期刊
CHEMICAL COMMUNICATIONS
卷 47, 期 5, 页码 1434-1436出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c0cc04670a
关键词
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资金
- University of Berne
- Swiss National Science Foundation
A combinatorial library of 15 536 cyclic decapeptide analogues of tyrocidine A and gramicidin S was prepared on photocleavable TentaGel beads. The beads were photolyzed without solvent, and spread onto an agar plate inoculated with bacterial lawn. Clear zones were formed around beads carrying antimicrobially active peptides such as E18 c(kVOrnLfThiYOrnLq), which inhibited growth of B. subtilis and selected MRSA strains.
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