Article
Chemistry, Multidisciplinary
Tao Yan, Linlin Ren, Fengyan Li, Feng Tian, Chengfang Jiang, Qi Wang, Xinyue Song, Shusheng Zhang
Summary: This sequentially responsive nanocarrier integrates bio-imaging, tumor microenvironment responsive chemotherapy, and cascade activation of upconversion photodynamic therapy. It shows site-specific degradation in the designed DNA outer nanoshell, leading to high cell apoptosis ratios and significant tumor inhibition.
CHEMICAL COMMUNICATIONS
(2022)
Article
Materials Science, Biomaterials
Yilin Wang, Xuefan Xiong, Yanxi Zhu, Xinyue Song, Qiong Li, Shusheng Zhang
Summary: In this study, a pH-responsive nanoplatform was developed to combine gene therapy and chemotherapy for cancer treatment. Results showed that the combination therapy achieved better therapeutic efficacy in tumor inhibition compared to monotherapy.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2022)
Article
Nanoscience & Nanotechnology
Huimin Zhou, Yao Jiang, Wenjing Zhao, Shusheng Zhang
Summary: In this study, a light-activated nanodevice based on DNA nanotechnology was constructed for high precision detection of low-abundance miRNA. The nanodevice enabled on-demand imaging of miRNA in living cells with high spatial and temporal control.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Analytical
Feifei Xu, Qing Wang, Ling Jiang, Fawei Zhu, Lei Yang, Shusheng Zhang, Xiangzhi Song
Summary: IPF is a chronic and fatal lung disease. The DCM-NO probe can quickly detect IPF by monitoring changes in NO concentration, showing good response properties in vitro and ability to evaluate treatment effects.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Yao Jiang, Huimin Zhou, Wenjing Zhao, Shusheng Zhang
Summary: This study presents a self-assembled three-dimensional (3D) DNA nanostructure drug delivery system that utilizes ATP-triggered drug release for tumor fluorescence imaging and targeted therapy. The Dox@3D DNA nanostructures are assembled through a simple annealing reaction and can release drugs rapidly in tumor cells induced by high concentrations of ATP, providing efficient accumulation of drugs in tumors and minimizing damage to normal tissues.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Xiaoru Zhang, Yonghao Ge, Minghui Liu, Yujiao Pei, Peng He, Weiling Song, Shusheng Zhang
Summary: In this study, stable Janus nanoparticles (JNPs) were successfully prepared and used for in situ SERS detection and imaging analysis of cancer cells. The results showed that this method can improve the accuracy and sensitivity of cancer diagnosis and achieve a synergistic antitumor effect of chemotherapy and photodynamic therapy.
ANALYTICAL CHEMISTRY
(2022)
Article
Biophysics
Jiaju Shi, Chunqin Zhao, Meiqi Shen, Zichao Chen, Jinhua Liu, Shusheng Zhang, Zhen Zhang
Summary: This article discusses the advantages and disadvantages of label-free and label-based methods commonly used in the isolation of CTCs, and systematically reviews the most recent advances in the combination of microfluidic chips and biosensing for the enrichment of circulating tumor cells, proposing the current barriers and developmental trends in CTCs research.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Engineering, Environmental
Cheng Tian, Lei Zhao, Jin Zhu, Shusheng Zhang
Summary: In this study, a new SERS aptasensor was developed to simultaneously detect Hg2+ and Ag+ using cascade nucleic acid amplification strategy, which greatly improved the sensitivity. It can be widely applied for the detection of multiple heavy metal ions or other toxic substances in environmental water.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Nanoscience & Nanotechnology
Yingnan Sun, Yuhan Song, Haohan Sun, Qingqing Tian, Qian Wang, Yongshu Liu, Shusheng Zhang
Summary: This study develops a strategy to transform superhydrophobic surfaces into large label-free SERS substrates with uniform and dense hot spots, enabling sensitive and high-throughput detection.
