Article
Chemistry, Physical
Joaquin Otarola-Sepulveda, Esteban Cea-Klapp, Paulo Aravena, Sebastian Ormazabal-Latorre, Roberto I. Canales, Jose Matias Garrido, Oscar Valerio
Summary: This study compares the solubility predictions of Flory-Huggins based on the Hansen Solubility Parameters (FH-HSP) model with openCOSMO-RS and PC-SAFT, finding good performance in predicting the solubility of thymol and L-menthol but significant deviations for solid solutes in cyclohexanone. For DES solubility predictions compared to experimental data, RMSLD values of FH-HSP, openCOSMO-RS, and PC-SAFT were 0.86, 0.27, and 0.93 respectively. The results suggest that the HSP theory can aid DES screening processes by identifying promising DES-solute pairs.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Pharmacology & Pharmacy
Sonia N. Pedro, Ana T. P. C. Gomes, Parastu Oskoei, Helena Oliveira, Adelaide Almeida, Mara G. Freire, Armando J. D. Silvestre, Carmen S. R. Freire
Summary: This study demonstrates the promising use of deep eutectic solvents (DES) formulations in improving the solubility, stability, and therapeutic efficacy of antibiotics, specifically ciprofloxacin. The developed formulations significantly enhance the susceptibility of bacteria to the antibiotic without promoting resistance, and decrease the toxicity of ciprofloxacin towards human cells.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Engineering, Environmental
Maria F. Nava-Ocampo, Lamya Al Fuhaid, Robert Verpoorte, Young Hae Choi, Mark C. M. van Loosdrecht, Johannes S. Vrouwenvelder, Geert J. Witkamp, Andreia S. F. Farinha, Szilard S. Bucs
Summary: The study demonstrates that NADES can act as a biofilm structural breaker, solubilizing the main components of biofilms and weakening their structure, potentially serving as an environmentally-friendly green solvent for biofilm treatment.
Article
Pharmacology & Pharmacy
Yiwen Liu, Yujing Wu, Jinming Liu, Wenxi Wang, Qingliang Yang, Gensheng Yang
Summary: Deep eutectic solvents (DESs) are versatile drug delivery systems widely used in the pharmaceutical industry, with their distinguished properties including biocompatibility, tunability, thermal and chemical stability.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Agricultural Engineering
Kai Nie, Boya Li, Yan Song, Xiaolong Qiao, Tao Zhao, Yuanming Zhang, Haoxi Ben, Arthur Ragauskas, Conger Wang, Wei Jiang, Guangting Han
Summary: In this study, deep eutectic solvents (DESs) were used for degumming kenaf bast. The alkalinity amide DES (CU) showed the best degumming effect, with an optimal processing temperature of 160 degrees C and a processing time of 2 h. The DES weakened the hydrogen bond interaction in kenaf fibers and removed lignin by deprotonation of phenolic hydroxyl groups and breakage of β-O-4 bonds. This study provided a simple and green degumming method for kenaf bast.
INDUSTRIAL CROPS AND PRODUCTS
(2023)
Article
Chemistry, Physical
Hao Qin, Zhen Song, Hongye Cheng, Liyuan Deng, Zhiwen Qi
Summary: Efficient capture of CO2 is crucial for addressing global warming. This study used halogen-free deep eutectic solvents (DESs) to absorb CO2, measured solubility, compared with other solvents, and analyzed interaction energies between CO2 and DESs to illustrate the absorption mechanism.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Review
Biochemistry & Molecular Biology
Iwona Cichowska-Kopczynska, Bartosz Nowosielski, Dorota Warminska
Summary: Nowadays, researchers are striving to find a solution to the problem of global warming, with a focus on reducing carbon dioxide emissions. The use of alkanolamines for carbon dioxide capture is problematic due to its corrosive nature, volatility, and high energy demand. Deep eutectic solvents (DESs) have emerged as a potential alternative, capable of physically and chemically absorbing carbon dioxide. Different strategies, such as the addition of water or co-solvents, have been proposed to enhance CO2 absorption using DESs. This review presents an overview of DESs, their impact on CO2 absorption, and practical considerations for their use in CO2 separation.
Review
Chemistry, Physical
Yanrong Liu, Zhengxing Dai, Zhibo Zhang, Shaojuan Zeng, Fangfang Li, Xiangping Zhang, Yi Nie, Lei Zhang, Suojiang Zhang, Xiaoyan Ji
Summary: This study comprehensively collected and summarized the solubilities of CO2 in physical- and chemical-based ILs/DESs, as well as the COSMO-RS models predicting these properties. Chemical-based ILs/DESs were found to be more effective for CO2 capture, especially those with functionalized cations and anions, and superbase DESs.
