Review
Chemistry, Inorganic & Nuclear
Christopher C. Rennie, Robert M. Edkins
Summary: Phototherapy, using light to selectively ablate cancerous tissue, shows promising prospects. The use of Pc-drug conjugates as targeted anticancer phototherapeutic systems has shown potential in improving treatment specificity and achieving precise, synergistic phototherapy.
DALTON TRANSACTIONS
(2022)
Article
Biophysics
Roman A. Barmin, Elizaveta A. Maksimova, Polina G. Rudakovskaya, Alexey Gayer, Evgeny A. Shirshin, Kirill S. Petrov, Daria A. Terentyeva, Olga Gusliakova, Olga A. Sindeeva, Oleg A. Klimenko, Roman N. Chuprov-Netochin, Alexander A. Solovev, Gaoshan Huang, Anastasia Ryabova, Victor B. Loschenov, Dmitry A. Gorin
Summary: Gas-liquid interfaces have gained interest in biomedicine, particularly in the use of microbubbles as theranostic platforms. In this study, two commercially available photosensitizers were conjugated to bovine serum albumin before microbubble synthesis to enhance photodynamic therapy. The conjugates increased microbubble concentration and stability compared to plain microbubbles. Agents based on one of the photosensitizers demonstrated higher photodynamic activity and microbubbles showed acoustic stability in human blood plasma. The study concludes that these microbubble platforms have potential for further applications in photodynamic therapy.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Chemistry, Applied
Siqi Xiao, Zehua Lu, Jianmin Yang, Xianai Shi, Yunquan Zheng
Summary: In this study, researchers found that the phycocyanobilin compound in phycocyanin can be used as a new anticancer photosensitizer with anti-inflammatory and immunomodulatory activities. The compound was produced rapidly with high purity and showed significant anticancer activity under light conditions. Its active oxygen quantum yield was much higher than that of chlorophyll, making it a promising candidate for cancer treatment.
Article
Biophysics
Ziming Yang, Puwang Li, Yu Chen, Enming Dong, Zhipan Feng, Zuyu He, Chuang Zhou, Chao Wang, Yunhao Liu, Changgen Feng
Summary: Researchers successfully developed a positively charged amphiphilic phosphonium chitosan nanomicelle for enhancing the solubility and encapsulation of zinc phthalocyanine photosensitizer in photodynamic therapy. The nanomicelle showed stable encapsulation of ZnPc and increased phototoxicity, providing a new strategy to improve the efficacy of PDT with hydrophobic photosensitizers.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Nanoscience & Nanotechnology
Hao Liu, Li-Li Lv, Huang Wen, Dong-Mei Zhao, Juhong Wu, Mei-Rong Ke, Bi-Yuan Zheng, Jinyu Li, Xingshu Li, Jian-Dong Huang
Summary: This paper presents a molecular and supramolecular approach for targeted phototherapy by modifying silicon (IV) phthalocyanines (Pcs) and interacting with albumin. The approach improves the photoactivities and tumor targeting of Pcs, and achieves high phototoxicity in HepG2 cells.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Biochemistry & Molecular Biology
Nokuphila Winifred Nompumelelo Simelane, Cherie Ann Kruger, Heidi Abrahamse
Summary: A bioactive nanoconjugate was successfully fabricated to improve the outcomes of colorectal cancer PDD and PDT, demonstrating enhanced performance in targeting CRC cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Nkune Williams Nkune, Gauta Gold Matlou, Heidi Abrahamse
Summary: This work presents the synthesis and characterization of a water-soluble zinc phthalocyanine (ZnPcTS41) and its application in photodynamic therapy combined with cannabidiol (CBD) on metastatic melanoma cells. The combination of CBD and ZnPcTS41-mediated PDT showed a significant reduction in cell viability and an increase in late apoptotic cell population.
Article
Materials Science, Coatings & Films
Meizi Cui, Jing Wu, Jinying Wei, Zhouxia Wei
Summary: This research successfully prepared a poly(vinylidene) fluoride (PVDF) based nanocomposite membrane with superhydrophobic property and near-infrared (NIR) light triggered photodynamic antibacterial activity, which showed great potential applications in a wide range of antimicrobial-related fields.
