期刊
CHEMICAL COMMUNICATIONS
卷 50, 期 67, 页码 9469-9472出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4cc04555f
关键词
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A facile regiospecific synthesis of 2,3-disubstituted indoles from isatins has been developed. Nucleophilic addition of Grignard reagents to commercially available isatins, followed by reduction with borane, afforded an array of structurally diverse 2,3-disubstituted indoles in moderate to good yields. The method described herein represents a novel and very simple approach to synthesize various 2,3-disubstituted indoles, extremely important structural motifs in the pharmaceutical industry and medicinal chemistry.
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