Article
Chemistry, Organic
Yetong Zhang, Lepeng Chen, Yinlin Shao, Fangjun Zhang, Zhongyan Chen, Ningning Lv, Jiuxi Chen, Renhao Li
Summary: The study presents a three-component tandem reaction allowing the synthesis of polysubstitution quinolines using 2-aminobenzonitriles, arylboronic acids, and ketones. This method is practical, efficient, and delivers functional quinolines with moderate to good yields and high functional group tolerance. Additionally, a new method for introducing halogen substituents into the target products has been developed, showing potential for further synthetic elaborations.
ORGANIC CHEMISTRY FRONTIERS
(2021)
Article
Chemistry, Organic
Qiuyu Li, Rui Pan, Meihui Wang, Hequan Yao, Aijun Lin
Summary: In this study, ligand-controlled, palladium-catalyzed asymmetric [4+4] and [2+4] cycloaddition reactions of benzofuran-derived azadienes were developed. Different chiral ligands were utilized to synthesize various cyclic compounds with high enantioselectivity.
Article
Chemistry, Organic
Ke Li, Zhenjie Gan, Er-Qing Li, Zheng Duan
Summary: A novel phosphine-catalyzed (4 + 2) cyclization reaction has been reported for the generation of functionalized dihydropyran skeletons from electron-deficient conjugated dienes and enones. Mechanistic investigation reveals the formation of a new phosphonium zwitterion, which undergoes consecutive reactions. An asymmetric variant has also been developed through efficient and economical chiral phosphine catalysis.
Article
Chemistry, Physical
Jingyang Sun, Yoona Song, Jae-Sang Ryu
Summary: The gold-catalyzed cascade process for the synthesis of dihydroquinazolinone scaffolds exhibits good yields, high regioselectivity, and broad substrate scope. It can also be applied to the synthesis of tetracyclic dihydroquinazolinones and seven-membered ring-fused dihydroquinazolinones.
Article
Chemistry, Multidisciplinary
Joel Gubler, Mitar Radic, Yannick Stoeferle, Peter Chen
Summary: Au-catalyzed hydroamination is successful for alkynes but not alkenes. Gas-phase binding energy studies suggest that differences in binding are not responsible for the different chemical behavior. The synthesis and characterization of 2-aminoalkylgold complexes reveal that protonation or alkylation leads to amine elimination, indicating that a non-competitive protodeauration step is responsible for the failure of Au-catalyzed alkene hydroamination.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Article
Chemistry, Physical
Shengtong Niu, Yingkun Luo, Chao Xu, Jinggong Liu, Shuang Yang, Xinqiang Fang
Summary: In this work, a general protocol for copper-catalyzed allylic substitutions using stable soft nucleophiles has been developed, resulting in the synthesis of highly selective functionalized 1,3- and 1,4-enynes. Mechanistic studies propose a copper acetylide-bonded allylic cation as the key intermediate, featuring an outer-sphere nucleophilic attack. The demonstrated diversified reactivities in this study will inspire further exploration.
Article
Chemistry, Multidisciplinary
Swastik Karmakar, Prasanta Das, Sandip Kundu
Summary: A silver-catalyzed domino reaction has been developed to synthesize a series of 2-aryl/-heteroaryl dihydrofuroquinolines using aldehydes and unprotected precursors.
NEW JOURNAL OF CHEMISTRY
(2021)
Article
Chemistry, Organic
Chi-Fan Zhu, Cong-Hui Gao, Wen-Juan Hao, Yi-Long Zhu, Shu-Jiang Tu, De-Cai Wang, Bo Jiang
Summary: A novel chelation-controlled hydrofuranization of unactivated olefins using a-alkynyl arylols has been reported, leading to the production of a variety of C-3-alkylated benzofurans with good yields under mild conditions. The use of a bidentate directing group helps to suppress competing reactions and no additional ligands, additives, or bases/acids are required, making the transformation simple and efficient. This catalysis opens up new possibilities for catalytic difunctionalization of alkynes and olefins with 100% atom utilization.
