Article
Polymer Science
Paolo Ravarino, Santanu Panja, Dave J. Adams
Summary: This paper proposes a new methodology to control the formation and growth of hydrogels by utilizing the diffusion and hydrolysis of a specific compound from an organic solution to the gel media.
MACROMOLECULAR RAPID COMMUNICATIONS
(2022)
Article
Chemistry, Physical
Dipankar Ghosh, Pooja Chaudhary, Aathira Pradeep, Surendra Singh, Jayakumar Rangasamy, Krishna K. Damodaran
Summary: Low molecular weight N-oxide hydrogelators were synthesized by modifying the pyridyl functional groups of hydrazone/semicarbazone compounds. The water solubility of the hydrazone gelator was enhanced by the structural modification to pyridyl-N-oxide hydrazides. The stability, morphology, and stimuli-responsive properties of the gels were analyzed, and the hydrazone gels showed antibacterial activity and biocompatibility.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Agriculture, Multidisciplinary
Most. Sharmin Sultana, Shun-ichi Yamamoto, Md. Sanaullah Biswas, Chisato Sakurai, Hayato Isoai, Jun'ichi Mano
Summary: This study reveals that reactive carbonyl species, generated downstream of reactive oxygen species, are the primary cause of plant growth retardation under salt stress.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Anna Pecherina, Marina Grinberg, Maria Ageyeva, Daria Zanegina, Elena Akinchits, Anna Brilkina, Vladimir Vodeneev
Summary: Salinity is a common factor that limits crop productivity. The negative effects of salt stress on plant processes are caused by osmotic stress and toxic ions. The study investigated how salinity affects photosynthesis, transpiration, water content, and cytosolic pH in tobacco and potato plants. Salinity decreased photosynthesis activity and led to a decrease in water content and transpiration. The cytosolic pH also decreased in tobacco and potato plants. The study analyzed potential mechanisms of the effects of salinity on photosynthesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Taiga Uekusa, Kiyohiko Sugano
Summary: During the dissolution of drug salt particles, liquid-liquid phase separation (LLPS) can occur within the unstirred water layer (UWL) when the concentration of the free form exceeds the intrinsic LLPS concentration. This study aimed to predict UWL-LLPS based on the physicochemical properties of drugs. Different model drug salts were selected and their pH and concentration values were calculated. The predicted UWL-LLPS was compared with observed results, showing good agreement except for one drug.
MOLECULAR PHARMACEUTICS
(2023)
Article
Biochemistry & Molecular Biology
Alejandro Heres, Marta Gallego, Leticia Mora, Fidel Toldra
Summary: Reducing salt in meat products can affect the natural mechanisms of proteolysis, leading to changes in texture and flavor. This study quantified the presence of dipeptides in low-salt Spanish dry-cured ham using mass spectrometry. The results showed a correlation between these dipeptides and taste attributes, as well as potential health benefits.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Patrick K. Capon, Aimee J. Horsfall, Jiawen Li, Erik P. Schartner, Asma Khalid, Malcolm S. Purdey, Robert A. McLaughlin, Andrew D. Abell
Summary: A new coating procedure for optical fibre sensors suitable for protein analytes detection was presented in this study. The detection of streptavidin by binding to functionalised D-biotin was demonstrated, with stability to washing and long-term exposure to water. Different coating methods were employed to isolate SBP-biotin on the outer surface of the silk layer for optimal detection.
Article
Engineering, Environmental
Zonglin Li, Chuanqi Sun, Longwei Lou, Zhimin Li
Summary: This study investigates a method to alter enzymatic pH adaptation by studying the PfkB family of enzymes. It is found that these enzymes have pH promiscuity, and changing a few amino acids in a specific region can significantly alter their pH adaptation without affecting their function. Structural analysis suggests that the pH adaptation of the enzyme is influenced by changes in the salt bridge network. Furthermore, the researchers successfully modified the pH adaptation of an enzyme unrelated to the PfkB function using the same strategy.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Chemistry, Inorganic & Nuclear
Mohammad Rasel Mian, Unjila Afrin, Shinya Takaishi, Brian K. Breedlove, Masahiro Yamashita, Hiroaki Iguchi
Summary: New Magnus' green salt (MGS) analogues with Pd and Pt ions were synthesized, forming linear chain structures with hexagonal plate crystals. An unusual trigonal grade separation of chain complexes was observed. These findings provide new insight for preparing large crystals of MGS analogues and constructing trigonal grade-separated nanowires in molecular crystals.
