Article
Chemistry, Multidisciplinary
Saurav Das, Tanushree Das, Priyam Das, Debapratim Das
Summary: Nature has developed a self-regulatory feedback mechanism that maintains an optimal internal cellular environment. Researchers have designed a pH responsive supramolecular peptide amphiphile to mimic the inhibitory behavior of certain enzymes. The resulting nanozymes showed tunable lifetimes and efficient reproducibility across multiple pH cycles.
Article
Chemistry, Physical
Nanhang Zhu, Yujia Zhang, Jia Cheng, Yanchao Mao, Ke Kang, Guohao Li, Qiangying Yi, Yao Wu
Summary: Researchers have proposed an 1-ADA responsive immuno-affinitive supramolecular magnetic nanoparticle (ISM-NPs) system for efficient capture and release of sEVs. This system shows high capture efficiency and good release performance, providing potential applications in biomarker enrichment.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Wei Zhang, Yang Luo, Jie Zhao, Chao Zhang, Xin-Long Ni, Zhu Tao, Xin Xiao
Summary: In this study, a linear supramolecular polymer with controllable features was constructed based on twisted cucurbit[14]uril and cucurbit[8]uril using an effective self-sorting strategy. By inserting and π-π stacking, the polymerization and depolymerization of the supramolecular polymer were achieved. This strategy provides a new approach for the design of supramolecular polymer materials and the application of twisted cucurbit[14]uril in supramolecular chemistry.
CHINESE CHEMICAL LETTERS
(2022)
Article
Chemistry, Multidisciplinary
De-Ao Xu, Qing-Yang Zhou, Xianyin Dai, Xin-Kun Ma, Ying-Ming Zhang, Xiufang Xu, Yu Liu
Summary: A phosphorescent supramolecular foldamer has been successfully constructed through the 1:1 host-guest complexation with cucurbit[8]uril and 1,2-diaminocyclohexane-bridged 4-(4-bromophenyl)-pyridinium salt. The foldamer exhibits green phosphorescence in aqueous solution and shows rapid and sensitive responsiveness to different antibiotics.
CHINESE CHEMICAL LETTERS
(2022)
Article
Chemistry, Applied
Hong-Guang Fu, Jinmao You
Summary: Multicolor emission materials responsive to visible light stimuli have great potential in biomedical engineering and materials science. In this study, a dual-visible-light responsive quaternary supramolecular assembly with tunable multicolor fluorescence outputs was constructed. The assembly exhibited three different photoluminescent colors, yellow, white, and blue, by varying the irradiation time, and showed promising applications in photocontrolled cell imaging and photoerasable fluorescent ink.
Article
Chemistry, Multidisciplinary
Miriam Colaco, Patricia Maximo, A. Jorge Parola, Nuno Basilio
Summary: The study focuses on the kinetics of a water-soluble host-guest system based on cucurbit[8]uril and two DTE photoswitches, demonstrating a method to control the binding kinetics in supramolecular systems using external stimuli. By modifying the structure of the DTE guest molecule, it is possible to significantly slow down the formation/dissociation rates of pseudorotaxane structures, leading to the emergence of a competitive metastable product with important impact on the overall binding kinetics. Additionally, the dissociation kinetics of the host-guest system can be controlled by approximately 100-fold by switching between closed and open DTE isomers.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Chemistry, Applied
Chen Xu, Xiaohan Lin, Xiang Ma
Summary: Highly emissive fluorescent dyes are important in fluorescence imaging technology and fluorescence spectrometry, but the insoluble nature of most organic dyes in water has limited their application. This study presents a one-step supramolecular strategy to enhance the aqueous quantum yields of fluorescent dyes by binding them with cucurbit[8]uril. The resulting assembly showed a significant increase in quantum yields from 3.9% to 46.9% and formed spherical supramolecular nanoparticles. The mechanism of fluorescence enhancement and self-assembly of the dye were also investigated.
Article
Biochemistry & Molecular Biology
Nikoleta Kircheva, Stefan Dobrev, Lyubima Dasheva, Valya Nikolova, Silvia Angelova, Todor Dudev
Summary: With the emergence of host-guest systems, complexation chemistry has found wide application in various industries. Cucurbiturils (CB) have gained popularity due to their better qualities as cavitands compared to cyclodextrins and calixarenes. Metal cations can enhance the complexation abilities of CB, either by competitively binding to the host entity or cooperatively associating with the CB@guest structures. This study investigates the role of two metal species (Mg2+ and Ga3+) in complex formation with three dye molecules and identifies various key factors influencing the process.