GREEN ENERGY & ENVIRONMENT
(2021)
Article
Chemistry, Multidisciplinary
Shiqin Sun, Shiwei Liu, Fengli Yu, Jian Zhang, Weiguo Xing, Shitao Yu
Summary: A deep eutectic solvent (DES) with adjustable Bronsted acidity was easily prepared using choline chloride (ChCI) and trifluoromethanesulfonic acid (TfOH). This DES [ChCl][TfOH](3) exhibited great stability and excellent catalytic performance in the Beckmann rearrangement reaction. Under mild conditions, high cydohexanone oxime (CHO) conversion (100%) and epsilon-caprolactam selectivity (98.8%) were achieved. The DES [ChCI][TfOH](3) could be easily prepared, recovered, and reused for multiple runs without significant loss of catalytic performance. The reaction had a free energy (Delta G) of -32.8 and an activation energy (E-a) of 39.82 kJ mol(-1). DFT results showed that the intermolecular hydrogen bond between ChCI and TfOH improved the thermal stability of DES and provided a good sponge effect for the active hydrogen catalytic center required for the reaction. This study demonstrated the potential practicality of the DES catalytic system for the Beckmann rearrangement reaction, offering advantages such as good yields, short reaction times, and easy catalyst recoveries.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2022)
Article
Engineering, Environmental
Ahmad Al-Bodour, Noor Alomari, Alberto Gutierrez, Santiago Aparicio, Mert Atilhan
Summary: This work investigates the solubility of carbon dioxide in four type V natural deep eutectic solvents (NADES). The results show that the solubility of carbon dioxide in monoterpenoid-based hydrophobic NADES increases with increasing pressure and decreasing temperature. In addition to their hydrophobic nature, these solvents have high CO2 sorption performance and rapid solubility rate, making them good candidates for future carbon management applications.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2022)
Article
Engineering, Environmental
Qianqian Chen, Meng Zhou, Jun Yuan, Jiaqian Cai, Hongxia Xie, Mengxiang Zhu, Libing Cai, Peng Wei, Chunyu Chang
Summary: In this study, a vacuum-assisted filtration method was used to prepare high-strength and recyclable hydroplastic cellulose nanofiber films. Hydrophobic cellulose nanofibers were obtained by esterification of natural cellulose and dissolved in a recyclable deep eutectic solvent to form films. The films exhibited high tensile strength and could be programmed into various shapes. They could also be reversibly engineered by kirigami, origami, and embossing. The waste films could be recycled.
CHEMICAL ENGINEERING JOURNAL
(2023)
Review
Biochemistry & Molecular Biology
Tomasz Swebocki, Alexandre Barras, Amar Abderrahmani, Kamel Haddadi, Rabah Boukherroub
Summary: In recent years, there has been a significant increase in the number of studies focusing on the synthesis and characterization of deep eutectic solvents (DESs). DESs, known for their stability, ease of synthesis, and ability to tailor properties, are considered one of the greenest solvent families used in various fields such as organic synthesis, catalysis, electrochemistry, and medicine. However, there is a lack of research on specific groups of DESs, particularly those comprising organic acids (OA-DESs), despite their potential in biomedical applications. This review aims to highlight the importance and applications of OA-DESs as antimicrobial agents and drug delivery enhancers, providing valuable insights for future developments in this field.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Sonia Trombino, Carlo Siciliano, Debora Procopio, Federica Curcio, Annarita S. Lagana, Maria Luisa Di Gioia, Roberta Cassano
Summary: Due to growing awareness of environmental impact, the use of safer and eco-friendly solvents like deep eutectic solvents (DESs) has seen significant growth in the pharmaceutical field. This study explores the use of DESs as non-aqueous liquid administration vehicles to enhance the solubility and topical delivery of dapsone. The findings suggest that DESs have great potential as dissolution and permeation enhancers in the development of novel and more effective drug delivery systems.
Article
Chemistry, Multidisciplinary
M. Panic, N. Macek Hrvat, M. Stokic, I. Radojcic Redovnikovic, Z. Kovarik, K. Radosevic
Summary: This study investigates natural deep eutectic solvents (NADES) as alternative solvents for the preparation of oxime RS194B, a potent antidote for organophosphate poisoning. The aim was to enhance the solubility of RS194B by preparing oxime formulations in NADES. The study demonstrates the potential of NADES in formulating antidotes for nerve agent poisoning.
