Article
Biochemistry & Molecular Biology
Sujeung Lim, Dmitri Leo M. Cordova, Alicia S. Robang, Yuyao Kuang, Kaleolani S. Ogura, Anant K. Paravastu, Maxx Q. Arguilla, Herdeline Ann M. Ardona
Summary: This study investigates the influence of charged peptide interactions on the thermochromicity of amphiphilic PDAs. The research reveals that oppositely charged peptide-PDA samples show distinct degrees of structural order, with the coassembled sample being in between the positive and negative peptide-PDA. It is also found that only coassemblies with electrostatic complementarity can stabilize coexisting blue and red PDA phases.
Article
Chemistry, Multidisciplinary
Gizem Beliktay, Tayyaba Shaikh, Emirhan Koca, Hande E. Cingil
Summary: In this study, a reversible colorimetric response of polydiacetylenes to pH change was achieved through structural modifications on the monomer and extended photopolymerization time. Enhanced hydrogen bond forming headgroups and longer UV exposure reduced the response efficiency but enabled reversibility. This research provides a possibility for customized sensing applications.
Article
Materials Science, Textiles
Ali Akbar Merati, Mohammad Hossein Moghimian, Maryam Yousefzadeh, Najmeh Moazeni
Summary: This study investigates the thermo-chromic reversibility of three component composite nanofibers produced by combining polyvinylidene fluoride (PVDF), 10,12-pentacosadinoic acid (PDA), and zinc oxide (ZnO) nanoparticles. The addition of ZnO nanoparticles increases the stability of the nanofiber structure against heat and chromic change. The best thermo-chromic reversibility is achieved with a sample containing 3% ZnO nanoparticles.
JOURNAL OF THE TEXTILE INSTITUTE
(2023)
Article
Chemistry, Physical
Angie Davina Tjandra, Andy-Hoai Pham, Rona Chandrawati
Summary: Volatile organic compound (VOC) detection has expanded to food quality control and disease diagnosis. Polydiacetylenes (PDAs) as colorimetric sensors have unique properties and are extensively studied. This Perspective provides an overview of PDA-based VOC detection systems and identifies areas for improvement in future research and considerations for device fabrication.
CHEMISTRY OF MATERIALS
(2022)
Article
Biophysics
Changheon Kim, Changgi Hong, Kangwon Lee
Summary: Polydiacetylene (PDA) is a versatile polymer with unique optical properties, allowing for color transitions and fluorescence emission under external stimuli, making it widely studied and applied in sensing applications.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Polymer Science
Wenwen Liu, Chanjuan Zeng, Fangqing Ge, Yunjie Yin, Chaoxia Wang
Summary: The novel functionalized poly(silanization alcoholamine diacetylene)/silica nanoparticles have achieved reversible thermochromism, transitioning from blue to red at specific temperatures, and returning to bluish violet after cooling. The strategy of extending the alkyl chain length with covalent bonding promotes interaction between alkyl chains, improving the reversibility of thermochromic polydiacetylene.
JOURNAL OF APPLIED POLYMER SCIENCE
(2021)
Article
Chemistry, Multidisciplinary
Hande E. Cingil, Gizem Beliktay, Eric M. M. Tan
Summary: Polydiacetylene(PDA) supramolecules exhibit a conformation-dependent colorimetric response to external triggers, transitioning from the blue phase to the red phase. The study shows that PDA vesicles prepared at an intermediate purple phase exhibit a more sensitive colorimetric response to external triggers compared to those prepared at the blue phase. The supramolecular interactions, including inter- and intra-chain interactions, play a crucial role in causing chain distortions and structural rearrangements of the PDA backbone, in addition to repulsive-ionic head group interactions.
MATERIALS CHEMISTRY FRONTIERS
(2023)
Review
Chemistry, Multidisciplinary
Bratati Das, Seiko Jo, Jianlu Zheng, Jiali Chen, Kaori Sugihara
Summary: This mini review summarizes recent progress in PDA mechanochromism, with a special focus on the quantitative and nanoscopic data that have emerged in recent years.
Article
Chemistry, Physical
Qingtao Zeng, Xuejun Lai, Hongqiang Li, Zhonghua Chen, Xingrong Zeng, Liqun Zhang
Summary: In this study, a high-efficiency and high-safety wood-based self-protection electrolyte (DW@SPE) was fabricated via vacuum soaking. It demonstrated excellent electrochemical performance and thermal response, with the capability of smart thermal-shutdown self-protection and accurate temperature-sensing fire-warning. It also showed outstanding flame retardancy.