DALTON TRANSACTIONS
(2023)
Article
Biochemistry & Molecular Biology
Tze-Yen Lin, Danye Jiang, Wan-Ru Chen, Jhih Syuan Lin, Xin-Yu Zhang, Chih-Hung Chen, Chia-Lang Hsu, Liang-Chuan Lai, Ping-Hung Chen, Kai-Chien Yang, Lauren H. Sansing, Che-Feng Chang
Summary: A high-salt diet leads to sustained sterile inflammation and worsens tissue injury, impairing long-term brain recovery after intracerebral hemorrhage. The mechanism involves the downregulation of NR4a family and mitochondrial oxidative phosphorylation, leading to innate immune priming and training in hematopoietic stem and progenitor cells. This research uncovers the link between high-salt diet-induced innate immune memory and persistent dysregulated inflammatory responses, highlighting NR4a1 as a potential therapeutic target.
Article
Chemistry, Inorganic & Nuclear
Sourav Sutradhar, Subham Basak, Dipankar Das, Biswa Nath Ghosh
Summary: We reported the ability of 4'- (4-methoxyphenyl) -2,2 ': 6',2''-terpyridine L to form hydrogels with different transition metal ions in a mild acidic medium. Irreversible, thixotropic and translucent hydrogels were obtained with divalent Cu2+, Zn2+, Cd2+ and Hg2+ ions. The hydrogels exhibited different structures, with Cu2+ hydrogel showing a fibrous network, Zn2+ hydrogel having a non-uniform fibrous structure, and Cd2+ and Hg2+ hydrogels having flake-like structures. Additionally, Zn2+, Cd2+ and Hg2+ hydrogels showed blue fluorescence when exposed to UV light (365 nm).
Article
Polymer Science
Kazi M. Zakir Hossain, Vincenzo Calabrese, Marcelo A. da Silva, Saffron J. Bryant, Julien Schmitt, Jennifer H. Ahn-Jarvis, Frederick J. Warren, Yaroslav Z. Khimyak, Janet L. Scott, Karen J. Edler
Summary: The study investigated the effects of salt content and different pH environments on the rheological properties of cellulose nanofibril and starch-based hydrogels. It was found that salt increased the stiffness of the gels, while pH affected the growth and stability of the gels.
Article
Biochemistry & Molecular Biology
Yuan Gao, Axue Wu, Yuan Li, Yaoguang Chang, Changhu Xue, Qingjuan Tang
Summary: The intake of carrageenan under high-sucrose or high-salt diet increases the risk of carrageenan-induced colitis and leads to changes in gut microbiota and metabolites.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Applied
Tongze Zhang, Kehu Li, Xinghua Ding, Zhongquan Sui, Qiong-Qiong Yang, Nagendra P. Shah, Guoqing Liu, Harold Corke
Summary: The study found that salt content and pH value have an impact on starch properties, with salt addition significantly altering thermal and pasting properties, while pH changes mainly affect Delta H. Other properties are generally stable under different pH conditions.
Article
Chemistry, Applied
Tongze Zhang, Kehu Li, Xinghua Ding, Zhongquan Sui, Qiong-Qiong Yang, Nagendra P. Shah, Guoqing Liu, Harold Corke
Summary: Variation in salt content and pH can affect the properties of proso millet starch, with salt addition significantly altering pasting properties and gelatinization temperatures. The pH mainly impacts Delta H, while the interactive effects of salt and pH affect Delta H in starch-water system. The response of different genotypes of starch to thermal and pasting properties under the same pH and salinity conditions varied, possibly due to the dual roles of ions in starch-water system.
