Article
Chemistry, Organic
Ali Nikbakht, Ahmadreza Ebrahimi Valdani, Hossein Zahedian Tejeneki, Alireza Abbasi Kejani, Nahid S. Alavijeh, Felix Bauer, Fatemeh Darvish, Bernhard Breit, Saeed Balalaie
Summary: A diastereoselective cascade annulation between allenoates and in-situ generated isoquinoline N-oxides is reported, leading to the formation of sp3-rich bridged polycyclic heterocycles through an unprecedented non-rearomatized rearrangement. The reaction exhibits high diastereoselectivity and good functional group tolerance, achieving yields of 38-93%. Density functional theory calculations offer insights into the reaction pathway and stereoselectivity.
Article
Chemistry, Multidisciplinary
Jia Liu, Yi-Ming Zhu, Xiao-Ping Xu, Shun-Jun Ji
Summary: A series of 3-acyl-substituted isoindolinone derivatives were synthesized in a one-pot manner, using easily available starting materials and featuring simple operation and high efficiency.
CHINESE JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Organic
Hong Zhang, Jieyin He, Wendi Xu, Liangliang Yang, Xue Zhang, Haiyang Wang, Ming Lang, Jian Wang, Shiyong Peng
Summary: A copper-catalyzed cascade reaction between 1,6-enynes and sulfoxonium ylides, leading to the formation of structurally intriguing 2,3-disubstituted indolines, has been reported. The reaction exhibited moderate to excellent yields and good chemo-, regio-, and diastereoselectivities under mild reaction conditions. Notably, the reactivity of sulfoxoniumylide-derived copper-carbene was found to be different from that of diazo copper-carbene. The proposed mechanism involves the formation of an initial ammonium ylide rather than an allene.
Article
Chemistry, Physical
Sidi Cheng, Yu Luo, Ting Yu, Jing Li, Chunfang Gan, Shuang Luo, Qiang Zhu
Summary: An unactivated alkene was successfully subjected to 1,2-difunctionalization through a palladium-catalyzed four-component cascade reaction, leading to the convenient synthesis of acetamides with various substituents and pyrrolo-fused heterocycles.
Review
Chemistry, Multidisciplinary
Jian Luo, Guo-Shu Chen, Shu-Jie Chen, Zhao-Dong Li, Yun-Lin Liu
Summary: This review discusses the recent advancements in catalytic enantioselective isocyanide-based reactions, highlighting the advantages, limitations, possible mechanisms, and synthetic applications of each reaction type. Additionally, it provides a personal outlook on potential opportunities for further exploration in this rapidly growing field.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
Yao Xiao, Xin Peng, Jie Shen, Lei Cui, Shanya Lu, Xueshun Jia, Chunju Li, Jian Li
Summary: This research has developed a simple and efficient method to synthesize structurally unusual compounds, providing new ideas and strategies for the field of chemical synthesis.
CHEMICAL COMMUNICATIONS
(2022)
Article
Chemistry, Organic
Luyao Wang, Mengting Li, Zhitao Ning, Xi Zhang, Ying Fu, Zhengyin Du
Summary: An efficient visible-light-assisted, copper-catalyzed tandem radical cyclization of N-propargylindoles with cyclic ethers has been established. A series of 2-oxoalkyl-9H-pyrrolo[1,2-a]indol-9-ones with potential biological activities were synthesized in moderate yields using a dual catalytic system with copper acetate as a transition metal catalyst and eosin Y as a visible light catalyst.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Applied
Samrat Mallick, Mrinmay Baidya, Suman De Sarkar
Summary: This study presents a metal and mediator-free electrochemical method for fabricating substituted imidazole scaffolds. The method involves electro-oxidation triggered successive bond formations and rapid aromatization, allowing the tolerance of various functionalities.
