Article
Polymer Science
Keisuke Hayashi, Arihiro Kanazawa, Sadahito Aoshima
Summary: The cationic copolymerization ofo-phthalaldehyde with various styrene derivatives and vinyl ethers was investigated, with a focus on the relationship between the structure and reactivity of vinyl monomers and the copolymerization behavior. The existence of alpha or beta-substituents on the vinyl group was found to be essential for efficient crossover reactions with styrene derivatives, while various vinyl ethers underwent copolymerization with o-phthalaldehyde. The use of vinyl monomers with both large steric hindrance and highly reactive beta-carbon was effective in achieving an alternating-like copolymerization. Additionally, degradable copolymers were successfully obtained from styrene derivatives.
Article
Polymer Science
Atsushi Sawamoto, Shin-nosuke Nishimura, Nobuyuki Higashi, Tomoyuki Koga
Summary: Controlling the thermoresponsive behavior of bio-based synthetic polymers is crucial for the development of smart functional materials. The synthesis of amino acid-derived vinyl polymers with different hydropathies and their thermal responses in water are reported, providing important insights for the precise design of stimuli-responsive bio-based polymers.
Article
Polymer Science
Nethmi De Alwis Watuthanthrige, M. A. Sachini N. Weerasinghe, Zachery Oestreicher, Dominik Konkolewicz
Summary: The photodegradation of polymer materials is a promising solution for plastic waste management. However, the degradation of phenyl vinyl ketone (PVK) polymer materials under simulated sunlight conditions can adversely affect their lifespan in practical applications. This study introduces a novel approach to control the degradation of PVK materials by incorporating a secondary network based on poly(ethyl acrylate) in the polymer matrix, enabling controlled photodegradation while manipulating the material's mechanical properties.
Article
Polymer Science
Hamin Kim, Raita Goseki, Chihiro Homma, Takashi Ishizone
Summary: In this study, the anionic polymerization of AB-type difunctional monomers derived from 4-vinyl-1,1-diphenylethylene (VD) was examined using Ph2CHK as the catalyst. The polymerizability of VD was modified by introducing different substituents at the 4'-position of the VD framework. The results showed that the substituents had an influence on the morphology and sequence of the resulting polymer. Through H-1 and C-13 NMR measurements and MALDI-TOF-MS analysis, it was found that ClVD, MeVD, and MeOVD underwent self-alternating polymerization, while Me2NVD formed a homopolymer.
Article
Polymer Science
Nikoletta Roka, Olga Kokkorogianni, Philippos Kontoes-Georgoudakis, Ioannis Choinopoulos, Marinos Pitsikalis
Summary: Recent advances in the controlled RAFT polymerization of complex macromolecular architectures based on PNVP are summarized in this review, with a focus on the synthesis of statistical copolymers, block copolymers, star polymers and copolymers, graft copolymers, and more complex architectures. The advantages and limitations of the synthetic methodologies are discussed in detail.
Article
Chemistry, Multidisciplinary
Keita Kuroda, Makoto Ouchi
Summary: This study reveals the peculiar isomerization propagation of benzyl vinyl ether with an electron-deficient acrylate in radical copolymerization. The backward isomerization of the radical species leads to a periodic consumption and allows the introduction of a benzyl ether structure in the resulting copolymer, leading to efficient degradation under acid conditions.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Yuanqing Song, Chuandong Sun, Chenxu Tian, Hao Ming, Yanjun Wang, Wenkai Liu, Nan He, Xueling He, Mingming Ding, Jiehua Li, Feng Luo, Hong Tan, Qiang Fu
Summary: This study reports the precise synthesis of polyurethanes (PUs) with desired molecular weight, narrow molecular weight distribution, and controlled block sequences from commercially available monomers. The study also shows that the sequence order of functional segments in PUs affects the self-assembly behavior of nanocarriers and has an impact on protein absorption, cell internalization, biodistribution, and antitumor effect. These findings provide a versatile platform for the development of precise multiblock PUs and facilitate the clinical translation of PUs in biomedicine.
