Article
Polymer Science
Sreejith Sudhakaran Jayabhavan, Baldur Kristinsson, Dipankar Ghosh, Charlene Breton, Krishna K. K. Damodaran
Summary: The nature of functional groups and their relative position and orientation play an important role in tuning the gelation properties of stimuli-responsive supramolecular gels. In this work, mono-/bis-pyridyl-N-oxide compounds of N-(4-pyridyl)nicotinamide (L-1-L-3) were synthesized and characterized. The gelation properties of these N-oxide compounds were compared with isomeric counterparts of N-(4-pyridyl)isonicotinamide.
Article
Mechanics
Arif Z. Z. Nelson
Summary: The Soft Matter Kitchen is an educational outreach project that utilizes food recipes and experiments to discuss concepts in soft matter and rheology. By comparing food flow behavior and the impact of material microstructure on properties and behavior, it aims to deepen the understanding and awareness of rheology.
Article
Pharmacology & Pharmacy
Max Borgolte, Oliver Riester, Tereza Kacerova, Simone Rentschler, Magnus S. Schmidt, Susanne Jacksch, Markus Egert, Stefan Laufer, Rene Csuk, Hans-Peter Deigner
Summary: Improving medical implants with functional polymer coatings is an effective way to enhance medical care, especially in wound healing where antibacterial and biofilm-preventing properties are crucial. Specific polymers synthesized in this study showed a reduction in biofilm formation and antibacterial growth without cytotoxic effects on fibroblasts.
Article
Biochemistry & Molecular Biology
Nishal M. Egodawaththa, Amy L. Knight, Jingxuan Ma, D. Andrew Knight, Eric Guisbert, Nasri Nesnas
Summary: Silver nanoparticles conjugated with organic ligands have been successfully synthesized and demonstrated significant antimicrobial activity and antibacterial capabilities against E. coli. The synthesis of functionalized silver nanoparticles is critical for the further development of silver-nanoconjugated antibacterial agents.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Chia-Hung Chen, Yen-Ping Peng, Ming-Hsun Lin, Ken-Lin Chang, Yung-Chang Lin, Jian Sun
Summary: This study successfully utilized Fe/TNAs to remove E. coli in a photoelectrochemical system, showing higher photocurrent and longer electron lifetime compared to traditional photolysis and photocatalysis methods. Fe/TNAs demonstrated the best removal efficiency for methyl orange degradation in terms of current-light response and electrochemical impedance spectroscopy measurements.
Article
Chemistry, Multidisciplinary
Hao Hu, Yang-Yang Zhang, He Ma, Yuchong Yang, Shan Mei, Jun Li, Jiang-Fei Xu, Xi Zhang
Summary: This study reports a supramolecular naphthalene diimide (NDI) radical anion with efficient NIR-II photothermal conversion for E. coli-responsive photothermal therapy. The supramolecular radical anion demonstrates excellent NIR-II photothermal antimicrobial activity and provides a new approach for constructing NIR-II photothermal agents and non-contact treatments for bacterial infections.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Inorganic & Nuclear
Olga Bakina, Elena Glazkova, Alexandr Pervikov, Aleksandr Lozhkomoev, Nikolay Rodkevich, Natalia Svarovskaya, Marat Lerner, Ludmila Naumova, Ekaterina Varnakova, Valeria Chjou
Summary: The study successfully synthesized Ag-Cu bimetallic nanoparticles with varying silver contents, demonstrating high antimicrobial activity and potential as a new generation antibacterial agent effective against resistant microorganisms.
JOURNAL OF CLUSTER SCIENCE
(2021)
Article
Chemistry, Multidisciplinary
Frances Abygail F. Genio, Monissa C. Paderes
Summary: This study found that bis-urea derivatives are effective supramolecular gelators in cosmetic solvents, with their gel's structure and network formation influenced by the solvent and gelator structure. Rheological and imaging analyses demonstrated the unique characteristics of the gels, indicating their stability is affected by solvophobic interactions.
