Article
Chemistry, Inorganic & Nuclear
Gilad Nahari, Edit Y. Tshuva
Summary: Fine-tuning of complex properties by different substitutions on the two aromatic rings resulted in enhanced solubility, high anticancer activity (IC50 < 4 mu M), and significant hydrolytic stability.
DALTON TRANSACTIONS
(2021)
Article
Chemistry, Physical
Wen-Bin Xie, Zhi Li
Summary: A series of chiral compounds were designed and synthesized for a highly enantioselective intramolecular hydroalkoxylation of nonactivated alkenes, resulting in the formation of 2-methylcoumarans with up to 99% yields and up to 97% enantiomeric excess under mild conditions.
Article
Pharmacology & Pharmacy
Ming-Chao Jiang, Hong-Bing Liu, Jia-Qi Wang, Shuang Li, Zhi Zheng, Dun Wang, Hua Wei, Cui-Yun Yu
Summary: By studying the effects of two different Apt incorporation strategies on the performance and properties of polymeric prodrugs, it was found that Apt-CS-FU demonstrated better tumor inhibition efficacy in murine tumor models compared to Apt/CS-FU, attributed to the smaller size of Apt-CS-FU leading to prolonged in vivo circulation.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Engineering, Chemical
Haibiao Yu, Yan Pan, Yingying Zhang, Lifeng Gong, Zhenning Lou, Weijun Shan, Ying Xiong
Summary: In this study, TiO2 nanoparticles were functionalized with organic acids containing different numbers of hydroxyl groups. The adjustment of surface functional groups significantly affected the Ge(IV) adsorption capacity. The tartaric acid-functionalized TiO2 nanoparticles showed higher hydroxyl content and adsorption capacity than previously reported adsorbents, and also exhibited remarkable affinity for Ge(IV) in a metallurgical simulated solution.
JOURNAL OF THE TAIWAN INSTITUTE OF CHEMICAL ENGINEERS
(2023)
Article
Chemistry, Inorganic & Nuclear
Andrea Sonstroem, Barbara Boldrini, Daniel Werner, Caecilia Maichle-Moessmer, Karsten Rebner, Maria Benedetta Casu, Reiner Anwander
Summary: Protonolysis reactions between dimethylamido titanium-(IV) catecholate and neopentanol or tris(tert-butoxy)silanol yielded catecholato-bridged dimers, while reactions with dimeric dimethylamido titanium(IV) (3,6-di-tert-butyl)catecholate produced monomeric complexes. The neopentoxide complex engaged in further reactions and was used for grafting onto mesoporous silica KIT-6. Comparisons were made with a sequential and an aqueous approach, which showed different surface species and band-gap reductions.
INORGANIC CHEMISTRY
(2023)
Article
Medicine, Research & Experimental
Sued Eustaquio Mendes Miranda, Janaina de Alcantara Lemos, Renata Salgado Fernandes, Juliana de Oliveira Silva, Flaviano M. Ottoni, Danyelle M. Townsend, Domenico Rubello, Ricardo Jose Alves, Geovanni Dantas Cassali, Lucas Antonio Miranda Ferreira, Andre Luis Branco de Barros
Summary: Lapachol-loaded nanoemulsion (NE-LAP) was prepared and showed high antitumor activity. NE-LAP exhibited stable physicochemical characteristics, with encapsulation efficiency greater than 85%, and demonstrated higher cytotoxicity activity in vitro. Tc-99m-labeled NE-LAP showed prolonged blood circulation and tumor affinity in a tumor model.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Alessandra Barbanente, Valentina Gandin, Cecilia Ceresa, Cristina Marzano, Nicoletta Ditaranto, James D. Hoeschele, Giovanni Natile, Fabio Arnesano, Concetta Pacifico, Francesco P. Intini, Nicola Margiotta
Summary: The Pt(IV) prodrug of kiteplatin, cis,trans,cis-[PtCl2(OBz)(2)(cis-1,4-DACH)], has shown promising anticancer activity at nanomolar concentrations, good stability in acidic conditions for oral administration, and comparable tumor reduction effectiveness to cisplatin in in vivo studies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Yuanyuan Li, Aiyang Tong, Peiyuan Niu, Wenjing Guo, Yangye Jin, Yi Hu, Pei Tao, Wenjun Miao
Summary: This study developed a near-infrared light-decomposable nanomicelle for controlled delivery of a hypoxia-activated bioreductive prodrug, which showed remarkable tumor cell-killing potential in breast cancer cells and significant tumor accumulation and inhibition of lung metastasis in mice, making it a promising strategy for hypoxia-enhanced phototherapies against metastatic breast cancer.
