Article
Chemistry, Multidisciplinary
Zahra Khorsandi, Abdol R. Hajipour, Mohamad Reza Sarfjoo, Rajender S. Varma
Summary: The nano-catalytic system described consists of magnetic nanoparticles as the core and edible natural ligands with functional groups as supports for cobalt species. It shows good catalytic activity in C-N cross-coupling reactions and demonstrates excellent efficiency and versatility in an array of coupling reactions. The system is easily accessible and has good recyclability for potential future applications.
Article
Chemistry, Multidisciplinary
Madasamy Hari Balakrishnan, Madasamy Kanagaraj, Velayudham Sankar, Mahesh Kumar Ravva, Subramaniyan Mannathan
Summary: An efficient palladium-catalyzed denitrogenative Suzuki-Miyaura type cross-coupling reaction was developed for the synthesis of various aryl and alkenyl compounds, including heteroaromatic boronic acids. Additionally, successful application of a reduction reaction was demonstrated to convert ortho-alkenylated products to ortho-alkylated products in high yields.
NEW JOURNAL OF CHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Lara E. Zetzsche, Jessica A. Yazarians, Suman Chakrabarty, Meagan E. Hinze, Lauren A. M. Murray, April L. Lukowski, Leo A. Joyce, Alison R. H. Narayan
Summary: This study demonstrates the use of cytochrome P450 enzymes for biocatalytic cross-coupling reactions, enabling the formation of sterically hindered biaryl bonds through oxidative C-C bond formation. By engineering the substrate and atroposelectivity of the P450 enzyme, a highly efficient and selective process has been developed.
Article
Chemistry, Multidisciplinary
Vincent M. Kassel, Christopher M. Hanneman, Connor P. Delaney, Scott E. Denmark
Summary: Reaction conditions have been developed for refractory heteroaryl-heteroaryl Suzuki-Miyaura cross-couplings using neopentyl heteroarylboronic esters, heteroaryl bromides and chlorides, and potassium trimethylsilanolate (TMSOK) under anhydrous conditions. The addition of trimethyl borate enhances reaction rates by several mechanisms, enabling cross-coupling of diverse reaction partners in good yields and short reaction times.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Chemistry, Organic
F. Wieland Goetzke, Stephen P. Fletcher
Summary: This Account describes the authors' progress in developing catalytic asymmetric C(sp(3))-C(sp(3)) and C(sp(3))-C(sp(2)) cross-coupling reactions, highlighting efficient mechanisms for deracemization and the applications of copper-catalyzed alkylation and rhodium-catalyzed Suzuki-Miyaura-type arylation reactions in complex-molecule syntheses.
Article
Chemistry, Organic
Samantha L. Gargaro, Bre'Shon Dunson, Joshua D. Sieber
Summary: The Suzuki-Miyaura cross-coupling reaction of 2-bromo-1,3-bis(trifluoromethyl)benzene with arylboronic acids leads to the formation of significant amounts of boronic acid homocoupling products, especially with electron-deficient arylboronic acids. Good yields of cross-coupling products can be achieved by utilizing dicyclohexyl(2',6'-dimethoxybiphenyl-2-yl)phosphine (SPhos) as the ligand.
Article
Chemistry, Organic
Matthew B. Minus, Sarah R. Moor, Fathima F. Pary, L. P. T. Nirmani, Malgorzata Chwatko, Brandon Okeke, Josh E. Singleton, Toby L. Nelson, Nathaniel A. Lynd, Eric Anslyn
Summary: The bimetallic methodology described in the study takes advantage of the distinct reactivities of palladium and copper to perform high yielding aryl-aryl dimerizations and polymerizations under ambient conditions. The process is facile and can be performed by simple mixing in an open vessel. This method demonstrates its utility in polymer synthesis by successfully creating various polymers at ambient temperature and open to air.
Article
Materials Science, Paper & Wood
Pouya Ghamari Kargar, Milad Nayebi, Zahra Parhizi, Rajender S. Varma
Summary: An eco-friendly approach was used to generate Ni nanoparticles on a magnetized cellulose biopolymer, resulting in a core-shell type nanocomposite (Fe3O4@CNF@Ni). The nanocomposite was characterized using various advanced techniques and its catalytic performance was evaluated in the synthesis of biaryl derivatives. The results showed that the nanocomposite exhibited high stability and catalytic efficiency.
Article
Chemistry, Organic
Wei Wu, Beibei Luo, Yi You, Zhiqiang Weng
Summary: A novel synthesis approach for the construction of 2-trifluoroethyl-substituted benzofurans under copper-catalyzed conditions has been developed, with moderate to excellent yields (up to 93%). This method is also applicable to the formation of 2-trifluoroethylated indoles.
ORGANIC CHEMISTRY FRONTIERS
(2021)
Review
Chemistry, Physical
Kuai Wang, Wangqing Kong
Summary: Organofluorine compounds have received significant attention in various industries due to their unique chemical and physical properties. However, the synthesis of these compounds still faces challenges, including difficulties in handling fluorinating reagents and controlling chemoselectivity. In recent decades, the development of Nickel-catalyzed defluorinative cross-couplings has provided powerful strategies for the construction of fluorinated organic compounds. This review summarizes important advances in this field, focusing on aryl fluorides, gem-difluorovinyl, and trifluoromethyl compounds.