Article
Neurosciences
Luca Biasetti, Stephanie Rey, Milena Fowler, Arjuna Ratnayaka, Kate Fennell, Catherine Smith, Karen Marshall, Catherine Hall, Mariana Vargas-Caballero, Louise Serpell, Kevin Staras
Summary: Alzheimer's disease is associated with increased levels of A beta in the brain, and this study investigates the impact of A beta on functional presynaptic vesicle pools. The researchers found that A beta treatment led to an enlargement of functional vesicles and an accumulation of recycled vesicles near endocytic sites. This resulted in deficits in vesicle retrieval pathways and limited information signaling capacity. Treatment with an antiepileptic drug partially rescued these transmission defects.
Review
Chemistry, Multidisciplinary
Dave J. Adams
Summary: Low molecular weight gels are formed by the self-assembly of small molecules into anisotropic structures that can immobilize solvents. Despite their common occurrence and wide range of applications, there are significant gaps and challenges in our understanding of these systems.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Polymer Science
Paolo Ravarino, Santanu Panja, Dave J. Adams
Summary: This paper proposes a new methodology to control the formation and growth of hydrogels by utilizing the diffusion and hydrolysis of a specific compound from an organic solution to the gel media.
MACROMOLECULAR RAPID COMMUNICATIONS
(2022)
Article
Mechanics
Osama M. Maklad, Kate McAulay, Sandra Lerouge, Dave J. Adams, Robert J. Poole
Summary: This article investigates the rheological properties of functionalised dipeptides that self-assemble in water to form micellar aggregates. The study demonstrates the high elasticity of the solutions and the significant normal-stress differences. The article also highlights the challenges in measuring the normal-stress differences using different rheometers and geometries.
Article
Chemistry, Multidisciplinary
Libby J. Marshall, Matthew Wallace, Najet Mahmoudi, Giuseppe Ciccone, Claire Wilson, Massimo Vassalli, Dave J. Adams
Summary: Multicomponent supramolecular systems can achieve different properties and new behaviors compared to single-component systems. In this study, a two-component system is used to modify the assembly of the gelling component, resulting in co-assembled structures that cannot be formed by the gelling component alone. The systems are characterized at multiple length scales, and the addition of a second component enhances the mechanical properties of the multicomponent noodles, allowing the preparation of hierarchical composite noodles.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Paolo Ravarino, Santanu Panja, Simona Bianco, Todor Koev, Matthew Wallace, Dave J. Adams
Summary: This study presents a new method to convert between co-assembled and self-sorted networks in multicomponent gels using a pH-driven annealing process. By controlling the pH changes, the gel structures and compositions can be manipulated, leading to a wide range of morphologies and complexities.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Inorganic & Nuclear
Gabrielle Audsley, Harry Carpenter, Nsikak B. Essien, James Lai-Morrice, Youssra Al-Hilaly, Louise C. Serpell, Geoffrey R. Akien, Graham J. Tizzard, Simon J. Coles, Cristina Pubill Ulldemolins, George E. Kostakis
Summary: Two propeller-shaped chiral CoIII3YIII complexes synthesized using fluorinated ligands were characterized by various techniques. These complexes were found to have sensing and discrimination abilities, which allowed for the development of an innovative 19F NMR chemosensory system. Control experiments and theoretical studies provided insights into the sensing mechanism, and the limitations of this method were discussed.
INORGANIC CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Qingwen Guan, Kate McAulay, Tian Xu, Sarah E. Rogers, Charlotte Edwards-Gayle, Ralf Schweins, Honggang Cui, Annela M. Seddon, Dave J. Adams
Summary: Self-sorting in functionalized dipeptide systems can occur based on the chirality of a single amino acid, both in the micellar state at high pH and in the gel state at low pH. The resulting structures are influenced by the relative concentrations of the components, demonstrating the complexity of this approach. The gel network's structures are determined by the micellar structures at high pH. Using small-angle neutron scattering and cryo-transmission electron microscopy (cryo-TEM), we provide strong evidence for self-sorting in both the micellar and gel phases, showing complete self-sorting across a range of relative concentrations.
