Article
Spectroscopy
Feng Li, Wen Yao, Chang-He Tian, Ya-Fei Du, Jun-Zheng Wang, Tian-Yang Zhang, Jun-Ying Miao, Bao-Xiang Zhao
Summary: A novel ratiometric fluorescent probe was developed for the detection of thiophenol derivatives, showing high fluorescence signal change ratio and low detection limit, suitable for environmental monitoring and biological research.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Chemistry, Analytical
Shifei Li, Lin Wang, Yanyan Ma, Weiying Lin
Summary: Abnormal levels of SO2 can lead to cardiovascular disease and respiratory allergies in organisms. Excessive addition of SO2 derivatives, which are used as food preservatives, can also be harmful to health. Therefore, a highly sensitive method for detecting SO2 and its derivatives in biological systems and real food samples is essential. In this study, a new fluorescent probe called TCMs was developed, which demonstrated high selectivity and sensitivity for detecting SO2 derivatives. The TCMs successfully identified both exogenous and endogenous SO2 derivatives and showed high sensitivity to SO2 derivatives in food samples. Moreover, test strips prepared using TCMs could accurately evaluate the content of SO2 derivatives in aqueous solutions, providing a potential chemical tool for detecting SO2 derivatives in living cells and real food samples.
Article
Chemistry, Analytical
Qi Song, Ning Wang, Fangkun Wang, Kaizhuo Guo, Jiwei Cui, Jingcheng Hao, Yong-Qiang Zhang, Jie Jiang
Summary: In this study, a hydrogen bonding-anchored sensing strategy was used to develop a NIR fluorescent probe CDM-1, which can detect N2H4 with ratiometric and colorimetric responses. The probe showed high selectivity and reactivity with a low limit of detection value and demonstrated its potential in monitoring N2H4 in living cells.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Chemistry, Multidisciplinary
O. Wa-Yi, Wing-Cheung Chan, Caifeng Xu, Jie-Ren Deng, Ben Chi-Bun Ko, Man-Kin Wong
Summary: A novel fluorescent quinolizinium-based turn-off probe has been developed for selective detection of cysteine which shows high selectivity and sensitivity, with a detection limit of 0.18 μM. The probe has low cytotoxicity when applied in living cells and demonstrates good recovery rates for quantitative analysis of spiked samples.
Article
Chemistry, Analytical
Xiaoye Wen, Fang Li, Furong Liu, Zhefeng Fan
Summary: In this paper, a D-pi-A near-infrared aggregation-induced fluorescent probe was developed for rapid and sensitive detection of SO2. The probe showed high sensitivity and low toxicity, making it potentially useful for monitoring SO2 in living cells and food analysis.
ANALYTICA CHIMICA ACTA
(2022)
Article
Chemistry, Physical
Zhaolun Liang, Zhiyong Jiang, Changli Zhang, Zhipeng Liu
Summary: A ratiometric fluorescent MGO probe based on isophorone was designed and synthesized for imaging MGO in living cells. The probe exhibited selective and sensitive response to MGO and showed promising imaging ability for studying the biological roles of MGO in living cells.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Biochemistry & Molecular Biology
Jia-Qi Xu, Meng-Jiao Gao, Jin-Shuang Guo, Yi-Hua Wang, Ran Wei, Ya-Li Meng, Yan-Fei Kang
Summary: In this study, a ratiometric fluorescent probe JQ-2 was developed for detecting ONOO-. JQ-2 showed a rapid response and high selectivity, and could emit signals in two channels for visualizing ONOO- in vitro and vivo.
BIOORGANIC CHEMISTRY
(2022)
Article
Polymer Science
Valeria Caponetti, Alexandra Mavridi-Printezi, Matteo Cingolani, Enrico Rampazzo, Damiano Genovese, Luca Prodi, Daniele Fabbri, Marco Montalti
Summary: Microplastics are emerging pollutants posing a threat to human health. Fluorescence-based detection methods provide a fast and sensitive way to detect these particles, with the use of a new probe demonstrating selective labeling of PVC microplastics.