Article
Biochemical Research Methods
Paula Novo, Marcos D. Garcia, Carlos Peinador, Elena Pazos
Summary: Many cellular processes in living organisms are regulated by complex regulatory networks involving relatively few proteins that switch between different assemblies to perform their functions. This study demonstrates that the conjugation of a specific scaffold to a transcription factor can control its dimerization through a supramolecular complex, allowing for reversible binding to DNA target in response to external stimuli.
BIOCONJUGATE CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Yawen Li, Qingfang Li, Xiaran Miao, Chunyan Qin, Dake Chu, Liping Cao
Summary: Achiral supramolecular organic framework (SOF-1) can exhibit adaptive chirality induced by specific compounds in water, leading to mirror-image circular dichroism and circularly polarized luminescence. This adaptive chirality can be utilized for determining the enantiopurity of amino acids and distinguishing biological chiral macromolecules.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Biochemistry & Molecular Biology
Zhong-Zheng Gao, Lei Shen, Yu-Lu Hu, Ji-Fu Sun, Gang Wei, Hui Zhao
Summary: This study thoroughly investigated the use of naphthyl groups as building blocks for the self-assembly of supramolecular crystal networks in both aqueous solution and solid state. Experimental data showed that double guest molecules could reside within the cavity of Q[8], forming highly stable homoternary complexes NapA(2)@Q[8] and Nap1(2)@Q[8]. Strong hydrogen-bonding and π···π interactions played critical roles in the formation of 1D supramolecular chain, as well as 2D and 3D networks in solid state.
Article
Chemistry, Multidisciplinary
Zeng-Hui Zhang, Rui-Lian Lin, Xiang-Yun Yu, Li-Xia Chen, Zhu Tao, Xin Xiao, Gang Wei, Carl Redshaw, Jing-Xin Liu
Summary: The study showed that Q[8] can encapsulate l-valine, d-leucine, and d-methionine in aqueous solution. X-ray crystallography revealed the structural details of the inclusion complexes formed between Q[8] and the amino acids, with the deformation degree of the Q[8] host being related to the molecular size of the encapsulated guests.
Article
Chemistry, Applied
Jie Ren, Xiaodong Zhang, Carl Redshaw, Xin-Long Ni
Summary: Concentration-dependent dynamic equilibria play a crucial role in various fields such as biology, supramolecular assemblies, and materials science. In this study, fluorescence emissions triggered by host-guest interactions were used to monitor the formation of concentration-dependent superstructures including supramolecular polymer and dimers. The unique photophysical properties of the dye guest in the rigid confined cavity of cucurbit[8]uril led to unprecedented concentration-dependent dynamic assemblies, which could be distinguished by multiple fluorescence emissions and by the naked-eye under UV-light.
Article
Materials Science, Multidisciplinary
Xiaolu Zhou, Xue Bai, Xuejian Zhang, Jing Wu, Yu Liu
Summary: A macrocyclic confinement-activated green phosphorescence and two-photon near-infrared (NIR) fluorescence supramolecular cascade assembly has been constructed by multivalent interaction. Through the use of CB[8]-induced macrocyclic confinement and molecular folding, the fluorescence of BTPA is effectively redshifted, and NIR fluorescence is enhanced through cascade confinement. Introduction of the PY/CB[8] complex leads to the fabrication of multicomponent nanoparticles, showing efficient NIR fluorescence and green phosphorescence emission for two-photon cancer cell-targeted imaging.
ADVANCED OPTICAL MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Wei Zhang, Yang Luo, Pan-hua Zhu, Xin-long Ni, Carl Redshaw, Zhu Tao, Xin Xiao
Summary: A new type of reticulated polymer material with sensitive specificity in recognizing and efficient removal of ferricyanide was prepared by supramolecular self-assembly, and an important component of the polymer material could be reused.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Engineering, Biomedical
Qianyu Lin, Zengping Liu, Daniel S. L. Wong, Chen Chuan Lim, Connie K. Liu, Liangfeng Guo, Xinxin Zhao, Yi Jian Boo, Joey H. M. Wong, Rebekah P. T. Tan, Kun Xue, Jason Y. C. Lim, Xinyi Su, Xian Jun Loh
Summary: Thermogels formed from hyper-branched amphiphilic copolymers show excellent biocompatibility and retention of retinal function in experimental settings, while also being naturally cleared from the vitreous. This novel transparent and biodegradable material has the potential to replace suboptimal existing standards for vitreous endotamponades.