ADVANCED SYNTHESIS & CATALYSIS
(2023)
Article
Chemistry, Physical
Takeshi Yasui, Keiji Yamada, Rine Tatsumi, Yoshihiko Yamamoto
Summary: In this study, a method for generating vinylallenes through cobalt/photoredox dual-catalysis was reported, allowing the formal 1,8-acyloxy migration of 1,6-diynyl esters. A cascade reaction involving 1,8-acyloxy migration/6 pi-electrocyclization was demonstrated using (hetero)aryl-substituted 1,6-diynyl esters, leading to the formation of arenol derivatives, and the method was also applied to cascade cyclizations involving [2 + 2] or [4 + 2] cycloadditions to furnish various polycyclic molecules.
Article
Chemistry, Organic
Xiaohu Zhao, Yuqiao Zhou, Bao-Lin Li, Guangxi Du, Zhipeng Yu
Summary: A highly efficient and catalyst-free method has been developed for the dearomatization of 3-(2-isocyanoethyl)indoles using in situ generated nitrile imines. This method involves a nucleophilic/Friedel-Crafts/aza-Mannich type cascade and 1,3-dipolar cycloaddition reaction, and allows for the rapid assembly of a wide range of polycyclic indoline scaffolds with moderate to excellent yields and diastereoselectivities.
ORGANIC CHEMISTRY FRONTIERS
(2022)
Article
Chemistry, Organic
Michio Yamada, Yuta Uokawa, Shino Sasaki, Naohiro Iha, Yoshihisa Hashimoto, Yuya Nagasaki, Yutaka Maeda, Mitsuaki Suzuki
Summary: In this study, a one-step strategy for synthesizing cyclobutene-annulated fullerene derivatives (cyclobutenofullerenes) was developed and their electronic properties were characterized. Despite steric strain, cyclobutenofullerenes can be easily prepared through a one-step reaction of C-60 with a secondary propargylic phosphate. Structural analysis of reaction intermediates suggests that the cascade reaction proceeds through a formal [2 + 2] cycloaddition of C-60 with an allene, caused by the 1,3-migration of the propargylic phosphate, followed by an additional 1,3-migration and subsequent 1,2-elimination of the phosphodiester moiety.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Organic
Michio Yamada, Yuta Uokawa, Shino Sasaki, Naohiro Iha, Yoshihisa Hashimoto, Yuya Nagasaki, Yutaka Maeda, Mitsuaki Suzuki
Summary: The physicochemical properties of fullerene-based materials can be influenced by the type and mode of addition of functional groups. Developing fullerene derivatives with novel structures is crucial for the advancement of materials science. This study presents an efficient one-step strategy for synthesizing cyclobutene-annulated fullerene derivatives and characterizing their electronic properties.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Applied
Valentina Ferraro, Roberto Sole, Lucia Alvarez-Miguel
Summary: Three neutral Cu(I) complexes with different triatomic pseudohalogen ligands (SCN-, OCN-, and N-3(-)) and 2,6-dimethylphenyl isocyanide (CNXyl) were successfully synthesized and characterized. The solid-state structures were determined through single-crystal X-ray diffraction, revealing unexpected bridging coordination modes in the case of OCN- and N-3(-). All the complexes showed interesting catalytic activity in azide-alkyne cycloaddition reactions, particularly the cyanato and azido Cu(I) complexes, which yielded 1,4-disubstituted-1,2,3-triazoles with high yields and 0.5 mol% of catalyst at 50 & DEG;C for 24 h. The azido Cu(I) complex also induced intramolecular CuAAC reactions in the presence of dimethyl acetylenedicarboxylate and benzyl bromide/phenylacetylene.