Article
Chemistry, Multidisciplinary
Lisa Thomson, Rebecca E. Ginesi, Daniel D. Osborne, Emily R. Draper, Dave J. Adams
Summary: Gels formed from PBI can exhibit the photothermal effect, where the formation of PBI radical anions results in new absorption bands that can be used to induce heating of the gel through irradiation. We demonstrate the use of electrochemical methods and multicomponent systems to generate radical anions without UV light, and how this photothermal effect can be used to induce phase transitions in solutions above the gels.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Materials Science, Multidisciplinary
Dipankar Ghosh, Libby J. Marshall, Giuseppe Ciccone, Wanli Liu, Adam Squires, Annela Seddon, Massimo Vassalli, Dave J. Adams
Summary: Supramolecular assembly can be used to fabricate complex functional materials, but controlling hierarchical assembly across multiple length scales is difficult. This study investigates the correlation between a supramolecular gel network and a pre-gelling aggregate using a functional dipeptide 2NapFF. By varying the counterions, different micellar structures can be formed at high pH. Replacing the counterions with a divalent calcium salt results in a cross-linked gel network or an analog gel noodles.
MACROMOLECULAR MATERIALS AND ENGINEERING
(2023)
Article
Biochemistry & Molecular Biology
Max J. S. Hill, Ana M. Fuentes-Caparros, Dave J. Adams
Summary: We investigated the effects of spatial constraints on hydrogels formed by dipeptide-based low molecular weight gelators. The gels were formed by either solvent switch or pH change methods in vessels of different sizes to produce gels of different thicknesses. Confocal microscopy and cavitation rheology were used to examine the microstructures and mechanical properties of the gels. Our results show that solvent-switch-triggered gels are sensitive to spatial constraints, while pH-triggered gels are not. These findings are important for applications requiring gels of different thicknesses.
Article
Chemistry, Physical
Libby J. Marshall, Simona Bianco, Rebecca E. Ginesi, James Doutch, Emily R. Draper, Dave J. Adams
Summary: Preparation of multicomponent systems allows for changing the properties of low molecular weight gelator-based systems. By varying the concentration ratio, we can tune the properties of the multicomponent systems before gelation, during gelation, and in the gel state. Changing the chirality of a single component also affects the properties of these systems. This work provides insights into tuning the properties of multicomponent systems composed of two gelators with the same basic structural design.
Article
Chemistry, Multidisciplinary
Courtenay Patterson, Santanu Panja, Wanli Liu, Andrew R. Mount, Adam Squires, Dave J. Adams
Summary: We demonstrate the use of Fmoc-3 to form hydrogels at basic pH and achieve the first electrodeposition of a low molecular weight gelator at high pH using an electrochemically generated pH gradient. Additionally, we show that electrodeposition can facilitate the simultaneous growth of two hydrogels at opposing pH extremes on different electrodes.
MATERIALS CHEMISTRY FRONTIERS
(2023)
Correction
Chemistry, Physical
Jaclyn Raeburn, Guillaume Pont, Lin Chen, Yann Cesbron, Raphael Levy, Dave J. Adams
Article
Chemistry, Multidisciplinary
Rui Huang, Daniel McDowall, Henry Ng, Lisa Thomson, Youssra K. Al-Hilaly, James Doutch, Sam Burholt, Louise C. Serpell, Robert J. Poole, Dave J. Adams
Summary: A functionalized dipeptide that self-assembles into wormlike micelles at high pH can act as a surfactant, and by varying salt concentration, the self-assembled structures and interactions can be changed, resulting in solutions with different shear and extensional viscosity. Gel noodles with different mechanical properties can be prepared from these solutions.
CHEMICAL COMMUNICATIONS
(2022)
Review
Chemistry, Multidisciplinary
Dan He, Yawen Li, Fuwen Zhao, Yuze Lin
Summary: High trap density in organic solar cells leads to localized charge carriers and reduced carrier lifetime, limiting device efficiency. This feature article summarizes the recent advances of trap suppression by material design and device engineering.
