期刊
CHEMICAL COMMUNICATIONS
卷 50, 期 29, 页码 3795-3798出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3cc48239a
关键词
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资金
- National Institutes of Health [AI072443]
Glutathione-complexed [2Fe-2S] cluster is shown to significantly stimulate the ATPase activity of an ABCB7-type transporter in both solution and proteoliposome-bound forms (K-D similar to 68 mu M). The cluster is a likely natural substrate for this transporter, which has been implicated in cytosolic Fe-S cluster protein maturation. A possible substrate-binding site is identified on a new structural model for the active transporter.
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