Article
Biology
Qian Li, Ruben Cebrian, Manuel Montalban-Lopez, Huan Ren, Weihui Wu, Oscar P. Kuipers
Summary: Li, Cebrian et al. demonstrate that a combination of peptide D-11 and vancomycin shows potent antimicrobial activity against a panel of Gram-negative pathogens without apparent toxicity. They also find that this combination effectively clears Pseudomonas aeruginosa in mice, providing a potential antimicrobial therapy for humans.
COMMUNICATIONS BIOLOGY
(2021)
Article
Biophysics
Zonghao Tang, Shuyun Liu, Ni Chen, Mao Luo, Jianbo Wu, Youkun Zheng
Summary: This study demonstrates the therapeutic potential of 4,6-diamino-2-mercaptopyrimidine-functionalized AuNCs (AuDAMP) for intracellular multidrug-resistant infections in a co-culture model of macrophages and methicillin-resistant Staphylococcus aureus (MRSA). AuNCs exhibit superior intracellular antibacterial capability, eliminate MRSA phagocytosed by macrophages, and have no cytotoxic effects on host RAW 264.7 macrophages. Additionally, AuDAMP treatment enhances the innate immune response, defends against pathogens invading host cells, and alleviates bacterial infection-induced inflammatory responses.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Microbiology
Christian Xedzro, Kwaku Tano-Debrah, Hiroyuki Nakano
Summary: The increase in food-borne outbreaks is a global public health concern, and the use of spices with antimicrobial properties has become an important tool for controlling food-borne pathogens. This study evaluated the antibacterial potential of Ghanaian spices against Listeria monocytogenes and other common food-borne pathogens, finding that cloves and negro peppers showed significant bactericidal activity.
MICROBIOLOGICAL RESEARCH
(2022)
Article
Chemistry, Medicinal
Joseph Blondeau, Heleen DeCory
Summary: The combination of besifloxacin with benzalkonium chloride can enhance the killing activity against common bacteria implicated in ophthalmic infections, potentially helping prevent resistance development and treat resistant organisms.
Article
Biochemistry & Molecular Biology
Raja Aadil Hussain Bhat, Victoria C. C. Khangembam, Vinita Pant, Ritesh Shantilal Tandel, Pramod Kumar Pandey, Dimpal Thakuria
Summary: Antimicrobial peptide RH12 was designed and evaluated for its potent activity against bacterial pathogens in aquaculture. It showed strong binding affinity to the virulence protein of Aeromonas sobria and exhibited good antibacterial activity against various bacteria. RH12 demonstrated stability and minimal toxicity towards fish red blood cells, suggesting its potential as a promising candidate for combating microbial infections in aquaculture.
INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS
(2023)
Article
Pharmacology & Pharmacy
Prapairat Seephonkai, Sutthira Sedlak, Komgrit Wongpakam, Kusavadee Sangdee, Aphidech Sangdee
Summary: The water extracts from Caesalpinia sappan and Ochna integerrima exhibited bacteriostatic or bactericidal activity against six tested pathogenic bacteria. The activity was observed to be dependent on bacterial strains and test concentrations, with bactericidal activity demonstrated at 2 x MIC. The morphological alterations of target bacterial cells, including changes in cell size, lysis, and formation of cell cavities, were detected after treatment with the water extracts.
JOURNAL OF PHARMACY & PHARMACOGNOSY RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Asesh Das, Biswajit Roy, Barlina Konwar, Aiyagari Ramesh, Gopal Das
Summary: Naphthalimide-based linear monourea receptors L-1 and L-2 can bind oxyanions and halide ions in both solid and solution states. Receptor L-1 efficiently fixes airborne CO2 induced by fluoride/hydroxide, forming air-stable dianions enclosed by n-TBA cations. Ligands L-1 and L-2 demonstrate bactericidal activity against E. coli MTCC 433 and are non-toxic to HEK 293 cells.