CHEMICAL COMMUNICATIONS
(2024)
Review
Chemistry, Multidisciplinary
Olivier Monfort, Arshitha Madhusudhan, Martin Motola
Summary: This article presents the advantages of coupling photocatalysis and Fenton-based processes for environmental remediation and discusses their synergy. It critically examines the simultaneous triggering of these two processes and provides insights into research approaches. The study aims to enhance understanding of this complex process and highlight the potential integration of new catalysts in current wastewater treatment technology.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Manideepa Dhar, Chittaranjan Mishra, Avijit Das, Uttam Manna
Summary: An approach of 'polymerization of monomers in its aggregated form' has been introduced to tailor the water wettability of fibrous and porous substrates, achieving hydrophobicity to superhydrophobicity transition, as well as patterned wettability. This facile chemical method provides a durable coating with adjustable and patterned wettability for various potential applications.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Saswat Ranjan Bhoi, Chhanda Debnath, Shikha Gandhi
Summary: In this article, a novel catalytic reaction using Pd(0) and Bronsted acid is reported for the synthesis of biologically important imidazolidinone-fused N-heterocycles through redox-neutral intramolecular N-allylation of indoles and pyrroles with alkynes. This atom-economical method is applicable to a wide range of substrates and eliminates the need for leaving groups or oxidizing agents commonly used in traditional allylation reactions.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Longkun Chen, Mingshuai Zhang, Meichen Liu, Zhuoyuan Liu, Yuetong Qiu, Zhilai Zhang, Fuchao Yu, Jiuzhong Huang
Summary: In this study, an efficient Rh(III)-catalyzed selective mono- and dual-C-H bond functionalization/cyclization with iodonium ylide as the sole coupling partner was demonstrated. Fused benzodiazepine skeletons were obtained in excellent yields, providing an improved approach to dual C-H unsymmetrical functionalization.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Alice Kennett, Sven Epple, Gabriella van der Valk, Irene Georgiou, Evelyne Gout, Romain R. Vives, Angela J. Russell
Summary: This study presents the design and synthesis of sulfated disaccharide inhibitors based on IdoA(2S)-GlcNS(6S), which showed potent inhibition of Sulf-2. The results suggest that IdoA(2S)-GlcNS(6S) is the shortest fragment size required for effective inhibition of Sulfs, and a trisulfated disaccharide is identified as the minimal fragment size of heparan sulfate for effective endosulfatase inhibition.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Mauro Garbini, Andrea Brunetti, Riccardo Pedrazzani, Magda Monari, Massimo Marcaccio, Giulio Bertuzzi, Marco Bandini
Summary: The self-adaptability of galvanostatic electrolysis was found to be helpful in a multistage chemo- and diastereoselective electrochemically promoted cyclodimerization of chalcones. Through a series of reductive events, densely functionalized cyclopentanes with five contiguous stereocenters were obtained (25 examples, yields up to 95%, dr values up to >20:1). Further experimental and electrochemical investigations indicated the crucial role of dynamic kinetic resolution of the aldol intermediate in the reaction mechanism.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Dhananjay S. Nipate, Neha Meena, Prakash N. Swami, Krishnan Rangan, Anil Kumar
Summary: In this study, the synthesis of functionalized benzo[a]phenazines and indazolo[2,3-a]quinolines was achieved through Rh(III)-catalyzed oxidative annulation of 2-arylquinoxalines and 2-aryl-2H-indazoles with allyl alcohols. The method showed a wide substrate scope, excellent functional group tolerance, good to high yields of annulated products, and the capability for scaled-up synthesis. A tentative mechanism of the annulation reaction was proposed based on a preliminary mechanistic investigation.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Ruonan Zhang, Abudukadi Tudi, Xia Yang, Xuping Wang, Zhihua Yang, Shujuan Han, Shilie Pan
Summary: A new lead tellurium borate material with a unique fundamental building block [B4O10] was synthesized and found to exhibit high birefringence. The structure-property relationship was discussed using first-principles calculations.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Amresh Kumar Singh, Baishali Thakurta, Anupam Giri, Monalisa Pal
Summary: This study introduces three key concepts for the quick synthesis of large-scale high-quality 2D materials films and their utilization in device fabrication.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Reina Hagiwara, Shun Nishimura, Kosuke Okeyoshi
Summary: A copolymer-conjugated nanocatalytic system has been developed to improve electron transfer and enhance photoinduced H2 generation.
CHEMICAL COMMUNICATIONS
(2024)
