Flash generation of α-(trifluoromethyl) vinyllithium and application to continuous flow three-component synthesis of α-trifluoromethylamides

alpha-(Trifluoromethyl)vinyllithium was generated and used for the reaction with electrophiles at -78 degrees C in a flow microreactor although the batch reaction should be carried out at ca. -100 degrees C, and the method was applied to continuous flow three-component synthesis of alpha-trifluoromethylamides.