Article
Chemistry, Multidisciplinary
Lianqian Wu, Zhihan Zhang, Dunqi Wu, Fei Wang, Pinhong Chen, Zhenyang Lin, Guosheng Liu
Summary: An unprecedented highly enantioselective radical azidation of acrylamides catalyzed by 1 mol% of a copper catalyst is reported. The use of a specific ligand is crucial for generating a monomeric Cu-II azide species for this highly enantioselective transformation.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Ashley J. Basson, Mark G. McLaughlin
Summary: The transformation reported is a sustainable, modular, rapid, and high-yielding method for synthesizing densely functionalized 5-aminooxazoles and thiazoles. It is tolerant to a wide range of functional groups and is typically complete in under 30 minutes. The process is environmentally friendly due to the choice of catalyst and solvent, as well as the production of benign alcoholic by-products.
Article
Chemistry, Multidisciplinary
Lingpu Meng, Jingjie Yang, Mei Duan, You Wang, Shaolin Zhu
Summary: Regio- and enantioselective hydroarylamination, hydroalkylamination and hydroamidation of styrenes have been developed using NiH catalysis with a simple bioxazoline ligand under mild conditions. A variety of enantioenriched benzylic arylamines, alkylamines and amides can be easily accessed by employing nitroarenes, hydroxylamines and dioxazolones as amination reagents. Chiral induction in these reactions is proposed to proceed through an enantiodifferentiating syn-hydronickellation step.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Physical
Leipeng Xie, Jimin Liang, Haohao Bai, Xuanyu Liu, Xiao Meng, Yuan-Qing Xu, Zhong-Yan Cao, Chao Wang
Summary: In this paper, a ligand-controlled, directing-group-assisted strategy was reported to promote NiH-catalyzed site-selective hydroamination of unactivated alkenes. Proper bidentate nitrogen-containing ligands were used to achieve good-to-excellent regioselectivity for the synthesis of 1,1-, 1,2-, and 1,3-diamines from the same substrates. Various O-benzoylhydroxylamine electrophiles with different functional groups can be installed via Ni migration or nonmigration. These protocols provide a method for the enantioselective synthesis of valuable 1,2-diamines and 1,3-diamines.
Article
Chemistry, Physical
Jacob Werth, Matthew S. Sigman
Summary: The study utilizes multivariate linear regression analysis to investigate different categories of BOX catalyzed reactions, developing predictive models for various asymmetric catalytic reactions including Cu, Ni, Fe, Mg, and Pd complexes, and reveals the structural requirements necessary for high selectivity through analysis of diverse organometallic intermediates.
Article
Chemistry, Multidisciplinary
Faju Li, Linhong Long, Yan-Mei He, Zeyu Li, Hui Chen, Qing-Hua Fan
Summary: A unique family of chiral macrocyclic ligands with a tunable saddle-shaped cavity is described. Using their manganese(I) complexes, the first example of earth-abundant transition metal-catalyzed asymmetric formal anti-Markovnikov hydroamination of allylic alcohols was achieved, providing a practical access to synthetically important chiral gamma-amino alcohols. The study revealed the remarkable role of the macrocyclic framework in the reaction process.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Tao Qin, Guowei Lv, Qi Meng, Ge Zhang, Tao Xiong, Qian Zhang
Summary: An efficient and general radical hydroamination of alkenes has been achieved using Co(salen) as catalyst, NFSI and its analogues as both nitrogen source and oxidant. Mechanistic experiments indicate that the reaction proceeds through a metal-hydride-mediated hydrogen atom transfer and a catalyst-controlled S(N)2-like pathway. Additionally, an unprecedented asymmetric version with good to excellent enantiocontrol was accomplished using a modified chiral cobalt(II)-salen catalyst.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Applied
Agnieszka J. Nawara-Hultzsch, Anandarup Goswami, Kai C. Hultzsch
Summary: A study on the influence of solvents and additives in enantioselective hydroamination/cyclization reactions showed that weakly coordinating polar solvents can increase reaction rates, while some additives can enhance enantioselectivity in cyclization reactions but decrease selectivity in hydroamination reactions.
ADVANCED SYNTHESIS & CATALYSIS
(2023)
Article
Chemistry, Physical
Zeng Gao, Chao-Xian Yan, Jinlong Qian, Huameng Yang, Panpan Zhou, Jinlong Zhang, Gaoxi Jiang
Summary: An efficient and rapid method for constructing a family of axially chiral sulfonamides with a wide functional group tolerance has been developed through Pd-catalyzed atroposelective hydroamination. Simple oxidation and gamma-addition enabled the synthesis of various valuable axially chiral sulfonamides and anilides, including non-natural amino acid derivatives. Preliminary DFT calculations were used to explain the origin of asymmetric induction.
