4.7 Article

Dendron-mediated self-assembly of highly PEGylated block copolymers: a modular nanocarrier platform

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CHEMICAL COMMUNICATIONS
卷 47, 期 37, 页码 10302-10304

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ROYAL SOC CHEMISTRY
DOI: 10.1039/c1cc14331j

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  1. University of Illinois Foundation
  2. NIH [C06RR15482]
  3. NATIONAL CENTER FOR RESEARCH RESOURCES [C06RR015482] Funding Source: NIH RePORTER

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PEGylated dendron coils (PDCs) were investigated as a novel potential nanocarrier platform. PDCs self-assembled into micelles at lower CMCs than linear copolymer counterparts by 1-2 orders of magnitude, due to the unique architecture of dendrons. MD simulations also supported thermodynamically favourable self-assembly mediated by dendrons.

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