Article
Chemistry, Analytical
Sorour Darvishi, Horst Pick, Emad Oveisi, Hubert H. Girault, Andreas Lesch
Summary: The study presents a complementary technique using Soft-Probe-SECM for micrometric electrochemical imaging of Escherichia coli biofilms, allowing for metabolic activity detection and differentiation of antibiotic-resistant bacteria. The method provides surface-confined analysis of entire biofilms and distinguishes between biofilms containing E. coli cells with different resistance profiles.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Biochemistry & Molecular Biology
Olga V. Zakharova, Valeria V. Belova, Peter A. Baranchikov, Anna A. Kostyakova, Dmitry S. Muratov, Gregory V. Grigoriev, Svetlana P. Chebotaryova, Denis V. Kuznetsov, Alexander A. Gusev
Summary: In this study, the antibacterial activity of TiS3 nanostructures in water and 0.9% NaCl solution suspensions was analyzed. The results showed that freshly prepared water solutions of TiS3 had the strongest toxicity against E. coli, but the antibacterial effect decreased significantly when the solutions were stored for 24 h or when saline solution was used instead of water. The toxicity of TiS3 in water was higher than that of TiO2 nanoparticles, but the opposite results were observed when saline solution was used. Additionally, there was no correlation between the antibacterial activity of water suspensions of nanoribbons and the stability of their colloidal systems, indicating a negligible contribution of aggregation processes to toxicity. In 0.9% NaCl solution suspensions, toxicity increased proportionally with the increase in zeta potential. It was hypothesized that the specificity of toxicity might be associated with the emission of hydrogen sulphide molecules from the surface of nanoribbons, which could either decrease or increase oxidative stress depending on the concentration. However, further investigation is needed to understand the exact underlying mechanisms. These findings highlight the importance of dispersion medium and storage period in the antibacterial activity of TiS3 nanoribbons, and have implications for nanotoxicological studies and the development of antibacterial substances and biomedical applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Microbiology
Noha Anwar Hassuna, E. M. Rabie, W. K. M. Mahd, Marwa M. M. Refaie, Rehab Kamal Mohamed Yousef, Wedad M. M. Abdelraheem
Summary: The study aimed to evaluate the influence of vitamin C as an antibacterial and anti-biofilm agent against uropathogenic E. coli strains. It was found that vitamin C could effectively inhibit the growth of most strains and showed a synergistic effect with various antibiotics. Additionally, vitamin C significantly suppressed biofilm formation and down-regulated the expression of related genes. In vivo experiments using a rat model demonstrated that the combination of vitamin C and nitrofurantoin had a better therapeutic effect for urinary tract infections.
Article
Food Science & Technology
Kai-Sheng Shen, Mei Shu, Meng-Xuan Tang, Wen-Yu Yang, Shu-Chao Wang, Chan Zhong, Guo-Ping Wu
Summary: This study cloned, expressed, and characterized an endolysin named LysJN01 from bacteriophage JN01. The recombinant LysJN01 showed strong lytic activity against E. coli O157:H7 and exhibited broad-spectrum antimicrobial activity against Gram-negative pathogens. Additionally, it significantly reduced the count of E. coli O157:H7 on contaminated lettuce.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Engineering, Environmental
Jacopo Foschi, Andrea Turolla, Manuela Antonelli
Summary: Real-time acquisition of indicator bacteria concentration is essential for chemical and ultraviolet wastewater disinfection, but culture-based methods are time-consuming. A novel soft sensor approach based on artificial neural networks outperformed linear models. Sensitivity analysis highlighted the importance of predictors and site-specific relationships. The artificial neural network model showed significant disinfectant savings in a realistic wastewater quality scenario.
Article
Environmental Sciences
Angrui Jiang, Wuxuan Pei, Rui Zhang, Kinjal J. Shah, Zhaoyang You
Summary: Contamination of disposable medical masks has become a global problem due to their widespread use and improper disposal. This study investigated the physical and chemical changes in microplastics of masks after aging, and studied the toxic effects and mechanism of aged mask microplastics on Escherichia coli. The results showed that the microplastics in the aged meltblown filler layer had the most significant inhibitory effect on E. coli growth, and also affected the ATPase activity and the release of exopolymeric substances.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Metallurgy & Metallurgical Engineering
Xiao-wei Ji, Pin-ting Liu, Jin-cheng Tang, Chang-jun Wan, Yan Yang, Zhi-li Zhao, Da-peng Zhao
Summary: The TNT arrays exhibit significant early antibacterial effects, mainly related to surface free energy and nano-topography. The antibacterial mechanisms include anti-attachment, anti-proliferation, and physical bactericidal effects.
TRANSACTIONS OF NONFERROUS METALS SOCIETY OF CHINA
(2021)
Review
Biotechnology & Applied Microbiology
Ana I. Benitez-Mateos, Francesca Paradisi
Summary: Extremophilic microorganisms are being used as tools for biotechnological applications due to their resistance to extreme conditions. Enzymes from Halomonas elongata are suitable for biocatalysis due to their resistance to salt and ease of production. This study highlights the diverse enzymes from H. elongata and their potential as efficient and sustainable biocatalysts, aiming to integrate biocatalysis in industrial set-ups.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
David Roura Padros, Francesca Paradisi
Summary: Protein bioinformatics has been widely used in enzyme engineering and discovery, but its application in enzyme immobilization is still limited. This study presents the use of bioinformatic tools to rationalize the results of protein immobilization, moving us closer to predictive enzyme immobilization protocols.