Article
Chemistry, Organic
Sean R. Barlow, Lily J. Callaghan, Vilius Franckevicius
Summary: The palladium-catalysed cyclisation of propargylic electrophiles with nucleophiles is a useful synthetic approach for the rapid construction of heterocyclic building blocks, but it poses challenges in controlling the chemo-, regio- and stereoselectivity simultaneously. The discovery of alpha-amido malonates as novel bis-nucleophiles in this reaction has shown high chemo- and regioselectivity, as well as moderate enantioselectivity in the formation of functionalised dihydrooxazine heterocycles, expanding the range of available heterocycles for medicinal chemists.
Article
Chemistry, Applied
Srinivasarao Yaragorla, Dandugula Sneha Latha, Pallava Rajesh
Summary: The study introduced a simple and efficient One-Pot three-component reaction using tert-propargyl alcohols, primary amines, and acyl ketones to synthesize fully substituted pyrroles and pyridine derivatives. A green calcium catalyst was employed to facilitate the formation of β-amino allene intermediate, leading to fully substituted five and six-membered azacyclic compounds through subsequent hydroamination and deacylation reactions.
ADVANCED SYNTHESIS & CATALYSIS
(2021)
Review
Chemistry, Multidisciplinary
Jorge Escorihuela, Agusti Lledos, Gregori Ujaque
Summary: Hydroamination, the addition of an N-H bond across a C-C multiple bond, is a reaction with significant synthetic potential. This review focuses on achieving anti-Markovnikov regioselectivity in intermolecular hydroaminations of terminal alkynes and alkenes. The mechanisms and factors that favor anti-Markovnikov regioselectivity are discussed, along with alternative pathways and different catalysts.
Article
Chemistry, Physical
Alexander N. Selikhov, Anton V. Cherkasov, Yulia V. Nelyubina, Alexander A. Trifonov
Summary: This article reports the synthesis and structures of two thermally stable base-free heterobimetallic benzhydryl complexes, which showed unprecedented catalytic activity and regioselectivity in intermolecular olefin hydroamination, involving a broad scope of substrates.
Article
Chemistry, Multidisciplinary
Huanran Miao, Meihui Guan, Tao Xiong, Ge Zhang, Qian Zhang
Summary: In this research, a Co-catalyzed asymmetric hydroamination reaction using commercially accessible secondary amines was developed, allowing for the efficient synthesis of alpha-chiral tertiary amines with good enantioselectivities. Mechanistic studies revealed that the reaction involves CoH-mediated hydrogen atom transfer and a pivotal catalyst-controlled S(N)2-like reaction pathway.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Physical
Uttam Chakraborty, Andrey Fedulin, Axel Jacobi Von Wangelin
Summary: In this study, a heteroleptic tri-coordinate amidoferrate with high catalytic activity in the regioselective hydrosilylation of alkenes was synthesized and reported.
Article
Chemistry, Inorganic & Nuclear
James C. Knight, Angelo J. Amoroso, Peter G. Edwards, Neha Singh, Benjamin D. Ward
DALTON TRANSACTIONS
(2016)
Article
Biochemistry & Molecular Biology
Ruchi Gaur, Diksha Kumari Choubey, Mohammad Usman, Benzamin D. Ward, Jagat Kumar Roy, Lallan Mishra
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2017)
Article
Chemistry, Inorganic & Nuclear
Lara M. Groves, Benjamin D. Ward, Paul D. Newman, Peter N. Horton, Simon J. Coles, Simon J. A. Pope
DALTON TRANSACTIONS
(2018)
Article
Chemistry, Inorganic & Nuclear
Emily E. Langdon-Jones, Benjamin D. Ward, Simon J. A. Pope
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2018)
Article
Polymer Science
Jack A. Stewart, Paul McKeown, Oliver J. Driscoll, Mary F. Mahon, Benjamin D. Ward, Matthew D. Jones
Article
Chemistry, Multidisciplinary
Jacopo Dosso, Tommaso Battisti, Benjamin D. Ward, Nicola Demitri, Colan E. Hughes, P. Andrew Williams, Kenneth D. M. Harris, Davide Bonifazi
CHEMISTRY-A EUROPEAN JOURNAL
(2020)
Article
Chemistry, Multidisciplinary
Jack Stewart, Martin Fuchs, Jack Payne, Oliver Driscoll, Gabrielle Kociok-Kohn, Benjamin D. Ward, Sonja Herres-Pawlis, Matthew D. Jones
Summary: Nine new complexes based on thioether appended iminophenolate (ONS) ligands have been synthesized and fully characterized using NMR spectroscopy. The solid-state structures and catalytic performance of these complexes in polymerization and degradation reactions have been investigated.