Article
Chemistry, Inorganic & Nuclear
Inga-Alexandra Bischoff, Bernd Morgenstern, Michael Zimmer, Aylin Koldemir, Rainer Poettgen, Andre Schafer
Summary: The synthesis and structure of two bis(germanocenes) and a bis(stannocene) are reported. DFT calculations show that the formation of these bis(tetrelocenes) is energetically favored over the formation of the corresponding [1]tetrelocenophanes. In the crystal structure, the tetrel(ii) centers are forced into close proximity, resulting in weak donor-acceptor interactions.
DALTON TRANSACTIONS
(2023)
Article
Pharmacology & Pharmacy
Xiao Kuang, Yuting Hu, Dongxu Chi, Haolin Zhang, Zhonggui He, Yiguo Jiang, Yongjun Wang
Summary: A series of disulfide bond introduced Pt(IV)-lipid prodrugs were designed, which can be activated by high intracellular glutathione (GSH) level for therapeutic effect; the longest axial branched Pt(IV) prodrug CSS18 showed the most impressive therapeutic outcome, providing insights into the rational design of reduction responsive platinum delivery system.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Chemistry, Physical
Shan Zhu, Yuanxi Wang, Changyi Zheng, Yanhui Wang, Qiang Tian, Mark Julian Henderson, Minhao Yan
Summary: Carrier colloids have been identified as the primary mechanism for enhancing the transport of actinides in the subsurface at former nuclear weapons facilities. However, there is a lack of sub-micrometer size investigations on the sorption/interactions between radionuclides and natural colloids. This study evaluated the interactions between Pu (IV)/Zr (IV) and colloids formed from Chinese Gaomiaozi bentonite, providing valuable insights into the potential migration of these elements in subsurface waters.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2022)
Article
Chemistry, Multidisciplinary
Ilhwan Ryu, Jee-Yeon Ryu, Geunpyo Choe, Hyemin Kwon, Hyeji Park, Young-Seok Cho, Rose Du, Sanggyu Yim
Summary: A real-time in vivo cancer detection method using attenuation-based plain X-ray imaging is proposed, successfully detecting 5 mm-sized Panc-1 cell tumors in mice. Quantum dot scintillators of CPB are used as markers, showing significant X-ray attenuation effects for clear signal observation under 2 cm-thick tissue.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Biotechnology & Applied Microbiology
Hui Ao, Zhuo Wang, Likang Lu, Hongwei Ma, Haowen Li, Jingxin Fu, Manzhen Li, Meihua Han, Yifei Guo, Xiangtao Wang
Summary: The study utilized blank PEGylated liposomes as tumor delivery enhancers and demonstrated that an over-threshold dosing strategy significantly enhanced the accumulation of liposomal drugs in tumors, leading to improved antitumor efficacy.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Chemistry, Applied
Guojun Lv, Yan Chen, Xuyang Zou, Jiangzhang Wang, Tao Wang, Fumin Wang, Xubin Zhang
Summary: In this study, vanadium-titanium doped MFI zeolite was synthesized and its synergistic catalytic effect in the epoxidation of 1-hexene and cyclohexene was investigated. The simultaneous incorporation of vanadium and titanium induced the partial charge transformation of titanium (IV) into titanium (III), leading to improved catalytic performance. Additionally, the dual insertion of vanadium and titanium increased the number of Lewis acid sites and external surface area, further enhancing the synergistic catalytic effect. The prepared VTS(0.15) zeolite exhibited high catalytic activity and good reusability.