ORGANIC CHEMISTRY FRONTIERS
(2021)
Article
Chemistry, Organic
Zhi-Yi Zhao, Xing-Guo Zhang, Hai-Yong Tu
Summary: A palladium-catalyzed cyclization reaction of phenols with trifluoromethyl-containing ortho-bromo-beta-chlorostyrenes has been developed, leading to the synthesis of 6-trifluoromethyldibenzo[b,d]oxepines through a tandem O-alkenylation and subsequent C-H arylation.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Robert J. Harris, Kohki Nakafuku, Alethea N. Duncan, Robert G. Carden, Jacob C. Timmerman, Ross A. Widenhoefer
Summary: The mechanism of intermolecular hydroamination of 3-methylbuta-1,2-diene with N-methylaniline catalyzed by (IPr)AuOTf has been studied, revealing a complex process involving reversible displacement reactions and the formation of cationic gold complexes.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Chemistry, Organic
Jia-Hui Yang, Lin Dong
Summary: A highly efficient Rh(III)-catalyzed tandem [4+2] annulation has been achieved to construct functional dihydroisoquinolinone derivatives with an alkenyl side chain by inserting into an N-O bond as an internal oxidation process. The wide range of 1,3-dienes as coupling partners makes this simple methodology even more useful.
SYNTHESIS-STUTTGART
(2022)
Article
Chemistry, Applied
Chunhao Yuan, Huimin Yang, Qi Gong, Shan Luo, Jing Gu, Yanqing Ge, Hongchao Guo, Lei Xie
Summary: A Bronsted base-catalyzed tandem reaction has been developed for the synthesis of functionalized thiazolo pyrones under mild conditions, showing fluorescent properties.
ADVANCED SYNTHESIS & CATALYSIS
(2021)
Article
Chemistry, Organic
Zhuo Chen, Xiao-Di Nie, Jian-Ting Sun, Ai-Mei Yang, Bang-Guo Wei
Summary: The Zn(OTf)(2)-catalyzed hydroamination of ynamides with aromatic amines has been developed, allowing for the synthesis of various substituted amidine compounds with moderate to excellent yields and high regioselectivities.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2021)
Article
Chemistry, Organic
Ming Li, Yuke Li, Wan-Yuan Jia, Guo-Qing Sun, Fan Gao, Guo-Xiao Zhao, Yi-Feng Qiu, Xi-Cun Wang, Yong-Min Liang, Zheng-Jun Quan
Summary: The free radical cyclization reaction is a promising strategy for the formation of ring frameworks. In this study, we report a copper-catalyzed tandem radical cyclization strategy for preparing substituted lactam derivatives. This reaction utilizes a radical coupling approach, allowing a wide range of alkenes and being compatible with primary, secondary, and tertiary radicals. Density functional theory calculations were also performed to gain insights into the reaction mechanism.
Article
Chemistry, Organic
Ryo Murakami, Hiroto Tanishima, Daisuke Naito, Hikari Kawamitsu, Ryoya Kamo, Ayaka Uchida, Kazuki Kawasaki, Chihiro Kiyohara, Motoki Matsuo, Kakeru Maeda, Fuyuhiko Inagaki
Summary: The study synthesized a cationic catalyst Au(DPB)X-3 with a specific ligand, which was successfully utilized in a specific reaction of yne-indoles.
TETRAHEDRON LETTERS
(2021)
Article
Biochemistry & Molecular Biology
F. Esra Onen-Bayram, Kerem Buran, Irem Durmaz, Barkin Berk, Rengul Cetin-Atalay
Article
Chemistry, Medicinal
F. Esra Onen Bayram, Hande Sipahi, Ebru Turkoz Acar, Reyhan Kahveci Ulugol, Kerem Buran, Hulya Akgun
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2016)
Article
Toxicology
M. Charehsaz, F. E. Onen-Bayram, H. Sipahi, K. Buran, A. K. Giri, A. Aydin
HUMAN & EXPERIMENTAL TOXICOLOGY
(2016)
Review
Chemistry, Physical
Veronika Urbanova, Gert-Wieland Kohring, Tobias Klein, Zhijie Wang, Olcay Mert, Mustafa Emrullahoglu, Kerem Buran, Ayhan S. Demir, Mathieu Etienne, Alain Walcarius
ZEITSCHRIFT FUR PHYSIKALISCHE CHEMIE-INTERNATIONAL JOURNAL OF RESEARCH IN PHYSICAL CHEMISTRY & CHEMICAL PHYSICS
(2013)
Article
Biochemistry & Molecular Biology
Kerem Buran, Silvia Bua, Giulio Poli, F. Esra Onen Bayram, Tiziano Tuccinardi, Claudiu T. Supuran
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Chemistry, Medicinal
Kerem Buran, Rengin Reis, Hande Sipahi, F. Esra Onen Bayram
Summary: In this study, 38 coumarin derivatives were synthesized by substituting carbon 8 of the benzopyran ring with some aromatic and aliphatically substituted piperidines and piperazines. Compounds 20 and 31 exhibited promising anti-inflammatory activity, showing better activity than the reference drugs.
