期刊
CHEMICAL COMMUNICATIONS
卷 49, 期 76, 页码 8441-8443出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3cc43457e
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资金
- Parkinson's UK
19-Substituted geldanamycin derivatives are efficient Hsp90 inhibitors, without the toxicity associated with the other benzoquinone ansamycins, thus giving them potential for use as molecular therapeutics in cancer and neurodegeneration. Here a new method of synthesising these important compounds is reported, eliminating the need for toxic metals and metalloids.
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