ACS APPLIED NANO MATERIALS
(2022)
Article
Nanoscience & Nanotechnology
Wenxiu Han, Zizhen Wei, Lu Feng, Mei Yao, Huairong Zhang, Shusheng Zhang
Summary: The study developed a therapeutic platform by wrapping doxorubicin in mesoporous CNTs/Fe-N-C with the cell membrane, showing high antitumor activity due to efficient catalytic ability, increased drug release rates, and significant photothermal effect.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Review
Chemistry, Inorganic & Nuclear
Jiaju Shi, Zichao Chen, Chunqin Zhao, Meiqi Shen, Han Li, Shusheng Zhang, Zhen Zhang
Summary: Tumor metastasis is a leading cause of patient mortality. Tumor markers play a crucial role in improving the treatment success rate by reflecting tumor progression and prognosis. Recently, photoelectrochemical (PEC) sensors have emerged as a highly promising strategy for tumor marker analysis due to their high sensitivity and cost-effectiveness. Combining PEC technique with biosensing strategies offers higher specificity and sensitivity compared to conventional sensing methods. The development of novel PEC nanosensors using nanotechnology holds great potential for building more powerful signal amplification systems. This review focuses on the signal amplification strategies of PEC biosensors for tumor marker detection in the past 5 years, and discusses the future prospects and challenges in PEC biosensor development.
COORDINATION CHEMISTRY REVIEWS
(2022)
Article
Engineering, Environmental
Xinyue Song, Fengyan Li, Tao Yan, Feng Tian, Linlin Ren, Chengfang Jiang, Qi Wang, Shusheng Zhang
Summary: The wide use of pesticides has led to serious environmental pollution and health hazards. Developing feasible, fast, and accurate analysis methods for pesticide residues detection is of great importance. Sample pretreatment techniques play a key role in solving the challenges of detecting pesticide residues in complex sample matrices.
PROCESS SAFETY AND ENVIRONMENTAL PROTECTION
(2022)
Article
Chemistry, Analytical
Cheng Tian, Lei Zhao, Guoliang Qi, Jin Zhu, Shusheng Zhang
Summary: In this study, a SERS aptasensor was developed for fast and sensitive detection of SARS-CoV-2 virus. The sensor has the advantages of convenience, speed, sensitivity, and selectivity, making it a promising tool for analyzing viral particles in the environment and monitoring virus sources.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Chemistry, Analytical
Xiaoru Zhang, Yonghao Ge, Minghui Liu, Yujiao Pei, Peng He, Weiling Song, Shusheng Zhang
Summary: This study developed stable Janus nanoparticles for in situ SERS detection and imaging analysis of cancer cells, which can improve the accuracy and sensitivity of diagnosis by monitoring ATP and acid conditions. Additionally, these nanoparticles can also achieve a synergistic antitumor effect through chemotherapy/photodynamic therapy.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Wenjing Zhao, Yao Jiang, Huimin Zhou, Shusheng Zhang
Summary: DNA self-assembling nanoprobes with self-transferability and resistance to nuclease degradation have been developed and applied in live cell bio-imaging. A hairpin-functionalized DNA tetrahedron (HFDT) intramolecular catalytic self-assembly platform was designed to detect low-abundance miRNAs using catalyzed hairpin assembly (CHA). This innovative strategy effectively changes the distribution and properties of biomaterials, increases accumulation of nanomaterials at the tumor site, and has promising applications in tumor imaging.
Review
Chemistry, Multidisciplinary
Dan He, Yawen Li, Fuwen Zhao, Yuze Lin
Summary: High trap density in organic solar cells leads to localized charge carriers and reduced carrier lifetime, limiting device efficiency. This feature article summarizes the recent advances of trap suppression by material design and device engineering.
