Article
Chemistry, Analytical
Jingfeng Yao, Guoxing Yin, Ting Yu, Haitao Li, Peng Yin
Summary: A fluorescent probe has been developed that can simultaneously distinguish Cys/Hcy and GSH, and perform fluorescence imaging in live cells.
ANALYTICAL METHODS
(2021)
Article
Chemistry, Analytical
Shaohui Han, Hui Zhang, Xiuxiu Yue, Jingpei Wang, Lei Yang, Benhua Wang, Xiangzhi Song
Summary: A ratiometric fluorescent probe CP was developed to selectively and rapidly discriminate between Cys and Hcy by introducing a phenylethynyl group. With distinct ratiometric fluorescence changes induced by the presence of Cys or Hcy, the probe was able to visualize and discriminate between intracellular Cys and Hcy in HeLa cells and zebrafish.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Chanjuan Zhang, Yan Qin, Changfeng Deng, Neng Zhu, Yaning Shi, Wei Wang, Li Qin
Summary: An off-on fluorescent probe (NBD-P) has been developed for detecting and visualizing intracellular glutathione (GSH) which can distinguish cancer tissues from normal tissues. This study also establishes a rapid drug screening method using NBD-P and identifies a natural GSH inhibitor from Tripterygium wilfordii Hook F. Additionally, insights into fluorescence probes for GSH inhibitors and cancer diagnosis, as well as the anti-cancer effects of Traditional Chinese Medicine (TCM), are provided.
ANALYTICA CHIMICA ACTA
(2023)
Article
Chemistry, Analytical
Wei Shu, Jin Yu, Huidan Wang, Anji Yu, Liyan Xiao, Zhuohang Li, Haitao Zhang, Yu Zhang, Yulong Wu
Summary: In this study, a reversible fluorescent probe GeP was designed for detecting intracellular glutathione. The probe exhibited fast response and high fluorescence change, and could target mitochondria. Additionally, GeP enabled superresolution fluorescence imaging of mitochondria.
ANALYTICA CHIMICA ACTA
(2022)
Article
Spectroscopy
Xiuxiu Yue, Jiali Chen, Wenqiang Chen, Benhua Wang, Hui Zhang, Xiangzhi Song
Summary: The endoplasmic reticulum, known as the largest organelle in many eukaryotic cells, plays a vital role in maintaining normal cell function. A novel endoplasmic reticulum-targeting fluorescent probe, ER-CP, has been developed for distinguishing and imaging Cys, Hcy, and GSH with favorable sensitivity and selectivity. ER-CP shows good ER-targeting property and has been successfully applied in imaging these biothiols in HeLa cells.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Article
Chemistry, Analytical
Lydia Colvin, Dandan Tu, Darin Dunlap, Alberto Rios, Gerard Cote
Summary: The field of glucose biosensors for diabetes management has been of great interest over the past 60 years. Continuous glucose monitoring (CGM) is important for better management of the disease. This study developed a glucose biosensor using ConA and a fluorescent probe, which showed promising results for subcutaneous glucose monitoring.
Article
Chemistry, Multidisciplinary
Junyan Ma, Yaoyu Xu, Wen Zhao, Beibei Wang, Chunhuan Zhang, Zhenxing Zhang
Summary: Researchers have developed a Tag-Sec fluorescent probe that can detect both thioredoxin reductase and selenocysteine with high sensitivity and selectivity, along with broad pH tolerance and good water solubility. This concept may serve as a useful guide for designing probes for detecting Sec-containing proteins in clinical diagnosis.
MATERIALS CHEMISTRY FRONTIERS
(2021)
Article
Chemistry, Analytical
Xinmiao Lu, Muyu Wu, Siwen Wang, Jingcan Qin, Peiyong Li
Summary: In this study, a near infrared fluorescent probe (HI) was developed to detect and report intracellular cysteine and glutathione, and monitor the development of drug resistance in tumor. The probe showed strong near infrared fluorescence in response to cysteine and glutathione, with high specificity and no interference from other amino acids. Incubation with PATU-8988 and PATU-8988/Fu cells allowed for clear imaging and monitoring of intracellular cysteine and glutathione, while application to tumor-bearing mice facilitated monitoring and reporting of drug resistance.