SUSTAINABLE CHEMISTRY AND PHARMACY
(2022)
Article
Chemistry, Physical
Jie Zhu, Hui Shao, Lin Feng, Yingzhou Lu, Hong Meng, Chunxi Li
Summary: The absorption behavior and stability of three ChCl-based deep eutectic solvents in removing HCl gas were studied, with ChCl-Gly showing higher viability for adsorption of HCl-bearing gas.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Chemistry, Physical
Gyanendra Sharma, Rosy Alphons Sequeira, Matheus M. Pereira, Tapan Kumar Maity, Nishith A. Chudasama, Kamalesh Prasad
Summary: The study found that ILs are more advantageous than DESs in terms of the dissolution and stability of DNA, mainly due to the higher dissolution capacity and better hydrogen bonding ability with DNA of ILs as compared to DESs.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Biochemistry & Molecular Biology
Supratim Chakraborty, Sachin M. Shet, Matheus M. Pereira, Sanna Kotrappanavar Nataraj, Dibyendu Mondal
Summary: This study introduces a biopolymer-based peroxidase mimicking system, in which three PECs were engineered by complexation of protonated chitosan and alginate with Fe2+, Fe-3+ and Fe3O4. Among them, Fe3+-PEC demonstrated high stability and activity, suitable for catalytic reactions in aqueous buffers and organic solvents.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Engineering, Environmental
Kanakaraj Aruchamy, Kalpana Dharmalingam, Chang Woo Lee, Dibyendu Mondal, Nataraj Sanna Kotrappanavar
Summary: In recent years, there has been a growing interest in developing cost-effective, simple, and environmentally friendly methods using abundant biomass resources to address water contamination issues and store renewable energy. This study successfully converted toxic weed Parthenium hysterophorous into porous activated carbon with excellent electrochemical performance and organic pollutant removal capabilities. The functional carbon materials showed promising potential for sustainable water purification in continuous flow systems.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Engineering, Environmental
Manohara Halanur Mruthunjayappa, Nataraj Sanna Kotrappanavar, Dibyendu Mondal
Summary: Proteinaceous materials have great potential in membrane technology due to their mechanical strength, functionalities, amphiphilicity, and high loading capacity. A novel strategy of functionalizing silk nanofibrils with metal oxyhydroxide has been demonstrated to fabricate ultrafast permeable multi-layered and self-cleaning membranes, which showed efficient purification of contaminated water with high rejection rates. The multilayered membrane also exhibited excellent performance in removing fluoride and As (V) from industrial wastewater, as well as in real water streams, with superior recyclability and self-cleaning properties.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Matam Pradeep, Dariusz Kruszka, Piotr Kachlicki, Dibyendu Mondal, Gregory Franklin
Summary: This study systematically investigated the mechanism of St. John's wort extract-mediated synthesis of silver nanoparticles, revealing the different roles of various phytochemicals in reducing silver ions and protecting the nanoparticles.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2022)
Review
Materials Science, Multidisciplinary
Manohara Halanur Mruthunjayappa, Nataraj Sanna Kotrappanavar, Dibyendu Mondal
Summary: This review article provides an overview of the advances and latest trends in solvothermal carbonization synthesized using ionic liquids, deep eutectic solvents, and eutectic salts as feedstock and/or solvents. It focuses on the unique properties of the carbon formation mechanism, large scale production advantages over conventional hydrothermal carbons, and applications in energy storage, water purification, and catalysis.
PROGRESS IN MATERIALS SCIENCE
(2022)
Article
Engineering, Chemical
Filipa A. Vicente, Leonor S. Castro, Dibyendu Mondal, Joao A. P. Coutinho, Ana P. M. Tavares, Sonia P. M. Ventura, Mara G. Freire
Summary: Immunoglobulin Y (IgY) was purified from egg yolk using a biocompatible and cost-effective downstream process. Thermoresponsive aqueous micellar two-phase systems were applied to achieve high purity extraction of IgY in a single step.
SEPARATION AND PURIFICATION TECHNOLOGY
(2022)
Article
Engineering, Chemical
Ashesh Mahto, Mahaveer Annappa Halakarni, Ashok Maraddi, Glenita 'Souza, Anita A. Samage, Utpal G. Thummar, Dibyendu Mondal, S. K. Nataraj
Summary: This work focuses on the recovery and conversion of cellulose acetate polymer from waste cigarette filters into semi-permeable membranes. The recycling process involved solvent washing, dissolution, filtration, and reprecipitation. The membranes fabricated from the recovered polymer showed excellent dye/salt separation performance and steady performance when tested with real industry effluent.