CRYSTAL GROWTH & DESIGN
(2022)
Article
Chemistry, Physical
Priya Mullick, Gopal Das, Aiyagari Ramesh
Summary: This study demonstrates the use of 2-dodecylmalonic acid as a template in biomineralization-inspired synthesis of hydroxyapatite nanoparticles, showing that it can regulate particle size and shape at different concentrations. The self-assembly of the amphiphilic template plays a nuanced role in the mineralization process, guiding scaffold design for bone tissue engineering applications.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Engineering, Environmental
Deepa Sachan, Gopal Das
Summary: In this study, a novel nanocomposite material was synthesized for the removal of toxic heavy metals from water. The nanocomposite showed high adsorption efficiency and followed Langmuir adsorption isotherm for copper and zinc. The findings suggest that this nanocomposite has the potential to be an eco-friendly, economical, and alternative adsorbent for heavy metal ions.
JOURNAL OF HAZARDOUS TOXIC AND RADIOACTIVE WASTE
(2022)
Article
Environmental Sciences
Deepa Sachan, Arnab Ghosh, Gopal Das
Summary: Salvinia minima proved to be an effective biosorbent for the selective removal of cationic dyes and heavy metal ions. The experimental conditions greatly influenced the adsorption process, and the maximum adsorption capacity for the dyes and heavy metal ions was determined.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL SCIENCE AND TECHNOLOGY
(2023)
Review
Chemistry, Multidisciplinary
Naresh Niranjan Dhanasekar, Durairaj Thiyagarajan, Dhiraj Bhatia
Summary: Nanopore-based technologies have greatly expanded the toolkit for label-free single-molecule sensing and biotechnological applications. DNA nanotechnology, especially DNA origami-based devices, allows for the construction of complex nanostructures with precise control over nanopore size/shape. This review discusses the use of DNA nanotechnology in constructing nanopores in lipid-based systems or coupled with solid-state devices and nanocapillaries, and summarizes the sensing properties of DNA-based and RNA-based nanopores.
CHEMISTRY-AN ASIAN JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Sagnik De, Oiyao Appun Pegu, Gopal Das
Summary: We designed three amphiphilic substituted urea compounds with different chain lengths. These hydrophobic amphiphiles exhibited aggregation-induced emission upon solvent switching. Microscopy was used to provide detailed information about the aggregates. The hydrophobicity of these AIEgens was utilized to create water-repelling fluorescent surfaces. The AIEgen, through photoinduced electron transfer-mediated mechanism, has been employed for the detection of nitroantibiotics. The analytical usefulness of the AIEgen in detecting nitroantibiotics in biofluids is being demonstrated.
Article
Chemistry, Applied
Partha Protim Bakal, Gopal Das
Summary: Potassium carbonate-activated biochar derived from Ricinus communis and Colocasia esculanta stems exhibited efficient removal of Cd2+ and Pb2+ from synthetic wastewater. The adsorption parameters and mechanisms were studied, with the findings indicating that biosorption followed the Freundlich isotherm and the pseudo-second-order kinetic model, and involved physical adsorption. The optimum conditions for Cd2+ and Pb2+ removal were determined, and the adsorption capacity was found to be 55 mg g(-1) for Cd and 76 mg g(-1) for Pb. Thermodynamics showed spontaneous and endothermic adsorption, and desorption studies indicated recyclability up to 5 cycles. These results highlight the potential of RCSB and CESB for efficient removal of heavy metal ions from aqueous environments.
JOURNAL OF WATER CHEMISTRY AND TECHNOLOGY
(2023)
Article
Green & Sustainable Science & Technology
Partha Protim Bakal, Gopal Das
Summary: In this study, low-temperature Ricinus communis stem-activated biochar (RCSB) was synthesized using chemical activation and heating method. The RCSB showed high selective adsorption capability for methylene blue and malachite green, and can be regenerated for reuse. The novelty of this work lies in the low synthesis temperature and cost-effectiveness of the biochar.
WATER CONSERVATION SCIENCE AND ENGINEERING
(2023)
Article
Chemistry, Multidisciplinary
Oiyao Appun Pegu, Rubi Moral, Gopal Das
Summary: The dipodal monourea anion receptors BPU-1 and BPU-2 can interact with various geometries of anions. BPU-1 selectively senses SO4 2-/HSO4 - in the aqueous medium, and both receptors undergo anion-induced intramolecular cyclization in the presence of F-/HO-.