Article
Automation & Control Systems
Lorenzo Castellino, Eugenio Alladio, Stefano Bertinetti, Gabriele Lando, Concetta De Stefano, Salvador Blasco, Enrique Garcia-Espana, Sofia Gama, Silvia Berto, Demetrio Milea
Summary: A new open-source Python application called PyES has been developed for concentrations calculation. It can handle both precipitation and solution equilibria and is the only open-source software that can perform calculations at variable ionic strength, taking into account the dependence of stability constants on it. The reliability of PyES has been verified through various tests with satisfying results. It is user-friendly, compatible with existing operative systems, and the data analysis results can be easily exported in different file formats.
CHEMOMETRICS AND INTELLIGENT LABORATORY SYSTEMS
(2023)
Article
Chemistry, Multidisciplinary
Lucia Robustini, Francesca Paradisi
Summary: Enzymatic synthesis always involves enantioselectivity, and it is possible to induce a switch in enantioselectivity by adjusting reaction conditions. For instance, the transaminase from Halomonas elongata (& omega;-HeWT) can shift from generating the S-enantiomer to the R-enantiomer at higher concentrations of amino acceptor or ionic strength. Similar behavior has been observed in other enzymes, and this article discusses some of them and their potential applications.
Article
Chemistry, Organic
David Lim, Francesca Paradisi
Summary: Glycosylation can improve the pharmacokinetic properties of bioactive molecules, but their syntheses often require tedious protecting group manipulations. In this study, we developed a method for direct aqueous conversion of unprotected sugars into glycosides, and demonstrated its application with various biomolecules including resorcinol, resveratrol, and gimeracil. We also showed that the bioactive drug can be released from the sugar in an oxidatively-triggered manner, making them suitable for medicinal applications. This novel transformation provides access to various selenium-containing glycomimetics and glycoconjugates.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Ana I. Benitez-Mateos, Francesca Paradisi
Summary: Flow biocatalysis is an empowering tool for automatized, sustainable, and efficient enzymatic reactions in industrial operations. Its development in the past fifteen years has been significant, although there are still challenges to be overcome.
JOURNAL OF FLOW CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Jorge Gonzalez-Garcia, Carolina Galiana, M. Auxiliadora Dea-Ayuela, Marijana Radic Stojkovic, Sonia Lopez-Molina, Cristina Galiana-Rosello, Salvador Blasco, Ivo Piantanida, Enrique Garcia-Espana
Summary: Metal complexes have become a focus of biomedical research due to their ability to explore unexplored chemical space and provide additional functionalities for diagnosis and therapy. This study evaluated the interaction between two polytopic polyaza ligands, their zinc complexes, and DNA/RNA using various spectroscopic assays. The results showed selective binding of zinc-PHENPOD complexes to GC-containing DNA and stabilization of AT-based DNA by PYPOD metal complexes. Additionally, the ligands and their trinuclear zinc complexes exhibited high antimicrobial activity. This research provides valuable insights into the nucle-arity of polytopic polyaza ligands in DNA/RNA binding and antimicrobial effects.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Organic
Begona Verdejo, Mario Inclan, Salvador Blasco, Rafael Ballesteros-Garrido, Matteo Savastano, Antonio Bianchi, Enrique Garcia-Espana
Summary: This study investigated the synthesis, acid-base behavior, and anion recognition of neurotransmitters (dopamine, tyramine, and serotonin) using aza-scorpiand ligands functionalized with hydroxyphenyl and phenyl moieties (L1-L3 and L4, respectively). The results showed that L1 selectively recognized serotonin at physiological pH due to complementary hydrogen bonding, p-p, and cation-p interactions, leading to stabilization of the receptors. NMR and molecular dynamics studies revealed rotation blockage in the neurotransmitter side chain upon complexation with L1.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2023)
Article
Chemistry, Organic
Sabrina de Lorenzo, Lauriane Pillet, David Lim, Francesca Paradisi
Summary: A one-pot synthesis method for glycosyl benzoates from unprotected sugars in water using 2-chloro-1,3-dimethylimidazolium chloride, thiobenzoic acid, and triethylamine was developed. These glycosyl donors were found to be excellent substrates for both wild-type and mutant glycosidases. The hydrolysis of β-glucosyl benzoate by the GH1 β-glucosidase from Halothermothrix orenii was demonstrated, and the donor's superiority in thioligase-mediated glycosylation was shown with high conversions.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2023)
