Article
Chemistry, Multidisciplinary
Taesung Ha, Thi Tuyet Mai Pham, Mikyung Kim, Yeon-Hee Kim, Ji-Hyun Park, Ji Hae Seo, Kyung-Min Kim, Eunyoung Ha
Summary: The outbreak of COVID-19 in 2020 has created an urgent need for the development of more effective antiviral materials. This study developed copper nanoparticles (Cu NPs) as an antiviral agent and demonstrated their superior antiviral activities compared to copper microparticles. Cu NPs showed spherical shape and uniform distribution, while commercially available copper microparticles had irregular shape. Virus inactivation assay and cell viability tests showed that Cu NPs effectively reduced the infectivity of H1N1 virus and improved the survival rate of infected cells.
Review
Chemistry, Analytical
Monireh Bakhshpour-Yucel, Sinem Diken Gur, Elif Seymour, Mete Aslan, Nese Lortlar Unlu, M. Selim Unlu
Summary: Pathogenic microorganisms and viruses can spread easily from one host to another, causing diseases in humans. Detecting these pathogens in a timely and cost-effective manner is a challenge for researchers. Sensor technologies have made significant advances in viral diagnostics, showing great potential as fast and sensitive detection platforms.
Article
Spectroscopy
Zhiwen Wei, Yifeng Lan, Chao Zhang, Juan Jia, Weifen Niu, Yanli Wei, Shanlin Fu, Keming Yun
Summary: A label-free Exo I-assisted fluorescence aptamer sensing platform was established for the detection of silver ions with high sensitivity and selectivity using berberine as the fluorescent probe and Exonuclease I as the background fluorescence reducing tool. Under optimized conditions, the detection limit of Ag+ was 4.4 nM with a linear range from 0.0059 mu M to 235.48 mu M, showing good recovery rates in tap water and human serum applications.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Article
Biotechnology & Applied Microbiology
Vaclav Brazda, Otilia Porubiakova, Alessio Cantara, Natalia Bohalova, Jan Coufal, Martin Bartas, Miroslav Fojta, Jean-Louis Mergny
Summary: The study identified multiple potential G-quadruplex forming sequences in the G4-EA-H1N1 genomes, which could serve as potential therapeutic targets.
Article
Biochemical Research Methods
Hanyuan Zhang, Alanna M. Klose, Benjamin L. Miller
Summary: The study utilized glycan-based receptor analogue microarrays on the AIR platform to achieve label-free, multiplex detection and discrimination of human and avian influenza viruses. The method can be expanded to systematically evaluate influenza virus adaptation in humans, facilitating global influenza surveillance and serving as a new tool enabling quick reactions in the face of a pandemic outbreak for health organizations, governments, research institutes, and laboratories.
BIOCONJUGATE CHEMISTRY
(2021)
Article
Chemistry, Analytical
Ji Hong Kim, Chae Hwan Cho, Jae Hwan Shin, Jin Chul Yang, Tae Jung Park, Jinyoung Park, Jong Pil Park
Summary: An affinity peptide specific to the influenza H5N1 virus neuraminidase (NA) was successfully identified via phage display technique and developed into an electrochemical biosensing system. The BSA/MXene nanocomposite-based peptide sensor displayed significant dissociation constant and detection limit, with good reproducibility, stability, and recovery in the presence of spiked human plasma. This study provides an alternative bioanalytical sensing platform for more sensitive virus detection.
ANALYTICA CHIMICA ACTA
(2023)
Article
Chemistry, Physical
Harim Oh, Alexander Pyatenko, Myeongkyu Lee
Summary: The study demonstrates that combining thermal and laser dewetting processes can generate more uniform metal nanoparticles, with pre-annealing leading to narrower size distribution. The obtained silver nanoparticles exhibit a strong single plasmonic resonance peak due to their narrow size distribution, showing enhanced refractive index sensitivity and figure of merit as a plasmonic sensing platform compared to particles produced via laser dewetting.
