期刊
CHEMICAL COMMUNICATIONS
卷 49, 期 21, 页码 2136-2138出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3cc00181d
关键词
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资金
- British Heart Foundation [29476]
- NIH [HL-083187]
Sphingosine kinase isoform 1 (SK1) inhibitors may serve as therapeutic agents for proliferative diseases, including hypertension. We synthesized a series of sphingosine-based SK1-selective inhibitors, the most potent of which is RB-005 (IC50 = 3.6 mu M), which also induced proteasomal degradation of SK1 in human pulmonary arterial smooth muscle cells.
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