Review
Chemistry, Analytical
Weng-I Katherine Chio, Huimin Xie, Yuewen Zhang, Yang Lan, Tung-Chun Lee
Summary: The article introduces the fabrication of surface-enhanced Raman spectroscopy (SERS) sensors through the hierarchical self-assembly of nanoparticles mediated by cucurbiturils (CBs), and discusses their potential applications in biosensing and environmental monitoring.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Xiangyu Liang, Guangda Chen, Iek Man Lei, Pei Zhang, Zeyu Wang, Xingmei Chen, Mengze Lu, Jiajun Zhang, Zongbao Wang, Taolin Sun, Yang Lan, Ji Liu
Summary: By harnessing multi-length-scale structural hierarchy and using bidirectional freeze-casting and compression-annealing, a hierarchically structured hydrogel material has been developed. The engineered 2D lamellar structures, well-defined nanocrystalline domains, and robust interfacial interaction contribute to the hydrogel's high impact resistance, high water content, and superior softness, resulting in record-high ballistic energy absorption capability.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Xiangyu Liang, Guangda Chen, Iek Man Lei, Pei Zhang, Zeyu Wang, Xingmei Chen, Mengze Lu, Jiajun Zhang, Zongbao Wang, Taolin Sun, Yang Lan, Ji Liu
ADVANCED MATERIALS
(2023)
Review
Cardiac & Cardiovascular Systems
Ruzhao Chen, Jiachen Xu, Yuge Wang, Benyue Jiang, Xiao Xu, Yang Lan, Jiang Wang, Xiufang Lin
Summary: This study found that sarcopenia has a high prevalence in patients with heart failure and is closely related to adverse clinical outcomes. The highest prevalence of sarcopenia in heart failure patients was observed in Asia, and patients with heart failure with reduced ejection fraction had a higher risk of poor outcomes from sarcopenia. Therefore, early identification and intervention for sarcopenia in heart failure patients are beneficial for improving prognosis.
CLINICAL CARDIOLOGY
(2023)
Article
Automation & Control Systems
Xingjuan Cai, Yang Lan, Zhixia Zhang, Jie Wen, Zhihua Cui, Wensheng Zhang
Summary: In this article, a skin cancer detection model based on federated learning integrated with deep generation model is proposed to address the problem of data insufficiency and data source privacy in healthcare IoT. The model utilizes dual generative adversarial networks and knee point-driven evolutionary algorithm to improve the quality of generated images and protect patient information privacy. Experimental results show high accuracy and area under the curve for the proposed model.
IEEE TRANSACTIONS ON INDUSTRIAL INFORMATICS
(2023)
Article
Computer Science, Artificial Intelligence
Jie Wen, Zhixia Zhang, Yang Lan, Zhihua Cui, Jianghui Cai, Wensheng Zhang
Summary: This paper systematically introduces the current research in federated learning (FL), including the basics knowledge, privacy and security protection mechanisms, communication overhead challenges, and heterogeneity problems. It also summarizes the research in practical applications and suggests future research directions for FL.
INTERNATIONAL JOURNAL OF MACHINE LEARNING AND CYBERNETICS
(2023)
Article
Chemistry, Inorganic & Nuclear
Yang Lan, Yuma Morimoto, Ikuma Shimizu, Hideki Sugimoto, Shinobu Itoh
Summary: Structures, physicochemical properties, and reactivity of a whole series of mononuclear copper(II)-halide complexes supported by a TMG(3)tach tridentate ligand have been investigated. The results demonstrate the importance of the ligand structure in determining the spectroscopic and electronic features as well as the reactivity towards C-H bond activation reaction. The bulky and strongly electron-donating TMG substituents enforce a tetrahedral geometry for the copper(II) complexes, resulting in specific optical and chemical properties.
INORGANIC CHEMISTRY
(2023)
Article
Urology & Nephrology
Jiayang He, Mengchang Yang, Xiangming Quan, Jingyu Wen, Yang Lan, Hongji Yang, Gaoping Zhao, Yifu Hou, Jun Lu, Linfeng Xu, Liang Wei
Summary: This study identifies the characteristics of gut microbiome and fecal metabolites in renal transplant recipients (RTRs) with post-transplantation diabetes mellitus (PTDM). The species Dialister invisus is significantly associated with fasting plasma glucose (FPG). RTRs with PTDM show enhanced functions of tryptophan and phenylalanine biosynthesis, while fructose and butyric acid metabolism functions are reduced.