Article
Chemistry, Organic
Virginie Carreras, Thierry Ollevier
Summary: A highly efficient route for the synthesis of 1-aryl-2,2-difluoroalkenes via 1,2-desilylative defluorination has been disclosed, demonstrating the usefulness of organosilanes in the preparation of fluorinated alkenes as synthetically useful targets. The reaction proceeds cleanly and with excellent yield under mild reaction conditions in a green solvent, showcasing its potential for practical applications in organic synthesis. Furthermore, a one-pot system involving sequential insertion and desilylative-defluorination is also suitable for this transformation, providing a versatile and convenient method for the synthesis of fluorinated alkenes.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Review
Chemistry, Multidisciplinary
Inci Sogutlu, Evan Abdulkarim Mahmood, Saeid Ahmadizadeh Shendy, Saeideh Ebrahimiasl, Esmail Vessally
Summary: This article discusses the carbonylative Suzuki cross-coupling reaction of aryl halides and arylboronic acids in the presence of carbon monoxide, resulting in the synthesis of biaryl ketones. Nano-sized metal catalysts are proven to be among the most efficient catalysts for this reaction due to their large surface area to volume ratio and reactive morphologies, allowing for faster reaction rates at lower CO pressures and catalyst loadings.
Review
Chemistry, Multidisciplinary
Shelesh Krishna Saraswat, Ramanjaneyulu Seemaladinne, Media Noori Abdullah, Halim Zaini, Nabeel Ahmad, Nafis Ahmad, Esmail Vessally
Summary: Aryl fluorosulfates are versatile building blocks in organic synthesis and have gained increasing attention in SuFEx click chemistry. They can be easily prepared from phenols using low-cost sulfuryl fluoride as a sulfonyl fluoride provider. They have been used as less toxic and more atom economical alternatives to triflates in numerous cross-coupling reactions. This review summarizes the recent advances and developments in utilizing aryl fluorosulfates as electrophilic partners in cross-coupling reactions.
Article
Biochemistry & Molecular Biology
Asma Hrizi, Manon Cailler, Moufida Romdhani-Younes, Yvan Carcenac, Jerome Thibonnet
Summary: This study describes a method for the preparation of polysubstituted indole-2-carbonitriles through a cross-coupling reaction. The reactivity of indole derivatives with iodine at position 3 was studied using various cross-coupling reactions. Sonogashira, Suzuki-Miyaura, Stille, and Heck cross-couplings provided a variety of di-, tri- and tetra-substituted indole-2-carbonitriles.
Article
Chemistry, Multidisciplinary
Sinem Cakir, Serdar Batikan Kavukcu, Hande Karabiyik, Senthil Rethinam, Hayati Turkmen
Summary: The N-heterocyclic carbene (NHC) palladium complexes have been successfully applied for the modulation of C-C coupling reactions. A series of azolium salts with CN-substituted benzyl moieties and their palladium complexes were systematically prepared to catalyze acylative Suzuki-Miyaura coupling reactions. Mechanistic studies showed that the presence of CN group in the (NHC)Pd complexes significantly increased the catalytic activities for both reactions, and the coordination of the complexes by the CN group played a crucial role in the catalytic cycles.
Article
Chemistry, Physical
Faqiang Leng, Iann C. Gerber, Pierre Lecante, Simona Moldovan, Maria Girleanu, M. Rosa Axet, Philippe Serp
Article
Chemistry, Multidisciplinary
F. Leng, I. C. Gerber, P. Lecante, W. Bacsa, J. Miller, J. R. Gallagher, S. Moldovan, M. Girleanu, M. R. Axet, P. Serp
Article
Chemistry, Multidisciplinary
Faqiang Leng, Iann C. Gerber, Maria Rosa Axet, Philippe Serp
COMPTES RENDUS CHIMIE
(2018)
Article
Chemistry, Applied
Yaping Wang, Xinjian Li, Faqiang Leng, Helong Zhu, Jingya Li, Dapeng Zou, Yangjie Wu, Yusheng Wu
ADVANCED SYNTHESIS & CATALYSIS
(2014)
Article
Chemistry, Multidisciplinary
Xinjian Li, Dapeng Zou, Faqiang Leng, Chunxia Sun, Jingya Li, Yangjie Wu, Yusheng Wu
CHEMICAL COMMUNICATIONS
(2013)
Article
Chemistry, Organic
Huicheng Cheng, Yu Pei, Faqiang Leng, Jingya Li, Apeng Liang, Dapeng Zou, Yangjie Wu, Yusheng Wu
TETRAHEDRON LETTERS
(2013)
Article
Chemistry, Multidisciplinary
Faqiang Leng, Iann C. Gerber, Pierre Lecante, Ahmed Bentaleb, Antonio Munoz, Beatriz M. Illescas, Nazario Martin, Georgian Melinte, Ovidiu Ersen, Herve Martinez, M. Rosa Axet, Philippe Serp
CHEMISTRY-A EUROPEAN JOURNAL
(2017)
Review
Chemistry, Multidisciplinary
Dan He, Yawen Li, Fuwen Zhao, Yuze Lin
Summary: High trap density in organic solar cells leads to localized charge carriers and reduced carrier lifetime, limiting device efficiency. This feature article summarizes the recent advances of trap suppression by material design and device engineering.