Article
Chemistry, Analytical
Ying-Jie Tang, Wen-Le Fang, Kui Ren, Xiao-Feng Guo, Hong Wang
Summary: FRET-based turn-on fluorescent probes like D-TMSPB offer high selectivity for detecting biothiols, with a response moiety of disulfide and BODIPY fluorophore performing both donor and acceptor roles. The probe shows weak fluorescence until reacting with biothiols, where FRET is disrupted, causing strong fluorescence ideal for lysosomal biothiol imaging in acidic conditions.
Article
Chemistry, Analytical
Jingyu Yang, Zizhen Zhao, Siyang Jiang, Lingyu Zhang, Kai Zhao, Zhan-Ting Li, Da Ma
Summary: A new design concept for pH-sensing supramolecular fluorescent probes is presented. These probes are designed based on pro-guests, which degrade under acidic conditions and displace encapsulated dyes to enhance fluorescence intensity. A library of potential probes is generated and screened for effective detection of acidic pH in solution. These supramolecular probes are capable of detecting the acidic environment in endosomal compartments in live cells.
Article
Chemistry, Analytical
Langping Zhou, Zhihao Yu, Guangzhu Zhang, Zechen Jin, Weibing Zhang, Junhong Qian
Summary: Five fluorescent probes TP1-5 were designed as two-input AND molecular logic gates for the simultaneous detection of thiols and protons. The probes showed significant fluorescence enhancements when both analytes were present, but weaker responses with the addition of a single analyte. The fluorescence outputs were modulated by the proton receptor and linker, while the length of spacer(1) affected the responses toward thiols and spacer(2) influenced the sensing performance toward protons. TP1-3 exhibited excellent AND logic function for simultaneous detection of protons and thiols and bioimaging of thiols in weakly acidic living cells, while TP4 and TP5 were not ideal candidates for executing AND logic operation.
ANALYTICAL METHODS
(2023)
Article
Chemistry, Applied
Dan Yue, Jiayan Zhu, Dong Chen, Weidong Li, Bowen Qin, Bing Zhang, Deri Liu, Xiaotong Yang, Yilei Zhang, Zhenling Wang
Summary: A stable and spindle-shaped metal-organic framework (Zn-DTBA) has been successfully synthesized for simultaneous detection of GSH and Cys. The framework has different fluorescence response for the two analytes and can be applied for detection in serum.
Article
Biochemical Research Methods
Pranab Chandra Saha, Tapas Bera, Tanima Chatterjee, Jayeeta Samanta, Arunima Sengupta, Maitree Bhattacharyya, Samit Guha
Summary: In this study, unsymmetrical visible Cy-3 and near-infrared Cy-5 chromophores were designed and synthesized, self-assembling into fluorescent nanotubes in solution and selectively accumulating inside mitochondria of human carcinoma cells. This accumulation led to early apoptosis targeted at malignant mitochondria, which was confirmed by annexin V-FITC/PI apoptosis detection assay.
BIOCONJUGATE CHEMISTRY
(2021)
Article
Chemistry, Analytical
Yuan Ye, Mengye He, Liping Wang, Xing-Can Shen, Hua Chen
Summary: This study developed a series of novel cyanine fluorophores for simultaneous visualization of cysteine level and mitochondrial viscosity during kidney ferroptosis. The results showed that ferroptosis process was accompanied by a decrease in cysteine channel and an increase in mitochondrial viscosity channel. Furthermore, the study also revealed dynamic changes of cysteine level and mitochondrial viscosity in a mouse kidney ferroptosis model in vivo.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Spectroscopy
Yi-Hang Sun, Hai-Hao Han, Jia-Min Huang, Jia Li, Yi Zang, Cheng-Yun Wang
Summary: DCIMA is a long-wavelength fluorescent probe for detecting Cys and GSH in living cells, with low detection limits and fast reaction speed, enabling sensitive imaging of biothiols located in lysosomes.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Review
Chemistry, Multidisciplinary
Dan He, Yawen Li, Fuwen Zhao, Yuze Lin
Summary: High trap density in organic solar cells leads to localized charge carriers and reduced carrier lifetime, limiting device efficiency. This feature article summarizes the recent advances of trap suppression by material design and device engineering.
