期刊
JOURNAL OF GENERAL VIROLOGY
卷 96, 期 -, 页码 2661-2669出版社
SOC GENERAL MICROBIOLOGY
DOI: 10.1099/vir.0.000213
关键词
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资金
- Health and Labour Sciences Research Grant for Research on Emerging and Re-emerging Infectious Diseases by the Ministry of Health, Labour, and Welfare in Japan [H24-Shinkou-007]
- JSPS [25460577]
- Japan Foundation for Pediatric Research [13-008]
- Grants-in-Aid for Scientific Research [25460577] Funding Source: KAKEN
The characteristics of genotype V Japanese encephalitis virus (GV JEV) remain poorly understood as only two strains have been isolated to date. In this study, we examined the effects of the GV JEV Muar strain on in vitro growth and pathogenicity in mice; we also evaluated the efficacy of inactivated JEV vaccines against the Muar strain. Although growth of the Muar strain in mouse neuroblastoma N18 cells was clearly worse than that of the Gill Beijing-1 and GI Mie/41/2002 strains, neuroinvasiveness of the Muar strain was similar to that of the Beijing-1 strain and significantly higher than that of the Mie/41/2002 strain. The results of a plaque reduction neutralization test suggested that the neutralization ability of the JEV vaccines against the Muar strain was reduced compared with the GI and GIII strains. However, the protection potency of the JEV vaccine against the Muar strain was similar to that for the Beijing-1 strain in mice. Our data indicate that GV JEV has unique growth, virulence and antigenicity features.
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