CHEMICAL COMMUNICATIONS
(2024)
Review
Chemistry, Multidisciplinary
Olivier Monfort, Arshitha Madhusudhan, Martin Motola
Summary: This article presents the advantages of coupling photocatalysis and Fenton-based processes for environmental remediation and discusses their synergy. It critically examines the simultaneous triggering of these two processes and provides insights into research approaches. The study aims to enhance understanding of this complex process and highlight the potential integration of new catalysts in current wastewater treatment technology.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Manideepa Dhar, Chittaranjan Mishra, Avijit Das, Uttam Manna
Summary: An approach of 'polymerization of monomers in its aggregated form' has been introduced to tailor the water wettability of fibrous and porous substrates, achieving hydrophobicity to superhydrophobicity transition, as well as patterned wettability. This facile chemical method provides a durable coating with adjustable and patterned wettability for various potential applications.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Saswat Ranjan Bhoi, Chhanda Debnath, Shikha Gandhi
Summary: In this article, a novel catalytic reaction using Pd(0) and Bronsted acid is reported for the synthesis of biologically important imidazolidinone-fused N-heterocycles through redox-neutral intramolecular N-allylation of indoles and pyrroles with alkynes. This atom-economical method is applicable to a wide range of substrates and eliminates the need for leaving groups or oxidizing agents commonly used in traditional allylation reactions.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Longkun Chen, Mingshuai Zhang, Meichen Liu, Zhuoyuan Liu, Yuetong Qiu, Zhilai Zhang, Fuchao Yu, Jiuzhong Huang
Summary: In this study, an efficient Rh(III)-catalyzed selective mono- and dual-C-H bond functionalization/cyclization with iodonium ylide as the sole coupling partner was demonstrated. Fused benzodiazepine skeletons were obtained in excellent yields, providing an improved approach to dual C-H unsymmetrical functionalization.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Alice Kennett, Sven Epple, Gabriella van der Valk, Irene Georgiou, Evelyne Gout, Romain R. Vives, Angela J. Russell
Summary: This study presents the design and synthesis of sulfated disaccharide inhibitors based on IdoA(2S)-GlcNS(6S), which showed potent inhibition of Sulf-2. The results suggest that IdoA(2S)-GlcNS(6S) is the shortest fragment size required for effective inhibition of Sulfs, and a trisulfated disaccharide is identified as the minimal fragment size of heparan sulfate for effective endosulfatase inhibition.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Mauro Garbini, Andrea Brunetti, Riccardo Pedrazzani, Magda Monari, Massimo Marcaccio, Giulio Bertuzzi, Marco Bandini
Summary: The self-adaptability of galvanostatic electrolysis was found to be helpful in a multistage chemo- and diastereoselective electrochemically promoted cyclodimerization of chalcones. Through a series of reductive events, densely functionalized cyclopentanes with five contiguous stereocenters were obtained (25 examples, yields up to 95%, dr values up to >20:1). Further experimental and electrochemical investigations indicated the crucial role of dynamic kinetic resolution of the aldol intermediate in the reaction mechanism.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Dhananjay S. Nipate, Neha Meena, Prakash N. Swami, Krishnan Rangan, Anil Kumar
Summary: In this study, the synthesis of functionalized benzo[a]phenazines and indazolo[2,3-a]quinolines was achieved through Rh(III)-catalyzed oxidative annulation of 2-arylquinoxalines and 2-aryl-2H-indazoles with allyl alcohols. The method showed a wide substrate scope, excellent functional group tolerance, good to high yields of annulated products, and the capability for scaled-up synthesis. A tentative mechanism of the annulation reaction was proposed based on a preliminary mechanistic investigation.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Ruonan Zhang, Abudukadi Tudi, Xia Yang, Xuping Wang, Zhihua Yang, Shujuan Han, Shilie Pan
Summary: A new lead tellurium borate material with a unique fundamental building block [B4O10] was synthesized and found to exhibit high birefringence. The structure-property relationship was discussed using first-principles calculations.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Amresh Kumar Singh, Baishali Thakurta, Anupam Giri, Monalisa Pal
Summary: This study introduces three key concepts for the quick synthesis of large-scale high-quality 2D materials films and their utilization in device fabrication.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Reina Hagiwara, Shun Nishimura, Kosuke Okeyoshi
Summary: A copolymer-conjugated nanocatalytic system has been developed to improve electron transfer and enhance photoinduced H2 generation.
CHEMICAL COMMUNICATIONS
(2024)