Article
Biochemistry & Molecular Biology
Sun Hyeok Lee, Chul Soon Park, Kyung Kwan Lee, Tae-Hee Han, Hyun Seung Ban, Chang-Soo Lee
Summary: In this study, novel near-infrared probes were synthesized for fluorescence imaging of NTR activity. NIR-HCy-NO2 1 exhibited superior performance compared to the other two probes in terms of catalytic efficiency and limit of detection. Furthermore, NIR-HCy-NO2 1 was found to react with type I mitochondrial NTR in live cell imaging. NIR-HCy-NO2 demonstrated great potential for various NTR-related applications, including NTR activity imaging in vivo.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Inorganic & Nuclear
Todd A. Gillam, Chiara Caporale, Robert D. Brooks, Christie A. Bader, Alexandra Sorvina, Melissa Werrett, Phillip J. Wright, Janna L. Morrison, Massimiliano Massi, Doug A. Brooks, Stefano Zacchini, Shane M. Hickey, Stefano Stagni, Sally E. Plush
Summary: Luminescent metal complexes are valuable for cell imaging agents. Neutral Re(I) complexes offer a more attractive platform for the development of bioconjugated imaging agents. These neutral complexes have localized within the endosomal/lysosomal network, demonstrating their utility in developing bioconjugated cell imaging agents.
INORGANIC CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Wuyu Mao, Jie Tang, Liqun Dai, Xinyu He, Jie Li, Larry Cai, Ping Liao, Ruotian Jiang, Jingwei Zhou, Haoxing Wu
Summary: A novel strategy has been developed to create highly fluorescent Huaxi-Fluor probes that exhibit significantly increased fluorescence upon forming the bioorthogonal reaction product, pyridazine. These probes have large Stokes shifts and high quantum yields, with emission wavelengths fine-tunable from 556 to 728 nm by manipulating the fluorophore skeleton. Highly photo-stable and biocompatible, these probes are suitable for live cell organelle visualization without washing steps and imaging tumors in live small animals to depths of 500 μm by two-photon excitation.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Ayan Mukherjee, Pranab Chandra Saha, Rabi Sankar Das, Tapas Bera, Samit Guha
Summary: In this study, a pH-activatable fluorescent dye was designed and synthesized, which can switch from visible to near-infrared spectrum under acidic conditions and be controlled by pH. The properties of this fluorescent dye were monitored using NMR, UV/vis, and fluorescence spectroscopies. The dye showed promising performance in live cell lysosomal imaging and has potential applications.
Review
Chemistry, Inorganic & Nuclear
Caiping Ding, Tianbing Ren
Summary: Near infrared (NIR) fluorescent probes have advantageous features including low background interference, strong tissue penetration, and minimal tissue damage. This paper provides a summary and discussion on the various types and properties of fluorophores used in the design of NIR fluorescent probes. It also discusses the latest research achievements in detecting and imaging reactive oxygen species, reactive nitrogen, and active sulfur in cells or in vivo. Additionally, a concise overview of the future development of NIR molecular fluorescence probes is proposed based on existing research, offering a reference for current research directions.
COORDINATION CHEMISTRY REVIEWS
(2023)
Article
Chemistry, Multidisciplinary
Lei G. Wang, Antonio R. Montano, Jason R. Combs, Nathan P. McMahon, Allison Solanki, Michelle M. Gomes, Kai Tao, William H. Bisson, Dani A. Szafran, Kimberley S. Samkoe, Kenneth M. Tichauer, Summer L. Gibbs
Summary: Non-destructive diffusion of fluorescent molecules across cell membranes is crucial for quantitative imaging in live cells and tissues. We have developed biologically compatible and cell-membrane-permeable fluorophores called OregonFluor (ORFluor), which allow for quantitative visualization of their intracellular distribution and protein target-specific binding using ratiometric imaging methodology. This provides a chemical toolkit for quantifying drug target availability in live cells and tissues.
Article
Chemistry, Multidisciplinary
Jiaguo Huang, Kanyi Pu
Summary: Near-infrared (NIR) fluorescence imaging shows great potential in both basic biomedical research and clinical practice, especially in the diagnosis of nephron-urological diseases. The development of molecular probes has improved detection specificity and contrast enhancement in imaging.
