Article
Chemistry, Organic
Kanna Mori, Kaori Sakurai
Summary: Rapid access to appropriately functionalized probes is crucial in chemical labeling approaches to target identification studies. We successfully demonstrated the utility of clickable gold-nanoparticles as generic probe precursors for one-step ligand derivatization by click chemistry and facile photoaffinity labeling application, using cholesterol as a model ligand for endogenously expressed oxysterol-binding protein (OSBP) in cell lysate.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2021)
Article
Materials Science, Multidisciplinary
Maria San Anselmo, Elena Lantero, Yunuen Avalos-Padilla, Ines Bouzon-Arnaiz, Miriam Ramirez, Alejandro Postigo, Jose Luis Serrano, Teresa Sierra, Silvia Hernandez-Ainsa, Xavier Fernandez-Busquets
Summary: The development of improved therapeutic compounds and targeted delivery strategies for antimalarial drugs is essential due to the increasing resistance of Plasmodium to existing medication. This study presents the use of dendronized hyperbranched polymers (DHPs) coated with heparin for specific targeting of Plasmodium-infected red blood cells. The resulting DHP-heparin complexes exhibit antimalarial activity and specific targeting capabilities.
ACS APPLIED POLYMER MATERIALS
(2023)
Review
Materials Science, Biomaterials
Xiaoli Cai, Ming Jin, Longfukang Yao, Bin He, Saeed Ahmed, Waseem Safdar, Ijaz Ahmad, Dong-Bing Cheng, Zhixin Lei, Taolei Sun
Summary: Nanocarriers are promising in drug controlled-release, but their clinical applications are limited due to unclear processes and mechanisms. This review summarizes the effects of nanocarrier properties on in vivo behaviors and medical applications, and provides strategies for enhancing clinical efficacy and safety by introducing tracing technology.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Materials Science, Biomaterials
Felix Reisbeck, Stefanie Wedepohl, Mathias Dimde, Ann-Cathrin Schmitt, Jens Dernedde, Miguel Alvaro-Benito, Christian Freund, Rainer Haag
Summary: The synthesis of dendritic polyglycerol (dPG) and dPG-based nanogels (NGs) as platforms for multivalent display of molecules and as carrier units is reported in this study. The functionalized nanogels successfully conjugated with model proteins and demonstrated potential in activating T cells. The results suggest the great potential of these platforms for a broad range of applications with the capability to attach biotinylated molecules straightforwardly.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Article
Polymer Science
Salma E. Ahmed, Nicholas L. Fletcher, Amber R. Prior, Pie Huda, Craig A. Bell, Kristofer J. Thurecht
Summary: Modern polymerisation techniques allow synthesis of functional block copolymers that can self-assemble into degradable nanoparticles. These polymeric platforms have great potential in delivering anticancer drugs in a targeted and controlled manner while reducing side effects. In this study, we synthesized amphiphilic block copolymers and formed crosslinked yet degradable micelles and polymersomes encapsulating doxorubicin. The results showed that these systems efficiently retained and released the drug, demonstrating high biocompatibility and enhanced cytotoxicities in cancer cells.
Article
Chemistry, Applied
Nagendra Kalva, Saji Uthaman, Eun Hye Jang, Rimesh Augustine, Su Hyeon Jeon, Kang Moo Huh, In-Kyu Park, Il Kim
Summary: A facile one-pot approach was developed to prepare amphiphilic aggregation-induced emission (AIE)-active hyperbranched fluorescent nanoparticles with a core-shell structure, showing strong blue luminescence in aqueous solution. These nanoparticles exhibited high water solubility, good photostability, and biological imaging properties, with low cytotoxicity and excellent biocompatibility indicated by cell viability assay and confocal microscopy imaging. Thus, TPE-HPG FPNs are promising for biomedical applications.
