Article
Biochemistry & Molecular Biology
Chitra Padmakumari Kurup, Syazana Abdullah Lim, Minhaz Uddin Ahmed
Summary: This paper provides a comprehensive review of electrochemiluminescent (ECL) nanomaterial-based aptasensors, including their challenges and applications. The incorporation of nanomaterials for signal amplification is highlighted, and various nanomaterials such as gold nanoparticles, metal nanoparticles, metal oxides, carbon nanomaterials, metal organic frameworks, and quantum dots are discussed. The review also presents relevant concepts and explanations for the design of ECL aptasensors and discusses the underlying problems and possibilities for future research and development in this field.
BIOELECTROCHEMISTRY
(2022)
Article
Biophysics
Zhenqiang Ning, Mengyuan Chen, Guoqiu Wu, Yuanjian Zhang, Yanfei Shen
Summary: Nucleic acids play a significant role in ECL biosensing, offering versatile selective molecular recognition and programmable self-assembly for robust nanostructure construction. ECL biosensing based on nucleic acids has seen rapid growth due to their unique structures and physiochemical properties, with applications as molecular recognition elements, signal amplification units, and sensing interface schemes for future developments.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Chemistry, Analytical
Shu-Ying Ye, Chang-Gang Pan, Yu-Hua Dai, Guo-Xi Liang
Summary: An ultrasensitive biosensor for the detection of telomerase activity was constructed utilizing gold@Carbon dots nanohybrids (Au@CDs) as a high efficiency electrochemiluminescence (ECL) emitter and nicking enzyme assisted signal amplification (NESA) technology. By employing a dual signal amplification strategy, the biosensor showed excellent sensitivity and detection limit for telomerase activity.
MICROCHEMICAL JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
Qian Zhang, Minying Wu, Yuanyuan Fang, Chao Deng, Hsin-Hui Shen, Yi Tang, Yajun Wang
Summary: In this study, Pt nanoparticles-loaded nitrogen-doped mesoporous carbon nanotube (Pt/NMCT) was successfully synthesized through a polydopamine-mediated one-pot co-deposition strategy. The loading process of Pt was studied and the catalytic performance of Pt/NMCT was investigated, showing the importance of the hierarchical pore structure for catalytic activity.
Article
Chemistry, Physical
Xinqi Liu, Huiling Yuan, Qian Zheng, Bingyuan Huang, Fang Liao, Hejun Gao, Hongquan Fu, Juan Zhang, Yunwen Liao
Summary: This study found that nitrogen- and oxygen-doped carbon nanotubes are effective agents for capturing iodine in a low concentration iodine solution. The iodine uptake capacity is determined by the presence of hydroxy-functional groups and oxygen and nitrogen species in the carbon nanotubes, rather than defects and surface area. Oxygen-doped carbon nanotubes exhibit more than 2.5 times higher iodine adsorption activity compared to nitrogen-doped carbon nanotubes, making them potential carbon materials for practical iodine adsorption applications. The theoretical study enhances our understanding of iodine adsorption sites on carbon nanotubes, providing a new method for designing and synthesizing high-performance radioactive iodine solid adsorbents in the future.
APPLIED SURFACE SCIENCE
(2023)
Article
Chemistry, Analytical
Yuchan Ma, Yu Zhang, Jiaqi Gao, Hui Ouyang, Yong He, Zhifeng Fu
Summary: Ni single-atom catalysts (SACs) were synthesized and functionalized to develop highly sensitive electrochemiluminescent (ECL) probes for biosensors. The functionalized Ni SACs exhibited good aqueous dispersibility and could significantly enhance the ECL signal, making them suitable for various applications in biosensing.