Article
Chemistry, Multidisciplinary
Xin Wei, Jingsheng Huang, Chi Zhang, Cheng Xu, Kanyi Pu, Yan Zhang
Summary: Researchers have synthesized a highly bright near-infrared chemiluminophore through molecular engineering of the electron-withdrawing group. This chemiluminophore shows a 3 to 5-fold higher quantum yield compared to existing ones. By combining it with a cathepsin B-responsive moiety, an activatable chemiluminescence probe has been developed for real-time detection of deeply buried tumor tissues and accurate chemiluminescence-guided laparotomy in living mice.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Applied
Xiao-Bo Xu, Yan-Yang He, Fenglin Wang, Wen Chen, Li Juan Tang, Jian-Hui Jiang
Summary: Researchers have developed a near-infrared fluorescent indicator called TAQ, which allows for activatable imaging of G4 structures in live cells. The indicator interacts with different G4 structures and exhibits high selectivity for G4s over other nucleic acids. It has a wide dynamic range for detecting G4 concentrations and can be used to track the dynamics of RNA/DNA G4s in live cells.
Article
Chemistry, Multidisciplinary
Zhiwei Ye, Wei Yang, Ying Zheng, Shujing Wang, Xiaodong Zhang, Haibo Yu, Shuangshuang Li, Chunxiong Luo, Xiaojun Peng, Yi Xiao
Summary: In this study, a new membrane probe and microfluidic platform were developed to enable synchronous use of super-resolution imaging and single-molecule tracking. This method allows high-throughput observation and analysis of the ultrastructural and dynamic details of living red blood cell membranes, providing new perspectives for future disease diagnostics.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Biochemical Research Methods
Pranab Chandra Saha, Rabi Sankar Das, Shreya Das, Nayim Sepay, Tanima Chatterjee, Ayan Mukherjee, Tapas Bera, Samiran Kar, Maitree Bhattacharyya, Arunima Sengupta, Samit Guha
Summary: Here, we design a water-soluble NIR fluorescent unsymmetrical Cy-5-Mal/TPP+ with a lipophilic cationic TPP+ subunit, which selectively targets and accumulates in live-cell inner mitochondrial matrix. The maleimide residue of the probe undergoes faster and site-specific covalent attachment with the exposed Cys residue of mitochondrion-specific proteins. This dual targeting approach enables long-term live-cell mitochondrial imaging and improves real-time tracking of mitochondria with multicolor imaging applications.
BIOCONJUGATE CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Dana Al Kelabi, Avishek Dey, Lukman O. Alimi, Hubert Piwonski, Satoshi Habuchi, Niveen M. Khashab
Summary: Fluorescent microscopy is a powerful technique for studying cellular dynamics. The organic fluorophore OC1, with high cell permeability, photostability, and selectivity for mitochondria, has been identified. The keto-enol tautomerization of OC1 allows for consistent fluorescence in dilute solutions through supramolecular self-assembly.
Article
Chemistry, Organic
Shuang Chao, Pei Huang, Ziyan Shen, Yuxin Pei, Yinghua Lv, Yuchao Lu, Zhichao Pei
Summary: This article presents a multifunctional nanodrug delivery system for targeted delivery and real-time monitoring of nonfluorescent drugs, which is one of the most important topics in cancer therapy. A novel supramolecular fluorescent probe was constructed to monitor the delivery of nonfluorescent drug gemcitabine (GEM) to cancer cells. The nanodrug delivery system exhibits excellent capabilities for targeted drug delivery and real-time monitoring of nonfluorescent drug release.