Article
Polymer Science
Hao Zhang, Zhou Zhou, Xiaofan Chen, Bo Yu, Zhenyang Luo, Xiang Li, Md Anisur Rahman, Ye Sha
Summary: Sequence-controlled organometallic polymers with side-chain metal functions such as ferrocene and ruthenocene have been prepared through regioselective ring-opening metathesis polymerization (ROMP). The properties of these polymers can be finely tailored by the metallocene sequence along the polymer chain, providing fundamental understanding of the structure-property relationship. This highly efficient chain-growth polymerization is expected to incorporate a variety of metal moieties into a single organometallic polymer for potential applications in electrochemical sensing, information processing, and magnetic materials.
Article
Chemistry, Multidisciplinary
Changjiu Sun, Yuanzhi Jiang, Li Zhang, Keyu Wei, Mingjian Yuan
Summary: Lead halide perovskite nanocrystals (LHP NCs) have great potential in optical sources, photovoltaics, and sensor fields. This Perspective summarizes representative attempts to achieve controlled synthesis of LHP NCs. By changing the synthesis method, LHP NCs with kinetic dominance and size tunability can be obtained. Undesired ripening effects can be eliminated, and homogeneous size distribution can be achieved through rational ligand selection and solvent engineering.
Article
Chemistry, Organic
Pan Gao, Qingzheng Zhang, Feng Chen
Summary: A new protocol for vinyl sulfide synthesis has been developed using an alkoxy base without the need for metal catalysts. This method allows for the conversion of aryl and alkenyl sulfonium triflates with various functionalities into vinyl sulfides with excellent reactivity. The reaction conditions are mild and safe, without the use of catalysts, transition metals, high-pressure gases, or high temperatures, while still maintaining efficiency.
Article
Chemistry, Multidisciplinary
Kazuki Takahata, Naoki Aizawa, Masashi Nagao, Satoshi Uchida, Raita Goseki, Takashi Ishizone
Summary: The study established a 1:1 addition reaction to regulate the sequence of vinyl compounds by enhancing the electrophilicity of DPE derivatives. By sequentially reacting two or three DPE derivatives in increasing order of their electrophilicity, well-defined sequence-controlled polystyrenes were successfully synthesized in a single reaction.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Chemistry, Applied
Paulina Varguez-Catzim, Wilberth Herrera-Kao, Rita Sulub-Sulub, Humberto Vazquez-Torres, Moises Alcaraz Calderon, Manuel Aguilar-Vega, Maria Ortencia Gonzalez-Diaz
Summary: Random copolymers of PVA and PAMPS were synthesized through free radical polymerization in water followed by alkaline hydrolysis in methanol. The copolymers exhibited higher thermal stabilities and well-correlated ion exchange capacities with the molar composition of PAMPS. They showed good solubility in water and had the ability to form dense and porous membranes, making them suitable for various polymeric membrane applications.
REACTIVE & FUNCTIONAL POLYMERS
(2023)
Article
Polymer Science
Xiaoxi Yu, Guofang Li, Bingqian Zheng, Gyusaang Youn, Ting Jiang, Suan P. Quah, Scott T. Laughlin, Nicole S. Sampson, Surita R. Bhatia
Summary: This study investigates the interfacial rheology of sequence-controlled copolymers and finds that an increase in microblock size enhances the interfacial storage modulus, thereby tuning surface and interfacial properties. The research indicates that microblock size can be utilized to control the interfacial rheology of amphiphilic copolymers, providing a new strategy for controlling the dynamics of fluid interfaces through precision sequence-controlled polymers.