Article
Materials Science, Multidisciplinary
Jian Sun, Yu-Lin Hong, Xiu-Qin Fang, Chang Wang, Cheng-Mei Liu
Summary: Fluorescent phosphine oxide-containing hyperbranched polyesters were synthesized via solvent-free polycondensation and exhibited bright blue fluorescence under 365 nm ultraviolet light due to the clustering of electron-rich moieties. HBP2 showed concentration-enhanced emission and excitation-dependent emission characteristics in dimethylformamide. It was also proven to be a selective and sensitive sensor for Fe3+ detection with a low detection limit of 0.59 mM.
JOURNAL OF MATERIALS CHEMISTRY C
(2023)
Article
Chemistry, Multidisciplinary
Asier R. R. Muguruza, Alessandro di Maio, Nikolas J. J. Hodges, Jessica M. A. Blair, Zoe Pikramenou
Summary: In this study, a novel hybrid silica nanoparticle system was designed, which carried membrane targeting groups and encapsulated antibiotics along with a ruthenium luminescent tracking agent for optical detection of nanoparticle delivery in bacterial cells. The hybrid system successfully delivered vancomycin and exhibited efficacy against various Gram-negative bacterial species. The penetration of nanoparticles in bacterial cells was confirmed via the luminescence of the ruthenium signal. These findings demonstrate that nanoparticles modified with aminopolycarboxylate chelating groups can serve as an effective delivery system for inhibiting bacterial growth in species where molecular antibiotics are ineffective. This design provides a new platform for delivering antibiotics that cannot penetrate the bacterial membrane alone.
NANOSCALE ADVANCES
(2023)
Article
Chemistry, Multidisciplinary
Subharanjan Biswas, Lakshmi Priya Datta, Tapan Kumar Das
Summary: This study reports a combinatorial strategy to design an antibacterial drug delivery scaffold effective against E. coli, which can deliver the anticancer drug doxorubicin in a stimuli-responsive manner. Such a combinational design is expected to establish a new avenue for the use of bioresources in therapeutic applications.
NEW JOURNAL OF CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Jing Sun, Xiaodan Yan, Lingzheng Wang, Zhenlang Xie, Guolong Tian, Lin Wang, Ayisha He, Simin Li, Qingxiang Guo, Jinlu He, Hui Shen
Summary: A family of 29 copper nanoclusters with precise structures has been prepared, showing different surface properties but the same Cu-13 kernel. These clusters exhibit distinct optical profiles and catalytic performance, indicating the importance of surface structure in shaping the behaviors of copper nanomolecules. This work not only exemplifies the efficiency of surface engineering for controlling properties of well-defined copper nanoclusters but also provides a new family of Cu materials with controlled surface motifs.
INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Zhicheng Jiang, Jinjie Duan, Xingjie Guo, Ya Ma, Chunjiong Wang, Bi Shi
Summary: In this study, gold (Au) nanoparticles supported on lignin-tannin (LT) micro-/nanoparticles were prepared via a green and novel method without the use of an additional reducing agent. Increasing the proportion of tannins led to higher amounts of Au species on LT particles, but also decreased the thermal stability of the particles.
Article
Chemistry, Physical
Dmitry A. Migulin, Julia Rozanova, Vasily A. Migulin, Georgy Cherkaev, Ivan B. Meshkov, Alexey A. Zezin, Aziz M. Muzafarov
Summary: In this study, two new types of polymers were synthesized and characterized for their ability to stabilize ultra-small silver nanoparticles and efficiently modify chemical surfaces. The size and distribution of the silver nanoparticles were controlled through a chemically assisted radiation process. The developed functional polymers have important applications in the preparation of nanocomposite coatings.
Review
Polymer Science
Shuaikai Ren, Mengjie Wang, Chunxin Wang, Yan Wang, Changjiao Sun, Zhanghua Zeng, Haixin Cui, Xiang Zhao
Summary: This review highlighted the importance of non-viral vectors in gene therapy and drug delivery, due to their low immunogenicity, good biocompatibility, easy synthesis and modification, and low cost of production. The review summarized various non-viral vectors including polymers, liposomes, gold nanoparticles, mesoporous silica nanoparticles and carbon nanotubes, discussing their physicochemical characteristics, synthesis methods, functional modifications, and research applications, as well as future research directions.