Article
Chemistry, Multidisciplinary
Sophie A. Fitzgerald, Xiao Xiao, Jianzhang Zhao, Peter N. Horton, Simon J. Coles, Richard C. Knighton, Benjamin D. Ward, Simon J. A. Pope
Summary: A series of 2-phenylquinoxaline ligands with CF3 or OCF3 groups were synthesized and investigated as cyclometalating reagents for platinum(II). The resulting complexes displayed efficient visible absorption and orange-red photoluminescence, which could be tuned by the ligand. The complexes also showed good upconversion efficiencies as photosensitizers for triplet-triplet annihilation energy upconversion.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Article
Environmental Sciences
Thomas Allison, Benjamin D. Ward, Michael Harbottle, Isabelle Durance
Summary: Consumer wet wipes sold as biodegradable and flushable have seen a threefold increase in market size in the last decade, reaching over $3 billion in 2022. However, research shows that these wipes, which consist mainly of cellulosic fibers, do not degrade as claimed and may have negative environmental impacts.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Polymer Science
Taylor B. Young, Owaen G. Guppy, Alysia J. Draper, Joshua M. Whitington, Benson M. Kariuki, Alison Paul, Mark Eaton, Simon J. A. Pope, Benjamin D. Ward
Summary: Polymers often lack the properties required for their intended applications. Additives such as plasticizers, flame retardants, stabilizers, and colorants are used to modify their physical properties to suit the final product. However, colorants pose challenges for recycling technologies as they cannot be removed through reprocessing. The authors have developed a method to prepare colored polymers by adding chromophore monomers to copolymerization reactions, achieving highly colored materials with minimal changes in properties from the base polymer. They have also successfully depolymerized the colored polymers and reformed them into colorless polymers, paving the way for recyclable polymers with tunable properties through the use of dopant-level monomers.
Article
Environmental Sciences
Charlotte Robison-Smith, Numair Masud, Eve C. Tarring, Benjamin D. Ward, Jo Cable
Summary: This study is the first to investigate the impacts of water-soluble polymers (WSPs) on two freshwater species, showing that these polymers can negatively affect fish growth and metabolic rate, while also exerting a certain level of harm on parasites. This suggests that the environmental leaching of WSPs may cause significant disruption to interspecies interactions within freshwater ecosystems.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Polymer Science
Matthew S. Shaw, Morgan R. Bates, Matthew D. Jones, Benjamin D. Ward
Summary: The ring-opening co-polymerisation of epoxides and cyclic anhydrides is a versatile route to new polyesters. This study introduces the use of metallocene complexes as catalysts for this reaction, demonstrating their effectiveness in the preparation of bio-derived recyclable polymers.
Article
Chemistry, Inorganic & Nuclear
Sandeep Kaler, Paul McKeown, Benjamin D. Ward, Matthew D. Jones
Summary: A series of photoactive Schiff base ligands with azobenzene moieties, as well as seven Al(iii) and Zn(ii) complexes, were investigated for their ability to undergo trans-cis isomerisation upon exposure to UV light. The activity of the Al(iii) complexes' isomers displayed marked differences in the ring-opening polymerisation (ROP) of epsilon-caprolactone.
INORGANIC CHEMISTRY FRONTIERS
(2021)
Article
Chemistry, Multidisciplinary
Mohammed A. Bahili, Emily C. Stokes, Robert C. Amesbury, Darren M. C. Ould, Bashar Christo, Rhian J. Horne, Benson M. Kariuki, Jack A. Stewart, Rebekah L. Taylor, P. Andrew Williams, Matthew D. Jones, Kenneth D. M. Harris, Benjamin D. Ward
CHEMICAL COMMUNICATIONS
(2019)
Article
Chemistry, Inorganic & Nuclear
Lara M. Groves, Catrin F. Williams, Anthony J. Hayes, Benjamin D. Ward, Marc D. Isaacs, Nadine O. Symonds, David Lloyd, Peter N. Horton, Simon J. Coles, Simon J. A. Pope
DALTON TRANSACTIONS
(2019)
Review
Chemistry, Multidisciplinary
Dan He, Yawen Li, Fuwen Zhao, Yuze Lin
Summary: High trap density in organic solar cells leads to localized charge carriers and reduced carrier lifetime, limiting device efficiency. This feature article summarizes the recent advances of trap suppression by material design and device engineering.