MICROPOROUS AND MESOPOROUS MATERIALS
(2022)
Article
Chemistry, Physical
Ghodrat Mahmoudi, Farhad Akbari Afkhami, Ennio Zangrando, Werner Kaminsky, Antonio Frontera, Damir A. Safin
Summary: The synthesis and detailed structural characterization of a new coordination compound with a complex structure and 3D supramolecular features were reported.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Chemistry, Multidisciplinary
Oleksii Nevskyi, Dmytro Sysoiev, Jes Dreier, Simon Christoph Stein, Alex Oppermann, Florian Lemken, Tobias Janke, Joerg Enderlein, Ilaria Testa, Thomas Huhn, Dominik Woell
Article
Environmental Sciences
Jasmin Frey, Fabian Schneider, Thomas Huhn, Dieter Spiteller, Bernhard Schink, David Schleheck
ENVIRONMENTAL MICROBIOLOGY REPORTS
(2018)
Article
Chemistry, Multidisciplinary
Eric Siemes, Oleksii Nevskyi, Dmytro Sysoiev, Sarah K. Turnhoff, Alex Oppermann, Thomas Huhn, Walter Richtering, Dominik Woell
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2018)
Article
Nanoscience & Nanotechnology
Jeongmin Koo, Yeonsik Jang, Leon Martin, Dongku Kim, Hyunhak Jeong, Keehoon Kang, Woocheol Lee, Junwoo Kim, Wang-Taek Hwang, Dong Xiang, Elke Scheer, Mikhail Kabdulov, Thomas Huhn, Fabian Pauly, Takhee Lee
ACS APPLIED MATERIALS & INTERFACES
(2019)
Article
Chemistry, Organic
Dmytro Sysoiev, Carolyn Barnes, Thomas Huhn
CHEMISTRY OF HETEROCYCLIC COMPOUNDS
(2019)
Article
Chemistry, Physical
Sergii Snegir, Thomas Huhn, Johannes Boneberg, Simon Haus, Olivier Pluchery, Elke Scheer
JOURNAL OF PHYSICAL CHEMISTRY C
(2020)
Article
Chemistry, Multidisciplinary
Bohdan Lenyk, Volker Schoeps, Johannes Boneberg, Mikhail Kabdulov, Thomas Huhn, Elke Scheer, Andreas Offenhaeusser, Dirk Mayer
Article
Chemistry, Multidisciplinary
Johannes Bayer, Jan Herberger, Lukas Holz, Rainer F. Winter, Thomas Huhn
CHEMISTRY-A EUROPEAN JOURNAL
(2020)
Article
Microbiology
Xiaoman Xie, Dieter Spiteller, Thomas Huhn, Bernhard Schink, Nicolai Mueller
FRONTIERS IN MICROBIOLOGY
(2020)
Article
Chemistry, Physical
Mani Lokamani, Jeffrey Kelling, Robin Ohmann, Jorg Meyer, Tim Kuehne, Gianaurelio Cuniberti, Jannic Wolf, Thomas Huhn, Peter Zahn, Francesca Moresco, Sibylle Gemming
Summary: The electronic and geometrical structure of PEEB molecules adsorbed on an Au(111) surface was studied, showing physisorption with minimal distortion of the molecular geometry and negligible charge transfer between the molecule and substrate.
Article
Multidisciplinary Sciences
Lokamani, Jeffrey Kelling, Robin Ohmann, Joerg Meyer, Tim Kuehne, Gianaurelio Cuniberti, Jannic Wolf, Guido Juckeland, Thomas Huhn, Peter Zahn, Francesca Moresco, Sibylle Gemming
Summary: Due to the low corrugation of the Au(111) surface, PEEB molecules can form quasi interlocked lateral patterns, which can potentially be exploited to form one-dimensional molecular wires on Au(111) based on the analysis of energy function selecting specific optimal patterns.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Organic
Johannes Bayer, Thomas Huhn
Summary: The regioselective functionalization of the bowl-shaped Idpc is crucial for the synthesis of hetero-bis-functionalized Idpc derivatives. By positioning halogen and methyl groups at specific positions in the rim area of Idpc, either through consecutive CuAAC and C-C cross-coupling reactions or by C-C cross-coupling alone, symmetric or non-symmetric bis-functionalized Idpc derivatives can be obtained.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Tiankun Zhao, Peng Wang, Nan Liu, Wenzhuo Zhao, Mingjun Yang, Shanjia Li, Zhongduo Yang, Bolu Sun, Thomas Huhn
Summary: Four novel Hf(IV) complexes stabilized by 2,6-dipicolinic acid (Dipic) were synthesized and characterized. These complexes demonstrated good stability in aqueous media and on silica gel. Among them, [L1-2Hf(IV)Dipic4-Cl] showed excellent anti-tumoral activity comparable to cisplatin.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2023)
Article
Chemistry, Physical
S. Snegir, Y. J. Dappe, D. Sysoiev, O. Pluchery, T. Huhn, E. Scheer
Summary: The study explores the formation of SAMs of a TATA platform on Au(111) through scanning tunneling microscopy (STM), providing insights into the localization of BF4 counterions and the stability of TATA-BF4 physisorbed on the surface influenced by the gold lattice and electric field of the STM tip.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2021)
Article
Biochemistry & Molecular Biology
Dmytro Sysoiev, Thomas Huhn
PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES
(2020)
Review
Chemistry, Multidisciplinary
Dan He, Yawen Li, Fuwen Zhao, Yuze Lin
Summary: High trap density in organic solar cells leads to localized charge carriers and reduced carrier lifetime, limiting device efficiency. This feature article summarizes the recent advances of trap suppression by material design and device engineering.
