Review
Polymer Science
Xiaoyi Feng, Yuning Luo, Fangjie Li, Xueting Jian, Yang Liu
Summary: Natural small molecular drugs, with unique rigid backbone structures and modifiable multiple sites, have been utilized as building blocks to form low-molecular-weight supramolecular gels with high drug loading, low toxicity, and outstanding stimulus responsiveness. These gels have overcome the shortcomings of natural drugs and are widely used in biomedical fields, showing great potential for further research.
Article
Biochemistry & Molecular Biology
Yao Jin, Friederike Adams, Judith Moeller, Lorenz Isert, Christoph M. M. Zimmermann, David Keul, Olivia M. M. Merkel
Summary: In this study, different formulations of low molecular weight PEI-based copolymers blended with or without PEG-PCL were investigated for siRNA delivery. The addition of PEG-PCL stabilized the nanoparticles and improved their biocompatibility and circulation time in vivo. The PEI-PCL-PEI/PEG-PCL nanoparticle system showed higher siRNA encapsulation efficiency, cellular uptake, and gene silencing efficiency, making it a promising vehicle for siRNA delivery.
MACROMOLECULAR BIOSCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Lisa Schlichter, Carmen C. Piras, David K. Smith
Summary: The study demonstrates the dynamic assembly of a pH-responsive low-molecular-weight gelator within a pre-formed gel matrix using acid diffusion, allowing for spatial and temporal control. Different acids and gel structures can create diverse gel assembly patterns and lasting pH gradients.
Article
Pharmacology & Pharmacy
Mingji Jin, Bowen Zeng, Yanhong Liu, Lili Jin, Yan Hou, Chao Liu, Wei Liu, Hao Wu, Liqing Chen, Zhonggao Gao, Wei Huang
Summary: The co-delivery of Itraconazole (ITZ) and VEGF siRNA using composite nanoparticles was shown to effectively inhibit angiogenesis and tumor growth in breast cancer, with low toxicity and side effects.
Article
Chemistry, Physical
Nitin Bansode, Julien Verget, Philippe Barthelemy
Summary: This study reports the synthesis of photo-cleavable glyconucleoside bolaamphiphiles that can form gels in aqueous media and the stiffness of the gels can be modulated through light irradiation.
Article
Chemistry, Physical
Nitin Bansode, Julien Verget, Philippe Barthelemy
Summary: This article presents a photo-cleavable glyconucleoside bolaamphiphile with a nitrophenyl unit, which can form gels in aqueous media. The stiffness of the gels based on this glyconucleoside bolaamphiphile can be modulated through light irradiation.
Article
Materials Science, Biomaterials
Haojie Zhai, Chi Zhang, Huilong Ou, Ming Chen
Summary: The study demonstrates that the combination of low-frequency sonophoresis and sponge Haliclona sp. spicules can significantly enhance transdermal drug delivery, especially for increasing the skin absorption of hydrophilic macromolecules like low-molecular-weight heparin.
BIOMATERIALS SCIENCE
(2021)
Article
Chemistry, Multidisciplinary
Shuanggen Wu, Wenbo Wang, Changyong Cai, Fenfang Li, Shengyi Dong
Summary: A low-molecular-weight supramolecular adhesive with strong adhesion capacity at low temperatures and in the presence of water has been reported.
CHINESE CHEMICAL LETTERS
(2023)
Article
Nanoscience & Nanotechnology
Mingji Jin, Yan Hou, Xiuquan Quan, Liqing Chen, Zhonggao Gao, Wei Huang
Summary: The study successfully utilized smart nanoparticles to co-deliver paclitaxel and siRNA against vascular endothelial growth factor in a mouse model of breast cancer, demonstrating a strong anti-tumor effect. This provides a new theoretical and practical basis for breast cancer therapy.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Materials Science, Multidisciplinary
Pengkai Wu, Shuai Yin, Tianqing Liu, Dan Ding, Kaikai Wang
Summary: By incorporating different functional ligands and linked reductive disulfides into low-molecular-weight PEI 1.8k, this study constructed reductive-responsive PEI-X-SS-X-PEI copolymers to enhance siRNA transfection efficiency. The strategy, named building-block crosslinking, showed a simple and smart way to synthesize new materials and improve gene delivery systems.