Article
Chemistry, Organic
Elley E. Rudebeck, Trent D. Ashton, Adam F. Henwood, Thorfinnur Gunnlaugsson, Frederick M. Pfeffer
Summary: In this study, the synthesis of 1,8-naphthalimides functionalised as the 3,4-dihydroxy-1,8-naphthalimide (catechol, Nap-Cat) and the corresponding 15-crown-5 (Nap-Crown) is reported. These compounds are the first examples where these two recognition groups are directly incorporated into the 1,8-naphthalimide ring system. The evaluation of Nap-Cat and Nap-Crown showed slow oxidation for Nap-Cat upon prolonged exposure to H2O2, while no significant changes in photophysical properties were observed for Nap-Crown upon treatment with metal ions.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2023)
Review
Chemistry, Multidisciplinary
Hippolyte Meersseman Arango, Ludivine van den Biggelaar, Patrice Soumillion, Patricia Luis, Tom Leyssens, Francesca Paradisi, Damien P. Debecker
Summary: Chiral amines are crucial for the synthesis of many valuable compounds, including active pharmaceutical ingredients. However, the current production methods are expensive and energy-intensive. Biocatalytic routes using amine transaminases offer a more sustainable and efficient alternative, but their industrial applications are limited due to operational restrictions and enzyme instability.
REACTION CHEMISTRY & ENGINEERING
(2023)
Article
Chemistry, Multidisciplinary
Isabel N. Hegarty, Dawn E. Barry, Joseph P. Byrne, Oxana Kotova, Thorfinnur Gunnlaugsson
Summary: In this study, the chiral bis-tridentate (1,2,3-triazol-4-yl)-picolinamide (tzpa) ligand 1 was used to form lanthanide di- and triple stranded di-metallic helicates in acetonitrile solution. The changes in the ground and Tb(iii) excited state properties were monitored to observe the formation of these supramolecular structures in situ under kinetic control.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Inorganic & Nuclear
Alex T. O'Neil, Anais Chalard, Jenny Malmstrom, Jonathan A. Kitchen
Summary: The synthesis and fabrication of a new Eu3+ complex [Eu(1)(3)] derived from the 1,8-naphthalimide containing ligand 1H and its spin-coated films are presented. The complex exhibits multi-emission, with blue emission from the 1,8-naphthalimide fluorophore and red emission from the Eu3+ center. The overall emission color can be tuned by changing the excitation wavelength.
DALTON TRANSACTIONS
(2023)
Review
Chemistry, Multidisciplinary
Huiyu Niu, Junwei Liu, Helen M. O'Connor, Thorfinnur Gunnlaugsson, Tony D. James, Hua Zhang
Summary: Typical PeT-based fluorescent probes are multi-component systems that utilize a fluorophore connected to a recognition/activating group through an unconjugated linker. These probes have been widely used in cell imaging and disease diagnosis due to their low background fluorescence and significant fluorescence enhancement towards the target. This review summarizes the research progress made in the past five years on PeT-based fluorescent probes targeting cell polarity, pH, and various biological species, emphasizing molecular design strategies, mechanisms, and applications. By providing guidance and promoting the development of new and improved PeT-based fluorescent probes, this review aims to promote the use of PeT-based systems for sensing, imaging, and disease therapy.
CHEMICAL SOCIETY REVIEWS
(2023)
Article
Biochemistry & Molecular Biology
Mario Inclan, Neus Torres Hernandez, Alejandro Martinez Serra, Gonzalo Torrijos Jabon, Salvador Blasco, Cecilia Andreu, Marcel li del Olmo, Beatriz Javega, Jose-Enrique O'Connor, Enrique Garcia-Espana
Summary: Antibiotic resistance is a major health concern, and the development of new antimicrobials is necessary. In this study, we synthesized a series of natural and synthetic polyamines and their derivatives, and tested their antimicrobial activity against yeast, Gram-positive, and Gram-negative bacteria. The conjugated derivatives showed higher antimicrobial activity than the unsubstituted polyamines, and their activity was influenced by various factors.
Review
Chemistry, Multidisciplinary
Dan He, Yawen Li, Fuwen Zhao, Yuze Lin
Summary: High trap density in organic solar cells leads to localized charge carriers and reduced carrier lifetime, limiting device efficiency. This feature article summarizes the recent advances of trap suppression by material design and device engineering.