JOURNAL OF MATERIALS CHEMISTRY A
(2023)
Article
Chemistry, Multidisciplinary
Xin Tao, Dongqing Liu, Tianwen Liu, Zhen Meng, Jinshan Yu, Haifeng Cheng
Summary: This research demonstrates a variable infrared emissivity device based on reversible silver electrodeposition (RSE) with excellent bistability of 24 hours. By using a silver layer fixed at the counter electrode as the charge mediator, bistability is achieved and the key factors affecting the bistability, such as electrolyte composition and driving voltage, are studied. The device can be scaled up and display discontinuous thermal patterns. This study is of great significance for dynamic infrared information display, adaptive infrared camouflage, and smart thermal management.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Materials Science, Multidisciplinary
Xiaojie Huang, Jie Ji, Guangyao Li, Guang Yang, Juan Hou
Summary: This article investigates the colorimetric behavior of fluorescein-substituted polydiacetylene (FPDA) in aqueous and solid films, revealing its reversible thermochromic and near-infrared light-responsive properties. The quantitative analysis of temperature in both solutions and solid films is also discussed. The authors' findings may contribute to the expansion of potential applications of PDA-based materials in sensors, display materials, photodetectors, and anticounterfeiting barcode systems.
ACS APPLIED POLYMER MATERIALS
(2022)
Article
Polymer Science
Nasim Afsari, Niloofar Eslahi, Mehdi Varsei, Hajar Ghanbari
Summary: This study aims to produce smart nanocomposite fibers for potential sensing applications using the electrospinning method. Polyvinylpyrrolidone (PVP) and polydiacetylene (PDA) solutions at varying ratios are electrospun, and graphene oxide (GO) is added to enhance the mechanical properties and sensitivity of the fibers. The incorporation of GO leads to a decrease in average fiber diameter and the colorimetric behavior of the fibers changes with temperature and pH, making them potential candidates as sensors.
JOURNAL OF APPLIED POLYMER SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Wenjie Dong, Renzhe Zhang, Guanhua Lin
Summary: By rationally designing a new l-Glu-derivatized diacetylene monomer to enhance hydrogen-bonding interactions and developing a method to fabricate PDA-Glu/PDMS films, researchers achieved excellent reversible thermochromism property. The formation of network structures in the film provided sufficient recovery force and free space for the structures to reversibly vary with temperature, endowing the film with not only reversible thermochromism property, but also good thermal stability and mechanical property. This research opens up a new pathway to improving material performance and introducing novel properties by modifying monomers at the molecular level.
MATERIALS CHEMISTRY FRONTIERS
(2021)
Article
Chemistry, Analytical
Hyunjeong Shin, Fadilatul Jannah, Eun Jin Yoo, Jong-Man Kim
Summary: This study describes a colorimetric and fluorescence turn-on sensor based on PDA-Im for the detection of Fe(III) ions. The PDA-Im sensor exhibits a blue-to-red color change and red fluorescence turn-on response to Fe(III) ions.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Materials Science, Multidisciplinary
X. K. Zhang, J. Y. Li, J. C. Lin, P. Tong, M. Wang, X. L. Wang, H. Y. Tong, Y. S. Zhang, W. H. Song, Y. P. Sun
Summary: The study reported a sharp change in thermal conductivity in hexagonal sulfides Ni1-xFexS bonded with silver, with up to 200% increase within a 40K temperature interval, surpassing other materials. The addition of silver improved the machinability and thermal cycling stability of Ni1-xFexS, presenting a promising material for thermal management applications.
Article
Biochemistry & Molecular Biology
Elisabetta Rosa, Lucas de Mello, Valeria Castelletto, Mark L. Dallas, Antonella Accardo, Jani Seitsonen, Ian W. Hamley
Summary: This study investigates the conformation and self-assembly behavior of four lipopeptides, and examines their potential applications in tissue engineering based on cytocompatibility assessments. The results show that all four lipopeptides can self-assemble into nanostructures at specific concentrations. Furthermore, these lipopeptides demonstrate promising prospects in tissue engineering.
Article
Biophysics
Francesca Torrini, Giada Goletta, Pasquale Palladino, Simona Scarano, Maria Minunni
Summary: Polycatecholamines (pCAs)-based molecularly imprinted polymers (MIPs) are a new generation of biocompatible ligand/receptor mimetics. Lysine (K) residues were found to effectively trigger the epitope imprinting process into a polynorepinephrine (PNE) matrix. Utilizing the N-3K tag strategy, excellent sensitivity (0.31 +/- 0.04 ng mL-1) and repeatability (avCV% = 4.5) were achieved in human serum samples. This strategy provides new insights for epitope design and tagging when native epitopes have low imprinting capabilities.