SCIENCE CHINA-MATERIALS
(2021)
Article
Materials Science, Biomaterials
Cheng Hu, Wenqi Liu, Linyu Long, Zhicun Wang, Yihui Yuan, Wen Zhang, ShuYi He, Jian Wang, Li Yang, Lu Lu, Yunbing Wang
Summary: A new multifunctional smart hydrogel was developed for the treatment of chronic diabetic wounds, which achieved on-demand release of antibacterial nanoparticles and tailored rhCol III to promote wound healing. The released nanoparticles demonstrated excellent antibacterial properties, while the rhCol III promoted cell proliferation and migration to accelerate wound healing.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Article
Chemistry, Multidisciplinary
Julie Tzu-Wen Wang, Ana C. Rodrigo, Anna K. Patterson, Kirsten Hawkins, Mazen M. S. Aly, Jia Sun, Khuloud T. Al Jamal, David K. Smith
Summary: The study demonstrates the use of a self-assembling hydrogel as a delivery vehicle for the Parkinson's disease drug l-DOPA, showing promising results for nasal drug delivery strategies.
Article
Engineering, Biomedical
Minmengqi Pan, Zhibin Ren, Xiaohui Ma, Lei Chen, Guanghao Lv, Xiaoying Liu, Shan Li, Xingyi Li, Jiaqing Wang
Summary: In this study, an antibiotic hydrogel eye drop was developed to extend the pre-corneal retention of drugs. The self-assembly ability of peptide-drug conjugate and the addition of calcium ions were utilized to improve drug delivery efficacy. This biomimetic design of antibiotic eye drops addresses the current issues of ocular drug delivery and provides potential solutions for treating bacterial keratitis.
ACTA BIOMATERIALIA
(2023)
Article
Pharmacology & Pharmacy
Shogo Nishida, Yuuki Takashima, Ryotaro Udagawa, Hisako Ibaraki, Yasuo Seta, Hiroshi Ishihara
Summary: This study aimed to develop a nanocarrier for the non-invasive delivery of siRNA to the retina by eyedrops. A hybrid nanocarrier based on a multifunctional peptide and liposomes was prepared and optimized. The results showed that the nanocarrier significantly enhanced siRNA transfection efficiency and effectively suppressed vascular endothelial growth factor expression in rat retinal pigment epithelium cells.
Article
Oncology
Yu Han, Yuming Yang, Qiuyang Sun, Bin Li, Caixia Yue, Yanlei Liu, Jesus M. de la Fuente, Daxiang Cui
Summary: The study developed a nanocage system based on up-conversion nanoparticles for targeted delivery of siRNA to tumor sites, which resulted in tumor suppression effects. The system protected siRNA from degradation while showing stable efficacy and longer survival times.
CANCER BIOLOGY & MEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Il Joon Lee, Sachin P. Patil, Karim Fhayli, Shahad Alsaiari, Niveen M. Khashab
CHEMICAL COMMUNICATIONS
(2015)
Article
Chemistry, Multidisciplinary
Sachin P. Patil, Basem A. Moosa, Shahad Alsaiari, Kholod Alamoudi, Aws Alshamsan, Abdulaziz AlMalik, Karim Adil, Mohamed Eddaoudi, Niveen M. Khashab
CHEMISTRY-A EUROPEAN JOURNAL
(2016)
Article
Chemistry, Multidisciplinary
Safa'a Al-Rehili, Karim Fhayli, Mohamed Amen Hammami, Basem Moosa, Sachin Patil, Daliang Zhang, Ohoud Alharbi, Mohamed Nejib Hedhili, Helmuth Moehwald, Niveen M. Khashab
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2017)
Article
Chemistry, Multidisciplinary
Shahad K. Alsaiari, Sachin Patil, Mram Alyami, Kholod O. Alamoudi, Fajr A. Aleisa, Jasmeen S. Merzaban, Mo Li, Niveen M. Khashab
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2018)
Article
Biotechnology & Applied Microbiology
Kholod Alamoudi, Patricia Martins, Jonas G. Croissant, Sachin Patil, Haneen Omar, Niveen M. Khashab
Article
Chemistry, Multidisciplinary
Sachin Patil, Widad Belhajjame, Basem Moosa, Niveen M. Khashab
SUPRAMOLECULAR CHEMISTRY
(2018)
Article
Biochemical Research Methods
Sachin Prakash Patil, Seong-Hoon Kim, Jyoti Ramesh Jadhav, Ju-hyun Lee, Eun Mi Jeon, Kyong-Tai Kim, Byeang Hyean Kim
BIOCONJUGATE CHEMISTRY
(2014)
Article
Chemistry, Medicinal
Tran Khac Vu, Sachin Prakash Patil, Yoo Jin Park, Do Thi Thao
LETTERS IN DRUG DESIGN & DISCOVERY
(2013)
Article
Biochemistry & Molecular Biology
Sachin Prakash Patil, Jeong Wu Yi, Eun-Kyoung Bang, Eun Mi Jeon, Byeang Hyean Kim
Article
Chemistry, Organic
Nilkanth G. Aher, Vandana S. Pore, Sachin P. Patil
Review
Chemistry, Multidisciplinary
Dan He, Yawen Li, Fuwen Zhao, Yuze Lin
Summary: High trap density in organic solar cells leads to localized charge carriers and reduced carrier lifetime, limiting device efficiency. This feature article summarizes the recent advances of trap suppression by material design and device engineering.