MACROMOLECULAR CHEMISTRY AND PHYSICS
(2022)
Article
Polymer Science
Alessandro Angelini, Anja Car, Ionel Adrian Dinu, Luigi Leva, Wilfredo Yave
Summary: Tailor-made poly(vinyl alcohol)-b-poly(styrene) copolymers (PVA-b-PS) for separation membranes are synthesized using reversible-deactivation radical polymerization techniques. These di-block copolymers have high molecular weight (>70 kDa), high PVA content (>80 wt%), and good film-forming property. They self-assemble in aqueous media to form micelles, which when cast on a porous substrate, result in thin-film membranes with higher water permeance than that of PVA homopolymer. The PS nanodomains within the PVA matrix act as cross-linking points, eliminating the need for chemical cross-linkers and acid catalysts. Thermal annealing further enhances membrane selectivity through improved microphase separation.
MACROMOLECULAR RAPID COMMUNICATIONS
(2023)
Article
Polymer Science
Xinyi Wang, Yewon L. Jeong, Christopher Love, Holly A. Stretz, Gila E. Stein, Brian K. Long
Summary: This study explored the modification of the service window of unfunctionalized vinyl-addition polynorbornene (VAPNB) through the use of norbornene monomers bearing alkyl, aryl, and aryl ether substituents. The resulting VAPNBs exhibited high T'(g)s and large service windows, comparable to other commercial engineering thermoplastics. The feasibility of melt processing was demonstrated by successfully extruding and molding a functionalized VAPNB material, indicating potential for compatibility with traditional processing techniques and emerging technologies.
Article
Engineering, Biomedical
Xinming Tong, Fan Yang
ADVANCED HEALTHCARE MATERIALS
(2018)
Article
Cell & Tissue Engineering
Danqing Zhu, Xinming Tong, Pavin Trinh, Fan Yang
TISSUE ENGINEERING PART A
(2018)
Article
Nanoscience & Nanotechnology
Alice E. Stanton, Xinming Tong, Soah Lee, Fan Yang
ACS APPLIED MATERIALS & INTERFACES
(2019)
Article
Engineering, Biomedical
Soah Lee, Alice E. Stanton, Xinming Tong, Fan Yang
Article
Engineering, Biomedical
Alice E. Stanton, Xinming Tong, Fan Yang
ACTA BIOMATERIALIA
(2019)
Article
Engineering, Biomedical
Heather Rogan, Francisco Ilagan, Xinming Tong, Constance R. Chu, Fan Yang
Article
Engineering, Biomedical
Masaya Ueno, Chi-Wen Lo, Danial Barati, Bogdan Conrad, Tzuhua Lin, Yusuke Kohno, Takeshi Utsunomiya, Ning Zhang, Masahiro Maruyama, Claire Rhee, Ejun Huang, Monica Romero-Lopez, Xinming Tong, Zhenyu Yao, Stefan Zwingenberger, Fan Yang, Stuart B. Goodman
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2020)
Article
Materials Science, Biomaterials
Courtney Gegg, Xinming Tong, Fan Yang
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2020)
Article
Biochemistry & Molecular Biology
Matthew P. Murphy, Lauren S. Koepke, Michael T. Lopez, Xinming Tong, Thomas H. Ambrosi, Gunsagar S. Gulati, Owen Marecic, Yuting Wang, Ryan C. Ransom, Malachia Y. Hoover, Holly Steininger, Liming Zhao, Marcin P. Walkiewicz, Natalina Quarto, Benjamin Levi, Derrick C. Wan, Irving L. Weissman, Stuart B. Goodman, Fan Yang, Michael T. Longaker, Charles K. F. Chan
Article
Cell & Tissue Engineering
Elisa Liu, Danqing Zhu, Eva Gonzalez Diaz, Xinming Tong, Fan Yang
Summary: This study demonstrates the use of gradient hydrogels to optimize matrix stiffness for cartilage regeneration by different cell types, showing that MSCs prefer softer hydrogels while chondrocytes perform better on stiffer matrices. The results validate the importance of niche cues optimization for tissue regeneration and suggest the potential of using gradient hydrogels for such purposes.