BIOSENSORS & BIOELECTRONICS
(2023)
Review
Nanoscience & Nanotechnology
Ian W. Hamley
Summary: This review focuses on the self-assembly, structural and functional properties of peptide conjugates containing bulky terminal aromatic substituents, with a particular emphasis on bioactivity. The driving force for self-assembly comes from pi-stacking and hydrophobic interactions, as well as hydrogen bonding, electrostatics, and other forces between short peptides. The balance of these interactions leads to a propensity for self-assembly, even for single amino acid conjugates. The resulting molecules often form hydrogels built from beta-sheet fibrils, with applications in biomaterials, drug delivery, catalysis, and optoelectronics.
ACS APPLIED BIO MATERIALS
(2023)
Article
Chemistry, Analytical
Francesca Torrini, Simona Scarano, Pasquale Palladino, Maria Minunni
Summary: In the past two decades, there has been a significant shift in bioanalytical approaches towards simpler, on-site techniques with faster analysis times and reduced costs. Along with this, the production of affinity reagents has advanced from natural receptors to biomimetic and abiotic receptors, including aptamers and molecular imprinted polymers (MIPs). This article aims to provide insights into the evolution of conventional and innovative analytical approaches for peptide hormones using chromatography, immunochemistry, and affinity sensing. The analysis of peptide hormones, exemplified by gonadorelin, presents a current challenge in biomedical, pharmaceutical, and anti-doping analysis due to its misuse in sports competitions.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2023)
Article
Chemistry, Multidisciplinary
Valeria Castelletto, Jani Seitsonen, Ian W. W. Hamley
Summary: This study investigates the self-assembly behavior of two monodisperse lipid A derivatives based on bacterial LPS structures in water and compares them to native Escherichia coli LPS using small-angle X-ray scattering and cryogenic transmission electron microscopy. The critical aggregation concentration and conformation are characterized using fluorescence probe experiments and circular dichroism spectroscopy, respectively. The E. coli LPS forms wormlike micelles, while the synthetic analogues self-assemble into nanosheets or vesicles depending on the number of lipid chains and saccharide head groups. These findings can be rationalized based on the surfactant packing parameter.
Article
Chemistry, Multidisciplinary
Biswanath Hansda, Jhilam Majumder, Biplab Mondal, Akash Chatterjee, Subhadeep Das, Sourav Kumar, Ratan Gachhui, Valeria Castelletto, Ian W. Hamley, Prosenjit Sen, Arindam Banerjee
Summary: A histidine-based amphiphilic peptide (P) was discovered to form an injectable transparent hydrogel with inherent antibacterial property in phosphate buffer solution. The peptide self-assembles into a nanofibrillar network structure and exhibits efficient antibacterial activity against both Gram-positive and Gram-negative bacteria. The hydrogel can also encapsulate and selectively release drugs, making it a potential antibacterial and drug delivering agent.
Article
Chemistry, Analytical
Mariagrazia Lettieri, Michele Spinelli, Laura Caponi, Simona Scarano, Pasquale Palladino, Angela Amoresano, Maria Minunni
Summary: We developed a simple colorimetric assay for catecholamine detection in human urine, demonstrating the time-dependent formation and molecular weight of melanochrome (MC) and 5,6-indolequinone (IQ) derived from levodopa (LD), dopamine (DA), and norepinephrine (NE) oxidation. This assay can quantitatively detect LD and DA in urine, showing potential applicability in therapeutic drug monitoring and clinical chemistry.
Article
Chemistry, Analytical
Mariagrazia Lettieri, Simona Scarano, Laura Caponi, Andrea Bertolini, Alessandro Saba, Pasquale Palladino, Maria Minunni
Summary: We developed a simple and low-cost assay for copper in urine using a serotonin-derived fluorophore. The assay showed good reproducibility and low detection limits in buffer and artificial urine, and demonstrated excellent analytical performances in human urine samples. This is the first example of copper ion detection exploiting the fluorescence quenching of a biopolymer, offering a potential diagnostic tool for copper-dependent diseases.
