Article
Chemistry, Multidisciplinary
Li Zhou, Xun-Hui Xu, Zhi-Qiang Jiang, Lei Xu, Ben-Fa Chu, Na Liu, Zong-Quan Wu
Summary: Inspired by natural helices, this study focused on the fabrication of helical materials with controlled handedness. It was found that helices of opposite handedness exhibited different activity, with the unfavored handedness being self-terminated and the favored handedness showing high activity.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Francisco Rey-Tarrio, Santiago Guisan-Ceinos, Juan M. Cuerva, Delia Miguel, Maria Ribagorda, Emilio Quinoa, Felix Freire
Summary: This study demonstrates the direct relationship between photochemical degradation in PPAs and their dynamic helical behavior. It suggests the possibility of improving photostability by designing PPAs with quasi-static helical behavior.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Multidisciplinary Sciences
Naoki Ousaka, Mark J. Maclachlan, Shigehisa Akine
Summary: Isolating one-handed alpha-helical peptides composed of only achiral components remains a challenge. Here, the authors achieved this by optical resolution of the racemic (quasi-)static alpha-helical peptide with double stapling.
NATURE COMMUNICATIONS
(2023)
Review
Chemistry, Analytical
Shuyi Yuan, Lei Zhao, Fangqin Wang, Lilan Tan, Datong Wu
Summary: Chiral resolution is important and challenging due to the different biological activity and physicochemical property of (R)- and (S)-isomers. Optically active helical polymers have been synthesized as chiral selectors, which are used for chromatographic chiral separation and enantioselective adsorption/crystallization, with good enantioseparation efficiency.
JOURNAL OF SEPARATION SCIENCE
(2023)
Article
Polymer Science
Satoshi Kometani, Tomoki Kato, Kei Manabe, Tamio Seko, Yu-Ning Chang, Huai-Rou Luo, Yoshihiro Agata, Noboru Ohta, Teruaki Hayakawa, Syuji Fujii, Yoshinobu Nakamura, Ming-Chia Li, Tomoyasu Hirai
Summary: A novel block copolymer with a well-controlled stereoregularity, isotactic polymethacrylate-functionalized POSS-b-polymethyl methacrylate (it-PMAPOSS-b-PMMA), was prepared and characterized using various techniques. The addition of a chiral dopant allowed for the controlled preferential helical conformation of the unilateral segment in achiral it-PMAPOSS-b-PMMA.
JOURNAL OF POLYMER SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Shoma Ikeda, Ryohei Takeda, Takaya Fujie, Naoto Ariki, Yuuya Nagata, Michinori Suginome
Summary: This study demonstrates the dynamic induction of single-handed helical conformation in polymers bearing only achiral substituents by utilizing chiral additives in achiral solvents. The new mode of screw-sense induction has led to the successful induction of homochiral screw-sense in virtually achiral polymers, enabling highly enantioselective reactions with up to 95% enantiomeric excess.
Article
Polymer Science
Yuanyuan Gu, Lijia Liu, Yudan Wang, Chunhong Zhang, Toshiki Aoki
Summary: Here, a new method of achieving a macromolecular single-handed helical twisting in optically inactive poly(1) is described. This method involves the removal of nonracemic amines from the polymer backbone rather than the presence of chiral guests. Two methodologies are proposed to achieve a completely one-handed helix by gradually removing chiral molecules and heating the solution. The effect of amine content on one-handed helical formation is also investigated.
Article
Chemistry, Multidisciplinary
Kei Manabe, Sung-Yu Tsai, Satoshi Kuretani, Satoshi Kometani, Katsuyuki Ando, Yoshihiro Agata, Noboru Ohta, Yeo-Wan Chiang, I-Ming Lin, Syuji Fujii, Yoshinobu Nakamura, Yu-Ning Chang, Yuta Nabae, Teruaki Hayakawa, Chien-Lung Wang, Ming-Chia Li, Tomoyasu Hirai
Summary: The strategy described involves using an achiral stereoregular polymer with POSS side chains to obtain chiral silica. By mixing it-PMAPOSS and a chiral dopant, the preferred helical conformation of the POSS-containing polymer can be achieved, leading to a chiral silica compound with exclusive optical activity even after the chiral dopant is removed at high temperatures.