Article
Chemistry, Analytical
Tingting Quan, Zhenhao Liang, Huaiting Pang, Guanling Zeng, Tongsheng Chen
Summary: In this study, a ratiometric fluorescent probe, FormAFP, based on excited state intramolecular photon transfer (ESIPT) was developed for rapid, selective, and sensitive detection of formaldehyde (FA) via 2-aza-Cope rearrangement. The probe showed fast response to both exogenous and endogenous FA in living cells, and was capable of monitoring FA released by folate degradation in MCF7 cells. FormAFP successfully detected fluctuations of endogenous FA levels in oxidative stress stimulation, showing potential as an ideal tool to explore FA biology.
Article
Chemistry, Analytical
Lidan Zhang, Chuang Wang, Yunhan Jiang, Huidong Li, Huizhen Wang, Haiyue Long, Pingxian Liu, Xiaoqiu Xu, Tao Yang
Summary: In this study, a new fluorescent probe IMQU-8 was developed for the selective and sensitive detection of Pd2+ under physiological conditions. The sensing mechanism of IMQU-8 was revealed, and its applicability for Pd2+ imaging and detoxification in living cells was demonstrated.
ANALYTICA CHIMICA ACTA
(2022)
Article
Chemistry, Physical
Bing Yang, Kaiyue Wang, Jiahua Zhou, Xinyi Shao, Xuefang Gu, Yunsheng Xue, Shu Tian
Summary: The development of rapid and accurate detection methods for H2O2-related metabolites is crucial in disease diagnosis and efficacy evaluation. A ratiometric SERS sensor using a pyrroloquinoline skeleton was designed to detect H2O2 and glucose. The sensor showed high sensitivity and selectivity, and demonstrated great potential in the determination of H2O2-related metabolites in real serum samples.
APPLIED SURFACE SCIENCE
(2022)
Article
Chemistry, Analytical
Dong-Peng Li, Fuyan Tang, Kai Wen, Zhikang Yang, Haibin Xiao, Ziyan Zhou
Summary: A new coumarin-hemicyanine dye was synthesized as a ratiometric fluorescent probe for detecting SO2 derivatives. The probe showed deep-red fluorescence, high selectivity, low detection limit, and was successfully used for imaging SO2 derivatives in living cells.
MICROCHEMICAL JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Duygu Aydin, Sukriye Nihan Karuk Elmas, Gonul Akin Geyik, Aykut Bostanci, Fatma Nur Arslan, Tahir Savran, Gokhan Sadi, Ibrahim Yilmaz
Summary: The novel chemoprobe NASP showed high sensitivity and selectivity towards Cys and Hcy in living cells, making it a promising tool for diagnosing biothiol-related illnesses.
NEW JOURNAL OF CHEMISTRY
(2021)
Article
Spectroscopy
Chen Chen, Changrui Zhou, Wenge Yang, Yonghong Hu
Summary: Chinese herbal medicine is gaining more attention both domestically and internationally, and the preservation of herbal medicines is crucial. Fumigation with sulfur is a common method, but it can leave behind SO2 residues that create sulfites when exposed to water. Excessive sulfites have negative effects on health and reduce the quality and effectiveness of therapeutic plants. This study developed a ratiometric fluorescent probe CPA using coumarin derivatives and pyridinium acrylonitrile structures with the FRET effect. The probe showed excellent detection properties for SO32- and low cytotoxicity, making it suitable for detecting endogenous sulfites in living cells.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Spectroscopy
Shuai Wang, Weimin Liu, Xiuli Zheng, Haohui Ren, Jiasheng Wu, Fan Li, Pengfei Wang
Summary: GGT serves as a biomarker for cancer, hepatitis, and other diseases, and its accurate analysis is crucial for early diagnosis. A ratiometric fluorescent probe, Probe 1, based on 2,3,5,6-tetrafluoroterephthalonitrile, was developed for GGT detection. The probe showed sensitive and selective detection of GGT in various solutions and biological systems, such as blood serum. Moreover, it successfully enabled ratiometric imaging of GGT in cancer cells and normal cells.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Review
Chemistry, Organic
Julika Schlosser, Heiko Ihmels
Summary: Apurinic and apyrimidinic sites are residues of duplex DNA with missing bases, which can be used for DNA repair and provide binding sites for guest molecules. Ligands that selectively bind to abasic sites can be used for analytical and therapeutic purposes. This review provides an overview of different classes of ligands for abasic site-containing DNA, including covalently and non-covalently binding substrates. It also summarizes reports on the fluorescent response of ligands upon binding to AP-DNA and presents a perspective for future development of fluorescent probes for AP-DNA.
