4.7 Article

Catalytic enantioselective synthesis of β-trifluoromethyl pyrrolines

期刊

CHEMICAL COMMUNICATIONS
卷 48, 期 34, 页码 4067-4069

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ROYAL SOC CHEMISTRY
DOI: 10.1039/c2cc18049a

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资金

  1. MEXT (Ministry of Education, Culture, Sports, Science and Technology) [21390030, 22106515, 2105]
  2. Asahi Glass Foundation
  3. MEXT [23915014]
  4. Grants-in-Aid for Scientific Research [23915014, 10J08891, 22106515] Funding Source: KAKEN

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Enantioselective synthesis of beta-trifluoromethylated pyrrolines has been developed by the organocatalyzed-conjugated addition of nitromethane to beta-trifluoromethylated enones, followed by a nitro-reduction/cyclization/dehydration sequence in a one-pot procedure with 97-98% ees.

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