CHEMICAL COMMUNICATIONS
(2024)
Review
Chemistry, Multidisciplinary
Olivier Monfort, Arshitha Madhusudhan, Martin Motola
Summary: This article presents the advantages of coupling photocatalysis and Fenton-based processes for environmental remediation and discusses their synergy. It critically examines the simultaneous triggering of these two processes and provides insights into research approaches. The study aims to enhance understanding of this complex process and highlight the potential integration of new catalysts in current wastewater treatment technology.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Manideepa Dhar, Chittaranjan Mishra, Avijit Das, Uttam Manna
Summary: An approach of 'polymerization of monomers in its aggregated form' has been introduced to tailor the water wettability of fibrous and porous substrates, achieving hydrophobicity to superhydrophobicity transition, as well as patterned wettability. This facile chemical method provides a durable coating with adjustable and patterned wettability for various potential applications.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Saswat Ranjan Bhoi, Chhanda Debnath, Shikha Gandhi
Summary: In this article, a novel catalytic reaction using Pd(0) and Bronsted acid is reported for the synthesis of biologically important imidazolidinone-fused N-heterocycles through redox-neutral intramolecular N-allylation of indoles and pyrroles with alkynes. This atom-economical method is applicable to a wide range of substrates and eliminates the need for leaving groups or oxidizing agents commonly used in traditional allylation reactions.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Longkun Chen, Mingshuai Zhang, Meichen Liu, Zhuoyuan Liu, Yuetong Qiu, Zhilai Zhang, Fuchao Yu, Jiuzhong Huang
Summary: In this study, an efficient Rh(III)-catalyzed selective mono- and dual-C-H bond functionalization/cyclization with iodonium ylide as the sole coupling partner was demonstrated. Fused benzodiazepine skeletons were obtained in excellent yields, providing an improved approach to dual C-H unsymmetrical functionalization.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Alice Kennett, Sven Epple, Gabriella van der Valk, Irene Georgiou, Evelyne Gout, Romain R. Vives, Angela J. Russell
Summary: This study presents the design and synthesis of sulfated disaccharide inhibitors based on IdoA(2S)-GlcNS(6S), which showed potent inhibition of Sulf-2. The results suggest that IdoA(2S)-GlcNS(6S) is the shortest fragment size required for effective inhibition of Sulfs, and a trisulfated disaccharide is identified as the minimal fragment size of heparan sulfate for effective endosulfatase inhibition.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Mauro Garbini, Andrea Brunetti, Riccardo Pedrazzani, Magda Monari, Massimo Marcaccio, Giulio Bertuzzi, Marco Bandini
Summary: The self-adaptability of galvanostatic electrolysis was found to be helpful in a multistage chemo- and diastereoselective electrochemically promoted cyclodimerization of chalcones. Through a series of reductive events, densely functionalized cyclopentanes with five contiguous stereocenters were obtained (25 examples, yields up to 95%, dr values up to >20:1). Further experimental and electrochemical investigations indicated the crucial role of dynamic kinetic resolution of the aldol intermediate in the reaction mechanism.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Dhananjay S. Nipate, Neha Meena, Prakash N. Swami, Krishnan Rangan, Anil Kumar
Summary: In this study, the synthesis of functionalized benzo[a]phenazines and indazolo[2,3-a]quinolines was achieved through Rh(III)-catalyzed oxidative annulation of 2-arylquinoxalines and 2-aryl-2H-indazoles with allyl alcohols. The method showed a wide substrate scope, excellent functional group tolerance, good to high yields of annulated products, and the capability for scaled-up synthesis. A tentative mechanism of the annulation reaction was proposed based on a preliminary mechanistic investigation.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Ruonan Zhang, Abudukadi Tudi, Xia Yang, Xuping Wang, Zhihua Yang, Shujuan Han, Shilie Pan
Summary: A new lead tellurium borate material with a unique fundamental building block [B4O10] was synthesized and found to exhibit high birefringence. The structure-property relationship was discussed using first-principles calculations.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Amresh Kumar Singh, Baishali Thakurta, Anupam Giri, Monalisa Pal
Summary: This study introduces three key concepts for the quick synthesis of large-scale high-quality 2D materials films and their utilization in device fabrication.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Reina Hagiwara, Shun Nishimura, Kosuke Okeyoshi
Summary: A copolymer-conjugated nanocatalytic system has been developed to improve electron transfer and enhance photoinduced H2 generation.
CHEMICAL COMMUNICATIONS
(2024)