Article
Chemistry, Analytical
Francesca Torrini, Federica Battaglia, Davide Sestaioni, Pasquale Palladino, Simona Scarano, Maria Minunni
Summary: Immunotherapy plays a crucial role in modern medicine and is the largest component of the bio-drugs market. There is a pressing need for reliable monitoring methods for monoclonal antibodies (mAbs) in this field. This study proposes a straightforward approach using magnetic beads combined with a specific biopolymer for real-time mAbs detection in biological samples. The optimized assay showed excellent analytical performance in terms of repeatability and sensitivity.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Biochemistry & Molecular Biology
Valeria Castelletto, Lucas de Mello, Emerson Rodrigo da Silva, Jani Seitsonen, Ian W. Hamley
Summary: Considerable interest has been shown in peptides with the Fmoc protecting group, as it can promote self-assembly and has applications in cell culture biomaterials. New amino acid analogues with the Smoc protecting group have been developed for water-based peptide synthesis. Self-assembly of Smoc-Ala, Smoc-Phe, and Smoc-Arg occurs above the critical aggregation concentration (CAC) and forms nanosheet, nanoribbon, or nanotube structures. Smoc-amino acids show excellent biocompatibility and are taken up by fibroblast cells without cytotoxicity.
Article
Chemistry, Physical
Thiago C. Lourenco, Lucas R. de Mello, Marcelo Y. Icimoto, Renata N. Bicev, Ian W. Hamley, Valeria Castelletto, Clovis R. Nakaie, Emerson R. da Silva
Summary: This study presents a strategy for fabricating highly ordered 1D nanostructures of Bradykinin (BK) using DNA fragments as a template for self-assembly. The nanoscale structure of BK-DNA complexes was revealed, showing the formation of ordered nanofibrils. The complexes retained the native bioactivity of BK and could induce a limited uptake of nucleotides by HEK-293t cells, which has not been previously reported.
Article
Chemistry, Physical
Elisabetta Rosa, Carlo Diaferia, Lucas De Mello, Jani Seitsonen, Ian W. Hamley, Antonella Accardo
Summary: Short and ultra-short peptides are now being used as building blocks for self-assembled materials, with peptide aggregation being influenced by the amino acids in the sequence as well as their ability to interact with each other. By modifying peptides with polymeric moieties, alkyl chains, or other organic molecules, further structural and functional properties can be achieved. In this study, we synthesized and investigated the aggregation behavior of peptide amphiphiles (PAs) containing cationic tetra- or hexa-peptides derivatized with an alkyl chain. These PAs were able to form highly ordered nanostructures and biocompatible hydrogels, showing potential for tissue engineering and diagnostic applications.
Article
Chemistry, Physical
Jinghua Liu, Jingqing Li, Binyuan Liu, Ian W. Hamley, Shichun Jiang
Summary: The Mpemba effect and its inverse can be explained by nonequilibrium thermodynamics. While changes of state in polymers are generally non-equilibrium processes, the Mpemba effect is rarely seen in their crystallization. Polybutene-1 (PB-1) has the lowest critical cooling rate among polyolefins and tends to maintain its original structure and properties in the melt. Experimental observations confirm the presence of the Mpemba effect in both the crystallization of PB-1 in form II and form I obtained at low melting temperatures.
Article
Chemistry, Analytical
Pasquale Palladino, Alberto Rainetti, Mariagrazia Lettieri, Giuseppe Pieraccini, Simona Scarano, Maria Minunni
Summary: This study reports a simple and inexpensive colorimetric method for quantifying carbidopa in anti-Parkinson drugs. The method is based on the condensation reaction between the hydrazine group from carbidopa and selected aldehydes in acidified hydroalcoholic solution. The results obtained by LC-MS analysis confirm the reliability of the method. The use of indole-3-carbaldehyde as a selective reagent provides better analytical performance compared to previous methods based on vanillin.
Article
Chemistry, Physical
Biswanath Hansda, Biplab Mondal, Soumyajit Hazra, Krishna Sundar Das, Valeria Castelletto, Ian W. Hamley, Arindam Banerjee
Summary: Peptide-based multicomponent hydrogels offer tunable mechanical properties and physical characteristics, demonstrating good cell compatibility and sustained drug release capabilities, and have the potential to serve as scaffold materials for tissue engineering.
Review
Chemistry, Multidisciplinary
Dan He, Yawen Li, Fuwen Zhao, Yuze Lin
Summary: High trap density in organic solar cells leads to localized charge carriers and reduced carrier lifetime, limiting device efficiency. This feature article summarizes the recent advances of trap suppression by material design and device engineering.