CURRENT ORGANIC SYNTHESIS
(2023)
Article
Chemistry, Medicinal
Romeo Romagnoli, Paola Oliva, Filippo Prencipe, Stefano Manfredini, Federico Ricci, Diana Corallo, Sanja Aveic, Elena Mariotto, Giampietro Viola, Roberta Bortolozzi, Maria Paola Germano, Laura De Luca
Summary: A series of cinnamide compounds linked with 1-aryl piperazines, derived from cinnamic acid derivatives, were synthesized and evaluated for their inhibitory activity against mushroom tyrosinase. The presence of a 3-chloro-4-fluorophenyl moiety at the N-1 position of the piperazine ring was found to be essential for a potent inhibitory effect. Molecular docking studies were conducted to investigate the interactions between the compounds and the active site of the enzyme. Some of the highly active compounds also showed potential in inhibiting melanogenesis. However, certain compounds exhibited toxicity at high concentrations.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Medicinal
Romeo Romagnoli, Paola Oliva, Filippo Prencipe, Stefano Manfredini, Federica Budassi, Andrea Brancale, Salvatore Ferla, Ernest Hamel, Diana Corallo, Sanja Aveic, Lorenzo Manfreda, Elena Mariotto, Roberta Bortolozzi, Giampietro Viola
Summary: A study was conducted to synthesize a series of new compounds with potential antitumor activity. Among these compounds, three showed significantly higher activity compared to others. These compounds demonstrated strong antiproliferative effects on different cancer cell lines and were able to induce apoptosis through various mechanisms. In vivo experiments using a zebrafish model also showed promising results in reducing tumor mass.
Article
Chemistry, Medicinal
Pilar M. Luque-Navarro, M. Paz Carrasco-Jimenez, Laura Goracci, Jose M. Paredes, Laura Espinar-Barranco, Javier Valverde-Pozo, Archimede Torretta, Emilio Parisini, Elena Mariotto, Chiara Marchioro, Alejandro Laso, Carmen Marco, Giampietro Viola, Daniela Lanari, Luisa Carlota Lopez Cara
Summary: We propose a series of bioisosteric inhibitors based on the introduction of sulphur, which are effective in inhibiting human choline kinase and reducing phosphatidylcholine biosynthesis. PL 48, PL 55, and PL 69 are identified as the most active compounds in the series. These compounds induce apoptosis through the mitochondrial pathway and significantly reduce the expression of anti-apoptotic protein Mcl-1.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Organic
Robin Schulte, Sandra Afflerbach, Heiko Ihmels
Summary: In this study, eight monoaryl-substituted norbornadienes with naphthyl, anthracenyl, or donor-acceptor-phenyl substituents were presented as improved photochromic systems for efficient reversible conversion of light into chemical energy. These compounds were synthesized by Suzuki-Miyaura coupling reactions and their absorption properties, key parameters of photochromic equilibrium, and energy storage density were examined. The results showed that these compounds had favorable properties for chemical energy storage, especially 2-(1-naphthyl)norbornadiene, which exhibited a pronounced red shift of absorption, long half-life (35 d), and relatively high energy storage density (361 KJ/Kg) of the respective quadricyclane. Therefore, monoaryl-norbornadienes should be considered as a useful and complementary class of compounds in the development of efficient molecular solar thermal energy storage (MOST) compounds.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Organic
Christoph Dohmen, Heiko Ihmels
Summary: A disulfide-functionalized bis-benzo[b]quinolizinium undergoes a quantitative intramolecular [4 + 4] photocycloaddition reaction to form cyclomers. Both the bis-quinolizinium and the photocyclomers react with glutathione (GSH) or dithiothreitol (DTT) to yield 9-(sulfanylmethyl)benzo[b]quinolizinium as the sole product. The different DNA-binding properties of the components in this reaction sequence allow for external control and switching of DNA association.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2023)
Article
Plant Sciences
Alexis Bienvenue Nama, Thomas Paululat, Guy Roland Ebede, Patrick Herve Diboue Betote, Dieudonne Emmanuel Pegnyemb, Joseph Thierry Ndongo, Heiko Ihmels, Hartmut Laatsch
Summary: Isolation studies on Tabernaemontana penduliflora leaves led to the discovery of two previously undescribed indole alkaloids, 7,10-dihydroxyindolenine (1a) and pendulifloramine (2), along with four known compounds. The structures of 1a and 2 were determined using NMR, mass spectra, and computer-assisted structure elucidation. Both compounds exhibited moderate radical-trapping activity and anti-inflammatory properties.