APPLIED SURFACE SCIENCE
(2021)
Article
Nanoscience & Nanotechnology
Qiushun Zou, Kai He, Jian Ou-Yang, Yueli Zhang, Yang Shen, Chongjun Jin
Summary: A high-performance strain sensor consisting of sea-urchin-shaped silver nanoparticles and poly(dimethylsiloxane) demonstrated high sensitivity and stretchability for monitoring human activities. The sensor showed fast response, good reproducibility, and long-term stability, making it suitable for wearable devices.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Nanoscience & Nanotechnology
Baoji Miao, Muhammad Arsalan, Amal BaQais, Vignesh Murugadoss, Imran Saddique, Mohammed A. Amin, Junna Ren, Azka Awais, Qingsong Zhu, Ben Bin Xu, Fengchun Wei
Summary: The tetrametallic PtNiCuCo alloy nanoparticles were prepared and deposited on FTO substrates as a catalyst for highly sensitive H2O2 sensing. The PtNiCuCo nanoparticles had an average particle size of 5 +/- 1 nm. They showed excellent electro-oxidation activity for H2O2 with a wide linear range and low detection limit.
ADVANCED COMPOSITES AND HYBRID MATERIALS
(2023)
Article
Biochemical Research Methods
Hongyu Zhou, Shengjun Bu, Yao Xu, Lulu Xue, Zhongyi Li, Zhuo Hao, Jiayu Wan, Feng Tang
Summary: This study presents a colorimetric biosensor for detecting H1N1 influenza virus using the CRISPR/Cas13a system and hybridization chain reaction (HCR). The biosensor exhibited excellent specificity and sensitivity, with a linear relationship ranging from 10 pM to 100 nM and a detection limit of 0.152 pM. This new and sensitive detection method holds promise as a rapid diagnostic test for influenza virus.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2022)
Article
Nanoscience & Nanotechnology
Jianyong Li, Rui Lin, Yi Yang, Rongtao Zhao, Shiping Song, Yi Zhou, Jiye Shi, Lihua Wang, Hongbin Song, Rongzhang Hao
Summary: The development of a multichannel electrochemical immunoassay platform for on-site detection of SARS-CoV-2 and A(H1N1) offers great potential for timely diagnosis and prevention of the spread of infectious diseases in communities or resource-limited regions.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Virology
Pan Tang, En-hui Cui, Wen-chi Chang, Chen Yu, Hao Wang, En-qi Du, Jing-yu Wang
Summary: This study evaluated the protective efficacy of a novel nanoparticle swine influenza vaccine in mice. The vaccine induced high levels of antibodies and efficient cytokine levels in mice, reducing viral loads and pathological damage. The findings suggest that this vaccine candidate can induce robust immunity and provide broad protection against drifted subtypes.
Article
Biochemical Research Methods
Carole Farre, Sara Viezzi, Alice Wright, Perrine Robin, Nathalie Lejal, Marisa Manzano, Jasmina Vidic, Carole Chaix
Summary: This study developed a sensitive magnetic bead-based enzyme-linked immunoassay (MELISA) for the comprehensive detection of Influenza A virus. The assay combined immunomagnetic beads and biotin-nanoparticle-based detection to quantify the viral nucleoprotein. The use of biotin-nanoparticles enabled low detection limits and the new MELISA method showed high specificity without cross-reactivity with a porcine respiratory virus.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Ji Sun Park, Sun-Ki Kim, Chang-Hyung Choi, Jong Pil Park, Kyeongsoon Park
Summary: The overproduction of hydrogen peroxide (H2O2) is closely associated with the progression of various diseases, making it an important diagnostic marker for in vivo molecular imaging. A novel Co2+-doped L012/magnesium peroxide-based chemiluminescence (CL) nanosystem (L-012/Co@MgO2) has been developed for visual detection and quantitative analysis of H2O2, which has potential applications in biosensing and bioimaging of H2O2.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Medicine, Research & Experimental
Yuchong Wang, Xujun Zhang, Kefan Bi, Hongyan Diao
Summary: MicroRNAs play important roles in regulating virus replication and host antiviral response during H1N1 infection, with some defending against the virus and others promoting viral replication. They are involved in host-viral interactions and have versatile functions in this process.
Article
Environmental Sciences
Wei Huang, Guodong Cao, Chengliang Deng, Yanyan Chen, Tao Wang, Da Chen, Zongwei Cai
Summary: This study investigated the effects of TCS exposure on kidney function in mice. The results showed that TCS caused renal injury, oxidative stress, inflammation, and fibrosis in a dose-dependent manner. Metabolite analysis revealed lipid accumulation and defective fatty acid metabolism in TCS-exposed mouse kidney, which may contribute to renal function impairment.
