donor-acceptor butadiene dyes. The reactions proceed in water under MW irradiation and the target products were characterized using various analysis methods.
Article
Chemistry, Multidisciplinary
Jesse L. Peltier, Melinda R. Serrato, Valentin Thery, Jacques Pecaut, Eder Tomas-Mendivil, Guy Bertrand, Rodolphe Jazzar, David Martin
Summary: An air-stable (amino)(amido)radical was prepared by the reaction of a cyclic (alkyl)(amino)carbene with carbazoyl chloride, followed by one-electron reduction. The neighboring radical center was found to weaken the amide bond, enabling the amino group to serve as a strong acceptor under steric constraint and enhancing the stabilizing captodative effect.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Organic
Valentin Thery, Cyriac Barra, Alexandra Simeoni, Jacques Pecaut, Eder Tomas-Mendivil, David Martin
Summary: This paper reports the synthesis and structural study of 2-substituted 1,3-bis(dimethylamino)pentalenes. The substituents donate two electrons, shifting the aromatic pattern to more suitable polarized structures. Depending on the steric trade-off, either planar cyclopentadienyl vinamidiniums or distorted structures featuring a pyramidalized ylidic carbon adjancent to a stabilized pi-conjugated iminium can be obtained. This study provides insights into unconventional distorted conformations of organic molecules.
Article
Chemistry, Multidisciplinary
Lucas Mele, Rachida Babouri, Jean-Luc Pirat, Eder Tomas-Mendivil, David Martin, Tahar Ayad, David Virieux
Summary: In the past 30 years, researchers have shown great interest in synthesizing atropochiral biaryls with steric congestion on the ortho-substituted arenes. This study presents an efficient approach to produce a new class of 2,2' disubstituted biaryls bridgehead phosphine oxides with exceptional conformational stability. The researchers found that by replacing only one hydrogen atom at the ortho position with a fluorine atom, the rotation of the biaryl backbone can be restricted at temperatures below 80°C, significantly extending the limits of atropostability. Additionally, their investigations revealed unique insights into the isomerization mechanism of these molecules.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Review
Chemistry, Physical
Pascale Crochet, Victorio Cadierno
Summary: N-Heterocyclic carbenes (NHCs) are widely used ligands in organometallic chemistry and catalysis due to their stability and flexibility. By functionalizing NHCs with hydrophilic groups, they can be used in aqueous catalysis, which is a hot topic in Green Chemistry. This review summarizes the research on hydrophilic NHC-gold catalysts and the catalytic applications of water-soluble gold nanoparticles stabilized by hydrophilic NHCs.
Article
Chemistry, Multidisciplinary
Ludivine Delfau, Nadhrata Assani, Samantha Nichilo, Jacques Pecaut, Christian Philouze, Julie Broggi, David Martin, Eder Tomas-Mendivil
Summary: We isolated and studied dimers derived from popular thiazol-2-ylidene organocatalysts. The model compound with 2,6-di(isopropyl)phenyl (Dipp) N-substituents was found to be a stronger reducing agent compared to previously studied bis(thiazol-2-ylidenes). Furthermore, the significant potential difference between the first and second oxidation of the dimer allows for the isolation of an air-persistent radical cation, which efficiently promotes the radical transformation of alpha-bromoamides into oxindoles.
ACS ORGANIC & INORGANIC AU
(2023)
Article
Chemistry, Organic
Valentin Thery, Cyriac Barra, Alexandra Simeoni, Jacques Pecaut, Eder Tomas-Mendivil, David Martin
Summary: We report the synthesis and structural study of 2-substituted 1,3-bis(dimethylamino)pentalenes, which exhibit shifted polarized structures due to the electron-donating substituents. Depending on the steric effects, the compounds can adopt planar cyclopentadienyl vinamidiniums or distorted structures mimicking key Breslow intermediates in thiamine-dependent enzymes. This study highlights the use of avoiding anti-aromaticity in accessing unconventional distorted conformations of organic molecules.
Article
Chemistry, Multidisciplinary
Valentin Thery, Florian Molton, Selim Sirach, Neven Tillet, Jacques Pecaut, Eder Tomas-Mendivil, David Martin
Summary: In this study, we report a peculiar Stenhouse salt that does not undergo cyclopentenones formation upon basification due to the steric hindrance of its bulky stable carbene patterns. This unique feature allowed us to observe and characterize the transient open-chain neutral derivative, which was isolated in its cyclized form. The cyclized form exhibits an unusually long reactive C-O bond (150 pm) and demonstrates rich electrochemistry, including oxidation into an air-persistent radical cation.
Review
Chemistry, Inorganic & Nuclear
Pascale Crochet, Victorio Cadierno
Summary: This review article focuses on the catalytic applications of arene-osmium(II) complexes, discussing transfer hydrogenation, hydrogenation, oxidation, and nitrile hydration reactions, as well as different C-C bond forming processes comprehensively, showing that they can achieve comparable or superior effectiveness in some instances compared to their ruthenium analogues.