ARCHIV DER PHARMAZIE
(2021)
Review
Chemistry, Multidisciplinary
Dan He, Yawen Li, Fuwen Zhao, Yuze Lin
Summary: High trap density in organic solar cells leads to localized charge carriers and reduced carrier lifetime, limiting device efficiency. This feature article summarizes the recent advances of trap suppression by material design and device engineering.
CHEMICAL COMMUNICATIONS
(2024)
Review
Chemistry, Multidisciplinary
Olivier Monfort, Arshitha Madhusudhan, Martin Motola
Summary: This article presents the advantages of coupling photocatalysis and Fenton-based processes for environmental remediation and discusses their synergy. It critically examines the simultaneous triggering of these two processes and provides insights into research approaches. The study aims to enhance understanding of this complex process and highlight the potential integration of new catalysts in current wastewater treatment technology.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Manideepa Dhar, Chittaranjan Mishra, Avijit Das, Uttam Manna
Summary: An approach of 'polymerization of monomers in its aggregated form' has been introduced to tailor the water wettability of fibrous and porous substrates, achieving hydrophobicity to superhydrophobicity transition, as well as patterned wettability. This facile chemical method provides a durable coating with adjustable and patterned wettability for various potential applications.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Saswat Ranjan Bhoi, Chhanda Debnath, Shikha Gandhi
Summary: In this article, a novel catalytic reaction using Pd(0) and Bronsted acid is reported for the synthesis of biologically important imidazolidinone-fused N-heterocycles through redox-neutral intramolecular N-allylation of indoles and pyrroles with alkynes. This atom-economical method is applicable to a wide range of substrates and eliminates the need for leaving groups or oxidizing agents commonly used in traditional allylation reactions.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Longkun Chen, Mingshuai Zhang, Meichen Liu, Zhuoyuan Liu, Yuetong Qiu, Zhilai Zhang, Fuchao Yu, Jiuzhong Huang
Summary: In this study, an efficient Rh(III)-catalyzed selective mono- and dual-C-H bond functionalization/cyclization with iodonium ylide as the sole coupling partner was demonstrated. Fused benzodiazepine skeletons were obtained in excellent yields, providing an improved approach to dual C-H unsymmetrical functionalization.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Alice Kennett, Sven Epple, Gabriella van der Valk, Irene Georgiou, Evelyne Gout, Romain R. Vives, Angela J. Russell
Summary: This study presents the design and synthesis of sulfated disaccharide inhibitors based on IdoA(2S)-GlcNS(6S), which showed potent inhibition of Sulf-2. The results suggest that IdoA(2S)-GlcNS(6S) is the shortest fragment size required for effective inhibition of Sulfs, and a trisulfated disaccharide is identified as the minimal fragment size of heparan sulfate for effective endosulfatase inhibition.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Mauro Garbini, Andrea Brunetti, Riccardo Pedrazzani, Magda Monari, Massimo Marcaccio, Giulio Bertuzzi, Marco Bandini
Summary: The self-adaptability of galvanostatic electrolysis was found to be helpful in a multistage chemo- and diastereoselective electrochemically promoted cyclodimerization of chalcones. Through a series of reductive events, densely functionalized cyclopentanes with five contiguous stereocenters were obtained (25 examples, yields up to 95%, dr values up to >20:1). Further experimental and electrochemical investigations indicated the crucial role of dynamic kinetic resolution of the aldol intermediate in the reaction mechanism.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Dhananjay S. Nipate, Neha Meena, Prakash N. Swami, Krishnan Rangan, Anil Kumar
Summary: In this study, the synthesis of functionalized benzo[a]phenazines and indazolo[2,3-a]quinolines was achieved through Rh(III)-catalyzed oxidative annulation of 2-arylquinoxalines and 2-aryl-2H-indazoles with allyl alcohols. The method showed a wide substrate scope, excellent functional group tolerance, good to high yields of annulated products, and the capability for scaled-up synthesis. A tentative mechanism of the annulation reaction was proposed based on a preliminary mechanistic investigation.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Ruonan Zhang, Abudukadi Tudi, Xia Yang, Xuping Wang, Zhihua Yang, Shujuan Han, Shilie Pan
Summary: A new lead tellurium borate material with a unique fundamental building block [B4O10] was synthesized and found to exhibit high birefringence. The structure-property relationship was discussed using first-principles calculations.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Amresh Kumar Singh, Baishali Thakurta, Anupam Giri, Monalisa Pal
Summary: This study introduces three key concepts for the quick synthesis of large-scale high-quality 2D materials films and their utilization in device fabrication.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Reina Hagiwara, Shun Nishimura, Kosuke Okeyoshi
Summary: A copolymer-conjugated nanocatalytic system has been developed to improve electron transfer and enhance photoinduced H2 generation.
CHEMICAL COMMUNICATIONS
(2024)