Article
Chemistry, Analytical
Zhenzhen Jia, Kangsheng Tu, Qiuran Xu, Wenhui Gao, Cui Liu, Biyun Fang, Mingzhen Zhang
Summary: A universal sensing platform based on DNA-Ag NC was developed for sensitive detection of disease-associated nucleic acids, showing excellent reproducibility, selectivity, and potential applications in human serum samples. The platform was successfully applied for miR-362 and HIV-related DNA detection, achieving low detection limits of 6.5 nM and 1.7 nM, respectively.
ANALYTICA CHIMICA ACTA
(2021)
Article
Chemistry, Analytical
Jingjing Gao, Hui Xu, Faju Hou, Shengxiao Zhang
Summary: A novel DNA-silver nanocluster probe was developed for detecting breast tumor-related mRNA markers, with a low detection limit and linear range, and the ability to accurately distinguish single-base mismatches.
ANALYTICAL SCIENCES
(2022)
Article
Chemistry, Analytical
Xiao-yan Sun, Xing Wei, Kai-xin Liu, Ze-jun Wang, Ming-li Chen, Jian-hua Wang
Summary: A near infrared light-activated probe for in site imaging of telomerase was successfully developed using upconversion nanoparticles and double-stranded DNA. The probe can autonomously enter cells, open under specific light conditions, and restore fluorescence through telomerase elongation. Experimental results demonstrate the excellent imaging performance of this probe in various tumor cells, suggesting its promising future in cancer diagnosis and treatment.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Chemistry, Inorganic & Nuclear
Shuvankar Naskar, Jens Mueller
Summary: Metal-mediated base pairs allow for the site-specific incorporation of transition metal ions into nucleic acid structures, creating nucleic acid-metal complexes with metal-based functionality. The design of nucleic acids with externally triggered metal-binding affinity, such as copper(II) ions upon light irradiation, can lead to the regulation of functionality in nucleic acids.
INORGANIC CHEMISTRY
(2021)
Article
Chemistry, Analytical
Jingpu Zhang, Lei Pan, Yan Wang, Lin Yin, Li Xu, Jie Tao, Lijun Zhang, Zhaoqin Zhu, Daxiang Cui, Feng Li, Tie Fu Liu
Summary: A label-free fluorescent nanosensor was developed for rapid and simple detection of tryptophan in plasma, which exhibited good resistance to interference from NaCl.
ANALYTICA CHIMICA ACTA
(2022)
Article
Chemistry, Applied
Li Guan, Yongbao Mao, Yanyan Zhou, Yile Fu, Anyang Li, Jiajie Mei, Huafeng Zhou, Guoping Han, Lili Yin, Lanying Wang
Summary: In this study, the fluorescent probe alpha-HBCy3.5 was developed to selectively detect and identify G-quadruplex (G4) structures. By introducing bulky benzyl substituent on the polymethine chain, alpha-HBCy3.5 showed excellent G4 selectivity and emitted red fluorescence in the presence of G4s. The probe also has the potential to stain mitochondrial DNA for real-time detection and monitoring of endogenous G4 DNA in living cells.
Article
Chemistry, Multidisciplinary
Zhihui Feng, Dongxue Zhang, Hui Guo, Wenqing Su, Yupeng Tian, Xiaohe Tian
Summary: RNA probes are essential for studying RNA dynamics in cellular function, but the lack of optimized imaging systems and excellent fluorescence emission performance hampers their availability. This study introduces a zinc terpyridine complex (Zn-T) with D-pi-A configuration and bright aggregation-induced fluorescence emission (AIE) for selective detection and real-time monitoring of RNA. Zn-T exhibits a large Stokes shift and three-photon absorption (3PA) activity and specifically interacts with an RNA pocket through hydrophobic interactions. The combination of AIE-assisted two-photon fluorescence and stimulated emission depletion (STED) microscopy of Zn-T provides a high-resolution and bright imaging platform for studying RNA-related physiological or pathological processes.
Article
Chemistry, Analytical
Xin-Ying Zhong, Qian-Yu Zhou, Jia-Hui Dong, Yue Yu, Ying-Lin Zhou, Xin-Xiang Zhang
Summary: A simple and highly-selective method for 5-methylcytosine detection of specific gene sequences was developed based on binary-probe DNA hybridization. The successful design of binary probes allowed for quantification of the average methylation levels of the target, demonstrating potential for pre-diagnosis of methylation-related diseases.
