期刊
CHEMICAL COMMUNICATIONS
卷 50, 期 8, 页码 994-996出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3cc47800a
关键词
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资金
- National Basic Research Program of China (973 Program) [2011CB808600]
- National Natural Science Foundation of China [21321061, 21290182, 21172151]
- Ministry of Education [20110181130014]
The first catalytic asymmetric hetero-Diels-Alder reaction of Brassard's dienes with isatins was realized using Mg(II)/N,N'-dioxide complexes as catalysts, affording the corresponding chiral spirolactones bearing tetrasubstituted centers in up to 99% yield with up to 99% ee and >99:1 dr within 3 hours. In the mechanism, based on the operando IR experiments, a predominant Diels-Alder pathway was found in the reaction. A possible transition state model was also proposed.
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