APPLIED ORGANOMETALLIC CHEMISTRY
(2023)
Article
Chemistry, Organic
Xiao-Feng Wang, Wen-Bin Cao, Hai-Yan Li, Xiao-Ping Xu, Shun-Jun Ji
Summary: A one-step cascade reaction using tryptamine-derived isocyanides and in situ generated nitrite oxides was described for the synthesis of fused spiroindolines, with moderate to good yields (42-87%). The protocol offers mild conditions, wide substrate scope, and high efficiency.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Organic
Wei-Hang Miao, Wen-Xia Gao, Xiao-Bo Huang, Miao-Chang Liu, Yun-Bing Zhou, Hua-Yue Wu
Summary: The method described involves a ring-opening dual halogenation of cyclopropenones with saturated oxygen heterocycles, catalyzed by CuX2 or I-2, providing an efficient synthesis route for 3-haloacrylates. This protocol is highly atom economical, exhibits excellent substrate scope, and can be scaled up for gram-scale reactions.
Article
Chemistry, Multidisciplinary
Frauke Schibilla, Anna Holthenrich, Boyi Song, Anna Livia Linard Matos, David Grill, Diego Rota Martir, Volker Gerke, Eli Zysman-Colman, Bart Jan Ravoo
Article
Chemistry, Organic
Shikuan Su, Ning Wang, Chunju Li, Boyi Song, Xueshun Jia, Jian Li
ASIAN JOURNAL OF ORGANIC CHEMISTRY
(2014)
Review
Nanoscience & Nanotechnology
Boyi Song, Ershuai Zhang, Xiangfei Han, Hui Zhu, Yuanjie Shi, Zhiqiang Cao
ACS APPLIED MATERIALS & INTERFACES
(2020)
Article
Nanoscience & Nanotechnology
Xiangfei Han, Yang Lu, Jinbing Xie, Ershuai Zhang, Hui Zhu, Hong Du, Ke Wang, Boyi Song, Chengbiao Yang, Yuanjie Shi, Zhiqiang Cao
NATURE NANOTECHNOLOGY
(2020)
Article
Chemistry, Multidisciplinary
Ershuai Zhang, Jianhai Yang, Ke Wang, Boyi Song, Hui Zhu, Xiangfei Han, Yuanjie Shi, Chengbiao Yang, Zhipeng Zeng, Zhiqiang Cao
Summary: Postoperative peritoneal adhesions are common complications that lead to medical problems and financial burden. Current anti-adhesion strategies focus on physical barriers, but a new biodegradable zwitterionic cream gel has shown promising results in preventing adhesions in animal models.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Multidisciplinary Sciences
Ershuai Zhang, Boyi Song, Yuanjie Shi, Hui Zhu, Xiangfei Han, Hong Du, Chengbiao Yang, Zhiqiang Cao
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Engineering, Biomedical
Yunjian Yu, Jie Li, Boyi Song, Zhuang Ma, Yufei Zhang, Haonan Sun, Xiaosong Wei, Yayun Bai, Xueguang Lu, Peng Zhang, Xinge Zhang
Summary: An all synthetic nanoparticle with PD-L1 blockade capability is developed for cancer photothermal-immunotherapy, offering a simple but promising approach for the treatment of metastatic cancer.
Review
Materials Science, Biomaterials
Xiangfei Han, Ershuai Zhang, Yuanjie Shi, Boyi Song, Hong Du, Zhiqiang Cao
JOURNAL OF MATERIALS CHEMISTRY B
(2019)
Review
Chemistry, Multidisciplinary
Dan He, Yawen Li, Fuwen Zhao, Yuze Lin
Summary: High trap density in organic solar cells leads to localized charge carriers and reduced carrier lifetime, limiting device efficiency. This feature article summarizes the recent advances of trap suppression by material design and device engineering.