Article
Chemistry, Multidisciplinary
Hongbo Chen, Hongxia Sun, Wende Zhang, Qin Zhang, Jun Ma, Qian Li, Xiaomeng Guo, Kanyan Xu, Yalin Tang
Summary: A fluorescent light-up ligand for i-motif structure, CHE, was reported in this study, showing significant increase in fluorescence intensity and weak response towards other DNA structures, making it advantageous in label-free fluorescence sensing systems.
NEW JOURNAL OF CHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Chenxu Yan, Zhiqian Guo, Weijie Chi, Wei Fu, Syed Ali Abbas Abedi, Xiaogang Liu, He Tian, Wei-Hong Zhu
Summary: This study presents a simple and generalizable strategy to reverse the electron-withdrawing target (EWT)-induced quenching mode in intramolecular charge transfer (ICT) fluorophores into a light-up mode by introducing an indazole building block into the ICT scaffold.
NATURE COMMUNICATIONS
(2021)
Article
Chemistry, Analytical
Junyang Chen, Mengke Wang, Chenyu Zhou, Jiabao Zhang, Xingguang Su
Summary: A label-free and fluorimetric/colorimetric dual-mode sensing strategy was developed for the quantitative determination of HPV DNA. By integrating fluorescent DNA-silver nanoclusters and G-quadruplex/hemin DNAzyme, this strategy improved the diversity and accuracy of analysis. It has been successfully applied to HPV DNA analysis in different real samples with excellent results, providing a universal strategy for various kinds of virus analysis.
Article
Biochemistry & Molecular Biology
Yongqiang Kang, Chunying Wei
Summary: In recent years, there has been a growing interest in the study of organic small molecule fluorescent probes targeting G-quadruplexes, as G-quadruplexes play a crucial role in various biological functions. This study reports the interactions of three crescent-shaped carbazole derivatives (4a-4c) with different DNA structures, and finds that compounds 4b and 4c have a stronger affinity to G-quadruplexes. Furthermore, these compounds are found to improve the stability and topology of G-quadruplexes, and induce G-rich sequences to fold into G-quadruplexes.
CHEMISTRY & BIODIVERSITY
(2022)
Article
Chemistry, Multidisciplinary
Jinrong Zheng, Shuheng Qin, Lijuan Gui, Hua Li, Lixue Fan, Yifei Yang, Haiyan Chen, Hui Xu, Zhenwei Yuan
Summary: The study developed a LDs-targeted probe based on solvatochromism, enabling high-resolution, biosafe imaging of LDs and LDs-rich tissues, and making LDs-associated behavior visible to the naked eye. This probe offers a new possibility for accurately diagnosing and analyzing LDs-related diseases in clinical and preclinical studies.
CHINESE CHEMICAL LETTERS
(2021)
Article
Chemistry, Multidisciplinary
Aigui Zhang, Simone Budow-Busse, Peter Leonard, Frank Seela
Summary: Dodecamer duplex DNA containing anomeric and enantiomeric mismatches were studied for base pair stability with silver ions present. The study found that stable duplexes were formed with silver-mediated cytosine-cytosine pairs, with stability changes depending on the composition of the mismatches. Notably, a new silver-mediated base pair was found to be superior in stability compared to a well-known pair.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Chemistry, Analytical
Chun-Li Yang, Yu-Qing Zhang, Jia-Yang He, Meng-Die Li, Ruo Yuan, Wen-Ju Xu
Summary: In this study, a ratiometric assay for label-free detection was developed using yellow-and red-silver nanoclusters as dual-emitting colorimetric reporters. The assay showed high sensitivity in detecting SARS-CoV-2 through amplification and recognition of a specific DNA trigger. This approach provides a promising strategy for bioanalytical assays and clinical diagnostics.
ANALYTICAL CHEMISTRY
(2022)
Review
Chemistry, Multidisciplinary
Dan He, Yawen Li, Fuwen Zhao, Yuze Lin
Summary: High trap density in organic solar cells leads to localized charge carriers and reduced carrier lifetime, limiting device efficiency. This feature article summarizes the recent advances of trap suppression by material design and device engineering.