INTERNATIONAL JOURNAL OF UROLOGY
(2023)
Article
Oncology
You-Li Wu, Feng Wu, Mian-Fu Cao, Yang Lan, Ming-Shan Du, Song-Tao Yu, Yan Wang, Xiao-Chu Yan, Xiu-Wu Bian, Guang-Jie Duan
Summary: This article describes a rare type of pulmonary tumor called primary pulmonary hyalinizing clear cell carcinoma (HCCC), of which there have been only 21 reported cases in the English literature. The diagnosis of HCCC is challenging in pathology, especially in small biopsy samples. In this case, the tumor was diagnosed through computed tomography-guided percutaneous lung biopsy. Although the tumor initially appeared to be mucoepidermoid carcinoma based on morphology and immunophenotype, further molecular genetic testing revealed a rare EWSR1::CREM fusion and a previously unreported IRF2::NTRK3 fusion.
FRONTIERS IN ONCOLOGY
(2023)
Article
Chemistry, Physical
Pengfei Yang, Linlin Xu, Panagiotis Trogadas, Marc-Olivier Coppens, Yang Lan
Summary: By incorporating cucurbit[n]urils (CB[n]) into sulfonated poly(ether ether ketone) (SPEEK) matrix, inspired by the proton conduction mechanism of bacteriorhodopsin, hybrid proton exchange membranes (PEMs) with enhanced proton conductivity are fabricated. The CB[n] carbonyl groups serve as proton-conducting sites, while the host-guest interaction between CB[n] and water molecules offers additional proton conducting pathways. The hybrid membranes exhibit significantly improved proton conductivity and superior fuel cell performance.
Article
Urology & Nephrology
Yang Lan, Duo Wang, Jiayang He, Hongji Yang, Yifu Hou, Wenjia Di, Hailian Wang, Xiangwei Luo, Liang Wei
Summary: This study integrated the analysis of gut microbiome and metabolites to identify the characteristics of Chronic Kidney Disease after transplantation (CKD-T). The results showed significant differences in gut microbiome diversity between CKD G1-2T group and CKD G3T group, with 8 flora including Akkermansia enriched in CKD G3T group. Compared to CKD G1-2T group, CKD G3T group had differential expression of amino acid metabolism, glycerophospholipid metabolism, amino acid biosynthesis, carbohydrate metabolism, and purine metabolism. Fecal metabolome analysis indicated a unique metabolite distribution characteristic in CKD G3T group.
Review
Medicine, Research & Experimental
Xiaohai Song, Yang Lan, Xiuli Zheng, Qianyu Zhu, Xuliang Liao, Kai Liu, Weihan Zhang, Qiangbo Peng, Yunfeng Zhu, Linyong Zhao, Xiaolong Chen, Yang Shu, Kun Yang, Jiankun Hu
Summary: Drug resistance poses a significant challenge for cancer patients undergoing chemotherapy and targeted therapy. Some cancer cells can enter a drug-tolerant state without genetic changes, enabling them to evade intense drug treatment. These drug-tolerant cells reside in the tumor region, display slow proliferation, and reversible characteristics, potentially serving as a reservoir for resistant phenotypes. Understanding the regulation of these cells and developing targeted therapies opens up new possibilities for overcoming drug resistance.
Proceedings Paper
Engineering, Electrical & Electronic
Lixian Wang, Yang Lan, Manish Sharma, Xiaolei Peng, Zhiping Jiang
Summary: This research explores the physical counterpart to the traditional spectral hole burning effect in erbium-doped fiber amplifiers, known as inhomogeneous saturable absorption, through theoretical and experimental investigations. A cost-effective compensation method is proposed based on this effect.
2023 OPTICAL FIBER COMMUNICATIONS CONFERENCE AND EXHIBITION, OFC
(2023)
Article
Acoustics
Yeqing Ren, Haipeng Peng, Lixiang Li, Xiaopeng Xue, Yang Lan, Yixian Yang
Summary: This paper proposes a generalized voice spoofing detection method based on integral knowledge amalgamation to detect both synthetic attacks and replay attacks. Two amalgamation mechanisms, feature amalgamation and structure amalgamation, are utilized to incorporate high-level semantic knowledge and ensure global structure consistency. Experimental results demonstrate that the proposed method outperforms advanced generalized voice spoofing detection methods and achieves state-of-the-art detection capability in the logical access (LA) scenario.
IEEE-ACM TRANSACTIONS ON AUDIO SPEECH AND LANGUAGE PROCESSING
(2023)
Review
Chemistry, Multidisciplinary
Dan He, Yawen Li, Fuwen Zhao, Yuze Lin
Summary: High trap density in organic solar cells leads to localized charge carriers and reduced carrier lifetime, limiting device efficiency. This feature article summarizes the recent advances of trap suppression by material design and device engineering.
