期刊
CHEMICAL COMMUNICATIONS
卷 48, 期 43, 页码 5313-5315出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2cc31466e
关键词
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资金
- Priority Research Centers Program [2011-0030744]
- Institute of Biological Engineering of Seoul National University
- Global PhD Fellowship Program [2011-0007317]
- WCU through National Research Foundation of Korea (NRF) [R31-2008-000-10075-0]
- Ministry for Food, Agriculture, Forestry and Fisheries, Republic of Korea [110031-3]
- National Science Foundation [0644864]
We rationally designed highly sensitive and selective polydiacetylene (PDA)-phospholipids liposomes for the facile detection of aminoglycosidic antibiotics. The detecting mechanism mimics the cellular membrane interactions between neomycin and phosphatidylinositol-4,5-bisphosphate (PIP2) phospholipids. The developed PDA-PIP2 sensory system showed a detection limit of 61 ppb for neomycin and was very specific to aminoglycosidic antibodies only.
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