CHEMICAL COMMUNICATIONS
(2024)
Review
Chemistry, Multidisciplinary
Olivier Monfort, Arshitha Madhusudhan, Martin Motola
Summary: This article presents the advantages of coupling photocatalysis and Fenton-based processes for environmental remediation and discusses their synergy. It critically examines the simultaneous triggering of these two processes and provides insights into research approaches. The study aims to enhance understanding of this complex process and highlight the potential integration of new catalysts in current wastewater treatment technology.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Manideepa Dhar, Chittaranjan Mishra, Avijit Das, Uttam Manna
Summary: An approach of 'polymerization of monomers in its aggregated form' has been introduced to tailor the water wettability of fibrous and porous substrates, achieving hydrophobicity to superhydrophobicity transition, as well as patterned wettability. This facile chemical method provides a durable coating with adjustable and patterned wettability for various potential applications.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Saswat Ranjan Bhoi, Chhanda Debnath, Shikha Gandhi
Summary: In this article, a novel catalytic reaction using Pd(0) and Bronsted acid is reported for the synthesis of biologically important imidazolidinone-fused N-heterocycles through redox-neutral intramolecular N-allylation of indoles and pyrroles with alkynes. This atom-economical method is applicable to a wide range of substrates and eliminates the need for leaving groups or oxidizing agents commonly used in traditional allylation reactions.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Longkun Chen, Mingshuai Zhang, Meichen Liu, Zhuoyuan Liu, Yuetong Qiu, Zhilai Zhang, Fuchao Yu, Jiuzhong Huang
Summary: In this study, an efficient Rh(III)-catalyzed selective mono- and dual-C-H bond functionalization/cyclization with iodonium ylide as the sole coupling partner was demonstrated. Fused benzodiazepine skeletons were obtained in excellent yields, providing an improved approach to dual C-H unsymmetrical functionalization.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Alice Kennett, Sven Epple, Gabriella van der Valk, Irene Georgiou, Evelyne Gout, Romain R. Vives, Angela J. Russell
Summary: This study presents the design and synthesis of sulfated disaccharide inhibitors based on IdoA(2S)-GlcNS(6S), which showed potent inhibition of Sulf-2. The results suggest that IdoA(2S)-GlcNS(6S) is the shortest fragment size required for effective inhibition of Sulfs, and a trisulfated disaccharide is identified as the minimal fragment size of heparan sulfate for effective endosulfatase inhibition.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Mauro Garbini, Andrea Brunetti, Riccardo Pedrazzani, Magda Monari, Massimo Marcaccio, Giulio Bertuzzi, Marco Bandini
Summary: The self-adaptability of galvanostatic electrolysis was found to be helpful in a multistage chemo- and diastereoselective electrochemically promoted cyclodimerization of chalcones. Through a series of reductive events, densely functionalized cyclopentanes with five contiguous stereocenters were obtained (25 examples, yields up to 95%, dr values up to >20:1). Further experimental and electrochemical investigations indicated the crucial role of dynamic kinetic resolution of the aldol intermediate in the reaction mechanism.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Dhananjay S. Nipate, Neha Meena, Prakash N. Swami, Krishnan Rangan, Anil Kumar
Summary: In this study, the synthesis of functionalized benzo[a]phenazines and indazolo[2,3-a]quinolines was achieved through Rh(III)-catalyzed oxidative annulation of 2-arylquinoxalines and 2-aryl-2H-indazoles with allyl alcohols. The method showed a wide substrate scope, excellent functional group tolerance, good to high yields of annulated products, and the capability for scaled-up synthesis. A tentative mechanism of the annulation reaction was proposed based on a preliminary mechanistic investigation.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Ruonan Zhang, Abudukadi Tudi, Xia Yang, Xuping Wang, Zhihua Yang, Shujuan Han, Shilie Pan
Summary: A new lead tellurium borate material with a unique fundamental building block [B4O10] was synthesized and found to exhibit high birefringence. The structure-property relationship was discussed using first-principles calculations.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Amresh Kumar Singh, Baishali Thakurta, Anupam Giri, Monalisa Pal
Summary: This study introduces three key concepts for the quick synthesis of large-scale high-quality 2D materials films and their utilization in device fabrication.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Reina Hagiwara, Shun Nishimura, Kosuke Okeyoshi
Summary: A copolymer-conjugated nanocatalytic system has been developed to improve electron transfer and enhance photoinduced H2 generation.
CHEMICAL COMMUNICATIONS
(2024)