Article
Biochemistry & Molecular Biology
Sachin M. Shet, Pranav Bharadwaj, Meena Bisht, Matheus M. Pereira, Sarath Kumar Thayallath, Veeresh Lokesh, Gregory Franklin, Nataraj Sanna Kotrappanavar, Dibyendu Mondal
Summary: The existence of numerous biomolecules in biological fluids leads to the phenomenon of macromolecular crowding, which is essential to maintain the active conformation of proteins. In this study, double helical DNA is used as a biomacromolecular crowding system to package cytochrome c (Cyt C), resulting in significantly enhanced catalytic activity and stability. The main interactions between DNA and Cyt C are electrostatic and hydrogen bonding. Furthermore, DNA-based macromolecular crowding media can effectively stabilize proteins against various stresses.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Green & Sustainable Science & Technology
Rangaswamy Puttaswamy, Chanchal Mondal, Dibyendu Mondal, Debasis Ghosh
Summary: Deep eutectic solvents (DES) have emerged as promising alternative electrolytes for rechargeable batteries and supercapacitors. DES possesses properties similar to ionic liquids, such as low vapor pressure, non-flammability, and high ionic conductivity. It is a cost-efficient and environmentally friendly option for energy storage devices. Recent research efforts have focused on designing and developing novel DES systems and investigating their physicochemical characteristics and electrochemical performances. The challenges and future prospects of DES electrolytes have also been discussed, along with proposed strategies for improving their performance.
SUSTAINABLE MATERIALS AND TECHNOLOGIES
(2022)
Article
Chemistry, Multidisciplinary
Pranav Bharadwaj, Dheeraj Kumar Sarkar, Meena Bisht, Sachin M. M. Shet, Nataraj Sanna Kotrappanavar, Veeresh Lokesh, Gregory Franklin, Jan Brezovsky, Dibyendu Mondal
Summary: Green and nano-structured catalytic media are important for protecting biocatalysts and enhancing their stability and activity. This study demonstrates the ability of ATP and cholinium salicylate IL to form nano-structures and enhance the stability and activity of Cytochrome c. These nano-structured hydrotropes offer a novel strategy for industrial biocatalysis with improved stability and activity under extreme conditions.
Review
Chemistry, Multidisciplinary
Meena Bisht, Sarath Kumar Thayallath, Pranav Bharadwaj, Gregory Franklin, Dibyendu Mondal
Summary: The unique catalytic properties of enzymes have led to the production of useful medicinal intermediates, foods, and biofuels from sustainable sources. Encapsulation of enzymes on suitable carriers would mitigate the instability issues faced in robust biocatalysis. Biodegradable and renewable biomass-derived functional materials (BDFMs) are envisaged as promising carriers for enzymes, with in-built chemical functionalities and desirable physicochemical properties.
Article
Chemistry, Multidisciplinary
Sarath Kumar Thayallath, Sachin M. M. Shet, Meena Bisht, Pranav Bharadwaj, Matheus M. M. Pereira, Gregory Franklin, S. K. Nataraj, Dibyendu Mondal
Summary: In this study, a simple approach to fabricate protein nanoconstructs using cytochrome C (Cyt C), silk nanofibrils (SNF), and choline dihydrogen phosphate ionic liquid (IL) was presented. The modified IL-Cyt C nanoconstruct (Cyt C + SNF + IL) showed significantly increased peroxidase activity (2.5 to 10-fold) compared to unmodified Cyt C and exhibited enhanced catalytic activity and stability under harsh conditions, suggesting its potential as a suitable protein packaging strategy.
CHEMICAL COMMUNICATIONS
(2023)
Review
Chemistry, Multidisciplinary
Smitha V. Kamath, Manohara Halanur Mruthunjayappa, Dibyendu Mondal, Nataraj Sanna Kotrappanavar
Summary: Increase in global population and rapid industrialization have led to water quality deterioration and water scarcity, but high-performance nanomaterials show great potential in adsorption and photo-degradation processes. Researchers have extensively studied nanomaterials and demonstrated their applications in water filtration and membrane materials.
ENVIRONMENTAL SCIENCE-NANO
(2022)
Review
Chemistry, Multidisciplinary
Halanur M. Manohara, Sooraj S. Nayak, Gregory Franklin, Sanna Kotrappanavar Nataraj, Dibyendu Mondal
Summary: Global water scarcity is on the rise, prompting researchers to explore the use of marine-derived biomaterials for water purification due to their environmentally friendly and renewable nature. These materials show great potential in effectively purifying water sources, with promising prospects for future development.
Review
Chemistry, Multidisciplinary
Dan He, Yawen Li, Fuwen Zhao, Yuze Lin
Summary: High trap density in organic solar cells leads to localized charge carriers and reduced carrier lifetime, limiting device efficiency. This feature article summarizes the recent advances of trap suppression by material design and device engineering.