ANALYTICAL CHEMISTRY
(2022)
Article
Environmental Sciences
Xue Zhang, Chunyue Cui, Qingzhu Zheng, Ying Wang, Jing Chang, Shuxian Wang
Summary: Nitrogen-doped carbon nanotubes (N-CNTs) were synthesized via a hydrothermal method and further modified with magnetic Co0.5Cu0.5Fe2O4 nanoparticles to enhance adsorption characteristics. The resulting materials, M-N-CNTs, showed high affinities towards different chlorophenols and exhibited good microwave absorption performance, with the ability to be regenerated by microwave irradiation with high efficiencies (>90%) and maintained high stabilities.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Chemistry, Analytical
Bo Shen, Li Li, Changjin Liu, Xinmin Li, Xinyu Li, Xiaoxue Cheng, Haiping Wu, Tiantian Yang, Wei Cheng, Shijia Ding
Summary: An ultrasensitive electrochemiluminescent (ECL) biosensor was constructed for accurate detection of exosomal microRNAs (exomiRNAs), using a three-dimensional (3D) walking nanomotor-mediated CRISPR/Cas12a and tetrahedral DNA nanostructures (TDNs)-modified nanoemitters (TCPP-Fe@HMUiO@Au-ABEI). The biosensor achieved a limit of detection down to 273.20 aM and successfully discriminated breast cancer patients.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Kentaro Ito, Kumi Y. Inoue, Kosuke Ino, Hitoshi Shiku
Summary: In this study, a high-sensitivity dual immunoassay using Lumulus amebocyte lysate (LAL) and blood coagulation cascade reactions with redox cycling in a nanoscale-gap electrode was developed. The dual immunoassay showed high sensitivity for detecting two types of analytes, and the signal amplification by the cascade reactions and the use of redox cycling in a nanoscale gap contributed to the high sensitivity. The cross reaction between the LAL and coagulation cascade reactions was minimized by bisecting the beads after the immunocomplex formation. The dual immunoassay demonstrated its potential for clinical diagnosis requiring the detection of multiple analytes.
ANALYTICAL CHEMISTRY
(2022)
Review
Biotechnology & Applied Microbiology
Yanna Shao, Huan Zhou, Qingping Wu, Yonghua Xiong, Juan Wang, Yu Ding
Summary: This study systematically discusses the importance of enzyme-based signal transduction patterns in immunoassay, as well as different strategies for enhancing the output signals of enzymes to significantly improve the sensitivity of enzyme-based immunosensors. The article categorizes these strategies into three categories and discusses the current focus and future direction of enzyme-based immunoassays.
BIOTECHNOLOGY ADVANCES
(2021)
Article
Chemistry, Analytical
Danli Hu, Haiyan Cui, Xinyang Wang, Fang Luo, Bin Qiu, Weicheng Cai, Hui Huang, Jian Wang, Zhenyu Lin
Summary: An innovative photo-electrochemical aptasensor based on Au/GaN photoelectrode has been developed for cancer biomarker detection. The sensor combines the characteristics of Au promoting charge transfer and aptamer high selectivity, showing high sensitivity and selectivity in detecting AFP concentration ranging from 1.0-150 ng/mL.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Physical
Tayyaba Najam, Shumaila Ibraheem, Muhammad Altaf Nazir, Asma Shaheen, Amir Waseem, Muhammad Sufyan Javed, Syed Shoaib Ahmad Shah, Xingke Cai
Summary: This study discusses a novel non-precious metal-based catalyst which shows remarkable performance in oxygen/hydrogen evolution reactions within nitrogen-doped carbon nanotubes, indicating potential for efficient water-splitting operations.
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
(2021)
Article
Chemistry, Analytical
Jie Liu, Yue Zhang, Ruo Yuan, Yaqin Chai
Summary: In this study, fluorine-nitrogen co-doped carbon dots (FNCDs) were used as a novel electrochemiluminescence (ECL) emitter for ultrasensitive detection of human immunodeficiency virus (HIV) DNA fragment. The doping of fluorine and nitrogen in carbon dots (CDs) improved the ECL intensity and stability of FNCDs by forming hydrogen bonds and changing the charge distribution. The ECL biosensor fabricated using exonuclease III (Exo III)-assisted amplification achieved ultrasensitive detection of HIV-DNA fragment.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Chemistry, Analytical
Xinxin Pi, Zhibin Qu, Fei Sun, Zekun Zhang, Jihui Gao
Summary: This study prepared nitrogen-doped hierarchical porous bio-char through a simple catalytic activation process, showing excellent adsorption properties for VOCs, especially significant advantages in the combined adsorption of multiple VOCs molecules.
JOURNAL OF ANALYTICAL AND APPLIED PYROLYSIS
(2021)
Article
Chemistry, Analytical
Mingwang Liu, Guojuan Chen, Ying Qin, Jinli Li, Liuyong Hu, Wenling Gu, Chengzhou Zhu
Summary: Nanozymes are recognized as promising alternatives to natural enzymes due to their high stability and superior activity. In this study, mesoporous trimetallic AuPtPd nanospheres were synthesized with efficient oxidase and peroxidase-like activities, which can synergistically catalyze different reactions. Inspired by the proton-dependent catalytic activity of nanozymes, researchers successfully established a self-regulated dual-modal PEC and electrochemical bioassay of urease activity.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Yu Du, Xiaoyue Zhang, Yue Jia, Rui Feng, Tingting Wu, Nuo Zhang, Huangxian Ju
Summary: The researchers proposed a host-guest recognition strategy to enhance the electrochemiluminescence (ECL) efficiency and stability of gold nanoclusters (AuNCs). The prepared AuNCs showed improved ECL emission efficiency and stability, and exhibited excellent sensing results for D-dimer.
ANALYTICAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Chao Wang, Songqin Liu, Huangxian Ju
Summary: This article reviews the origin and development of electrochemiluminescent nanoemitters and their application in sensitive detection of protein biomarkers. It specifically focuses on metal-organic frameworks (MOFs)-based nanoemitters and discusses effective strategies to enhance the electrochemiluminescent response and improve immunosensing sensitivity. The article comprehensively presents the application of electrochemiluminescent nanoemitters in the diagnosis of cancers and other diseases, particularly lung cancer and heart diseases. The recent advancement of electrochemiluminescent imaging with nanoemitters for the detection of multiplex protein biomarkers on single cell membranes is also highlighted. Finally, the future opportunities and challenges in the field of electrochemiluminescent biosensing are discussed.
BIOELECTROCHEMISTRY
(2023)
Article
Chemistry, Analytical
Junjie Hu, Fei Liu, Yunlong Chen, Jia Fu, Huangxian Ju
Summary: This work proposed a signal-on mass spectrometric biosensing strategy with a phospholipid-structured mass-encoded microplate for assessment of multiplex MMP activities, which is of great importance for cancer diagnosis and staging.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Ze-Rui Zhou, Da-Wei Li, Ruo-Can Qian, Huangxian Ju
Summary: We developed a DNAzyme-powered DNA walker to visualize the cooperative expression of mutant p53 and telomerase in living cells. The DNA walker allows for real-time monitoring of mutant p53 and active telomerase expression in cancer cells, providing new insights into the study of cancer pathway-relevant biomarkers.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Lele Li, Siqi Yu, Jie Wu, Huangxian Ju
Summary: We developed a sensitive electrochemiluminescence (ECL) biosensing strategy for the detection of activated CRISPR/Cas12a using polymer dots (Pdots) as emitters. The strategy involves the regulation of binding between Pdots-DNA and a biosensor, and the enhancement of ECL emission through the local surface plasmon resonance (LSPR) effect of electrochemically deposited Au nanoparticles (depAuNPs). The integration of target DNA-triggered catalysis and the LSPR effect greatly improves the sensitivity of ECL analysis.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Weisu Kong, Da Zhu, Yong Zhang, Rengan Luo, Jing Ma, Jianping Lei, Huangxian Ju
Summary: To improve the photoelectrochemical performance, an additional electron donor/acceptor is typically needed to suppress electron-hole recombination. However, the enhancement is limited due to long-distance diffusion. In this study, a self-supplying electron strategy is designed by coordinating an electron donor 1.4-diazabicyclo[2.2.2]octane (Dabco) in a metal-organic framework (MOF) to enhance PEC performance. The presence of Dabco effectively inhibits electron-hole recombination and leads to a 23.2-fold enhancement in photocurrent. This work provides a new approach for improving the PEC performance of nanomaterials.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Shiyi Bi, Wei Chen, Yanyun Fang, Yingfei Wang, Qing Zhang, Hongqian Guo, Huangxian Ju, Ying Liu
Summary: Clustering of cell membrane receptors can regulate cell behaviors. This study presents a Raji cell Selective MAnipulation of Receptor Clustering (SMARC) strategy for CD20, which is driven by endogenous secretion of Raji cells. The strategy utilizes retractable DNA nanostrings anchored to the cell membrane CD20, which contract in response to Raji cell-secreted VEGF with corresponding CD20 clustering. The SMARC strategy selectively induces apoptosis in Raji cells with minimal interference to normal B cells, and shows promising in vivo therapeutic efficacy.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Review
Chemistry, Multidisciplinary
Rengan Luo, Da Zhu, Huangxian Ju, Jianping Lei
Summary: Electrochemiluminescence (ECL) is a powerful technique that relies on charge transfer between electrochemical intermediates and co-reactants/emitters to form excited emitters. The development of molecular nanocrystals, such as metal-organic frameworks (MOFs) and covalent organic frameworks (COFs), has allowed for the exploration of ECL mechanisms and enhancement strategies. Reticular crystalline nanoemitters with different topologies provide a platform for understanding ECL fundamentals and designing next-generation ECL devices.