JOURNAL OF ENVIRONMENTAL SCIENCES
(2023)
Article
Multidisciplinary Sciences
Chen Xiao, Kaien Li, Jingmin Hua, Zhao He, Feng Zhang, Qiongfang Li, Hailei Zhang, Lei Yang, Shuying Pan, Zongwei Cai, Zhiling Yu, Kam-Bo Wong, Yiji Xia
Summary: Arabidopsis DXO1 is an essential component in the methylation of the guanosine cap to form the m(7)G cap. It activates RNA guanosine-7 methyltransferase (AtRNMT1) to catalyze this conversion. This study reveals an important mechanism in m(7)G capping in plants and the role of DXO1 in this process.
NATURE COMMUNICATIONS
(2023)
Article
Nanoscience & Nanotechnology
Chao Zhong, Guorong Li, Wenchang Tian, Dan Ouyang, Yin Ji, Zongwei Cai, Zian Lin
Summary: Enzyme immobilization is crucial for its application in various fields. Covalent organic frameworks (COFs) are ideal for enzyme immobilization due to their controlled porous structures. However, constructing COFs-based enzyme immobilization systems with high activity using existing methods is still challenging.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Analytical
Peiru Luo, Mengke Bai, Qingyun He, Zifang Peng, Lingyun Wang, Chuan Dong, Zenghua Qi, Wenfen Zhang, Yanhao Zhang, Zongwei Cai
Summary: The widespread use of plastic products has led to a significant release of microplastics (MPs) into the environment. However, the study of MPs in atmospheric fine particulate matter (PM2.5) is limited due to the lack of appropriate analytical methods. This study developed a novel strategy using pyrolysis-gas chromatography-tandem mass spectrometry (Pyr-GC-MS/MS) to accurately quantify polyethylene MPs (PE-MPs) in PM2.5 without sample pretreatment. The results showed relatively serious pollution of PE-MPs in Taiyuan and suggested the widespread occurrence and potential human exposure risks of PM2.5-bound PE-MPs.
ANALYTICAL CHEMISTRY
(2023)
Article
Agriculture, Multidisciplinary
Tong Li, Ruiguo Wang, Ruijie Yin, Hongyan Xu, Xiaoxu Han, Qiuling Du, Jie Cheng, Zhenyu Lin, Peilong Wang
Summary: A novel Zr(IV)-based metal-organic framework (MOF), named BUT-16, was synthesized and utilized for the extraction and enrichment of bisphenol compounds (BPs) in milk samples. The method showed a detection limit as low as 0.05 ng/mL and was successfully applied to the detection of BPs in real milk samples, yielding results consistent with previous methods.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Biochemical Research Methods
Liang Wang, Ying Cheng, Cuiqin Wu, Fang Luo, Zhenyu Lin, Ravi Naidu
Summary: The study used SPME to sample soil gas and GC/MS to detect petroleum hydrocarbon volatile organic compounds (pH-VOCs) in underground pipeline leaks. By optimizing the extraction method and sample conditioning, the analytical efficiency and accuracy were improved, resulting in reliable research data with minimized environmental impacts.
JOURNAL OF CHROMATOGRAPHY A
(2023)
Article
Chemistry, Analytical
Liangzhen Xu, Shuang Hou, Xiaocui Huang, Mengyuan Wang, Cheng Li, Nuo Dong, Zhenyu Lin
Summary: A homogeneous electrochemiluminescence (ECL) biosensor based on catalyze hairpin assembly (CHA) and hybridization chain reaction (HCR) and magnetic assisted enrichment has been developed for miR-155 detection in dry eye diseases caused by Sjogren's syndrome. The biosensor offers a simple and sensitive detection method and has been successfully applied in clinical samples.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Xiaojian Shao, Hailei Zhang, Zhou Zhu, Fenfen Ji, Zhao He, Zhu Yang, Yiji Xia, Zongwei Cai
Summary: The recent discovery of noncanonical RNA caps, such as NAD(+) and dpCoA, has expanded our understanding of RNA caps. To identify and characterize dpCoA-RNAs, a method called dpCoA tagSeq was developed. This method efficiently tags and captures dpCoA-capped RNAs, allowing for further functional investigations.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Peiqing Luo, Xiaocui Huang, Fang Luo, Zhonghui Chen, Yu Chen, Cuiying Lin, Jian Wang, Bin Qiu, Zhenyu Lin
Summary: In this study, a sensitive ECL biosensor for hepatitis B virus DNA detection was developed by utilizing the high amplification efficiency of hybridization chain reaction (HCR), high specificity of the CRISPR/Cas12a system, and convenience of the homogeneous electrochemiluminescence (ECL) assay. The sensor exhibits high reproducibility, accuracy, and sensitivity, making it a promising tool for clinical testing.