Article
Chemistry, Multidisciplinary
Mahboobeh Jafari, Samira Sadat Abolmaali, Sedigheh Borandeh, Haniyeh Najafi, Zahra Zareshahrabadi, Omid Koohi-Hosseinabadi, Negar Azarpira, Kamiar Zomorodian, Ali Mohammad Tamaddon
Summary: In this study, new polyhedral oligomeric silsesquioxane – hyperbranched polyglycerol dendrimers were developed to improve the safety and therapeutic efficacy of AMB. The synthesized dendrimers showed lower concentrations and toxicities against Candida spp. compared to conventional formulations, and they effectively protected mice from severe Candida infections and reduced organ injuries caused by AMB.
Review
Pharmacology & Pharmacy
Yuxue Cao, Prarthana Rewatkar, Ran Wang, Sumaira Z. Hasnain, Amirali Popat, Tushar Kumeria
Summary: Biologics, or macromolecular therapeutics of biological origin, have emerged as a rapidly growing class of drugs for the treatment of chronic and acute conditions. However, their administration via the parenteral route results in high cost, low patient compliance, and systemic toxicity, prompting researchers to focus on developing carriers for oral delivery. This review examines the challenges of oral biologics delivery, discusses conventional formulation strategies and their limitations, and explores the progress and limitations of using nanocarriers for oral delivery of biologics.
TRENDS IN PHARMACOLOGICAL SCIENCES
(2021)
Article
Multidisciplinary Sciences
Damiano G. Barone, Alejandro Carnicer-Lombarte, Panagiotis Tourlomousis, Russell S. Hamilton, Malwina Prater, Alexandra L. Rutz, Ivan B. Dimov, George G. Malliaras, Stephanie P. Lacour, Avril A. B. Robertson, Kristian Franze, James W. Fawcett, Clare E. Bryant
Summary: Fibrotic scarring caused by foreign body reaction (FBR) obstructs the functional interaction of implantable medical devices with host tissue. In a peripheral nerve injury-implant model, FBR shows dysregulated innate immune features and increased myofibroblast activity and inflammasome constituents. The use of NLRP3 inflammasome inhibitor MCC950 can reduce fibrosis and inflammation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Biochemistry & Molecular Biology
Walhan Alshaer, Hamdi Nsairat, Zainab Lafi, Omar M. Hourani, Abdulfattah Al-Kadash, Ezaldeen Esawi, Alaaldin M. Alkilany
Summary: Nanomedicine is a growing field and liposomal formulations are a major platform in this field. Quality by design (QbD) is a powerful approach that can be applied to develop liposomal-based nano-pharmaceuticals, ensuring efficient and safe therapeutics. This review discusses the current practices of employing QbD in this area.
Article
Nanoscience & Nanotechnology
Sagnik Middya, Alejandro Carnicer-Lombarte, Vincenzo F. F. Curto, Sam Hilton, Andreas Genewsky, Alexandra L. L. Rutz, Damiano G. Barone, Gabriele S. Kaminski S. Schierle, Anton Sirota, George G. G. Malliaras
Summary: Traditionally, silicon probes have limitations in studying the brain due to the mechanical mismatch and resulting chronic damage to neural tissue. To overcome this, a flexible neural probe design that imitates the functionality of silicon arrays is presented, offering a tissue-compatible alternative for recording neural activity. The probe is delivered using a detachable 3D printed implanter through hydrophobic-coated shuttles, allowing for minimal movement. Validation experiments demonstrate the feasibility of long-term chronic monitoring of neural ensembles.
