期刊
CHEMICAL COMMUNICATIONS
卷 49, 期 34, 页码 3582-3584出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3cc00241a
关键词
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资金
- NIH [HHSN261200800001E, R01NS076619]
- NSF [CBET-0952624, CBET-1158447]
- NSF of China [11074047, 11274075, 91227102]
- Directorate For Engineering
- Div Of Chem, Bioeng, Env, & Transp Sys [0952624, 1158447] Funding Source: National Science Foundation
We computationally and experimentally showed that tau protein fibrils can be formed at high temperature. When cooled, the fibrils dissociate back to monomers. Heparin promotes tau fibril formation and prevents its reversion. Our results revealed the physicochemical mechanism of reversible formation of tau fibrils.
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