CHEMICAL COMMUNICATIONS
(2024)
Review
Chemistry, Multidisciplinary
Olivier Monfort, Arshitha Madhusudhan, Martin Motola
Summary: This article presents the advantages of coupling photocatalysis and Fenton-based processes for environmental remediation and discusses their synergy. It critically examines the simultaneous triggering of these two processes and provides insights into research approaches. The study aims to enhance understanding of this complex process and highlight the potential integration of new catalysts in current wastewater treatment technology.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Manideepa Dhar, Chittaranjan Mishra, Avijit Das, Uttam Manna
Summary: An approach of 'polymerization of monomers in its aggregated form' has been introduced to tailor the water wettability of fibrous and porous substrates, achieving hydrophobicity to superhydrophobicity transition, as well as patterned wettability. This facile chemical method provides a durable coating with adjustable and patterned wettability for various potential applications.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Saswat Ranjan Bhoi, Chhanda Debnath, Shikha Gandhi
Summary: In this article, a novel catalytic reaction using Pd(0) and Bronsted acid is reported for the synthesis of biologically important imidazolidinone-fused N-heterocycles through redox-neutral intramolecular N-allylation of indoles and pyrroles with alkynes. This atom-economical method is applicable to a wide range of substrates and eliminates the need for leaving groups or oxidizing agents commonly used in traditional allylation reactions.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Longkun Chen, Mingshuai Zhang, Meichen Liu, Zhuoyuan Liu, Yuetong Qiu, Zhilai Zhang, Fuchao Yu, Jiuzhong Huang
Summary: In this study, an efficient Rh(III)-catalyzed selective mono- and dual-C-H bond functionalization/cyclization with iodonium ylide as the sole coupling partner was demonstrated. Fused benzodiazepine skeletons were obtained in excellent yields, providing an improved approach to dual C-H unsymmetrical functionalization.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Alice Kennett, Sven Epple, Gabriella van der Valk, Irene Georgiou, Evelyne Gout, Romain R. Vives, Angela J. Russell
Summary: This study presents the design and synthesis of sulfated disaccharide inhibitors based on IdoA(2S)-GlcNS(6S), which showed potent inhibition of Sulf-2. The results suggest that IdoA(2S)-GlcNS(6S) is the shortest fragment size required for effective inhibition of Sulfs, and a trisulfated disaccharide is identified as the minimal fragment size of heparan sulfate for effective endosulfatase inhibition.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Mauro Garbini, Andrea Brunetti, Riccardo Pedrazzani, Magda Monari, Massimo Marcaccio, Giulio Bertuzzi, Marco Bandini
Summary: The self-adaptability of galvanostatic electrolysis was found to be helpful in a multistage chemo- and diastereoselective electrochemically promoted cyclodimerization of chalcones. Through a series of reductive events, densely functionalized cyclopentanes with five contiguous stereocenters were obtained (25 examples, yields up to 95%, dr values up to >20:1). Further experimental and electrochemical investigations indicated the crucial role of dynamic kinetic resolution of the aldol intermediate in the reaction mechanism.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Dhananjay S. Nipate, Neha Meena, Prakash N. Swami, Krishnan Rangan, Anil Kumar
Summary: In this study, the synthesis of functionalized benzo[a]phenazines and indazolo[2,3-a]quinolines was achieved through Rh(III)-catalyzed oxidative annulation of 2-arylquinoxalines and 2-aryl-2H-indazoles with allyl alcohols. The method showed a wide substrate scope, excellent functional group tolerance, good to high yields of annulated products, and the capability for scaled-up synthesis. A tentative mechanism of the annulation reaction was proposed based on a preliminary mechanistic investigation.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Ruonan Zhang, Abudukadi Tudi, Xia Yang, Xuping Wang, Zhihua Yang, Shujuan Han, Shilie Pan
Summary: A new lead tellurium borate material with a unique fundamental building block [B4O10] was synthesized and found to exhibit high birefringence. The structure-property relationship was discussed using first-principles calculations.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Amresh Kumar Singh, Baishali Thakurta, Anupam Giri, Monalisa Pal
Summary: This study introduces three key concepts for the quick synthesis of large-scale high-quality 2D materials films and their utilization in device fabrication.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Reina Hagiwara, Shun Nishimura, Kosuke Okeyoshi
Summary: A copolymer-conjugated nanocatalytic system has been developed to improve electron transfer and enhance photoinduced H2 generation.
CHEMICAL COMMUNICATIONS
(2024)