ADVANCED ELECTRONIC MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Abner Magalhaes Nunes, Priscila Falagan-Lotsch, Ayman Roslend, Mario Roberto Meneghetti, Catherine Jones Murphy
Summary: In this study, gold mini-rods and gold nanospheres of different sizes and shapes were synthesized and tested on human dermal fibroblasts. It was observed that the mini gold nanorods did not significantly affect cell viability, mitochondrial membrane potential, and levels of reactive oxygen species. The production of extracellular vesicles by the cells was also unaffected by exposure to gold nanoparticles. These results suggest that these mini gold nanorods are suitable for a wide range of short-term cellular applications.
NANOSCALE ADVANCES
(2023)
Review
Chemistry, Multidisciplinary
Katherine M. Greskovich, Kelly M. Powderly, Maegen M. Kincanon, Nathan B. Forney, Catherine A. Jalomo, Anita Wo, Catherine J. Murphy
Summary: Gold nanoparticles (AuNPs) and gold nanorods (AuNRs) have unique properties that make them applicable in various fields such as biosensing, medicine, and catalysis. This Account focuses on the soft surface coatings of AuNPs, which play a crucial role in their interactions with the surrounding environment. The postmodification of AuNP surface chemistry can significantly alter the colloidal stability, nano-bio interactions, and functionality of the nanoparticles. Techniques such as nuclear magnetic resonance (NMR) spectroscopy and electron energy loss spectroscopy (EELS) have been used to study the ligands on the surface of AuNPs and their distribution.
ACCOUNTS OF CHEMICAL RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Ephraim G. Morado, Mara L. Paterson, Douglas G. Ivanoff, Hsuan-Chin Wang, Alayna Johnson, Darius Daniels, Aoon Rizvi, Nancy R. Sottos, Steven C. Zimmerman
Summary: A mechanism for degrading polymers called cyclization-triggered chain cleavage (CATCH cleavage) that achieves dual requirements of strength and degradability has been reported. CATCH cleavage features a glycerol-based acyclic acetal unit as a trap for controlled chain breaks. Organic acid induces transient chain breaks with subsequent cyclization to fully depolymerize the polymer backbone at room temperature. This strategy has the potential for upcycling and may be applicable to various synthetic polymers and their waste streams.
Article
Multidisciplinary Sciences
Amy E. Rochford, Alejandro Carnicer-Lombarte, Malak Kawan, Amy Jin, Sam Hilton, Vincenzo F. Curto, Alexandra L. Rutz, Thomas Moreau, Mark R. N. Kotter, George G. Malliaras, Damiano G. Barone
Summary: The development of neural interfaces with improved biocompatibility and tissue integration is crucial for restoring neurological functions in the nervous system. To increase the resolution for mapping neuronal inputs onto implants, a new type of neural interface using iPSC-derived myocytes as biological targets has been developed. Long-term survival and functional integration of this biohybrid device have been demonstrated in freely moving rats, showing potential for restorative therapies using regenerative bioelectronics.
Article
Chemistry, Multidisciplinary
Sophia M. McClain, Moses H. Milchberg, Chad M. Rienstra, Catherine J. Murphy
Summary: The interaction between alpha-synuclein and synaptic vesicle mimics depends on the malleability and rigidity of the mimics, with higher binding affinities observed for rigid mimics. The lipid composition of the mimics also affects the interaction. The study provides insights into the behavior of alpha-synuclein and its relation to membrane properties.
Article
Chemistry, Multidisciplinary
Anis Daou, Shijimol M. Arakkal, Alaaldin M. Alkilany
Summary: In chemistry, a eutectic mixture is a mixture of two or more components in which the lowest possible freezing point is observed. Despite its significance in pharmaceutical compounding and formulation, the eutectic mixture is not extensively covered in standard pharmacy curricula. This study demonstrates the eutectic phenomenon using camphor and menthol as pharmaceutical active ingredients within practical temperature ranges, and shows its impact in drug compounding and formulation by preparing semisolid pharmaceutical dosage forms.
JOURNAL OF CHEMICAL EDUCATION
(2023)
Article
Chemistry, Multidisciplinary
Khoi Nguyen L. Hoang, Catherine J. Murphy
Summary: This study examines the interactions between oxidized and reduced PDI with citrate-coated AuNPs using various techniques. It is found that PDI adsorbs to the AuNP surface, leading to a reduction in its enzymatic activity, with limited changes in secondary structures.