CHEMICAL COMMUNICATIONS
(2024)
Review
Chemistry, Multidisciplinary
Olivier Monfort, Arshitha Madhusudhan, Martin Motola
Summary: This article presents the advantages of coupling photocatalysis and Fenton-based processes for environmental remediation and discusses their synergy. It critically examines the simultaneous triggering of these two processes and provides insights into research approaches. The study aims to enhance understanding of this complex process and highlight the potential integration of new catalysts in current wastewater treatment technology.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Manideepa Dhar, Chittaranjan Mishra, Avijit Das, Uttam Manna
Summary: An approach of 'polymerization of monomers in its aggregated form' has been introduced to tailor the water wettability of fibrous and porous substrates, achieving hydrophobicity to superhydrophobicity transition, as well as patterned wettability. This facile chemical method provides a durable coating with adjustable and patterned wettability for various potential applications.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Saswat Ranjan Bhoi, Chhanda Debnath, Shikha Gandhi
Summary: In this article, a novel catalytic reaction using Pd(0) and Bronsted acid is reported for the synthesis of biologically important imidazolidinone-fused N-heterocycles through redox-neutral intramolecular N-allylation of indoles and pyrroles with alkynes. This atom-economical method is applicable to a wide range of substrates and eliminates the need for leaving groups or oxidizing agents commonly used in traditional allylation reactions.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Longkun Chen, Mingshuai Zhang, Meichen Liu, Zhuoyuan Liu, Yuetong Qiu, Zhilai Zhang, Fuchao Yu, Jiuzhong Huang
Summary: In this study, an efficient Rh(III)-catalyzed selective mono- and dual-C-H bond functionalization/cyclization with iodonium ylide as the sole coupling partner was demonstrated. Fused benzodiazepine skeletons were obtained in excellent yields, providing an improved approach to dual C-H unsymmetrical functionalization.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Alice Kennett, Sven Epple, Gabriella van der Valk, Irene Georgiou, Evelyne Gout, Romain R. Vives, Angela J. Russell
Summary: This study presents the design and synthesis of sulfated disaccharide inhibitors based on IdoA(2S)-GlcNS(6S), which showed potent inhibition of Sulf-2. The results suggest that IdoA(2S)-GlcNS(6S) is the shortest fragment size required for effective inhibition of Sulfs, and a trisulfated disaccharide is identified as the minimal fragment size of heparan sulfate for effective endosulfatase inhibition.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Mauro Garbini, Andrea Brunetti, Riccardo Pedrazzani, Magda Monari, Massimo Marcaccio, Giulio Bertuzzi, Marco Bandini
Summary: The self-adaptability of galvanostatic electrolysis was found to be helpful in a multistage chemo- and diastereoselective electrochemically promoted cyclodimerization of chalcones. Through a series of reductive events, densely functionalized cyclopentanes with five contiguous stereocenters were obtained (25 examples, yields up to 95%, dr values up to >20:1). Further experimental and electrochemical investigations indicated the crucial role of dynamic kinetic resolution of the aldol intermediate in the reaction mechanism.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Dhananjay S. Nipate, Neha Meena, Prakash N. Swami, Krishnan Rangan, Anil Kumar
Summary: In this study, the synthesis of functionalized benzo[a]phenazines and indazolo[2,3-a]quinolines was achieved through Rh(III)-catalyzed oxidative annulation of 2-arylquinoxalines and 2-aryl-2H-indazoles with allyl alcohols. The method showed a wide substrate scope, excellent functional group tolerance, good to high yields of annulated products, and the capability for scaled-up synthesis. A tentative mechanism of the annulation reaction was proposed based on a preliminary mechanistic investigation.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Ruonan Zhang, Abudukadi Tudi, Xia Yang, Xuping Wang, Zhihua Yang, Shujuan Han, Shilie Pan
Summary: A new lead tellurium borate material with a unique fundamental building block [B4O10] was synthesized and found to exhibit high birefringence. The structure-property relationship was discussed using first-principles calculations.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Amresh Kumar Singh, Baishali Thakurta, Anupam Giri, Monalisa Pal
Summary: This study introduces three key concepts for the quick synthesis of large-scale high-quality 2D materials films and their utilization in device fabrication.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Reina Hagiwara, Shun Nishimura, Kosuke Okeyoshi
Summary: A copolymer-conjugated nanocatalytic system has been developed to improve electron transfer and enhance photoinduced H2 generation.
CHEMICAL COMMUNICATIONS
(2024)