Synthesis of borasiloxane-based macrocycles by multicomponent condensation reactions in solution or in a ball mill

Large macrocycles containing imine and borasiloxane links are obtained in polycondensation reactions of 4-formylbenzeneboronic acid, t-Bu2Si(OH)(2), and diamines. The multicomponent reactions can be performed in solution or - advantageously - by mechanochemical syntheses in a ball mill.