SURFACE & COATINGS TECHNOLOGY
(2023)
Review
Chemistry, Inorganic & Nuclear
Maura Pellei, Fabio Del Bello, Marina Porchia, Carlo Santini
Summary: Zinc is an essential element for humans, and any malfunctions of its homeostasis can lead to different disease states, including cancer. Zinc complexes have shown promising biological activities, such as preventive effects on infectious diseases and low toxicity, making them appealing for applications in medicinal chemistry.
COORDINATION CHEMISTRY REVIEWS
(2021)
Article
Pharmacology & Pharmacy
Anpu Yang, Yanan Sun, Bochen Lyu, Binlong Chen, Zhipu Fan, Minghui Li, Yao Zhao, Jijun Fu, Bing He, Hua Zhang, Xueqing Wang, Wenbing Dai, Qiang Zhang
Summary: This study demonstrates the high potential of the PCT nanodispersion in tumor combined therapy by simply associating three readily available materials (single-walled carbon nanohorns, zinc phthalocyanine, and surfactant TPGS) together. The PCT exhibits promising photothermal and photodynamic effects, effectively destroying tumor cells in vitro and inhibiting the growth and metastasis of tumors in vivo.
ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Engineering, Biomedical
Benedito Marcio de Oliveira, Jessica Beatriz Miranda Teodoro, Jessica Aparecida Ribeiro Ambrosio, Erika Peterson Goncalves, Milton Beltrame, Luciana Maria Cortez Marcolino, Juliana Guerra Pinto, Juliana Ferreira-Strixino, Andreza Ribeiro Simioni
Summary: Development of nanoparticle delivery systems, such as PLA nanoparticles loaded with the photosensitizer ZnPc, show promising potential in biomedical research. The nanoparticles exhibited good encapsulation efficiency, stability, and photobiological effects, making them a viable drug delivery system for photodynamic therapy.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2022)
Article
Chemistry, Physical
Dongmu Zhao, Ancheng Ouyang, Xianglei Wang, Wei Zhang, Guanghui Cheng, Bin Lv, Wei Liu
Summary: This study investigated the use of photodynamic therapy (PDT) for the treatment of thyroid cancer and found that axial choline substituted SiPc1 showed higher photodynamic activity, making it a promising candidate for the treatment of thyroid cancer.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Zhengqi Zha, Yinghua Miao, Huiling Tang, Daniela D. Herrera-Balandrano, Hongping Yin, Su-Yan Wang
Summary: By preparing heparosan-based nanoparticles, the solubility of ZnPc was improved and its effectiveness in melanoma treatment was enhanced. These nanoparticles exhibited excellent photodynamic toxicity in melanoma cells while showing no cytotoxicity to normal cells in the dark. Furthermore, these nanoparticles demonstrated good stability in both powder and medium.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Inorganic & Nuclear
Dmitriy A. Lazovskiy, Ivan A. Skvortsov, Veronika Novakova, Pavel A. Stuzhin
Summary: Phosphorus(v) complexes of octaphenyltetrapyrazinocorrolazine with two aryloxy groups were synthesized. Complex 2a with axial PhO groups fluoresces in multiple solvents and generates singlet oxygen effectively. The introduction of NMe2 and OH groups significantly affects fluorescence parameters and photosensitizing properties, with solvent and pH sensitivity.
DALTON TRANSACTIONS
(2022)
Article
Chemistry, Organic
Lucia Kociscakova, Carola Rando, Magdalena Kozlikova, Miloslav Machacek, Veronika Novakova, Vladimir Sindelar, Petr Zimcik
Summary: In this work, a supramolecular approach based on the interaction of aminoadamantyl-substituted phthalocyanines (Pcs) with bulky and hydrophilic cucurbit[7]uril (CB[7]) was developed to increase the levels of Pc monomers in water. The interaction between CB[7] and Pcs weakened H-type aggregation, improved both fluorescence and singlet oxygen production. However, the activity of the prepared Pcs decreased after host-guest interaction with CB[7] due to the reduced cellular uptake.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Review
Chemistry, Multidisciplinary
Dan He, Yawen Li, Fuwen Zhao, Yuze Lin
Summary: High trap density in organic solar cells leads to localized charge carriers and reduced carrier lifetime, limiting device efficiency. This feature article summarizes the recent advances of trap suppression by material design and device engineering.