CRYSTAL GROWTH & DESIGN
(2023)
Article
Chemistry, Applied
Rubi Moral, Oiyao Appun Pegu, Gopal Das
Summary: Three receptors (L1-3) based on 4-(dimethylamino)cinnamaldehyde were prepared to investigate the influence of aromatic core substitution on self-assembly behavior. The receptors demonstrated different micro/nanostructures depending on solvent polarities and hydrogen-bonding abilities, which significantly affected the supramolecular self-assembly process. The selective sensing of picric acid among nitro-aromatic compounds, known for its high explosiveness, was thoroughly studied in both solid and solution states by the receptors, along with their mechanistic details. Real water samples were used to demonstrate the practical utility of this study, including economical paper-strip applications.
Review
Chemistry, Multidisciplinary
Megha Basak, Gopal Das
Summary: Fresh air and clean water are crucial for humans, fauna, and flora. Due to the high toxicity and widespread presence of NACs and VOCs in the environment, the development of chemosensors for these contaminants has gained significant attention. This review focuses on the latest advancements in fluorescent chemosensors, specifically small molecular frameworks, for NACs and VOCs from 2015 to 2022. The detection methods on various platforms and their potential applications in natural water bodies, vapor phase, and paper strip analysis are also discussed.
Article
Chemistry, Multidisciplinary
Megha Basak, Gopal Das
Summary: A versatile bifunctional probe, L-1, was developed for visualizing and quantitatively analyzing Hg2+ and GSH separately in water. Probe L-1 showed rapid sensing towards Hg2+ (LOD = about 17.35 ppb) and GSH (LOD = about 25.83 ppb) with a significant turn-on fluorescence response and red-shifted emission maxima. The sensing strategy was successfully applied to detect Hg2+ and GSH in contaminated natural water, simulated physiological media, and real biological samples. Affordable test strips for visual and quantitative detection of Hg2+ and GSH may have great potential for rapid preliminary environmental monitoring.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Physical
Sagnik De, Gopal Das
Summary: We designed five propellor-shaped molecules based on the quinoxaline scaffold with functional group variation. These molecules exhibit aggregation-induced emission and their responses to different solvents were studied spectroscopically and microscopically. The aggregation facet was analyzed in both solid and solution states. Notably, one of the molecules, L-2, showed specific interaction with a cationic surfactant unlike the other congeners which proceeded via disaggregation. Real sample analysis on freshwater and waste effluent samples demonstrated the analytical and environmental significance of these molecules.
Article
Chemistry, Multidisciplinary
Rubi Moral, Oiyao Appun Pegu, Gopal Das
Summary: This study reports the aggregation and sensing properties of two neutral benzimidazole-based urea receptors. R1 exhibits aggregation-induced emission (AIE) properties, while R2 shows typical aggregation-caused quenching (ACQ) behavior. Both R1 and R2 can sense SO42-/HSO4- in an aqueous medium, although with different binding affinities.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Nanoscience & Nanotechnology
Basu Bhattacharjee, Asesh Das, Gopal Das, Aiyagari Ramesh
Summary: The present study demonstrates that a urea-based ligand can serve as an efflux pump inhibitor to restore the efficacy of ciprofloxacin against MRSA. This ligand significantly inhibits efflux pump activity, downregulates norA gene expression, and prevents the emergence of ciprofloxacin resistance. Furthermore, a nanocarrier loaded with the urea-based ligand shows promising anti-MRSA activity.
ACS APPLIED BIO MATERIALS
(2022)
Review
Chemistry, Multidisciplinary
Dan He, Yawen Li, Fuwen Zhao, Yuze Lin
Summary: High trap density in organic solar cells leads to localized charge carriers and reduced carrier lifetime, limiting device efficiency. This feature article summarizes the recent advances of trap suppression by material design and device engineering.