CHEMICAL COMMUNICATIONS
(2024)
Review
Chemistry, Multidisciplinary
Olivier Monfort, Arshitha Madhusudhan, Martin Motola
Summary: This article presents the advantages of coupling photocatalysis and Fenton-based processes for environmental remediation and discusses their synergy. It critically examines the simultaneous triggering of these two processes and provides insights into research approaches. The study aims to enhance understanding of this complex process and highlight the potential integration of new catalysts in current wastewater treatment technology.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Manideepa Dhar, Chittaranjan Mishra, Avijit Das, Uttam Manna
Summary: An approach of 'polymerization of monomers in its aggregated form' has been introduced to tailor the water wettability of fibrous and porous substrates, achieving hydrophobicity to superhydrophobicity transition, as well as patterned wettability. This facile chemical method provides a durable coating with adjustable and patterned wettability for various potential applications.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Saswat Ranjan Bhoi, Chhanda Debnath, Shikha Gandhi
Summary: In this article, a novel catalytic reaction using Pd(0) and Bronsted acid is reported for the synthesis of biologically important imidazolidinone-fused N-heterocycles through redox-neutral intramolecular N-allylation of indoles and pyrroles with alkynes. This atom-economical method is applicable to a wide range of substrates and eliminates the need for leaving groups or oxidizing agents commonly used in traditional allylation reactions.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Longkun Chen, Mingshuai Zhang, Meichen Liu, Zhuoyuan Liu, Yuetong Qiu, Zhilai Zhang, Fuchao Yu, Jiuzhong Huang
Summary: In this study, an efficient Rh(III)-catalyzed selective mono- and dual-C-H bond functionalization/cyclization with iodonium ylide as the sole coupling partner was demonstrated. Fused benzodiazepine skeletons were obtained in excellent yields, providing an improved approach to dual C-H unsymmetrical functionalization.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Alice Kennett, Sven Epple, Gabriella van der Valk, Irene Georgiou, Evelyne Gout, Romain R. Vives, Angela J. Russell
Summary: This study presents the design and synthesis of sulfated disaccharide inhibitors based on IdoA(2S)-GlcNS(6S), which showed potent inhibition of Sulf-2. The results suggest that IdoA(2S)-GlcNS(6S) is the shortest fragment size required for effective inhibition of Sulfs, and a trisulfated disaccharide is identified as the minimal fragment size of heparan sulfate for effective endosulfatase inhibition.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Mauro Garbini, Andrea Brunetti, Riccardo Pedrazzani, Magda Monari, Massimo Marcaccio, Giulio Bertuzzi, Marco Bandini
Summary: The self-adaptability of galvanostatic electrolysis was found to be helpful in a multistage chemo- and diastereoselective electrochemically promoted cyclodimerization of chalcones. Through a series of reductive events, densely functionalized cyclopentanes with five contiguous stereocenters were obtained (25 examples, yields up to 95%, dr values up to >20:1). Further experimental and electrochemical investigations indicated the crucial role of dynamic kinetic resolution of the aldol intermediate in the reaction mechanism.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Dhananjay S. Nipate, Neha Meena, Prakash N. Swami, Krishnan Rangan, Anil Kumar
Summary: In this study, the synthesis of functionalized benzo[a]phenazines and indazolo[2,3-a]quinolines was achieved through Rh(III)-catalyzed oxidative annulation of 2-arylquinoxalines and 2-aryl-2H-indazoles with allyl alcohols. The method showed a wide substrate scope, excellent functional group tolerance, good to high yields of annulated products, and the capability for scaled-up synthesis. A tentative mechanism of the annulation reaction was proposed based on a preliminary mechanistic investigation.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Ruonan Zhang, Abudukadi Tudi, Xia Yang, Xuping Wang, Zhihua Yang, Shujuan Han, Shilie Pan
Summary: A new lead tellurium borate material with a unique fundamental building block [B4O10] was synthesized and found to exhibit high birefringence. The structure-property relationship was discussed using first-principles calculations.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Amresh Kumar Singh, Baishali Thakurta, Anupam Giri, Monalisa Pal
Summary: This study introduces three key concepts for the quick synthesis of large-scale high-quality 2D materials films and their utilization in device fabrication.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Reina Hagiwara, Shun Nishimura, Kosuke Okeyoshi
Summary: A copolymer-conjugated nanocatalytic system has been developed to improve electron transfer and enhance photoinduced H2 generation.
CHEMICAL COMMUNICATIONS
(2024)