CHEMICAL COMMUNICATIONS
(2024)
Review
Chemistry, Multidisciplinary
Olivier Monfort, Arshitha Madhusudhan, Martin Motola
Summary: This article presents the advantages of coupling photocatalysis and Fenton-based processes for environmental remediation and discusses their synergy. It critically examines the simultaneous triggering of these two processes and provides insights into research approaches. The study aims to enhance understanding of this complex process and highlight the potential integration of new catalysts in current wastewater treatment technology.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Manideepa Dhar, Chittaranjan Mishra, Avijit Das, Uttam Manna
Summary: An approach of 'polymerization of monomers in its aggregated form' has been introduced to tailor the water wettability of fibrous and porous substrates, achieving hydrophobicity to superhydrophobicity transition, as well as patterned wettability. This facile chemical method provides a durable coating with adjustable and patterned wettability for various potential applications.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Saswat Ranjan Bhoi, Chhanda Debnath, Shikha Gandhi
Summary: In this article, a novel catalytic reaction using Pd(0) and Bronsted acid is reported for the synthesis of biologically important imidazolidinone-fused N-heterocycles through redox-neutral intramolecular N-allylation of indoles and pyrroles with alkynes. This atom-economical method is applicable to a wide range of substrates and eliminates the need for leaving groups or oxidizing agents commonly used in traditional allylation reactions.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Longkun Chen, Mingshuai Zhang, Meichen Liu, Zhuoyuan Liu, Yuetong Qiu, Zhilai Zhang, Fuchao Yu, Jiuzhong Huang
Summary: In this study, an efficient Rh(III)-catalyzed selective mono- and dual-C-H bond functionalization/cyclization with iodonium ylide as the sole coupling partner was demonstrated. Fused benzodiazepine skeletons were obtained in excellent yields, providing an improved approach to dual C-H unsymmetrical functionalization.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Alice Kennett, Sven Epple, Gabriella van der Valk, Irene Georgiou, Evelyne Gout, Romain R. Vives, Angela J. Russell
Summary: This study presents the design and synthesis of sulfated disaccharide inhibitors based on IdoA(2S)-GlcNS(6S), which showed potent inhibition of Sulf-2. The results suggest that IdoA(2S)-GlcNS(6S) is the shortest fragment size required for effective inhibition of Sulfs, and a trisulfated disaccharide is identified as the minimal fragment size of heparan sulfate for effective endosulfatase inhibition.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Mauro Garbini, Andrea Brunetti, Riccardo Pedrazzani, Magda Monari, Massimo Marcaccio, Giulio Bertuzzi, Marco Bandini
Summary: The self-adaptability of galvanostatic electrolysis was found to be helpful in a multistage chemo- and diastereoselective electrochemically promoted cyclodimerization of chalcones. Through a series of reductive events, densely functionalized cyclopentanes with five contiguous stereocenters were obtained (25 examples, yields up to 95%, dr values up to >20:1). Further experimental and electrochemical investigations indicated the crucial role of dynamic kinetic resolution of the aldol intermediate in the reaction mechanism.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Dhananjay S. Nipate, Neha Meena, Prakash N. Swami, Krishnan Rangan, Anil Kumar
Summary: In this study, the synthesis of functionalized benzo[a]phenazines and indazolo[2,3-a]quinolines was achieved through Rh(III)-catalyzed oxidative annulation of 2-arylquinoxalines and 2-aryl-2H-indazoles with allyl alcohols. The method showed a wide substrate scope, excellent functional group tolerance, good to high yields of annulated products, and the capability for scaled-up synthesis. A tentative mechanism of the annulation reaction was proposed based on a preliminary mechanistic investigation.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Ruonan Zhang, Abudukadi Tudi, Xia Yang, Xuping Wang, Zhihua Yang, Shujuan Han, Shilie Pan
Summary: A new lead tellurium borate material with a unique fundamental building block [B4O10] was synthesized and found to exhibit high birefringence. The structure-property relationship was discussed using first-principles calculations.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Amresh Kumar Singh, Baishali Thakurta, Anupam Giri, Monalisa Pal
Summary: This study introduces three key concepts for the quick synthesis of large-scale high-quality 2D materials films and their utilization in device fabrication.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Reina Hagiwara, Shun Nishimura, Kosuke Okeyoshi
Summary: A copolymer-conjugated nanocatalytic system has been developed to improve electron transfer and enhance photoinduced H2 generation.
CHEMICAL COMMUNICATIONS
(2024)