Article
Polymer Science
Zhichun Shi, Jiaxiang Wen, Yingnan Zhao, Jianjun Wang, Jun Li, Ming Zhao, Masahiro Teraguchi, Toshiki Aoki, Takashi Kaneko
Summary: A novel substituted phenylacetylene with a pendant betulin derivative group was successfully designed and synthesized. The structure of the monomer was confirmed using various spectroscopic techniques. The resulting polymer exhibited a strong Cotton effect in the circular dichroism spectra, indicating the formation of a one-handed helical backbone induced by the chiral source on the side chain. The rigid betulin derivatives in the polymer also contributed to its porous morphology and thermal stability.
Article
Polymer Science
Bao-Rui Gao, Yong-Jie Wu, Lei Xu, Hui Zou, Li Zhou, Na Liu, Zong-Quan Wu
Summary: Helical polycarbenes with optical activity were designed and synthesized in an environmentally friendly manner. These polymers exhibited stable helical conformations with preferred handedness and showed efficient chiral separation ability.
Article
Polymer Science
Kai Yang, Shuo Ma, Yingjie Zhang, Biao Zhao, Jianping Deng
Summary: This study successfully prepared a series of chiral helical substituted polyacetylenes using helix-sense-selective polymerization (HSSP), and fabricated them into blend films that exhibited strong optical activity and circularly polarized luminescence (CPL). The research also found that the monomer ratio and physical state of the copolymers significantly affected their chiroptical and CPL properties, and demonstrated the universality of the strategy by using different achiral fluorescent monomers.
MACROMOLECULAR RAPID COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Kazuki Sato, Tomohiro Umeno, Atsushi Ueda, Takuma Kato, Mitsunobu Doi, Masakazu Tanaka
Summary: The N-terminal thiourea-modified l-Leu-based peptide catalyst demonstrated high enantioselectivity in the 1,4-addition reaction, requiring only a small amount for efficient reaction under different substrate and donor conditions.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
David R. Benson, Bin Deng, Maithri M. Kashipathy, Scott Lovell, Kevin P. Battaile, Anne Cooper, Philip Gao, Aron W. Fenton, Hao Zhu
Summary: NADH cytochrome b(5) oxidoreductase (Ncb5or) is a cytosolic ferric reductase implicated in diabetes and neurological conditions. The study reveals for the first time an ancient origin of a helical motif in the N/b(5) module.
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
(2023)
Article
Chemistry, Multidisciplinary
Seila Leiras, Esteban Suarez-Picado, Emilio Quinoa, Ricardo Riguera, Felix Freire
Summary: The helical sense and elongation of a helical polymer can be tuned by tetraalkylammoniumanion salts, leading to color changes in the poly(phenylacetylene) depending on the anion and tetraalkylammonium group size. The colorimetric switch is attributed to the association of PPA with tetraalkylammonium salts, resulting in elongation changes and conjugation of the polyene, accompanied by color changes in dry conditions and solid state environments.
Review
Chemistry, Multidisciplinary
Dan He, Yawen Li, Fuwen Zhao, Yuze Lin
Summary: High trap density in organic solar cells leads to localized charge carriers and reduced carrier lifetime, limiting device efficiency. This feature article summarizes the recent advances of trap suppression by material design and device engineering.