CHEMICAL COMMUNICATIONS
(2024)
Review
Chemistry, Multidisciplinary
Olivier Monfort, Arshitha Madhusudhan, Martin Motola
Summary: This article presents the advantages of coupling photocatalysis and Fenton-based processes for environmental remediation and discusses their synergy. It critically examines the simultaneous triggering of these two processes and provides insights into research approaches. The study aims to enhance understanding of this complex process and highlight the potential integration of new catalysts in current wastewater treatment technology.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Manideepa Dhar, Chittaranjan Mishra, Avijit Das, Uttam Manna
Summary: An approach of 'polymerization of monomers in its aggregated form' has been introduced to tailor the water wettability of fibrous and porous substrates, achieving hydrophobicity to superhydrophobicity transition, as well as patterned wettability. This facile chemical method provides a durable coating with adjustable and patterned wettability for various potential applications.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Saswat Ranjan Bhoi, Chhanda Debnath, Shikha Gandhi
Summary: In this article, a novel catalytic reaction using Pd(0) and Bronsted acid is reported for the synthesis of biologically important imidazolidinone-fused N-heterocycles through redox-neutral intramolecular N-allylation of indoles and pyrroles with alkynes. This atom-economical method is applicable to a wide range of substrates and eliminates the need for leaving groups or oxidizing agents commonly used in traditional allylation reactions.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Longkun Chen, Mingshuai Zhang, Meichen Liu, Zhuoyuan Liu, Yuetong Qiu, Zhilai Zhang, Fuchao Yu, Jiuzhong Huang
Summary: In this study, an efficient Rh(III)-catalyzed selective mono- and dual-C-H bond functionalization/cyclization with iodonium ylide as the sole coupling partner was demonstrated. Fused benzodiazepine skeletons were obtained in excellent yields, providing an improved approach to dual C-H unsymmetrical functionalization.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Alice Kennett, Sven Epple, Gabriella van der Valk, Irene Georgiou, Evelyne Gout, Romain R. Vives, Angela J. Russell
Summary: This study presents the design and synthesis of sulfated disaccharide inhibitors based on IdoA(2S)-GlcNS(6S), which showed potent inhibition of Sulf-2. The results suggest that IdoA(2S)-GlcNS(6S) is the shortest fragment size required for effective inhibition of Sulfs, and a trisulfated disaccharide is identified as the minimal fragment size of heparan sulfate for effective endosulfatase inhibition.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Mauro Garbini, Andrea Brunetti, Riccardo Pedrazzani, Magda Monari, Massimo Marcaccio, Giulio Bertuzzi, Marco Bandini
Summary: The self-adaptability of galvanostatic electrolysis was found to be helpful in a multistage chemo- and diastereoselective electrochemically promoted cyclodimerization of chalcones. Through a series of reductive events, densely functionalized cyclopentanes with five contiguous stereocenters were obtained (25 examples, yields up to 95%, dr values up to >20:1). Further experimental and electrochemical investigations indicated the crucial role of dynamic kinetic resolution of the aldol intermediate in the reaction mechanism.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Dhananjay S. Nipate, Neha Meena, Prakash N. Swami, Krishnan Rangan, Anil Kumar
Summary: In this study, the synthesis of functionalized benzo[a]phenazines and indazolo[2,3-a]quinolines was achieved through Rh(III)-catalyzed oxidative annulation of 2-arylquinoxalines and 2-aryl-2H-indazoles with allyl alcohols. The method showed a wide substrate scope, excellent functional group tolerance, good to high yields of annulated products, and the capability for scaled-up synthesis. A tentative mechanism of the annulation reaction was proposed based on a preliminary mechanistic investigation.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Ruonan Zhang, Abudukadi Tudi, Xia Yang, Xuping Wang, Zhihua Yang, Shujuan Han, Shilie Pan
Summary: A new lead tellurium borate material with a unique fundamental building block [B4O10] was synthesized and found to exhibit high birefringence. The structure-property relationship was discussed using first-principles calculations.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Amresh Kumar Singh, Baishali Thakurta, Anupam Giri, Monalisa Pal
Summary: This study introduces three key concepts for the quick synthesis of large-scale high-quality 2D materials films and their utilization in device fabrication.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Reina Hagiwara, Shun Nishimura, Kosuke Okeyoshi
Summary: A copolymer-conjugated nanocatalytic system has been developed to improve electron transfer and enhance photoinduced H2 generation.
CHEMICAL COMMUNICATIONS
(2024)