ORGANIC CHEMISTRY FRONTIERS
(2023)
Review
Chemistry, Multidisciplinary
Qing Shen, Leichen Wang, Xiaohong Ruan, Na Li, Weili Wang, Wenjun Wang, Jinjun Shao, Xiaochen Dong
Summary: Photoacoustic (PA) imaging is a promising biomedical imaging technique that combines the advantages of high-contrast optical imaging and deep tissue penetration of acoustic imaging. This review focuses on the recent research progress of stimuli-responsive organic NIR probes for PA imaging, including temperature, pH, redox, metal ion, and enzyme response. The stimuli-responsive mechanisms are highlighted, and the perspectives and challenges are discussed.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Guanyu Chi, Yinghua Lv, Shuang Chao, Chenxi Hou, Yuxin Pei, Zhichao Pei
Summary: This study presents multifunctional glyconanoparticles with activatable near-infrared probes for tumor imaging and targeted drug delivery. Experimental results demonstrate that the nanoparticles show great tumor-targeting ability, efficient fluorescence restoration, and high anticancer efficacy in cancer cells with high GSH concentration, highlighting the potential of integrating tumor imaging and targeted drug delivery for improved chemotherapy outcomes.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Chemistry, Analytical
Weifen Niu, Li Fan, Ming Nan, Zengbo Li, Dongtao Lu, Man Shing Wong, Shaomin Shuang, Chuan Dong
ANALYTICAL CHEMISTRY
(2015)
Article
Chemistry, Analytical
Zhen Chena, Dongtao Lu, Guomei Zhang, Jun Yang, Chuan Dong, Shaomin Shuang
SENSORS AND ACTUATORS B-CHEMICAL
(2014)
Article
Spectroscopy
Dongtao Lu, Lili Liu, Fengxia Li, Shaomin Shuang, Yingfu Li, Matin M. F. Choi, Chuan Dong
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2014)
Article
Chemistry, Analytical
Wei Bian, Jing Ma, Wenrong Guo, Dongtao Lu, Meng Fan, Yanli Wei, Yingfu Li, Shaomin Shuang, Martin M. F. Choi
Article
Materials Science, Biomaterials
Li Fan, Qiaoling Liu, Dongtao Lu, Heping Shi, Yunfeng Yang, Yingfu Li, Chuan Dong, Shaomin Shuang
JOURNAL OF MATERIALS CHEMISTRY B
(2013)
Article
Polymer Science
Wenting Liang, Yu Huang, Dongtao Lu, Xuewen Ma, Tao Gong, Xiaodong Cui, Baofeng Yu, Cheng Yang, Chuan Dong, Shaomin Shuang
Article
Chemistry, Analytical
Xiuying Peng, Yelong Zhang, Dongtao Lu, Yujing Guo, Shaojun Guo
SENSORS AND ACTUATORS B-CHEMICAL
(2019)
Article
Nanoscience & Nanotechnology
Xiuying Peng, Wanxin Jia, Dongtao Lu, Qiao Zhang, Cheng Yang, Shaomin Shuang, Yujing Guo, Chuan Dong
MICRO & NANO LETTERS
(2019)
Article
Nanoscience & Nanotechnology
Xiuying Peng, Dongtao Lu, Yingnan Qin, Miaomiao Li, Yujing Guo, Shaojun Guo
ACS APPLIED MATERIALS & INTERFACES
(2020)
Article
Nanoscience & Nanotechnology
Wanxin Jia, Dongtao Lu, Shaomin Shuang, Jun Yang, Chuan Dong
JOURNAL OF NANO RESEARCH
(2017)
Article
Chemistry, Analytical
Lei Zhang, Qin Hu, Zhongping Li, Yan Zhang, Dongtao Lu, Shaomin Shuang, Martin M. F. Choi, Chuan Dong
ANALYTICAL METHODS
(2017)
Article
Chemistry, Analytical
Dongtao Lu, Zhen Chen, Yingfu Li, Jun Yang, Shaomin Shuang, Chuan Dong
ANALYTICAL LETTERS
(2015)
Article
Chemistry, Multidisciplinary
Yanqing Guo, Yanmei Zhao, Dongtao Lu, Hongjuan Wu, Meng Fan, Yanli Wei, Shaomin Shuang, Chuan Dong
JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY
(2014)
Review
Chemistry, Multidisciplinary
Dan He, Yawen Li, Fuwen Zhao, Yuze Lin
Summary: High trap density in organic solar cells leads to localized charge carriers and reduced carrier lifetime, limiting device efficiency. This feature article summarizes the recent advances of trap suppression by material design and device engineering.