ANALYTICAL CHEMISTRY
(2023)
Article
Engineering, Environmental
Jing Chen, Peisi Xie, Pengfei Wu, Zian Lin, Yu He, Zongwei Cai
Summary: This study used metabolomics and lipidomics combined with mass spectrometry imaging to reveal the mechanisms of enhanced growth of MCF-7 breast cancer cell spheroids exposed to triclosan (TCS). The results showed that TCS and TCS sulfate penetrated the entire area of the cell spheroids initially, but localized in the inner area later. Metabolomics data indicated that TCS exposure induced alterations in energy metabolism and the biosynthesis of glycerophospholipids and glycerolipids. Mass spectrometry imaging revealed enhanced energy supply in the peripheral area and increased energy storage in the inner area as potential contributors to the enhanced growth of MCF-7 breast cancer cell spheroids exposed to TCS.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Engineering, Environmental
Xuemei Wang, Chin Wai Leung, Zongwei Cai, Di Hu
Summary: Organophosphate flame retardants (OPFRs) were found in PM2.5 in Hong Kong, with chlorinated OPFRs being the dominant component. Plastic processing and waste disposal were identified as the main emission sources. Health risk assessment revealed a low-risk level for PM2.5-bound OPFRs, but relatively high noncarcinogenic and carcinogenic risks were associated with chlorinated OPFRs emitted from plastic processing and waste disposal.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Environmental Sciences
Xiaoou Wei, Jiang Yu, Yong Tian, Yujie Ben, Zongwei Cai, Chunmiao Zheng
Summary: Accurately predicting influent wastewater quality is crucial for the efficient operation and maintenance of wastewater treatment plants. This study evaluated three machine learning models and successfully applied them to three full-scale WWTPs in Shenzhen, China. The study provides a model framework for forecasting wastewater loads and sets the groundwork for smart management.
Article
Chemistry, Analytical
Jiajing Chen, Huan Huang, Dan Ouyang, Jiali Lin, Zhuling Chen, Zongwei Cai, Zian Lin
Summary: Analysis of cis-diol compounds is crucial due to their important roles in various fields. Researchers have developed a matrix-assisted laser desorption/ionisation mass spectrometry (MALDI-MS) method to effectively analyse cis-diol compounds. This method utilizes a unique reactive matrix (BMQI) for in situ derivatization of cis-diol compounds, resulting in improved speed, reproducibility, and signal intensity, as well as reduced background interference. Additionally, the method has been successfully applied to the rapid screening and identification of sugar alcohols in different sugar-free foods.
Article
Chemistry, Analytical
Peiqing Luo, Xiaocui Huang, Fang Luo, Zhonghui Chen, Yu Chen, Cuiying Lin, Jian Wang, Bin Qiu, Zhenyu Lin
Summary: In this study, a sensitive ECL biosensor for hepatitis B virus DNA was developed by combining HCR amplification, CRISPR/Cas12a system, and regulation of negative charge on reporting probes. The sensor exhibited low background, high reproducibility, and high sensitivity, and showed high accuracy in detecting clinical samples.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Weixin Li, Xinyang Wang, Lifen Chen, Fang Luo, Longhua Guo, Cuiying Lin, Jian Wang, Bin Qiu, Zhenyu Lin
Summary: This study proposes a homogeneous photoelectrochemical sensor based on three-dimensional ZnO/Au/two-dimensional MoS2 for ultrasensitive detection of tetracycline (TET). MoS2 is uniformly embedded on the 3D ZnO/Au surface using ordered self-assembly, replacing the conventional chemical modification method. Under optimal conditions, this method has successfully detected TET in milk, honey, pig kidney, and pork samples with reliable results. We believe that this study presents a method for the preparation of sensing carriers and target detection with great potential for application.
Review
Chemistry, Multidisciplinary
Dan He, Yawen Li, Fuwen Zhao, Yuze Lin
Summary: High trap density in organic solar cells leads to localized charge carriers and reduced carrier lifetime, limiting device efficiency. This feature article summarizes the recent advances of trap suppression by material design and device engineering.