CHEMICAL COMMUNICATIONS
(2024)
Review
Chemistry, Multidisciplinary
Olivier Monfort, Arshitha Madhusudhan, Martin Motola
Summary: This article presents the advantages of coupling photocatalysis and Fenton-based processes for environmental remediation and discusses their synergy. It critically examines the simultaneous triggering of these two processes and provides insights into research approaches. The study aims to enhance understanding of this complex process and highlight the potential integration of new catalysts in current wastewater treatment technology.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Manideepa Dhar, Chittaranjan Mishra, Avijit Das, Uttam Manna
Summary: An approach of 'polymerization of monomers in its aggregated form' has been introduced to tailor the water wettability of fibrous and porous substrates, achieving hydrophobicity to superhydrophobicity transition, as well as patterned wettability. This facile chemical method provides a durable coating with adjustable and patterned wettability for various potential applications.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Saswat Ranjan Bhoi, Chhanda Debnath, Shikha Gandhi
Summary: In this article, a novel catalytic reaction using Pd(0) and Bronsted acid is reported for the synthesis of biologically important imidazolidinone-fused N-heterocycles through redox-neutral intramolecular N-allylation of indoles and pyrroles with alkynes. This atom-economical method is applicable to a wide range of substrates and eliminates the need for leaving groups or oxidizing agents commonly used in traditional allylation reactions.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Longkun Chen, Mingshuai Zhang, Meichen Liu, Zhuoyuan Liu, Yuetong Qiu, Zhilai Zhang, Fuchao Yu, Jiuzhong Huang
Summary: In this study, an efficient Rh(III)-catalyzed selective mono- and dual-C-H bond functionalization/cyclization with iodonium ylide as the sole coupling partner was demonstrated. Fused benzodiazepine skeletons were obtained in excellent yields, providing an improved approach to dual C-H unsymmetrical functionalization.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Alice Kennett, Sven Epple, Gabriella van der Valk, Irene Georgiou, Evelyne Gout, Romain R. Vives, Angela J. Russell
Summary: This study presents the design and synthesis of sulfated disaccharide inhibitors based on IdoA(2S)-GlcNS(6S), which showed potent inhibition of Sulf-2. The results suggest that IdoA(2S)-GlcNS(6S) is the shortest fragment size required for effective inhibition of Sulfs, and a trisulfated disaccharide is identified as the minimal fragment size of heparan sulfate for effective endosulfatase inhibition.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Mauro Garbini, Andrea Brunetti, Riccardo Pedrazzani, Magda Monari, Massimo Marcaccio, Giulio Bertuzzi, Marco Bandini
Summary: The self-adaptability of galvanostatic electrolysis was found to be helpful in a multistage chemo- and diastereoselective electrochemically promoted cyclodimerization of chalcones. Through a series of reductive events, densely functionalized cyclopentanes with five contiguous stereocenters were obtained (25 examples, yields up to 95%, dr values up to >20:1). Further experimental and electrochemical investigations indicated the crucial role of dynamic kinetic resolution of the aldol intermediate in the reaction mechanism.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Dhananjay S. Nipate, Neha Meena, Prakash N. Swami, Krishnan Rangan, Anil Kumar
Summary: In this study, the synthesis of functionalized benzo[a]phenazines and indazolo[2,3-a]quinolines was achieved through Rh(III)-catalyzed oxidative annulation of 2-arylquinoxalines and 2-aryl-2H-indazoles with allyl alcohols. The method showed a wide substrate scope, excellent functional group tolerance, good to high yields of annulated products, and the capability for scaled-up synthesis. A tentative mechanism of the annulation reaction was proposed based on a preliminary mechanistic investigation.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Ruonan Zhang, Abudukadi Tudi, Xia Yang, Xuping Wang, Zhihua Yang, Shujuan Han, Shilie Pan
Summary: A new lead tellurium borate material with a unique fundamental building block [B4O10] was synthesized and found to exhibit high birefringence. The structure-property relationship was discussed using first-principles calculations.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Amresh Kumar Singh, Baishali Thakurta, Anupam Giri, Monalisa Pal
Summary: This study introduces three key concepts for the quick synthesis of large-scale high-quality 2D materials films and their utilization in device fabrication.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Reina Hagiwara, Shun Nishimura, Kosuke Okeyoshi
Summary: A copolymer-conjugated nanocatalytic system has been developed to improve electron transfer and enhance photoinduced H2 generation.
CHEMICAL COMMUNICATIONS
(2024)