ACCOUNTS OF CHEMICAL RESEARCH
(2023)
Article
Chemistry, Analytical
Xue Wang, Dongquan Leng, Faying Li, Lei Liu, Xiang Ren, Jin Yong Lee, Huangxian Ju, Qin Wei
Summary: An efficient photoelectrochemical (PEC) split-type sensor based on a controlled release strategy was successfully established for ultrasensitive and accurate physiological monitoring, with improved visible light absorption efficiency and stability. The sensor separated the immune reaction from the photoelectrochemical conversion process, eliminating interference. The use of Cu2O nanocubes as labels and acid etching improved the sensitivity of the sensor. Under optimized conditions, the PEC sensor showed a wide concentration linear range and a low detection limit for CYFRA21-1 target detection.
ANALYTICA CHIMICA ACTA
(2023)
Article
Chemistry, Multidisciplinary
Shiya Zhao, Yuanjiao Yang, Yuru Wang, Huipu Liu, Huangxian Ju, Yunlong Chen
Summary: This study presents a functional dendrimer probe that can conveniently detect newly generated sialic acid groups in vivo using a dual-color imaging strategy. It enables the in situ semiquantitative evaluation of sialylation differences between tumor and normal tissues, allowing the investigation of sialylation-related biological events and facilitating clinical tumor diagnosis.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Jun Sun, Jie Wu, Huangxian Ju
Summary: The motion ability of enzyme-powered micro/nanomotors is primarily determined by the size of the silica rather than the asymmetric coating of the enzyme. Silica micro/nanomotors at sizes of 500 nm and 2 μm show significant increases in diffusion coefficient, while those larger than 5 μm do not exhibit self-propulsion behavior at all. Although asymmetry enhances the diffusion of the micro/nanomotors, only those at a size of 2 μm are sensitive to the level of asymmetry.
CHEMISTRY-AN ASIAN JOURNAL
(2023)
Article
Chemistry, Analytical
Xue Dong, Xiaoyue Zhang, Xiang Ren, Hongmin Ma, Nuo Zhang, Faying Li, Huangxian Ju, Qin Wei
Summary: In this study, a bandgap-regulated ECL enhancement strategy was developed to improve the ECL efficiency of ZrO2. Through the synthesis of ZrCuO3, which exhibited a narrower bandgap and higher electron transfer efficiency, the ECL efficiency of ZrO2 was enhanced. This strategy provides a novel approach for the sensitive detection of target substances.
ANALYTICAL CHEMISTRY
(2023)
Review
Chemistry, Multidisciplinary
Yuanjiao Yang, Shan Wu, Yunlong Chen, Huangxian Ju
Summary: The detection and mapping of cellular biomarkers is crucial for understanding physiological and pathological processes. SERS technology, with its high sensitivity and multiplex detection capabilities, has emerged as a powerful tool for this purpose.
Article
Chemistry, Multidisciplinary
Farukh Mansoor, Huangxian Ju, Madiha Saeed, Shamsa Kanwal
Summary: This work explores a new precursor for the facile synthesis of gold nanocubes by controlling the morphology of silver nanocubes. The Ag@4MBA@AuNCs nanostructure exhibits a 1010-times enhancement in surface enhanced Raman scattering (SERS) signal, making it a highly sensitive imaging probe for the detection of breast cancer cells. Additionally, this study achieves the catalytic reduction of toxic chemicals through the incorporation of alloy nanoparticles.
Article
Chemistry, Analytical
Jiajun Liu, Yu Du, Aiping Guo, Nuo Zhang, Lei Liu, Dawei Fan, Xue Dong, Qin Wei, Huangxian Ju
Summary: In this study, a sandwich sensing platform was developed using silica-coated silver nanoparticles as a luminescent material and cerium dioxide as a signal quencher for sensitive neuro-specific enolase detection. The core-shell structure protected the silver nanoparticles and improved their luminescence properties. Amino-functionalized cerium dioxide efficiently diminished the luminescence signal, resulting in a highly sensitive and accurate detection mode. This detection strategy showed a powerful capability for biomolecule detection.
Review
Chemistry, Multidisciplinary
Dan He, Yawen Li, Fuwen Zhao, Yuze Lin
Summary: High trap density in organic solar cells leads to localized charge carriers and reduced carrier lifetime, limiting device efficiency. This feature article summarizes the recent advances of trap suppression by material design and device engineering.