Article
Chemistry, Multidisciplinary
Matthew T. Gole, Mohan T. Dronadula, Narayana R. Aluru, Catherine J. Murphy
Summary: Understanding the adsorption behavior of proteins on rough and wrinkled surfaces is crucial for biosensor and flexible biomedical device applications. This study investigates the nanoscale adsorption behavior of immunoglobulin M (IgM) and immunoglobulin G (IgG) on wrinkled and crumpled surfaces using atomic force microscopy (AFM). The results show that the presence of negative curvature on the wrinkled surface reduces protein surface coverage, mainly due to geometric hindrance and reduced binding energy, while smaller IgG molecules are not affected by this degree of curvature.
NANOSCALE ADVANCES
(2023)
Article
Chemistry, Multidisciplinary
Maegen Kincanon, Catherine J. Murphy
Summary: The self-assembly of colloidal nanocrystals is of great interest for creating hierarchical nanomaterials with advanced function. Gold nanocrystals can enhance local electric fields and provide plasmonic fields for surface-enhanced spectroscopies. A selective biotinylation method was developed for gold nanorods, allowing for self-assembly upon addition of streptavidin. The self-assembly was analyzed for different sized nanorods, showing high yield for larger nanorods and low yield for smaller nanorods.
Article
Materials Science, Biomaterials
Anna P. Goestenkors, Tianran Liu, Somtochukwu S. Okafor, Barbara A. Semar, Riley M. Alvarez, Sandra K. Montgomery, Lianna Friedman, Alexandra L. Rutz
Summary: The effect of gelling agent concentration (ionic liquid) on PEDOT:PSS hydrogel fabrication and properties was investigated. Gelation kinetics, stability, swelling, stiffness, conductivity, and support of seeded cells were characterized.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Chemistry, Multidisciplinary
Christian A. Reardon-Lochbaum, Ravithree D. Senanayake, Rocio Amaro Marquez, Kha Trinh, Khoi Nguyen L. Hoang, Tobias Rangel Guillen, Catherine J. Murphy, Robert J. Hamers, Joel A. Pedersen, Rigoberto Hernandez
Summary: Supported lipid bilayers are commonly used as model systems for studying interactions between biological membranes and proteins or nanoparticles. The choice of substrate material, such as gold or SiO2, influences the interactions and adsorption behavior of anionic nanoparticles and cytochrome c to the bilayers. The underlying substrate material plays a role in determining the extent of interaction between nanoscale analytes and supported lipid bilayers.
ENVIRONMENTAL SCIENCE-NANO
(2023)
Article
Chemistry, Medicinal
Sarah B. Krueger, Steven C. Zimmerman
Summary: This study reports a target-guided screening method based on dynamic covalent chemistry for identifying multitarget inhibitors. A library of amine- or aldehyde-containing fragments was synthesized and assembled, resulting in a diverse set of hit combinations. These hit combinations selectively and cooperatively inhibited transcription of myotonic dystrophy type 1 and Huntington's disease repeat sequences in vitro.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Review
Chemistry, Multidisciplinary
Dan He, Yawen Li, Fuwen Zhao, Yuze Lin
Summary: High trap density in organic solar cells leads to localized charge carriers and reduced carrier lifetime, limiting device efficiency. This feature article summarizes the recent advances of trap suppression by material design and device engineering.