TISSUE ENGINEERING PART A
(2021)
Article
Multidisciplinary Sciences
Thomas H. Ambrosi, Owen Marecic, Adrian McArdle, Rahul Sinha, Gunsagar S. Gulati, Xinming Tong, Yuting Wang, Holly M. Steininger, Malachia Y. Hoover, Lauren S. Koepke, Matthew P. Murphy, Jan Sokol, Eun Young Seo, Ruth Tevlin, Michael Lopez, Rachel E. Brewer, Shamik Mascharak, Laura Lu, Oyinkansola Ajanaku, Stephanie D. Conley, Jun Seita, Maurizio Morri, Norma F. Neff, Debashis Sahoo, Fan Yang, Irving L. Weissman, Michael T. Longaker, Charles K. F. Chan
Summary: Aging of skeletal stem cells in mice alters bone marrow signaling and differentiation of bone and blood lineages, resulting in fragile bones with poor regeneration. Aged SSCs have decreased bone-forming potential but produce more stromal lineages expressing pro-inflammatory cytokines, contributing to bone marrow niche transformation.
Article
Multidisciplinary Sciences
Tom W. Andrew, Lauren S. Koepke, Yuting Wang, Michael Lopez, Holly Steininger, Danielle Struck, Tatiana Boyko, Thomas H. Ambrosi, Xinming Tong, Yuxi Sun, Gunsagar S. Gulati, Matthew P. Murphy, Owen Marecic, Ruth Telvin, Katharina Schallmoser, Dirk Strunk, Jun Seita, Stuart B. Goodman, Fan Yang, Michael T. Longaker, George P. Yang, Charles K. F. Chan
Summary: This study investigates the regulation of bone-related sexually dimorphic traits at the stem cell level. The researchers find that estrogen signaling directly controls skeletal stem cells (SSCs) in female mice, but not in male mice. They also demonstrate that estrogen is necessary for the self-renewal and differentiation of SSCs, and suggest a potential clinical strategy for bone healing using localized estrogen hormone therapy.
NATURE COMMUNICATIONS
(2022)
Article
Engineering, Biomedical
Sauradeep Sinha, Manish Ayushman, Xinming Tong, Fan Yang
Summary: Glioblastoma multiforme (GBM) is a common and aggressive brain tumor in adults. Viscoelasticity has been identified as an important factor in regulating GBM cell fate and drug response. Using a new hydrogel system, researchers were able to manipulate stress relaxation while keeping other factors constant. The results showed that increasing stress relaxation promoted invasive behavior and enhanced proliferation and drug sensitivity in GBM. These findings provide valuable insights into the regulation of GBM cell fate and the importance of incorporating viscoelasticity into 3D in vitro models.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Medicine, Research & Experimental
Yaohui Tang, Xinming Tong, Bogdan Conrad, Fan Yang
Article
Engineering, Biomedical
Alice E. Stanton, Xinming Tong, Fan Yang
APL BIOENGINEERING
(2019)
Review
Chemistry, Multidisciplinary
Dan He, Yawen Li, Fuwen Zhao, Yuze Lin
Summary: High trap density in organic solar cells leads to localized charge carriers and reduced carrier lifetime, limiting device efficiency. This feature article summarizes the recent advances of trap suppression by material design and device engineering.