PHYTOCHEMISTRY LETTERS
(2023)
Article
Chemistry, Multidisciplinary
Julika Schlosser, Julian F. M. Hebborn, Daria V. Berdnikova, Heiko Ihmels
Summary: A cyclophane containing styrylpyridine and diethylenetriamine linkers was used as a host system to study the association with nucleotides through photometric and fluorimetric titrations. 1:1 complexes were formed with log K-b values ranging from 2.3 to 3.2 for pyrimidine nucleotides and 3.8 to 5.0 for purine nucleotides. The fluorimetric response to complex formation differed depending on the type of nucleotide, with quenching observed for purine bases and significant fluorescence enhancement for pyrimidine bases.
CHEMISTRY-SWITZERLAND
(2023)
Article
Chemistry, Multidisciplinary
Robin Schulte, Sandra Afflerbach, Thomas Paululat, Heiko Ihmels
Summary: Molecular solar thermal energy storage (MOST) systems using phenyl- and naphthyl-linked bis- and tris-norbornadienes show high energy densities and have potential for efficient solar energy conversion and storage. These substrates were synthesized using Suzuki-Miyaura coupling reactions and their absorption properties and characteristics for MOST applications were investigated. The norbornadiene derivatives showed absorption onsets at 386 nm and photoisomerization quantum yields of 56% per photoisomerization event. The resulting quadricyclane products have half-lifes up to 14 days and very high energy densities of up to 734 kJ/kg.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Physical
Julika Schlosser, Nils Stotzel, Yuri Fedorov, Heiko Ihmels
Summary: The photocyclization reaction of sterically demanding styrylpyridine derivatives was investigated, and the interaction with DNA was found to depend on the DNA type. Specifically, this ligand preferentially binds to DNA containing abasic sites, and the complex formation can be achieved by irradiation of the styrylpyridine substrate.
Article
Chemistry, Organic
Christoph Dohmen, Heiko Ihmels
Summary: We present a disulfide-functionalized photoactive DNA ligand that can control its DNA-binding properties by a photocycloaddition reaction and the redox reactivity of the sulfide/disulfide functionalities. The ligand initially binds to DNA through intercalation and groove-binding, but the binding is interrupted by an intramolecular [4 + 4] photocycloaddition. Cleavage of these cycloadducts with dithiothreitol (DTT) temporarily regains DNA-intercalating ligand and eventually converts it into a non-binding benzothiophene.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Philipp Gross, Renee S. Hoffmann, Mareike Mueller, Holger Schoenherr, Heiko Ihmels
Summary: DNA-sensitive fluorescent light-up probes based on berberine were developed, which exhibit predictable fluorescence quenching in aqueous solution and a fluorescence light-up effect upon DNA binding. These probes have high affinity for DNA and can generate distinct staining patterns in eukaryotic cells.
Article
Chemistry, Medicinal
Federica Budassi, Chiara Marchioro, Martina Canton, Annagiulia Favaro, Mattia Sturlese, Chiara Urbinati, Marco Rusnati, Romeo Romagnoli, Giampietro Viola, Elena Mariotto
Summary: A new compound FB49 with high affinity to BAG3 protein has been discovered, which exhibits antiproliferative activity in various human tumor cell lines without toxicity to healthy cells. Moreover, FB49 can block cell cycle and induce apoptosis and autophagy.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Meeting Abstract
Oncology
Roberta Bortolozzi, Elena Mariotto, Elena Rampazzo, Lorenzo Manfreda, Chiara Marchioro, Fatlum Rruga, Luca Persano, Giampietro Viola
Meeting Abstract
Oncology
Elena Mariotto, Elena Rampazzo, Roberta Bortolozzi, Fatlum Rruga, Lorenzo Manfreda, Chiara Marchioro, Silvia Bresolin, Giampietro Viola, Luca Persano
Review
Chemistry, Multidisciplinary
Dan He, Yawen Li, Fuwen Zhao, Yuze Lin
Summary: High trap density in organic solar cells leads to localized charge carriers and reduced carrier lifetime, limiting device efficiency. This feature article summarizes the recent advances of trap suppression by material design and device engineering.