CHEMICAL COMMUNICATIONS
(2024)
Review
Chemistry, Multidisciplinary
Olivier Monfort, Arshitha Madhusudhan, Martin Motola
Summary: This article presents the advantages of coupling photocatalysis and Fenton-based processes for environmental remediation and discusses their synergy. It critically examines the simultaneous triggering of these two processes and provides insights into research approaches. The study aims to enhance understanding of this complex process and highlight the potential integration of new catalysts in current wastewater treatment technology.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Manideepa Dhar, Chittaranjan Mishra, Avijit Das, Uttam Manna
Summary: An approach of 'polymerization of monomers in its aggregated form' has been introduced to tailor the water wettability of fibrous and porous substrates, achieving hydrophobicity to superhydrophobicity transition, as well as patterned wettability. This facile chemical method provides a durable coating with adjustable and patterned wettability for various potential applications.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Saswat Ranjan Bhoi, Chhanda Debnath, Shikha Gandhi
Summary: In this article, a novel catalytic reaction using Pd(0) and Bronsted acid is reported for the synthesis of biologically important imidazolidinone-fused N-heterocycles through redox-neutral intramolecular N-allylation of indoles and pyrroles with alkynes. This atom-economical method is applicable to a wide range of substrates and eliminates the need for leaving groups or oxidizing agents commonly used in traditional allylation reactions.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Longkun Chen, Mingshuai Zhang, Meichen Liu, Zhuoyuan Liu, Yuetong Qiu, Zhilai Zhang, Fuchao Yu, Jiuzhong Huang
Summary: In this study, an efficient Rh(III)-catalyzed selective mono- and dual-C-H bond functionalization/cyclization with iodonium ylide as the sole coupling partner was demonstrated. Fused benzodiazepine skeletons were obtained in excellent yields, providing an improved approach to dual C-H unsymmetrical functionalization.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Alice Kennett, Sven Epple, Gabriella van der Valk, Irene Georgiou, Evelyne Gout, Romain R. Vives, Angela J. Russell
Summary: This study presents the design and synthesis of sulfated disaccharide inhibitors based on IdoA(2S)-GlcNS(6S), which showed potent inhibition of Sulf-2. The results suggest that IdoA(2S)-GlcNS(6S) is the shortest fragment size required for effective inhibition of Sulfs, and a trisulfated disaccharide is identified as the minimal fragment size of heparan sulfate for effective endosulfatase inhibition.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Mauro Garbini, Andrea Brunetti, Riccardo Pedrazzani, Magda Monari, Massimo Marcaccio, Giulio Bertuzzi, Marco Bandini
Summary: The self-adaptability of galvanostatic electrolysis was found to be helpful in a multistage chemo- and diastereoselective electrochemically promoted cyclodimerization of chalcones. Through a series of reductive events, densely functionalized cyclopentanes with five contiguous stereocenters were obtained (25 examples, yields up to 95%, dr values up to >20:1). Further experimental and electrochemical investigations indicated the crucial role of dynamic kinetic resolution of the aldol intermediate in the reaction mechanism.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Dhananjay S. Nipate, Neha Meena, Prakash N. Swami, Krishnan Rangan, Anil Kumar
Summary: In this study, the synthesis of functionalized benzo[a]phenazines and indazolo[2,3-a]quinolines was achieved through Rh(III)-catalyzed oxidative annulation of 2-arylquinoxalines and 2-aryl-2H-indazoles with allyl alcohols. The method showed a wide substrate scope, excellent functional group tolerance, good to high yields of annulated products, and the capability for scaled-up synthesis. A tentative mechanism of the annulation reaction was proposed based on a preliminary mechanistic investigation.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Ruonan Zhang, Abudukadi Tudi, Xia Yang, Xuping Wang, Zhihua Yang, Shujuan Han, Shilie Pan
Summary: A new lead tellurium borate material with a unique fundamental building block [B4O10] was synthesized and found to exhibit high birefringence. The structure-property relationship was discussed using first-principles calculations.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Amresh Kumar Singh, Baishali Thakurta, Anupam Giri, Monalisa Pal
Summary: This study introduces three key concepts for the quick synthesis of large-scale high-quality 2D materials films and their utilization in device fabrication.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Reina Hagiwara, Shun Nishimura, Kosuke Okeyoshi
Summary: A copolymer-conjugated nanocatalytic system has been developed to improve electron transfer and enhance photoinduced H2 generation.
CHEMICAL COMMUNICATIONS
(2024)