CHEMICAL COMMUNICATIONS
(2024)
Review
Chemistry, Multidisciplinary
Olivier Monfort, Arshitha Madhusudhan, Martin Motola
Summary: This article presents the advantages of coupling photocatalysis and Fenton-based processes for environmental remediation and discusses their synergy. It critically examines the simultaneous triggering of these two processes and provides insights into research approaches. The study aims to enhance understanding of this complex process and highlight the potential integration of new catalysts in current wastewater treatment technology.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Manideepa Dhar, Chittaranjan Mishra, Avijit Das, Uttam Manna
Summary: An approach of 'polymerization of monomers in its aggregated form' has been introduced to tailor the water wettability of fibrous and porous substrates, achieving hydrophobicity to superhydrophobicity transition, as well as patterned wettability. This facile chemical method provides a durable coating with adjustable and patterned wettability for various potential applications.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Saswat Ranjan Bhoi, Chhanda Debnath, Shikha Gandhi
Summary: In this article, a novel catalytic reaction using Pd(0) and Bronsted acid is reported for the synthesis of biologically important imidazolidinone-fused N-heterocycles through redox-neutral intramolecular N-allylation of indoles and pyrroles with alkynes. This atom-economical method is applicable to a wide range of substrates and eliminates the need for leaving groups or oxidizing agents commonly used in traditional allylation reactions.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Longkun Chen, Mingshuai Zhang, Meichen Liu, Zhuoyuan Liu, Yuetong Qiu, Zhilai Zhang, Fuchao Yu, Jiuzhong Huang
Summary: In this study, an efficient Rh(III)-catalyzed selective mono- and dual-C-H bond functionalization/cyclization with iodonium ylide as the sole coupling partner was demonstrated. Fused benzodiazepine skeletons were obtained in excellent yields, providing an improved approach to dual C-H unsymmetrical functionalization.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Alice Kennett, Sven Epple, Gabriella van der Valk, Irene Georgiou, Evelyne Gout, Romain R. Vives, Angela J. Russell
Summary: This study presents the design and synthesis of sulfated disaccharide inhibitors based on IdoA(2S)-GlcNS(6S), which showed potent inhibition of Sulf-2. The results suggest that IdoA(2S)-GlcNS(6S) is the shortest fragment size required for effective inhibition of Sulfs, and a trisulfated disaccharide is identified as the minimal fragment size of heparan sulfate for effective endosulfatase inhibition.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Mauro Garbini, Andrea Brunetti, Riccardo Pedrazzani, Magda Monari, Massimo Marcaccio, Giulio Bertuzzi, Marco Bandini
Summary: The self-adaptability of galvanostatic electrolysis was found to be helpful in a multistage chemo- and diastereoselective electrochemically promoted cyclodimerization of chalcones. Through a series of reductive events, densely functionalized cyclopentanes with five contiguous stereocenters were obtained (25 examples, yields up to 95%, dr values up to >20:1). Further experimental and electrochemical investigations indicated the crucial role of dynamic kinetic resolution of the aldol intermediate in the reaction mechanism.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Dhananjay S. Nipate, Neha Meena, Prakash N. Swami, Krishnan Rangan, Anil Kumar
Summary: In this study, the synthesis of functionalized benzo[a]phenazines and indazolo[2,3-a]quinolines was achieved through Rh(III)-catalyzed oxidative annulation of 2-arylquinoxalines and 2-aryl-2H-indazoles with allyl alcohols. The method showed a wide substrate scope, excellent functional group tolerance, good to high yields of annulated products, and the capability for scaled-up synthesis. A tentative mechanism of the annulation reaction was proposed based on a preliminary mechanistic investigation.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Ruonan Zhang, Abudukadi Tudi, Xia Yang, Xuping Wang, Zhihua Yang, Shujuan Han, Shilie Pan
Summary: A new lead tellurium borate material with a unique fundamental building block [B4O10] was synthesized and found to exhibit high birefringence. The structure-property relationship was discussed using first-principles calculations.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Amresh Kumar Singh, Baishali Thakurta, Anupam Giri, Monalisa Pal
Summary: This study introduces three key concepts for the quick synthesis of large-scale high-quality 2D materials films and their utilization in device fabrication.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Reina Hagiwara, Shun Nishimura, Kosuke Okeyoshi
Summary: A copolymer-conjugated nanocatalytic system has been developed to improve electron transfer and enhance photoinduced H2 generation.
CHEMICAL COMMUNICATIONS
(2024)