CHEMICAL COMMUNICATIONS
(2024)
Review
Chemistry, Multidisciplinary
Olivier Monfort, Arshitha Madhusudhan, Martin Motola
Summary: This article presents the advantages of coupling photocatalysis and Fenton-based processes for environmental remediation and discusses their synergy. It critically examines the simultaneous triggering of these two processes and provides insights into research approaches. The study aims to enhance understanding of this complex process and highlight the potential integration of new catalysts in current wastewater treatment technology.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Manideepa Dhar, Chittaranjan Mishra, Avijit Das, Uttam Manna
Summary: An approach of 'polymerization of monomers in its aggregated form' has been introduced to tailor the water wettability of fibrous and porous substrates, achieving hydrophobicity to superhydrophobicity transition, as well as patterned wettability. This facile chemical method provides a durable coating with adjustable and patterned wettability for various potential applications.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Saswat Ranjan Bhoi, Chhanda Debnath, Shikha Gandhi
Summary: In this article, a novel catalytic reaction using Pd(0) and Bronsted acid is reported for the synthesis of biologically important imidazolidinone-fused N-heterocycles through redox-neutral intramolecular N-allylation of indoles and pyrroles with alkynes. This atom-economical method is applicable to a wide range of substrates and eliminates the need for leaving groups or oxidizing agents commonly used in traditional allylation reactions.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Longkun Chen, Mingshuai Zhang, Meichen Liu, Zhuoyuan Liu, Yuetong Qiu, Zhilai Zhang, Fuchao Yu, Jiuzhong Huang
Summary: In this study, an efficient Rh(III)-catalyzed selective mono- and dual-C-H bond functionalization/cyclization with iodonium ylide as the sole coupling partner was demonstrated. Fused benzodiazepine skeletons were obtained in excellent yields, providing an improved approach to dual C-H unsymmetrical functionalization.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Alice Kennett, Sven Epple, Gabriella van der Valk, Irene Georgiou, Evelyne Gout, Romain R. Vives, Angela J. Russell
Summary: This study presents the design and synthesis of sulfated disaccharide inhibitors based on IdoA(2S)-GlcNS(6S), which showed potent inhibition of Sulf-2. The results suggest that IdoA(2S)-GlcNS(6S) is the shortest fragment size required for effective inhibition of Sulfs, and a trisulfated disaccharide is identified as the minimal fragment size of heparan sulfate for effective endosulfatase inhibition.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Mauro Garbini, Andrea Brunetti, Riccardo Pedrazzani, Magda Monari, Massimo Marcaccio, Giulio Bertuzzi, Marco Bandini
Summary: The self-adaptability of galvanostatic electrolysis was found to be helpful in a multistage chemo- and diastereoselective electrochemically promoted cyclodimerization of chalcones. Through a series of reductive events, densely functionalized cyclopentanes with five contiguous stereocenters were obtained (25 examples, yields up to 95%, dr values up to >20:1). Further experimental and electrochemical investigations indicated the crucial role of dynamic kinetic resolution of the aldol intermediate in the reaction mechanism.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Dhananjay S. Nipate, Neha Meena, Prakash N. Swami, Krishnan Rangan, Anil Kumar
Summary: In this study, the synthesis of functionalized benzo[a]phenazines and indazolo[2,3-a]quinolines was achieved through Rh(III)-catalyzed oxidative annulation of 2-arylquinoxalines and 2-aryl-2H-indazoles with allyl alcohols. The method showed a wide substrate scope, excellent functional group tolerance, good to high yields of annulated products, and the capability for scaled-up synthesis. A tentative mechanism of the annulation reaction was proposed based on a preliminary mechanistic investigation.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Ruonan Zhang, Abudukadi Tudi, Xia Yang, Xuping Wang, Zhihua Yang, Shujuan Han, Shilie Pan
Summary: A new lead tellurium borate material with a unique fundamental building block [B4O10] was synthesized and found to exhibit high birefringence. The structure-property relationship was discussed using first-principles calculations.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Amresh Kumar Singh, Baishali Thakurta, Anupam Giri, Monalisa Pal
Summary: This study introduces three key concepts for the quick synthesis of large-scale high-quality 2D materials films and their utilization in device fabrication.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Reina Hagiwara, Shun Nishimura, Kosuke Okeyoshi
Summary: A copolymer-conjugated nanocatalytic system has been developed to improve electron transfer and enhance photoinduced H2 generation.
CHEMICAL COMMUNICATIONS
(2024)