CHEMICAL COMMUNICATIONS
(2024)
Review
Chemistry, Multidisciplinary
Olivier Monfort, Arshitha Madhusudhan, Martin Motola
Summary: This article presents the advantages of coupling photocatalysis and Fenton-based processes for environmental remediation and discusses their synergy. It critically examines the simultaneous triggering of these two processes and provides insights into research approaches. The study aims to enhance understanding of this complex process and highlight the potential integration of new catalysts in current wastewater treatment technology.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Manideepa Dhar, Chittaranjan Mishra, Avijit Das, Uttam Manna
Summary: An approach of 'polymerization of monomers in its aggregated form' has been introduced to tailor the water wettability of fibrous and porous substrates, achieving hydrophobicity to superhydrophobicity transition, as well as patterned wettability. This facile chemical method provides a durable coating with adjustable and patterned wettability for various potential applications.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Saswat Ranjan Bhoi, Chhanda Debnath, Shikha Gandhi
Summary: In this article, a novel catalytic reaction using Pd(0) and Bronsted acid is reported for the synthesis of biologically important imidazolidinone-fused N-heterocycles through redox-neutral intramolecular N-allylation of indoles and pyrroles with alkynes. This atom-economical method is applicable to a wide range of substrates and eliminates the need for leaving groups or oxidizing agents commonly used in traditional allylation reactions.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Longkun Chen, Mingshuai Zhang, Meichen Liu, Zhuoyuan Liu, Yuetong Qiu, Zhilai Zhang, Fuchao Yu, Jiuzhong Huang
Summary: In this study, an efficient Rh(III)-catalyzed selective mono- and dual-C-H bond functionalization/cyclization with iodonium ylide as the sole coupling partner was demonstrated. Fused benzodiazepine skeletons were obtained in excellent yields, providing an improved approach to dual C-H unsymmetrical functionalization.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Alice Kennett, Sven Epple, Gabriella van der Valk, Irene Georgiou, Evelyne Gout, Romain R. Vives, Angela J. Russell
Summary: This study presents the design and synthesis of sulfated disaccharide inhibitors based on IdoA(2S)-GlcNS(6S), which showed potent inhibition of Sulf-2. The results suggest that IdoA(2S)-GlcNS(6S) is the shortest fragment size required for effective inhibition of Sulfs, and a trisulfated disaccharide is identified as the minimal fragment size of heparan sulfate for effective endosulfatase inhibition.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Mauro Garbini, Andrea Brunetti, Riccardo Pedrazzani, Magda Monari, Massimo Marcaccio, Giulio Bertuzzi, Marco Bandini
Summary: The self-adaptability of galvanostatic electrolysis was found to be helpful in a multistage chemo- and diastereoselective electrochemically promoted cyclodimerization of chalcones. Through a series of reductive events, densely functionalized cyclopentanes with five contiguous stereocenters were obtained (25 examples, yields up to 95%, dr values up to >20:1). Further experimental and electrochemical investigations indicated the crucial role of dynamic kinetic resolution of the aldol intermediate in the reaction mechanism.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Dhananjay S. Nipate, Neha Meena, Prakash N. Swami, Krishnan Rangan, Anil Kumar
Summary: In this study, the synthesis of functionalized benzo[a]phenazines and indazolo[2,3-a]quinolines was achieved through Rh(III)-catalyzed oxidative annulation of 2-arylquinoxalines and 2-aryl-2H-indazoles with allyl alcohols. The method showed a wide substrate scope, excellent functional group tolerance, good to high yields of annulated products, and the capability for scaled-up synthesis. A tentative mechanism of the annulation reaction was proposed based on a preliminary mechanistic investigation.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Ruonan Zhang, Abudukadi Tudi, Xia Yang, Xuping Wang, Zhihua Yang, Shujuan Han, Shilie Pan
Summary: A new lead tellurium borate material with a unique fundamental building block [B4O10] was synthesized and found to exhibit high birefringence. The structure-property relationship was discussed using first-principles calculations.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Amresh Kumar Singh, Baishali Thakurta, Anupam Giri, Monalisa Pal
Summary: This study introduces three key concepts for the quick synthesis of large-scale high-quality 2D materials films and their utilization in device fabrication.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Reina Hagiwara, Shun Nishimura, Kosuke Okeyoshi
Summary: A copolymer-conjugated nanocatalytic system has been developed to improve electron transfer and enhance photoinduced H2 generation.
CHEMICAL COMMUNICATIONS
(2024)