CHEMICAL COMMUNICATIONS
(2024)
Review
Chemistry, Multidisciplinary
Olivier Monfort, Arshitha Madhusudhan, Martin Motola
Summary: This article presents the advantages of coupling photocatalysis and Fenton-based processes for environmental remediation and discusses their synergy. It critically examines the simultaneous triggering of these two processes and provides insights into research approaches. The study aims to enhance understanding of this complex process and highlight the potential integration of new catalysts in current wastewater treatment technology.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Manideepa Dhar, Chittaranjan Mishra, Avijit Das, Uttam Manna
Summary: An approach of 'polymerization of monomers in its aggregated form' has been introduced to tailor the water wettability of fibrous and porous substrates, achieving hydrophobicity to superhydrophobicity transition, as well as patterned wettability. This facile chemical method provides a durable coating with adjustable and patterned wettability for various potential applications.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Saswat Ranjan Bhoi, Chhanda Debnath, Shikha Gandhi
Summary: In this article, a novel catalytic reaction using Pd(0) and Bronsted acid is reported for the synthesis of biologically important imidazolidinone-fused N-heterocycles through redox-neutral intramolecular N-allylation of indoles and pyrroles with alkynes. This atom-economical method is applicable to a wide range of substrates and eliminates the need for leaving groups or oxidizing agents commonly used in traditional allylation reactions.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Longkun Chen, Mingshuai Zhang, Meichen Liu, Zhuoyuan Liu, Yuetong Qiu, Zhilai Zhang, Fuchao Yu, Jiuzhong Huang
Summary: In this study, an efficient Rh(III)-catalyzed selective mono- and dual-C-H bond functionalization/cyclization with iodonium ylide as the sole coupling partner was demonstrated. Fused benzodiazepine skeletons were obtained in excellent yields, providing an improved approach to dual C-H unsymmetrical functionalization.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Alice Kennett, Sven Epple, Gabriella van der Valk, Irene Georgiou, Evelyne Gout, Romain R. Vives, Angela J. Russell
Summary: This study presents the design and synthesis of sulfated disaccharide inhibitors based on IdoA(2S)-GlcNS(6S), which showed potent inhibition of Sulf-2. The results suggest that IdoA(2S)-GlcNS(6S) is the shortest fragment size required for effective inhibition of Sulfs, and a trisulfated disaccharide is identified as the minimal fragment size of heparan sulfate for effective endosulfatase inhibition.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Mauro Garbini, Andrea Brunetti, Riccardo Pedrazzani, Magda Monari, Massimo Marcaccio, Giulio Bertuzzi, Marco Bandini
Summary: The self-adaptability of galvanostatic electrolysis was found to be helpful in a multistage chemo- and diastereoselective electrochemically promoted cyclodimerization of chalcones. Through a series of reductive events, densely functionalized cyclopentanes with five contiguous stereocenters were obtained (25 examples, yields up to 95%, dr values up to >20:1). Further experimental and electrochemical investigations indicated the crucial role of dynamic kinetic resolution of the aldol intermediate in the reaction mechanism.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Dhananjay S. Nipate, Neha Meena, Prakash N. Swami, Krishnan Rangan, Anil Kumar
Summary: In this study, the synthesis of functionalized benzo[a]phenazines and indazolo[2,3-a]quinolines was achieved through Rh(III)-catalyzed oxidative annulation of 2-arylquinoxalines and 2-aryl-2H-indazoles with allyl alcohols. The method showed a wide substrate scope, excellent functional group tolerance, good to high yields of annulated products, and the capability for scaled-up synthesis. A tentative mechanism of the annulation reaction was proposed based on a preliminary mechanistic investigation.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Ruonan Zhang, Abudukadi Tudi, Xia Yang, Xuping Wang, Zhihua Yang, Shujuan Han, Shilie Pan
Summary: A new lead tellurium borate material with a unique fundamental building block [B4O10] was synthesized and found to exhibit high birefringence. The structure-property relationship was discussed using first-principles calculations.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Amresh Kumar Singh, Baishali Thakurta, Anupam Giri, Monalisa Pal
Summary: This study introduces three key concepts for the quick synthesis of large-scale high-quality 2D materials films and their utilization in device fabrication.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Reina Hagiwara, Shun Nishimura, Kosuke Okeyoshi
Summary: A copolymer-conjugated nanocatalytic system has been developed to improve electron transfer and enhance photoinduced H2 generation.
CHEMICAL COMMUNICATIONS
(2024)