CHEMICAL COMMUNICATIONS
(2024)
Review
Chemistry, Multidisciplinary
Olivier Monfort, Arshitha Madhusudhan, Martin Motola
Summary: This article presents the advantages of coupling photocatalysis and Fenton-based processes for environmental remediation and discusses their synergy. It critically examines the simultaneous triggering of these two processes and provides insights into research approaches. The study aims to enhance understanding of this complex process and highlight the potential integration of new catalysts in current wastewater treatment technology.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Manideepa Dhar, Chittaranjan Mishra, Avijit Das, Uttam Manna
Summary: An approach of 'polymerization of monomers in its aggregated form' has been introduced to tailor the water wettability of fibrous and porous substrates, achieving hydrophobicity to superhydrophobicity transition, as well as patterned wettability. This facile chemical method provides a durable coating with adjustable and patterned wettability for various potential applications.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Saswat Ranjan Bhoi, Chhanda Debnath, Shikha Gandhi
Summary: In this article, a novel catalytic reaction using Pd(0) and Bronsted acid is reported for the synthesis of biologically important imidazolidinone-fused N-heterocycles through redox-neutral intramolecular N-allylation of indoles and pyrroles with alkynes. This atom-economical method is applicable to a wide range of substrates and eliminates the need for leaving groups or oxidizing agents commonly used in traditional allylation reactions.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Longkun Chen, Mingshuai Zhang, Meichen Liu, Zhuoyuan Liu, Yuetong Qiu, Zhilai Zhang, Fuchao Yu, Jiuzhong Huang
Summary: In this study, an efficient Rh(III)-catalyzed selective mono- and dual-C-H bond functionalization/cyclization with iodonium ylide as the sole coupling partner was demonstrated. Fused benzodiazepine skeletons were obtained in excellent yields, providing an improved approach to dual C-H unsymmetrical functionalization.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Alice Kennett, Sven Epple, Gabriella van der Valk, Irene Georgiou, Evelyne Gout, Romain R. Vives, Angela J. Russell
Summary: This study presents the design and synthesis of sulfated disaccharide inhibitors based on IdoA(2S)-GlcNS(6S), which showed potent inhibition of Sulf-2. The results suggest that IdoA(2S)-GlcNS(6S) is the shortest fragment size required for effective inhibition of Sulfs, and a trisulfated disaccharide is identified as the minimal fragment size of heparan sulfate for effective endosulfatase inhibition.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Mauro Garbini, Andrea Brunetti, Riccardo Pedrazzani, Magda Monari, Massimo Marcaccio, Giulio Bertuzzi, Marco Bandini
Summary: The self-adaptability of galvanostatic electrolysis was found to be helpful in a multistage chemo- and diastereoselective electrochemically promoted cyclodimerization of chalcones. Through a series of reductive events, densely functionalized cyclopentanes with five contiguous stereocenters were obtained (25 examples, yields up to 95%, dr values up to >20:1). Further experimental and electrochemical investigations indicated the crucial role of dynamic kinetic resolution of the aldol intermediate in the reaction mechanism.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Dhananjay S. Nipate, Neha Meena, Prakash N. Swami, Krishnan Rangan, Anil Kumar
Summary: In this study, the synthesis of functionalized benzo[a]phenazines and indazolo[2,3-a]quinolines was achieved through Rh(III)-catalyzed oxidative annulation of 2-arylquinoxalines and 2-aryl-2H-indazoles with allyl alcohols. The method showed a wide substrate scope, excellent functional group tolerance, good to high yields of annulated products, and the capability for scaled-up synthesis. A tentative mechanism of the annulation reaction was proposed based on a preliminary mechanistic investigation.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Ruonan Zhang, Abudukadi Tudi, Xia Yang, Xuping Wang, Zhihua Yang, Shujuan Han, Shilie Pan
Summary: A new lead tellurium borate material with a unique fundamental building block [B4O10] was synthesized and found to exhibit high birefringence. The structure-property relationship was discussed using first-principles calculations.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Amresh Kumar Singh, Baishali Thakurta, Anupam Giri, Monalisa Pal
Summary: This study introduces three key concepts for the quick synthesis of large-scale high-quality 2D materials films and their utilization in device fabrication.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Reina Hagiwara, Shun Nishimura, Kosuke Okeyoshi
Summary: A copolymer-conjugated nanocatalytic system has been developed to improve electron transfer and enhance photoinduced H2 generation.
CHEMICAL COMMUNICATIONS
(2024)
