A novel magnetic mesoporous silica packed S-shaped microfluidic reactor for online proteolysis of low-MW proteome

Magnetic mesoporous silica with a magnetic cover and mesoporous core was synthesized, filled with trypsin and located in an S-shaped microfluidic reactor. High-molecular weight (MW) proteins were split to waste by fractionation, whilst low-MW proteins were retained on the chip to be digested.