CHEMICAL COMMUNICATIONS
(2024)
Review
Chemistry, Multidisciplinary
Olivier Monfort, Arshitha Madhusudhan, Martin Motola
Summary: This article presents the advantages of coupling photocatalysis and Fenton-based processes for environmental remediation and discusses their synergy. It critically examines the simultaneous triggering of these two processes and provides insights into research approaches. The study aims to enhance understanding of this complex process and highlight the potential integration of new catalysts in current wastewater treatment technology.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Manideepa Dhar, Chittaranjan Mishra, Avijit Das, Uttam Manna
Summary: An approach of 'polymerization of monomers in its aggregated form' has been introduced to tailor the water wettability of fibrous and porous substrates, achieving hydrophobicity to superhydrophobicity transition, as well as patterned wettability. This facile chemical method provides a durable coating with adjustable and patterned wettability for various potential applications.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Saswat Ranjan Bhoi, Chhanda Debnath, Shikha Gandhi
Summary: In this article, a novel catalytic reaction using Pd(0) and Bronsted acid is reported for the synthesis of biologically important imidazolidinone-fused N-heterocycles through redox-neutral intramolecular N-allylation of indoles and pyrroles with alkynes. This atom-economical method is applicable to a wide range of substrates and eliminates the need for leaving groups or oxidizing agents commonly used in traditional allylation reactions.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Longkun Chen, Mingshuai Zhang, Meichen Liu, Zhuoyuan Liu, Yuetong Qiu, Zhilai Zhang, Fuchao Yu, Jiuzhong Huang
Summary: In this study, an efficient Rh(III)-catalyzed selective mono- and dual-C-H bond functionalization/cyclization with iodonium ylide as the sole coupling partner was demonstrated. Fused benzodiazepine skeletons were obtained in excellent yields, providing an improved approach to dual C-H unsymmetrical functionalization.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Alice Kennett, Sven Epple, Gabriella van der Valk, Irene Georgiou, Evelyne Gout, Romain R. Vives, Angela J. Russell
Summary: This study presents the design and synthesis of sulfated disaccharide inhibitors based on IdoA(2S)-GlcNS(6S), which showed potent inhibition of Sulf-2. The results suggest that IdoA(2S)-GlcNS(6S) is the shortest fragment size required for effective inhibition of Sulfs, and a trisulfated disaccharide is identified as the minimal fragment size of heparan sulfate for effective endosulfatase inhibition.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Mauro Garbini, Andrea Brunetti, Riccardo Pedrazzani, Magda Monari, Massimo Marcaccio, Giulio Bertuzzi, Marco Bandini
Summary: The self-adaptability of galvanostatic electrolysis was found to be helpful in a multistage chemo- and diastereoselective electrochemically promoted cyclodimerization of chalcones. Through a series of reductive events, densely functionalized cyclopentanes with five contiguous stereocenters were obtained (25 examples, yields up to 95%, dr values up to >20:1). Further experimental and electrochemical investigations indicated the crucial role of dynamic kinetic resolution of the aldol intermediate in the reaction mechanism.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Dhananjay S. Nipate, Neha Meena, Prakash N. Swami, Krishnan Rangan, Anil Kumar
Summary: In this study, the synthesis of functionalized benzo[a]phenazines and indazolo[2,3-a]quinolines was achieved through Rh(III)-catalyzed oxidative annulation of 2-arylquinoxalines and 2-aryl-2H-indazoles with allyl alcohols. The method showed a wide substrate scope, excellent functional group tolerance, good to high yields of annulated products, and the capability for scaled-up synthesis. A tentative mechanism of the annulation reaction was proposed based on a preliminary mechanistic investigation.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Ruonan Zhang, Abudukadi Tudi, Xia Yang, Xuping Wang, Zhihua Yang, Shujuan Han, Shilie Pan
Summary: A new lead tellurium borate material with a unique fundamental building block [B4O10] was synthesized and found to exhibit high birefringence. The structure-property relationship was discussed using first-principles calculations.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Amresh Kumar Singh, Baishali Thakurta, Anupam Giri, Monalisa Pal
Summary: This study introduces three key concepts for the quick synthesis of large-scale high-quality 2D materials films and their utilization in device fabrication.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Reina Hagiwara, Shun Nishimura, Kosuke Okeyoshi
Summary: A copolymer-conjugated nanocatalytic system has been developed to improve electron transfer and enhance photoinduced H2 generation.
CHEMICAL COMMUNICATIONS
(2024)