CHEMICAL COMMUNICATIONS
(2024)
Review
Chemistry, Multidisciplinary
Olivier Monfort, Arshitha Madhusudhan, Martin Motola
Summary: This article presents the advantages of coupling photocatalysis and Fenton-based processes for environmental remediation and discusses their synergy. It critically examines the simultaneous triggering of these two processes and provides insights into research approaches. The study aims to enhance understanding of this complex process and highlight the potential integration of new catalysts in current wastewater treatment technology.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Manideepa Dhar, Chittaranjan Mishra, Avijit Das, Uttam Manna
Summary: An approach of 'polymerization of monomers in its aggregated form' has been introduced to tailor the water wettability of fibrous and porous substrates, achieving hydrophobicity to superhydrophobicity transition, as well as patterned wettability. This facile chemical method provides a durable coating with adjustable and patterned wettability for various potential applications.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Saswat Ranjan Bhoi, Chhanda Debnath, Shikha Gandhi
Summary: In this article, a novel catalytic reaction using Pd(0) and Bronsted acid is reported for the synthesis of biologically important imidazolidinone-fused N-heterocycles through redox-neutral intramolecular N-allylation of indoles and pyrroles with alkynes. This atom-economical method is applicable to a wide range of substrates and eliminates the need for leaving groups or oxidizing agents commonly used in traditional allylation reactions.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Longkun Chen, Mingshuai Zhang, Meichen Liu, Zhuoyuan Liu, Yuetong Qiu, Zhilai Zhang, Fuchao Yu, Jiuzhong Huang
Summary: In this study, an efficient Rh(III)-catalyzed selective mono- and dual-C-H bond functionalization/cyclization with iodonium ylide as the sole coupling partner was demonstrated. Fused benzodiazepine skeletons were obtained in excellent yields, providing an improved approach to dual C-H unsymmetrical functionalization.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Alice Kennett, Sven Epple, Gabriella van der Valk, Irene Georgiou, Evelyne Gout, Romain R. Vives, Angela J. Russell
Summary: This study presents the design and synthesis of sulfated disaccharide inhibitors based on IdoA(2S)-GlcNS(6S), which showed potent inhibition of Sulf-2. The results suggest that IdoA(2S)-GlcNS(6S) is the shortest fragment size required for effective inhibition of Sulfs, and a trisulfated disaccharide is identified as the minimal fragment size of heparan sulfate for effective endosulfatase inhibition.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Mauro Garbini, Andrea Brunetti, Riccardo Pedrazzani, Magda Monari, Massimo Marcaccio, Giulio Bertuzzi, Marco Bandini
Summary: The self-adaptability of galvanostatic electrolysis was found to be helpful in a multistage chemo- and diastereoselective electrochemically promoted cyclodimerization of chalcones. Through a series of reductive events, densely functionalized cyclopentanes with five contiguous stereocenters were obtained (25 examples, yields up to 95%, dr values up to >20:1). Further experimental and electrochemical investigations indicated the crucial role of dynamic kinetic resolution of the aldol intermediate in the reaction mechanism.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Dhananjay S. Nipate, Neha Meena, Prakash N. Swami, Krishnan Rangan, Anil Kumar
Summary: In this study, the synthesis of functionalized benzo[a]phenazines and indazolo[2,3-a]quinolines was achieved through Rh(III)-catalyzed oxidative annulation of 2-arylquinoxalines and 2-aryl-2H-indazoles with allyl alcohols. The method showed a wide substrate scope, excellent functional group tolerance, good to high yields of annulated products, and the capability for scaled-up synthesis. A tentative mechanism of the annulation reaction was proposed based on a preliminary mechanistic investigation.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Ruonan Zhang, Abudukadi Tudi, Xia Yang, Xuping Wang, Zhihua Yang, Shujuan Han, Shilie Pan
Summary: A new lead tellurium borate material with a unique fundamental building block [B4O10] was synthesized and found to exhibit high birefringence. The structure-property relationship was discussed using first-principles calculations.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Amresh Kumar Singh, Baishali Thakurta, Anupam Giri, Monalisa Pal
Summary: This study introduces three key concepts for the quick synthesis of large-scale high-quality 2D materials films and their utilization in device fabrication.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Reina Hagiwara, Shun Nishimura, Kosuke Okeyoshi
Summary: A copolymer-conjugated nanocatalytic system has been developed to improve electron transfer and enhance photoinduced H2 generation.
CHEMICAL COMMUNICATIONS
(2024)