CHEMICAL COMMUNICATIONS
(2024)
Review
Chemistry, Multidisciplinary
Olivier Monfort, Arshitha Madhusudhan, Martin Motola
Summary: This article presents the advantages of coupling photocatalysis and Fenton-based processes for environmental remediation and discusses their synergy. It critically examines the simultaneous triggering of these two processes and provides insights into research approaches. The study aims to enhance understanding of this complex process and highlight the potential integration of new catalysts in current wastewater treatment technology.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Manideepa Dhar, Chittaranjan Mishra, Avijit Das, Uttam Manna
Summary: An approach of 'polymerization of monomers in its aggregated form' has been introduced to tailor the water wettability of fibrous and porous substrates, achieving hydrophobicity to superhydrophobicity transition, as well as patterned wettability. This facile chemical method provides a durable coating with adjustable and patterned wettability for various potential applications.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Saswat Ranjan Bhoi, Chhanda Debnath, Shikha Gandhi
Summary: In this article, a novel catalytic reaction using Pd(0) and Bronsted acid is reported for the synthesis of biologically important imidazolidinone-fused N-heterocycles through redox-neutral intramolecular N-allylation of indoles and pyrroles with alkynes. This atom-economical method is applicable to a wide range of substrates and eliminates the need for leaving groups or oxidizing agents commonly used in traditional allylation reactions.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Longkun Chen, Mingshuai Zhang, Meichen Liu, Zhuoyuan Liu, Yuetong Qiu, Zhilai Zhang, Fuchao Yu, Jiuzhong Huang
Summary: In this study, an efficient Rh(III)-catalyzed selective mono- and dual-C-H bond functionalization/cyclization with iodonium ylide as the sole coupling partner was demonstrated. Fused benzodiazepine skeletons were obtained in excellent yields, providing an improved approach to dual C-H unsymmetrical functionalization.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Alice Kennett, Sven Epple, Gabriella van der Valk, Irene Georgiou, Evelyne Gout, Romain R. Vives, Angela J. Russell
Summary: This study presents the design and synthesis of sulfated disaccharide inhibitors based on IdoA(2S)-GlcNS(6S), which showed potent inhibition of Sulf-2. The results suggest that IdoA(2S)-GlcNS(6S) is the shortest fragment size required for effective inhibition of Sulfs, and a trisulfated disaccharide is identified as the minimal fragment size of heparan sulfate for effective endosulfatase inhibition.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Mauro Garbini, Andrea Brunetti, Riccardo Pedrazzani, Magda Monari, Massimo Marcaccio, Giulio Bertuzzi, Marco Bandini
Summary: The self-adaptability of galvanostatic electrolysis was found to be helpful in a multistage chemo- and diastereoselective electrochemically promoted cyclodimerization of chalcones. Through a series of reductive events, densely functionalized cyclopentanes with five contiguous stereocenters were obtained (25 examples, yields up to 95%, dr values up to >20:1). Further experimental and electrochemical investigations indicated the crucial role of dynamic kinetic resolution of the aldol intermediate in the reaction mechanism.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Dhananjay S. Nipate, Neha Meena, Prakash N. Swami, Krishnan Rangan, Anil Kumar
Summary: In this study, the synthesis of functionalized benzo[a]phenazines and indazolo[2,3-a]quinolines was achieved through Rh(III)-catalyzed oxidative annulation of 2-arylquinoxalines and 2-aryl-2H-indazoles with allyl alcohols. The method showed a wide substrate scope, excellent functional group tolerance, good to high yields of annulated products, and the capability for scaled-up synthesis. A tentative mechanism of the annulation reaction was proposed based on a preliminary mechanistic investigation.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Ruonan Zhang, Abudukadi Tudi, Xia Yang, Xuping Wang, Zhihua Yang, Shujuan Han, Shilie Pan
Summary: A new lead tellurium borate material with a unique fundamental building block [B4O10] was synthesized and found to exhibit high birefringence. The structure-property relationship was discussed using first-principles calculations.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Amresh Kumar Singh, Baishali Thakurta, Anupam Giri, Monalisa Pal
Summary: This study introduces three key concepts for the quick synthesis of large-scale high-quality 2D materials films and their utilization in device fabrication.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Reina Hagiwara, Shun Nishimura, Kosuke Okeyoshi
Summary: A copolymer-conjugated nanocatalytic system has been developed to improve electron transfer and enhance photoinduced H2 generation.
CHEMICAL COMMUNICATIONS
(2024)