CHEMICAL COMMUNICATIONS
(2024)
Review
Chemistry, Multidisciplinary
Olivier Monfort, Arshitha Madhusudhan, Martin Motola
Summary: This article presents the advantages of coupling photocatalysis and Fenton-based processes for environmental remediation and discusses their synergy. It critically examines the simultaneous triggering of these two processes and provides insights into research approaches. The study aims to enhance understanding of this complex process and highlight the potential integration of new catalysts in current wastewater treatment technology.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Manideepa Dhar, Chittaranjan Mishra, Avijit Das, Uttam Manna
Summary: An approach of 'polymerization of monomers in its aggregated form' has been introduced to tailor the water wettability of fibrous and porous substrates, achieving hydrophobicity to superhydrophobicity transition, as well as patterned wettability. This facile chemical method provides a durable coating with adjustable and patterned wettability for various potential applications.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Saswat Ranjan Bhoi, Chhanda Debnath, Shikha Gandhi
Summary: In this article, a novel catalytic reaction using Pd(0) and Bronsted acid is reported for the synthesis of biologically important imidazolidinone-fused N-heterocycles through redox-neutral intramolecular N-allylation of indoles and pyrroles with alkynes. This atom-economical method is applicable to a wide range of substrates and eliminates the need for leaving groups or oxidizing agents commonly used in traditional allylation reactions.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Longkun Chen, Mingshuai Zhang, Meichen Liu, Zhuoyuan Liu, Yuetong Qiu, Zhilai Zhang, Fuchao Yu, Jiuzhong Huang
Summary: In this study, an efficient Rh(III)-catalyzed selective mono- and dual-C-H bond functionalization/cyclization with iodonium ylide as the sole coupling partner was demonstrated. Fused benzodiazepine skeletons were obtained in excellent yields, providing an improved approach to dual C-H unsymmetrical functionalization.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Alice Kennett, Sven Epple, Gabriella van der Valk, Irene Georgiou, Evelyne Gout, Romain R. Vives, Angela J. Russell
Summary: This study presents the design and synthesis of sulfated disaccharide inhibitors based on IdoA(2S)-GlcNS(6S), which showed potent inhibition of Sulf-2. The results suggest that IdoA(2S)-GlcNS(6S) is the shortest fragment size required for effective inhibition of Sulfs, and a trisulfated disaccharide is identified as the minimal fragment size of heparan sulfate for effective endosulfatase inhibition.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Mauro Garbini, Andrea Brunetti, Riccardo Pedrazzani, Magda Monari, Massimo Marcaccio, Giulio Bertuzzi, Marco Bandini
Summary: The self-adaptability of galvanostatic electrolysis was found to be helpful in a multistage chemo- and diastereoselective electrochemically promoted cyclodimerization of chalcones. Through a series of reductive events, densely functionalized cyclopentanes with five contiguous stereocenters were obtained (25 examples, yields up to 95%, dr values up to >20:1). Further experimental and electrochemical investigations indicated the crucial role of dynamic kinetic resolution of the aldol intermediate in the reaction mechanism.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Dhananjay S. Nipate, Neha Meena, Prakash N. Swami, Krishnan Rangan, Anil Kumar
Summary: In this study, the synthesis of functionalized benzo[a]phenazines and indazolo[2,3-a]quinolines was achieved through Rh(III)-catalyzed oxidative annulation of 2-arylquinoxalines and 2-aryl-2H-indazoles with allyl alcohols. The method showed a wide substrate scope, excellent functional group tolerance, good to high yields of annulated products, and the capability for scaled-up synthesis. A tentative mechanism of the annulation reaction was proposed based on a preliminary mechanistic investigation.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Ruonan Zhang, Abudukadi Tudi, Xia Yang, Xuping Wang, Zhihua Yang, Shujuan Han, Shilie Pan
Summary: A new lead tellurium borate material with a unique fundamental building block [B4O10] was synthesized and found to exhibit high birefringence. The structure-property relationship was discussed using first-principles calculations.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Amresh Kumar Singh, Baishali Thakurta, Anupam Giri, Monalisa Pal
Summary: This study introduces three key concepts for the quick synthesis of large-scale high-quality 2D materials films and their utilization in device fabrication.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Reina Hagiwara, Shun Nishimura, Kosuke Okeyoshi
Summary: A copolymer-conjugated nanocatalytic system has been developed to improve electron transfer and enhance photoinduced H2 generation.
CHEMICAL COMMUNICATIONS
(2024)