Article
Chemistry, Organic
Rebeca Gonzalez-Fernandez, Pascale Crochet, Victorio Cadierno
Summary: The title compound was synthesized by electrophilic cyanation of commercially available (R)-4-chloro-alpha-methylbenzylamine, yielding a yellow oil in 84% yield. It was characterized using various methods such as H-1 and C-13{H-1] NMR, IR, HRMS, and specific rotation measurements.
Review
Chemistry, Multidisciplinary
Dan He, Yawen Li, Fuwen Zhao, Yuze Lin
Summary: High trap density in organic solar cells leads to localized charge carriers and reduced carrier lifetime, limiting device efficiency. This feature article summarizes the recent advances of trap suppression by material design and device engineering.
CHEMICAL COMMUNICATIONS
(2024)
Review
Chemistry, Multidisciplinary
Olivier Monfort, Arshitha Madhusudhan, Martin Motola
Summary: This article presents the advantages of coupling photocatalysis and Fenton-based processes for environmental remediation and discusses their synergy. It critically examines the simultaneous triggering of these two processes and provides insights into research approaches. The study aims to enhance understanding of this complex process and highlight the potential integration of new catalysts in current wastewater treatment technology.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Manideepa Dhar, Chittaranjan Mishra, Avijit Das, Uttam Manna
Summary: An approach of 'polymerization of monomers in its aggregated form' has been introduced to tailor the water wettability of fibrous and porous substrates, achieving hydrophobicity to superhydrophobicity transition, as well as patterned wettability. This facile chemical method provides a durable coating with adjustable and patterned wettability for various potential applications.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Saswat Ranjan Bhoi, Chhanda Debnath, Shikha Gandhi
Summary: In this article, a novel catalytic reaction using Pd(0) and Bronsted acid is reported for the synthesis of biologically important imidazolidinone-fused N-heterocycles through redox-neutral intramolecular N-allylation of indoles and pyrroles with alkynes. This atom-economical method is applicable to a wide range of substrates and eliminates the need for leaving groups or oxidizing agents commonly used in traditional allylation reactions.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Longkun Chen, Mingshuai Zhang, Meichen Liu, Zhuoyuan Liu, Yuetong Qiu, Zhilai Zhang, Fuchao Yu, Jiuzhong Huang
Summary: In this study, an efficient Rh(III)-catalyzed selective mono- and dual-C-H bond functionalization/cyclization with iodonium ylide as the sole coupling partner was demonstrated. Fused benzodiazepine skeletons were obtained in excellent yields, providing an improved approach to dual C-H unsymmetrical functionalization.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Alice Kennett, Sven Epple, Gabriella van der Valk, Irene Georgiou, Evelyne Gout, Romain R. Vives, Angela J. Russell
Summary: This study presents the design and synthesis of sulfated disaccharide inhibitors based on IdoA(2S)-GlcNS(6S), which showed potent inhibition of Sulf-2. The results suggest that IdoA(2S)-GlcNS(6S) is the shortest fragment size required for effective inhibition of Sulfs, and a trisulfated disaccharide is identified as the minimal fragment size of heparan sulfate for effective endosulfatase inhibition.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Mauro Garbini, Andrea Brunetti, Riccardo Pedrazzani, Magda Monari, Massimo Marcaccio, Giulio Bertuzzi, Marco Bandini
Summary: The self-adaptability of galvanostatic electrolysis was found to be helpful in a multistage chemo- and diastereoselective electrochemically promoted cyclodimerization of chalcones. Through a series of reductive events, densely functionalized cyclopentanes with five contiguous stereocenters were obtained (25 examples, yields up to 95%, dr values up to >20:1). Further experimental and electrochemical investigations indicated the crucial role of dynamic kinetic resolution of the aldol intermediate in the reaction mechanism.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Dhananjay S. Nipate, Neha Meena, Prakash N. Swami, Krishnan Rangan, Anil Kumar
Summary: In this study, the synthesis of functionalized benzo[a]phenazines and indazolo[2,3-a]quinolines was achieved through Rh(III)-catalyzed oxidative annulation of 2-arylquinoxalines and 2-aryl-2H-indazoles with allyl alcohols. The method showed a wide substrate scope, excellent functional group tolerance, good to high yields of annulated products, and the capability for scaled-up synthesis. A tentative mechanism of the annulation reaction was proposed based on a preliminary mechanistic investigation.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Ruonan Zhang, Abudukadi Tudi, Xia Yang, Xuping Wang, Zhihua Yang, Shujuan Han, Shilie Pan
Summary: A new lead tellurium borate material with a unique fundamental building block [B4O10] was synthesized and found to exhibit high birefringence. The structure-property relationship was discussed using first-principles calculations.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Amresh Kumar Singh, Baishali Thakurta, Anupam Giri, Monalisa Pal
Summary: This study introduces three key concepts for the quick synthesis of large-scale high-quality 2D materials films and their utilization in device fabrication.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Reina Hagiwara, Shun Nishimura, Kosuke Okeyoshi
Summary: A copolymer-conjugated nanocatalytic system has been developed to improve electron transfer and enhance photoinduced H2 generation.
CHEMICAL COMMUNICATIONS
(2024)