CHEMICAL COMMUNICATIONS
(2024)
Review
Chemistry, Multidisciplinary
Olivier Monfort, Arshitha Madhusudhan, Martin Motola
Summary: This article presents the advantages of coupling photocatalysis and Fenton-based processes for environmental remediation and discusses their synergy. It critically examines the simultaneous triggering of these two processes and provides insights into research approaches. The study aims to enhance understanding of this complex process and highlight the potential integration of new catalysts in current wastewater treatment technology.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Manideepa Dhar, Chittaranjan Mishra, Avijit Das, Uttam Manna
Summary: An approach of 'polymerization of monomers in its aggregated form' has been introduced to tailor the water wettability of fibrous and porous substrates, achieving hydrophobicity to superhydrophobicity transition, as well as patterned wettability. This facile chemical method provides a durable coating with adjustable and patterned wettability for various potential applications.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Saswat Ranjan Bhoi, Chhanda Debnath, Shikha Gandhi
Summary: In this article, a novel catalytic reaction using Pd(0) and Bronsted acid is reported for the synthesis of biologically important imidazolidinone-fused N-heterocycles through redox-neutral intramolecular N-allylation of indoles and pyrroles with alkynes. This atom-economical method is applicable to a wide range of substrates and eliminates the need for leaving groups or oxidizing agents commonly used in traditional allylation reactions.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Longkun Chen, Mingshuai Zhang, Meichen Liu, Zhuoyuan Liu, Yuetong Qiu, Zhilai Zhang, Fuchao Yu, Jiuzhong Huang
Summary: In this study, an efficient Rh(III)-catalyzed selective mono- and dual-C-H bond functionalization/cyclization with iodonium ylide as the sole coupling partner was demonstrated. Fused benzodiazepine skeletons were obtained in excellent yields, providing an improved approach to dual C-H unsymmetrical functionalization.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Alice Kennett, Sven Epple, Gabriella van der Valk, Irene Georgiou, Evelyne Gout, Romain R. Vives, Angela J. Russell
Summary: This study presents the design and synthesis of sulfated disaccharide inhibitors based on IdoA(2S)-GlcNS(6S), which showed potent inhibition of Sulf-2. The results suggest that IdoA(2S)-GlcNS(6S) is the shortest fragment size required for effective inhibition of Sulfs, and a trisulfated disaccharide is identified as the minimal fragment size of heparan sulfate for effective endosulfatase inhibition.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Mauro Garbini, Andrea Brunetti, Riccardo Pedrazzani, Magda Monari, Massimo Marcaccio, Giulio Bertuzzi, Marco Bandini
Summary: The self-adaptability of galvanostatic electrolysis was found to be helpful in a multistage chemo- and diastereoselective electrochemically promoted cyclodimerization of chalcones. Through a series of reductive events, densely functionalized cyclopentanes with five contiguous stereocenters were obtained (25 examples, yields up to 95%, dr values up to >20:1). Further experimental and electrochemical investigations indicated the crucial role of dynamic kinetic resolution of the aldol intermediate in the reaction mechanism.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Dhananjay S. Nipate, Neha Meena, Prakash N. Swami, Krishnan Rangan, Anil Kumar
Summary: In this study, the synthesis of functionalized benzo[a]phenazines and indazolo[2,3-a]quinolines was achieved through Rh(III)-catalyzed oxidative annulation of 2-arylquinoxalines and 2-aryl-2H-indazoles with allyl alcohols. The method showed a wide substrate scope, excellent functional group tolerance, good to high yields of annulated products, and the capability for scaled-up synthesis. A tentative mechanism of the annulation reaction was proposed based on a preliminary mechanistic investigation.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Ruonan Zhang, Abudukadi Tudi, Xia Yang, Xuping Wang, Zhihua Yang, Shujuan Han, Shilie Pan
Summary: A new lead tellurium borate material with a unique fundamental building block [B4O10] was synthesized and found to exhibit high birefringence. The structure-property relationship was discussed using first-principles calculations.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Amresh Kumar Singh, Baishali Thakurta, Anupam Giri, Monalisa Pal
Summary: This study introduces three key concepts for the quick synthesis of large-scale high-quality 2D materials films and their utilization in device fabrication.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Reina Hagiwara, Shun Nishimura, Kosuke Okeyoshi
Summary: A copolymer-conjugated nanocatalytic system has been developed to improve electron transfer and enhance photoinduced H2 generation.
CHEMICAL COMMUNICATIONS
(2024)
