期刊
CHEMICAL COMMUNICATIONS
卷 46, 期 35, 页码 6602-6604出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c0cc01933j
关键词
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资金
- Australian Research Council, U. Wollongong, Srinakharinwirot University
- Thailand Research Fund [MRG 4980158]
- Thai Commission on Higher Education
ESI mass spectrometry was used to assess the binding of 13-substituted, 5-nitro-2-phenylindolyl- and 2-naphthalenyl-based berberine derivatives to inter- and intramolecular G-quadruplex DNA molecules. In contrast with the parent berberine, the compounds showed selectivity for quadruplex over duplex DNA and stabilised the quadruplex structure. They represent a new class of quadruplex DNA-selective ligands.
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