CHEMICAL COMMUNICATIONS
(2024)
Review
Chemistry, Multidisciplinary
Olivier Monfort, Arshitha Madhusudhan, Martin Motola
Summary: This article presents the advantages of coupling photocatalysis and Fenton-based processes for environmental remediation and discusses their synergy. It critically examines the simultaneous triggering of these two processes and provides insights into research approaches. The study aims to enhance understanding of this complex process and highlight the potential integration of new catalysts in current wastewater treatment technology.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Manideepa Dhar, Chittaranjan Mishra, Avijit Das, Uttam Manna
Summary: An approach of 'polymerization of monomers in its aggregated form' has been introduced to tailor the water wettability of fibrous and porous substrates, achieving hydrophobicity to superhydrophobicity transition, as well as patterned wettability. This facile chemical method provides a durable coating with adjustable and patterned wettability for various potential applications.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Saswat Ranjan Bhoi, Chhanda Debnath, Shikha Gandhi
Summary: In this article, a novel catalytic reaction using Pd(0) and Bronsted acid is reported for the synthesis of biologically important imidazolidinone-fused N-heterocycles through redox-neutral intramolecular N-allylation of indoles and pyrroles with alkynes. This atom-economical method is applicable to a wide range of substrates and eliminates the need for leaving groups or oxidizing agents commonly used in traditional allylation reactions.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Longkun Chen, Mingshuai Zhang, Meichen Liu, Zhuoyuan Liu, Yuetong Qiu, Zhilai Zhang, Fuchao Yu, Jiuzhong Huang
Summary: In this study, an efficient Rh(III)-catalyzed selective mono- and dual-C-H bond functionalization/cyclization with iodonium ylide as the sole coupling partner was demonstrated. Fused benzodiazepine skeletons were obtained in excellent yields, providing an improved approach to dual C-H unsymmetrical functionalization.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Alice Kennett, Sven Epple, Gabriella van der Valk, Irene Georgiou, Evelyne Gout, Romain R. Vives, Angela J. Russell
Summary: This study presents the design and synthesis of sulfated disaccharide inhibitors based on IdoA(2S)-GlcNS(6S), which showed potent inhibition of Sulf-2. The results suggest that IdoA(2S)-GlcNS(6S) is the shortest fragment size required for effective inhibition of Sulfs, and a trisulfated disaccharide is identified as the minimal fragment size of heparan sulfate for effective endosulfatase inhibition.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Mauro Garbini, Andrea Brunetti, Riccardo Pedrazzani, Magda Monari, Massimo Marcaccio, Giulio Bertuzzi, Marco Bandini
Summary: The self-adaptability of galvanostatic electrolysis was found to be helpful in a multistage chemo- and diastereoselective electrochemically promoted cyclodimerization of chalcones. Through a series of reductive events, densely functionalized cyclopentanes with five contiguous stereocenters were obtained (25 examples, yields up to 95%, dr values up to >20:1). Further experimental and electrochemical investigations indicated the crucial role of dynamic kinetic resolution of the aldol intermediate in the reaction mechanism.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Dhananjay S. Nipate, Neha Meena, Prakash N. Swami, Krishnan Rangan, Anil Kumar
Summary: In this study, the synthesis of functionalized benzo[a]phenazines and indazolo[2,3-a]quinolines was achieved through Rh(III)-catalyzed oxidative annulation of 2-arylquinoxalines and 2-aryl-2H-indazoles with allyl alcohols. The method showed a wide substrate scope, excellent functional group tolerance, good to high yields of annulated products, and the capability for scaled-up synthesis. A tentative mechanism of the annulation reaction was proposed based on a preliminary mechanistic investigation.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Ruonan Zhang, Abudukadi Tudi, Xia Yang, Xuping Wang, Zhihua Yang, Shujuan Han, Shilie Pan
Summary: A new lead tellurium borate material with a unique fundamental building block [B4O10] was synthesized and found to exhibit high birefringence. The structure-property relationship was discussed using first-principles calculations.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Amresh Kumar Singh, Baishali Thakurta, Anupam Giri, Monalisa Pal
Summary: This study introduces three key concepts for the quick synthesis of large-scale high-quality 2D materials films and their utilization in device fabrication.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Reina Hagiwara, Shun Nishimura, Kosuke Okeyoshi
Summary: A copolymer-conjugated nanocatalytic system has been developed to improve electron transfer and enhance photoinduced H2 generation.
CHEMICAL COMMUNICATIONS
(2024)